Identification
HMDB Protein ID CDBP04290
Secondary Accession Numbers Not Available
Name Y+L amino acid transporter 2
Description Not Available
Synonyms
  1. Cationic amino acid transporter, y+ system
  2. Solute carrier family 7 member 6
  3. Y+LAT2
  4. y(+)L-type amino acid transporter 2
  5. y+LAT-2
Gene Name SLC7A6
Protein Type Transporter
Biological Properties
General Function Involved in transport
Specific Function Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires co-expression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Also acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Involved in the transport of L-arginine in monocytes. Reduces uptake of ornithine in retinal pigment epithelial (RPE) cells
GO Classification
Component
membrane
cell part
Function
active transmembrane transporter activity
transmembrane transporter activity
amine transmembrane transporter activity
amino acid transmembrane transporter activity
transporter activity
Process
establishment of localization
transport
amine transport
amino acid transport
transmembrane transport
Cellular Location
  1. Multi-pass membrane protein
  2. Basolateral cell membrane
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 16q22.1
SNPs SLC7A6
Gene Sequence
>1548 bp
ATGGAAGCCAGGGAGCCTGGGAGGCCCACACCCACCTACCATCTTGTCCCTAACACCAGC
CAGTCCCAGGTGGAAGAAGATGTCAGCTCGCCACCTCAAAGGTCCTCCGAAACTATGCAG
CTGAAGAAGGAGATCTCCCTGCTGAATGGGGTCAGCCTGGTGGTGGGCAACATGATCGGC
TCAGGGATCTTTGTCTCACCCAAGGGTGTGCTGGTACACACTGCCTCCTATGGGATGTCA
CTGATTGTGTGGGCCATTGGTGGGCTCTTCTCTGTTGTGGGTGCCCTTTGTTATGCAGAG
CTGGGGACCACCATCACCAAGTCGGGAGCCAGCTACGCTTATATTCTAGAGGCCTTTGGG
GGCTTCATTGCCTTCATCCGCCTGTGGGTCTCACTGCTAGTTGTTGAGCCCACCGGTCAG
GCCATCATCGCCATCACCTTTGCCAACTACATCATCCAGCCGTCCTTCCCCAGCTGTGAT
CCCCCATACCTGGCCTGCCGTCTCCTGGCTGCTGCTTGCATATGTCTGCTGACATTTGTG
AACTGTGCCTATGTCAAGTGGGGCACACGTGTGCAGGACACGTTCACTTACGCCAAGGTC
GTAGCGCTCATTGCCATCATTGTCATGGGCCTTGTTAAACTGTGCCAGGGACACTCTGAG
CACTTTCAGGACGCCTTTGAGGGTTCCTCCTGGGACATGGGAAACCTCTCTCTTGCCCTC
TACTCTGCCCTCTTCTCTTACTCAGGTTGGGACACCCTTAATTTTGTAACAGAAGAAATC
AAAAACCCAGAAAGAAATTTGCCCTTGGCCATTGGGATTTCTATGCCAATTGTGACGCTC
ATCTACATCCTGACCAATGTGGCCTATTACACAGTGCTGAACATTTCAGATGTCCTTAGC
AGTGATGCTGTGGCTGTGACATTTGCTGACCAGACGTTTGGCATGTTCAGCTGGACCATC
CCCATTGCTGTTGCCCTGTCCTGCTTTGGGGGCCTCAATGCATCCATCTTTGCTTCATCA
AGGTTGTTCTTCGTGGGCTCCCGGGAGGGCCACCTACCGGACCTTCTGTCCATGATCCAC
ATTGAGCGTTTTACACCTATCCCTGCTTTACTGTTCAATTGCACCATGGCACTCATCTAC
CTCATCGTGGAGGATGTTTTCCAGCTTATCAACTACTTCAGCTTCAGCTACTGGTTCTTC
GTGGGCCTGTCTGTTGTTGGACAGCTCTACCTCCGCTGGAAGGAGCCCAAGCGGCCCCGG
CCTCTCAAGCTGAGCGTGTTTTTCCCCATCGTGTTCTGCATATGCTCCGTGTTTCTGGTG
ATAGTGCCCCTCTTCACTGACACCATTAATTCCCTCATTGGCATCGGGATTGCCCTTTCT
GGAGTCCCTTTCTACTTCATGGGTGTTTACCTGCCAGAGTCCCGGAGGCCATTGTTTATT
CGGAATGTCCTGGCTGCTATCACCAGAGGCACCCAGCAGCTTTGCTTTTGTGTCCTGACT
GAGCTTGATGTAGCCGAAGAAAAAAAGGATGAGAGGAAAACTGACTAG
Protein Properties
Number of Residues 515
Molecular Weight 56826.9
Theoretical pI 5.69
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["45-65", "79-99", "115-135", "168-188", "195-215", "236-256", "267-287", "312-332", "364-384", "386-406", "426-446", "452-472"]
Protein Sequence
>Y+L amino acid transporter 2
MEAREPGRPTPTYHLVPNTSQSQVEEDVSSPPQRSSETMQLKKEISLLNGVSLVVGNMIG
SGIFVSPKGVLVHTASYGMSLIVWAIGGLFSVVGALCYAELGTTITKSGASYAYILEAFG
GFIAFIRLWVSLLVVEPTGQAIIAITFANYIIQPSFPSCDPPYLACRLLAAACICLLTFV
NCAYVKWGTRVQDTFTYAKVVALIAIIVMGLVKLCQGHSEHFQDAFEGSSWDMGNLSLAL
YSALFSYSGWDTLNFVTEEIKNPERNLPLAIGISMPIVTLIYILTNVAYYTVLNISDVLS
SDAVAVTFADQTFGMFSWTIPIAVALSCFGGLNASIFASSRLFFVGSREGHLPDLLSMIH
IERFTPIPALLFNCTMALIYLIVEDVFQLINYFSFSYWFFVGLSVVGQLYLRWKEPKRPR
PLKLSVFFPIVFCICSVFLVIVPLFTDTINSLIGIGIALSGVPFYFMGVYLPESRRPLFI
RNVLAAITRGTQQLCFCVLTELDVAEEKKDERKTD
GenBank ID Protein 20381372
UniProtKB/Swiss-Prot ID Q92536
UniProtKB/Swiss-Prot Entry Name YLAT2_HUMAN
PDB IDs Not Available
GenBank Gene ID BC028216
GeneCard ID SLC7A6
GenAtlas ID SLC7A6
HGNC ID HGNC:11064
References
General References Not Available