Cannabis Compound Database: Showing Compound Card for PA(16:0/16:0) (CDB000806)

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Identification Taxonomy Ontology Physical properties Spectra Protein target Pathways Concentrations Links References enzymes (55)transporters (13) Show 109 proteins XML

Record Information

Version

1.0

Created at

2020-03-30 17:44:01 UTC

Updated at

2020-12-07 19:07:47 UTC

CannabisDB ID

CDB000806

Secondary Accession Numbers

Not Available

Cannabis Compound Identification

Common Name

PA(16:0/16:0)

Description

PA(16:0/16:0)is a phosphatidic acid. It is a glycerophospholipid in which a phosphate moiety occupies a glycerol substitution site. As is the case with diacylglycerols, phosphatidic acids can have many different combinations of fatty acids of varying lengths and saturation attached at the C-1 and C-2 positions. Fatty acids containing 16, 18 and 20 carbons are the most common. PA(16:0/16:0), in particular, consists of two hexadecanoyl chain at positions C-1 and C2. The oleic acid moiety is derived from vegetable oils, especially olive and canola oil, while the oleic acid moiety is derived from vegetable oils, especially olive and canola oil. Phosphatidic acids are quite rare but are extremely important as intermediates in the biosynthesis of triacylglycerols and phospholipids. This compound is expected to be in Cannabis as all living plants are known to produce and metabolize it.

Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
1,2-Dipalmitoyl-3-sn-phosphatidic acid	ChEBI
1,2-Dipalmitoyl-sn-glycerol-3-phosphate	ChEBI
1,2-Dipalmitoyl-sn-glycerol-3-phosphoric acid	ChEBI
Dipalmitoyl phosphatidic acid	ChEBI
PA(32:0)	ChEBI
Phosphatidic acid(16:0/16:0)	ChEBI
Phosphatidic acid(32:0)	ChEBI
1,2-Dipalmitoyl-3-sn-phosphatidate	Generator
Dipalmitoyl phosphatidate	Generator
Phosphatidate(16:0/16:0)	Generator
Phosphatidate(32:0)	Generator
1,2-Di-O-palmitoyl-3-sn-glyceryl-O-phosphorate	HMDB
1,2-Di-O-palmitoyl-3-sn-glyceryl-O-phosphoric acid	HMDB
1,2-Dihexadecanoyl-rac-phosphatidic acid	HMDB
1,2-Dipalmitoyl-sn-glycerol 3-phosphate	HMDB
1,2-Dipalmitoyl-sn-glycerol-3-phosphorate	HMDB
Dipalmitoyl-L-a-phosphatidate	HMDB
Dipalmitoyl-L-a-phosphatidic acid	HMDB
Dipalmitoyl-L-alpha-phosphatidate	HMDB
Dipalmitoyl-L-alpha-phosphatidic acid	HMDB
Dipalmitoylphosphatidate	HMDB
Dipalmitoylphosphatidic acid	HMDB
L-a-Dipalmitoyl-phosphatidate	HMDB
L-a-Dipalmitoyl-phosphatidic acid	HMDB
L-a-Dipalmitoylphosphatidate	HMDB
L-a-Dipalmitoylphosphatidic acid	HMDB
L-alpha-Dipalmitoyl-phosphatidate	HMDB
L-alpha-Dipalmitoyl-phosphatidic acid	HMDB
L-alpha-Dipalmitoylphosphatidate	HMDB
L-alpha-Dipalmitoylphosphatidic acid	HMDB
Dipalmitoylphosphatidic acid, calcium salt	HMDB
Dipalmitoylphosphatidic acid, ammonium salt	HMDB
1,2-Dipalmitoyl-sn-glycero-3-phosphate	HMDB
Dipalmitoylphosphatidic acid, sodium salt	HMDB
Dipalmitoylphosphatidic acid, (+-)-isomer	HMDB
Dipalmitoylphosphatidic acid, (R)-isomer	HMDB

Chemical Formula

C₃₅H₆₉O₈P

Average Molecular Weight

648.9

Monoisotopic Molecular Weight

648.473

IUPAC Name

[(2R)-2,3-bis(hexadecanoyloxy)propoxy]phosphonic acid

Traditional Name

dipalmitoyl

CAS Registry Number

7091-44-3

SMILES

[H][C@@](COC(=O)CCCCCCCCCCCCCCC)(COP(O)(O)=O)OC(=O)CCCCCCCCCCCCCCC

InChI Identifier

InChI=1S/C35H69O8P/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-34(36)41-31-33(32-42-44(38,39)40)43-35(37)30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h33H,3-32H2,1-2H3,(H2,38,39,40)/t33-/m1/s1

InChI Key

PORPENFLTBBHSG-MGBGTMOVSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as 1,2-diacylglycerol-3-phosphates. These are glycerol-3-phosphates in which the glycerol moiety is bonded to two aliphatic chains through ester linkages.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Glycerophospholipids

Sub Class

Glycerophosphates

Direct Parent

1,2-diacylglycerol-3-phosphates

Alternative Parents

Substituents

1,2-diacylglycerol-3-phosphate
Fatty acid ester
Monoalkyl phosphate
Dicarboxylic acid or derivatives
Fatty acyl
Alkyl phosphate
Phosphoric acid ester
Organic phosphoric acid derivative
Carboxylic acid ester
Carboxylic acid derivative
Hydrocarbon derivative
Organic oxide
Organic oxygen compound
Carbonyl group
Organooxygen compound
Aliphatic acyclic compound

Molecular Framework

Aliphatic acyclic compounds

External Descriptors

1-acyl-2-hexadecanoyl-sn-glycero-3-phosphate (CHEBI:73246 )
Diacylglycerophosphates (LMGP10010027 )

Ontology

Physiological effect

Organoleptic effect:

Touch:

Smooth

Disposition

Route of exposure:

Enteral:

Ingestion

Source:

Biological:

Animal

Biological location:

Biofluid and excreta:

Blood

Cell and elements:

Extracellular

Subcellular:

Role

Industrial application:

Food and nutrition:

Biological role:

Physical Properties

State

Solid

Experimental Properties

Property	Value	Reference
Melting Point	161 - 165 °C	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
logP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	8.66	ALOGPS
logP	11.88	ChemAxon
logS	-6.7	ALOGPS
pKa (Strongest Acidic)	1.32	ChemAxon
pKa (Strongest Basic)	-6.7	ChemAxon
Physiological Charge	-2	ChemAxon
Hydrogen Acceptor Count	5	ChemAxon
Hydrogen Donor Count	2	ChemAxon
Polar Surface Area	119.36 Å²	ChemAxon
Rotatable Bond Count	36	ChemAxon
Refractivity	178.57 m³·mol⁻¹	ChemAxon
Polarizability	80.08 Å³	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	No	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

EI-MS/GC-MS

Type	Description	Splash Key	View
Predicted GC-MS	PA(16:0/16:0), non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	splash10-0005-9236341000-d0296e5b3dd53599a39d	Spectrum

MS/MS

Type	Description	Splash Key	View
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 10V, Negative (Annotated)	splash10-0002-0000009000-b3b708036c56c15fec89	2012-07-24	View Spectrum
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 25V, Negative (Annotated)	splash10-0a4i-1492100000-5624ed03f664b67f79ec	2012-07-24	View Spectrum
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 40V, Negative (Annotated)	splash10-0a4i-1490000000-1ba8a217ef22599ee07c	2012-07-24	View Spectrum
MS/MS	LC-MS/MS Spectrum - 35V, Negative	splash10-0002-0002009000-7bdcaa7752c2e2970fdf	2021-09-20	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-000i-0000900000-42187062de8aa3a7fcef	2016-09-19	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-0a71-4092103000-08a70ad05021be172e3b	2017-09-01	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-004i-9050000000-dc7f569f98cd450257d0	2017-09-01	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-004i-9000000000-f628227e9a0ceffbeaf0	2017-09-01	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-00di-0000009000-8e723670c2d6da7d1500	2021-09-22	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-00di-0000099000-cef7e1d91751b702106e	2021-09-22	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-00xr-0000946000-9592d132939363ae4ad4	2021-09-22	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-0002-0000009000-5d6932d42201ac99e40a	2021-09-23	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-052e-1166109000-3a40d8a06827026e1331	2021-09-23	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-0a4i-1191101000-55ca7d5b11a7d0030aea	2021-09-23	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-001j-0000009000-6c5d51790d44b8f28697	2021-09-25	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-0f6t-0000059000-f0c15a320524af660ac4	2021-09-25	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-0udl-0006093000-7e3d155745f467b43ae7	2021-09-25	View Spectrum

NMR

Type	Description	View
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, experimental)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, H₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, H₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, H₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, H₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, H₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, H₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, H₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, H₂O, predicted)	Spectrum
2D NMR	[¹H, ¹³C]-HSQC NMR Spectrum (2D, 600 MHz, CD₃OD, experimental)	Spectrum

Pathways

Name	SMPDB/Pathwhiz	KEGG
Phospholipid Biosynthesis
Glycerolipid Metabolism
Glycerol Kinase Deficiency		Not Available
D-glyceric acidura		Not Available
Familial lipoprotein lipase deficiency		Not Available

Protein Targets

Enzymes

Protein Name	Gene Name	Locus	Uniprot ID	Details
Phospholipase D2	PLD2	17p13.1	O14939	details
Diacylglycerol kinase theta	DGKQ	4p16.3	P52824	details
Diacylglycerol kinase gamma	DGKG	3q27.2-q27.3	P49619	details
Lipid phosphate phosphohydrolase 2	PPAP2C	19p13	O43688	details
Diacylglycerol kinase alpha	DGKA	12q13.3	P23743	details
Diacylglycerol kinase delta	DGKD	2q37.1	Q16760	details
Lipid phosphate phosphohydrolase 1	PPAP2A	5q11	O14494	details
Diacylglycerol kinase beta	DGKB	7p21.2	Q9Y6T7	details
Diacylglycerol kinase iota	DGKI	7q32.3-q33	O75912	details
Lipid phosphate phosphohydrolase 3	PPAP2B	1p32.2	O14495	details
Diacylglycerol kinase zeta	DGKZ	11p11.2	Q13574	details
Phospholipase DDHD1	DDHD1	14q21	Q8NEL9	details
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	PDE4D	5q12	Q08499	details
Phosphatidate cytidylyltransferase 2	CDS2	20p13	O95674	details
Phosphatidate cytidylyltransferase 1	CDS1	4q21.23	Q92903	details
Probable phospholipid-transporting ATPase IG	ATP11C		Q8NB49	details
Probable phospholipid-transporting ATPase IH	ATP11A	13q34	P98196	details
Probable phospholipid-transporting ATPase VA	ATP10A	15q11.2	O60312	details
Probable phospholipid-transporting ATPase IC	ATP8B1	18q21-q22\|18q21.31	O43520	details
Probable phospholipid-transporting ATPase IIA	ATP9A	20q13.2	O75110	details
Probable phospholipid-transporting ATPase VD	ATP10D	4p12	Q9P241	details
Probable phospholipid-transporting ATPase IB	ATP8A2	13q12	Q9NTI2	details
Probable phospholipid-transporting ATPase IA	ATP8A1	4p13	Q9Y2Q0	details
Probable phospholipid-transporting ATPase IM	ATP8B4	15q21.2	Q8TF62	details
Probable phospholipid-transporting ATPase IF	ATP11B	3q27	Q9Y2G3	details
Probable phospholipid-transporting ATPase IK	ATP8B3	19p13.3	O60423	details
1-acyl-sn-glycerol-3-phosphate acyltransferase gamma	AGPAT3	21q22.3	Q9NRZ7	details
1-acyl-sn-glycerol-3-phosphate acyltransferase beta	AGPAT2	9q34.3	O15120	details
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha	AGPAT1	6p21.3	Q99943	details
Phosphatidylinositol-glycan-specific phospholipase D	GPLD1	6p22.1	P80108	details
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2	AGAP2	12q14.1	Q99490	details
1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon	AGPAT5	8p23.1	Q9NUQ2	details
2-acylglycerol O-acyltransferase 2	MOGAT2	11q13.5	Q3SYC2	details
Diacylglycerol kinase eta	DGKH	13q14.11	Q86XP1	details
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3	PLCD3	17q21.31	Q8N3E9	details
1-acyl-sn-glycerol-3-phosphate acyltransferase delta	AGPAT4	6q26	Q9NRZ5	details
Diacylglycerol kinase kappa	DGKK		Q5KSL6	details
Probable phospholipid-transporting ATPase VB	ATP10B	5q34	O94823	details
Probable phospholipid-transporting ATPase ID	ATP8B2	1q21.3	P98198	details
N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D	NAPEPLD	7q22.1	Q6IQ20	details
Lysocardiolipin acyltransferase 1	LCLAT1	2p23.1	Q6UWP7	details
Lipase member H	LIPH	3q27	Q8WWY8	details
Lipase member I	LIPI	21q11.2	Q6XZB0	details
Lipid phosphate phosphatase-related protein type 4	LPPR4	1p21.2	Q7Z2D5	details
Lipid phosphate phosphatase-related protein type 5	LPPR5	1p21.3	Q32ZL2	details
Presqualene diphosphate phosphatase	PPAPDC2	9p24.1	Q8IY26	details
Probable lipid phosphate phosphatase PPAPDC3	PPAPDC3	9q34.13	Q8NBV4	details
Phosphatidate phosphatase PPAPDC1A	PPAPDC1A	10q26.12	Q5VZY2	details
Phosphatidate phosphatase PPAPDC1B	PPAPDC1B	8p11.23	Q8NEB5	details
Acylglycerol kinase, mitochondrial	AGK	7q34	Q53H12	details
Phospholipase D1 variant			Q59EA4	details
1-acylglycerol-3-phosphate O-acyltransferase 6 (Lysophosphatidic acid acyltransferase, zeta), isoform CRA_b	AGPAT6	8p11.21	Q2TU73	details
Diacylglycerol kinase, epsilon 64kDa	DGKE	17q22	A1L4Q0	details
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1	AGAP1	2q37	Q9UPQ3	details
Phospholipase DDHD2	DDHD2	8p11.23	O94830	details

Transporters

Protein Name	Gene Name	Locus	Uniprot ID	Details
Probable phospholipid-transporting ATPase IG	ATP11C		Q8NB49	details
Probable phospholipid-transporting ATPase IH	ATP11A	13q34	P98196	details
Probable phospholipid-transporting ATPase VA	ATP10A	15q11.2	O60312	details
Probable phospholipid-transporting ATPase IC	ATP8B1	18q21-q22\|18q21.31	O43520	details
Probable phospholipid-transporting ATPase IIA	ATP9A	20q13.2	O75110	details
Probable phospholipid-transporting ATPase VD	ATP10D	4p12	Q9P241	details
Probable phospholipid-transporting ATPase IB	ATP8A2	13q12	Q9NTI2	details
Probable phospholipid-transporting ATPase IA	ATP8A1	4p13	Q9Y2Q0	details
Probable phospholipid-transporting ATPase IM	ATP8B4	15q21.2	Q8TF62	details
Probable phospholipid-transporting ATPase IF	ATP11B	3q27	Q9Y2G3	details
Probable phospholipid-transporting ATPase IK	ATP8B3	19p13.3	O60423	details
Probable phospholipid-transporting ATPase VB	ATP10B	5q34	O94823	details
Probable phospholipid-transporting ATPase ID	ATP8B2	1q21.3	P98198	details

Metal Bindings

Protein Name	Gene Name	Locus	Uniprot ID	Details
Diacylglycerol kinase gamma	DGKG	3q27.2-q27.3	P49619	details
Diacylglycerol kinase alpha	DGKA	12q13.3	P23743	details
Diacylglycerol kinase beta	DGKB	7p21.2	Q9Y6T7	details
Phospholipase DDHD1	DDHD1	14q21	Q8NEL9	details
cAMP-specific 3',5'-cyclic phosphodiesterase 4D	PDE4D	5q12	Q08499	details
Probable phospholipid-transporting ATPase IG	ATP11C		Q8NB49	details
Probable phospholipid-transporting ATPase IH	ATP11A	13q34	P98196	details
Probable phospholipid-transporting ATPase VA	ATP10A	15q11.2	O60312	details
Probable phospholipid-transporting ATPase IC	ATP8B1	18q21-q22\|18q21.31	O43520	details
Probable phospholipid-transporting ATPase IIA	ATP9A	20q13.2	O75110	details
Probable phospholipid-transporting ATPase VD	ATP10D	4p12	Q9P241	details
Probable phospholipid-transporting ATPase IB	ATP8A2	13q12	Q9NTI2	details
Probable phospholipid-transporting ATPase IA	ATP8A1	4p13	Q9Y2Q0	details
Probable phospholipid-transporting ATPase IM	ATP8B4	15q21.2	Q8TF62	details
Probable phospholipid-transporting ATPase IF	ATP11B	3q27	Q9Y2G3	details
Probable phospholipid-transporting ATPase IK	ATP8B3	19p13.3	O60423	details
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2	AGAP2	12q14.1	Q99490	details
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3	PLCD3	17q21.31	Q8N3E9	details
Probable phospholipid-transporting ATPase VB	ATP10B	5q34	O94823	details
Probable phospholipid-transporting ATPase ID	ATP8B2	1q21.3	P98198	details
N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D	NAPEPLD	7q22.1	Q6IQ20	details
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1	ACAP1	17p13.1	Q15027	details
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1	AGAP1	2q37	Q9UPQ3	details
Phospholipase DDHD2	DDHD2	8p11.23	O94830	details
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2	ACAP2	3q29	Q15057	details

Receptors

Protein Name	Gene Name	Locus	Uniprot ID	Details
Phospholipase D2	PLD2	17p13.1	O14939	details
Diacylglycerol kinase theta	DGKQ	4p16.3	P52824	details
Diacylglycerol kinase gamma	DGKG	3q27.2-q27.3	P49619	details
Diacylglycerol kinase alpha	DGKA	12q13.3	P23743	details
Diacylglycerol kinase delta	DGKD	2q37.1	Q16760	details
Lipid phosphate phosphohydrolase 1	PPAP2A	5q11	O14494	details
Diacylglycerol kinase beta	DGKB	7p21.2	Q9Y6T7	details
Diacylglycerol kinase iota	DGKI	7q32.3-q33	O75912	details
Lipid phosphate phosphohydrolase 3	PPAP2B	1p32.2	O14495	details
Diacylglycerol kinase zeta	DGKZ	11p11.2	Q13574	details
Phosphatidylinositol-glycan-specific phospholipase D	GPLD1	6p22.1	P80108	details
Diacylglycerol kinase eta	DGKH	13q14.11	Q86XP1	details
Diacylglycerol kinase kappa	DGKK		Q5KSL6	details
Acylglycerol kinase, mitochondrial	AGK	7q34	Q53H12	details
Diacylglycerol kinase, epsilon 64kDa	DGKE	17q22	A1L4Q0	details

Transcriptional Factors

Protein Name	Gene Name	Locus	Uniprot ID	Details
Lipid phosphate phosphohydrolase 3	PPAP2B	1p32.2	O14495	details

Concentrations Data

Not Available

External Links

HMDB ID

HMDB0000674

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

FDB022175

KNApSAcK ID

Not Available

Chemspider ID

393518

KEGG Compound ID

C00416

BioCyc ID

CPD0-1422

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

5644

PubChem Compound

446066

PDB ID

Not Available

ChEBI ID

73246

References

General References

Not Available

Only showing the first 10 proteins. There are 109 proteins in total.

Show All

Enzymes

Enzyme Details

1. Phospholipase D2

General function:: Involved in protein binding
Specific function:: May have a role in signal-induced cytoskeletal regulation and/or endocytosis (By similarity).
Gene Name:: PLD2
Uniprot ID:: O14939
Molecular weight:: 104656.485

Enzyme Details

2. Diacylglycerol kinase theta

General function:: Involved in diacylglycerol kinase activity
Specific function:: Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). May regulate the activity of protein kinase C by controlling the balance between these two signaling lipids. Activated in the nucleus in response to alpha-thrombin and nerve growth factor. May be involved in cAMP- induced activation of NR5A1 and subsequent steroidogenic gene transcription by delivering PA as ligand for NR5A1. Acts synergistically with NR5A1 on CYP17 transcriptional activity
Gene Name:: DGKQ
Uniprot ID:: P52824
Molecular weight:: 101154.0

Enzyme Details

3. Diacylglycerol kinase gamma

General function:: Involved in diacylglycerol kinase activity
Specific function:: Reverses the normal flow of glycerolipid biosynthesis by phosphorylating diacylglycerol back to phosphatidic acid
Gene Name:: DGKG
Uniprot ID:: P49619
Molecular weight:: 89095.3

Enzyme Details

4. Lipid phosphate phosphohydrolase 2

General function:: Involved in catalytic activity
Specific function:: Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is PA > C-1-P > LPA > S-1-P.
Gene Name:: PPAP2C
Uniprot ID:: O43688
Molecular weight:: 32573.435

Enzyme Details

5. Diacylglycerol kinase alpha

General function:: Involved in diacylglycerol kinase activity
Specific function:: Upon cell stimulation converts the second messenger diacylglycerol into phosphatidate, initiating the resynthesis of phosphatidylinositols and attenuating protein kinase C activity
Gene Name:: DGKA
Uniprot ID:: P23743
Molecular weight:: 82629.5

Enzyme Details

6. Diacylglycerol kinase delta

General function:: Involved in diacylglycerol kinase activity
Specific function:: Isoform 2 may be involved in cell growth and tumorigenesis. Involved in clathrin-dependent endocytosis
Gene Name:: DGKD
Uniprot ID:: Q16760
Molecular weight:: 134524.2

Enzyme Details

7. Lipid phosphate phosphohydrolase 1

General function:: Involved in catalytic activity
Specific function:: Broad-specificity phosphohydrolase that dephosphorylates exogenous bioactive glycerolipids and sphingolipids. Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). Pivotal regulator of lysophosphatidic acid (LPA) signaling in the cardiovascular system. Major enzyme responsible of dephosphorylating LPA in platelets, which terminates signaling actions of LPA. May control circulating, and possibly also regulate localized, LPA levels resulting from platelet activation. It has little activity towards ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is LPA > PA > S-1-P > C-1-P. It's down-regulation may contribute to the development of colon adenocarcinoma.
Gene Name:: PPAP2A
Uniprot ID:: O14494
Molecular weight:: 32155.715

Enzyme Details

8. Diacylglycerol kinase beta

General function:: Involved in diacylglycerol kinase activity
Specific function:: Exhibits high phosphorylation activity for long-chain diacylglycerols
Gene Name:: DGKB
Uniprot ID:: Q9Y6T7
Molecular weight:: 90594.7

Enzyme Details

9. Diacylglycerol kinase iota

General function:: Involved in diacylglycerol kinase activity
Specific function:: ATP + 1,2-diacylglycerol = ADP + 1,2-diacyl- sn-glycerol 3-phosphate
Gene Name:: DGKI
Uniprot ID:: O75912
Molecular weight:: 116996.2

Enzyme Details

10. Lipid phosphate phosphohydrolase 3

General function:: Involved in catalytic activity
Specific function:: Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is LPA = PA > C-1-P > S-1-P. May be involved in cell adhesion and in cell-cell interactions.
Gene Name:: PPAP2B
Uniprot ID:: O14495
Molecular weight:: 35115.61

Transporters

Enzyme Details

1. Probable phospholipid-transporting ATPase IG

General function:: Involved in ATP binding
Specific function:: ATP + H(2)O + phospholipid(In) = ADP + phosphate + phospholipid(Out)
Gene Name:: ATP11C
Uniprot ID:: Q8NB49
Molecular weight:: 129476.0

Enzyme Details

2. Probable phospholipid-transporting ATPase IH

General function:: Involved in ATP binding
Specific function:: ATP + H(2)O + phospholipid(In) = ADP + phosphate + phospholipid(Out)
Gene Name:: ATP11A
Uniprot ID:: P98196
Molecular weight:: 129754.6

Enzyme Details

3. Probable phospholipid-transporting ATPase VA

General function:: Involved in ATP binding
Specific function:: ATP + H(2)O + phospholipid(In) = ADP + phosphate + phospholipid(Out)
Gene Name:: ATP10A
Uniprot ID:: O60312
Molecular weight:: 167686.6

Enzyme Details

4. Probable phospholipid-transporting ATPase IC

General function:: Involved in ATP binding
Specific function:: May play a role in the transport of aminophospholipids from the outer to the inner leaflet of various membranes and the maintenance of asymmetric distribution of phospholipids in the canicular membrane. May have a role in transport of bile acids into the canaliculus, uptake of bile acids from intestinal contents into intestinal mucosa or both
Gene Name:: ATP8B1
Uniprot ID:: O43520
Molecular weight:: 143694.1

Enzyme Details

5. Probable phospholipid-transporting ATPase IIA

General function:: Involved in ATP binding
Specific function:: ATP + H(2)O + phospholipid(In) = ADP + phosphate + phospholipid(Out)
Gene Name:: ATP9A
Uniprot ID:: O75110
Molecular weight:: 118581.5

Enzyme Details

6. Probable phospholipid-transporting ATPase VD

General function:: Involved in ATP binding
Specific function:: ATP + H(2)O + phospholipid(In) = ADP + phosphate + phospholipid(Out)
Gene Name:: ATP10D
Uniprot ID:: Q9P241
Molecular weight:: 160272.3

Enzyme Details

7. Probable phospholipid-transporting ATPase IB

General function:: Involved in ATP binding
Specific function:: ATP + H(2)O + phospholipid(In) = ADP + phosphate + phospholipid(Out)
Gene Name:: ATP8A2
Uniprot ID:: Q9NTI2
Molecular weight:: 129240.4

Enzyme Details

8. Probable phospholipid-transporting ATPase IA

General function:: Involved in ATP binding
Specific function:: May play a role in the transport of aminophospholipids from the outer to the inner leaflet of various membranes and the maintenance of asymmetric distribution of phospholipids, mainly in secretory vesicles
Gene Name:: ATP8A1
Uniprot ID:: Q9Y2Q0
Molecular weight:: 131368.2

Enzyme Details

9. Probable phospholipid-transporting ATPase IM

General function:: Involved in ATP binding
Specific function:: ATP + H(2)O + phospholipid(In) = ADP + phosphate + phospholipid(Out)
Gene Name:: ATP8B4
Uniprot ID:: Q8TF62
Molecular weight:: 135867.0

Enzyme Details

10. Probable phospholipid-transporting ATPase IF

General function:: Involved in ATP binding
Specific function:: ATP + H(2)O + phospholipid(In) = ADP + phosphate + phospholipid(Out)
Gene Name:: ATP11B
Uniprot ID:: Q9Y2G3
Molecular weight:: 134188.6

Only showing the first 10 proteins. There are 109 proteins in total.

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Showing Compound Card for PA(16:0/16:0) (CDB000806)

Structure for CDB000806 (PA(16:0/16:0))

Enzymes

Transporters