Cannabis Compound Database: Showing Compound Card for L-Serine (CDB000131)

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Record Information

Version

1.0

Created at

2020-03-18 23:25:56 UTC

Updated at

2022-12-13 23:36:22 UTC

CannabisDB ID

CDB000131

Secondary Accession Numbers

Not Available

Cannabis Compound Identification

Common Name

L-Serine

Description

Serine (or L-serine), abbreviated as Ser or S, is a nonessential amino acid derived from glycine. As all amino acid are building blocks of protein and peptides, serine can become essential under certain conditions, and is thus important in maintaining health and preventing disease. Muscles have low-average concentration of serine compared to other amino acids. . In contrast, serine is highly concentrated in all cell membranes. L-Serine may be derived from four possible sources: dietary intake, biosynthesis from the glycolytic intermediate 3-phosphoglycerate, from glycine, and by protein and phospholipid degradation. Little data is available on the relative contributions of each of these four sources of L-serine to serine homoeostasis. It is likely that the predominant source of L-serine varies in different tissues and during different stages of human development. In the biosynthetic pathway, the glycolytic intermediate 3-phosphoglycerate is converted to serine by a three enzyme cascade. First, 3-phosphoglycerate is converted into phosphohydroxypyruvate by 3-phosphoglycerate dehydrogenase (3- PGDH; EC 1.1.1.95). Second, phosphohydroxypyruvate is metabolized to phosphoserine by phosphohydroxypyruvate aminotransferase (EC 2.6.1.52) and third, phosphoserine is converted into l-serine by phosphoserine phosphatase (PSP; EC 3.1.3.3). In liver tissue, the serine biosynthetic pathway is regulated in response to dietary and hormonal changes. Of the three biosynthetic enzymes, the properties of 3-PGDH and PSP are the best documented. Hormonal factors such as glucagon and corticosteroids also influence 3-PGDH and PSP activities in interactions dependent upon the diet. L-serine plays a central role in cellular proliferation. L-Serine is the predominant source of one-carbon groups for the de novo synthesis of purine nucleotides and deoxythymidine monophosphate. It has long been recognized that, in cell cultures, L-serine is a conditional essential amino acid, because it cannot be synthesized in sufficient quantities to meet the cellular demands for its utilization. In recent years, L-serine and the products of its metabolism have been recognized not only to be essential for cell proliferation, but also to be necessary for specific functions in the central nervous system. The findings of altered levels of serine and glycine in patients with psychiatric disorders and the severe neurological abnormalities in patients with defects of L-serine synthesis underscore the importance of L-serine in brain development and function (PMID: 12534373 ). L-serine is also found in Cannabis plants (PMID: 6991645 ).

Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
(2S)-2-Amino-3-hydroxypropanoic acid	ChEBI
(S)-(-)-Serine	ChEBI
(S)-2-Amino-3-hydroxypropanoic acid	ChEBI
(S)-alpha-Amino-beta-hydroxypropionic acid	ChEBI
(S)-Serine	ChEBI
beta-Hydroxy-L-alanine	ChEBI
beta-Hydroxyalanine	ChEBI
L-(-)-Serine	ChEBI
L-2-Amino-3-hydroxypropionic acid	ChEBI
L-3-Hydroxy-2-aminopropionic acid	ChEBI
L-3-Hydroxy-alanine	ChEBI
L-Ser	ChEBI
L-Serin	ChEBI
S	ChEBI
Ser	ChEBI
SERINE	ChEBI
(2S)-2-Amino-3-hydroxypropanoate	Generator
(S)-2-Amino-3-hydroxypropanoate	Generator
(S)-a-Amino-b-hydroxypropionate	Generator
(S)-a-Amino-b-hydroxypropionic acid	Generator
(S)-alpha-Amino-beta-hydroxypropionate	Generator
(S)-Α-amino-β-hydroxypropionate	Generator
(S)-Α-amino-β-hydroxypropionic acid	Generator
b-Hydroxy-L-alanine	Generator
Β-hydroxy-L-alanine	Generator
b-Hydroxyalanine	Generator
Β-hydroxyalanine	Generator
L-2-Amino-3-hydroxypropionate	Generator
L-3-Hydroxy-2-aminopropionate	Generator
(-)-Serine	HMDB
(S)-2-Amino-3-hydroxy-propanoate	HMDB
(S)-2-Amino-3-hydroxy-propanoic acid	HMDB
(S)-b-Amino-3-hydroxypropionate	HMDB
(S)-b-Amino-3-hydroxypropionic acid	HMDB
(S)-beta-Amino-3-hydroxypropionate	HMDB
(S)-beta-Amino-3-hydroxypropionic acid	HMDB
2-Amino-3-hydroxypropanoate	HMDB
2-Amino-3-hydroxypropanoic acid	HMDB
3-Hydroxy-L-alanine	HMDB
L Serine	HMDB
(3R,3'r,6S)-4,5-DIDEHYDRO-5,6-dihydro-BETA,BETA-carotene-3,3'-diol	HMDB
Bo-xan	HMDB
e 161b	HMDB
Xanthophyll	HMDB
(3R,3'r,6S)-4,5-DIDEHYDRO-5,6-dihydro-b,b-carotene-3,3'-diol	HMDB
(3R,3'r,6S)-4,5-DIDEHYDRO-5,6-dihydro-β,β-carotene-3,3'-diol	HMDB

Chemical Formula

C₃H₇NO₃

Average Molecular Weight

105.09

Monoisotopic Molecular Weight

105.0426

IUPAC Name

(2S)-2-amino-3-hydroxypropanoic acid

Traditional Name

L-serine

CAS Registry Number

6898-95-9

SMILES

N[C@@H](CO)C(O)=O

InChI Identifier

InChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1

InChI Key

MTCFGRXMJLQNBG-REOHCLBHSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as serine and derivatives. Serine and derivatives are compounds containing serine or a derivative thereof resulting from reaction of serine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom.

Kingdom

Organic compounds

Super Class

Organic acids and derivatives

Class

Carboxylic acids and derivatives

Sub Class

Amino acids, peptides, and analogues

Direct Parent

Serine and derivatives

Alternative Parents

Substituents

Serine or derivatives
Alpha-amino acid
L-alpha-amino acid
Beta-hydroxy acid
Hydroxy acid
Amino acid
Carboxylic acid
Monocarboxylic acid or derivatives
Alcohol
Primary amine
Primary alcohol
Organooxygen compound
Organonitrogen compound
Hydrocarbon derivative
Primary aliphatic amine
Organic oxide
Organopnictogen compound
Carbonyl group
Organic oxygen compound
Amine
Organic nitrogen compound
Aliphatic acyclic compound

Molecular Framework

Aliphatic acyclic compounds

External Descriptors

proteinogenic amino acid (CHEBI:17115 )
L-alpha-amino acid (CHEBI:17115 )
serine (CHEBI:17115 )
serine family amino acid (CHEBI:17115 )
Common amino acids (C00065 )

Ontology

Leukemia

Cardiac disorders:

Heart failure

Disposition

Route of exposure:

Enteral:

Ingestion

Source:

Synthetic:

Personal care product

Biological:

Animal

Plant:

Biological location:

Tissue and substructures:

Organ and components:

Prostate

Biofluid and excreta:

Subcellular:

Cell and elements:

Extracellular

Role

Industrial application:

Pharmaceutical industry:

Pharmaceutical

Physical Properties

State

Solid

Experimental Properties

Property	Value	Reference
Melting Point	228 °C	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	425 mg/mL	Not Available
logP	-3.07	HANSCH,C ET AL. (1995)

Predicted Properties

Property	Value	Source
logP	-3.4	ALOGPS
logP	-3.9	ChemAxon
logS	0.66	ALOGPS
pKa (Strongest Acidic)	2.03	ChemAxon
pKa (Strongest Basic)	8.93	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	4	ChemAxon
Hydrogen Donor Count	3	ChemAxon
Polar Surface Area	83.55 Å²	ChemAxon
Rotatable Bond Count	2	ChemAxon
Refractivity	22.04 m³·mol⁻¹	ChemAxon
Polarizability	9.39 Å³	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

EI-MS/GC-MS

Type	Description	Splash Key	View
EI-MS	Mass Spectrum (Electron Ionization)	splash10-0200-9000000000-dc5e2afcfab602641180	2018-05-25	View Spectrum
GC-MS	L-Serine, 3 TMS, GC-MS Spectrum	splash10-0udi-0940000000-59d5e0f76fd204be8110	Spectrum
GC-MS	L-Serine, 3 TMS, GC-MS Spectrum	splash10-0udi-0980000000-ab49fc3ee88db87d1a16	Spectrum
GC-MS	L-Serine, 2 TMS, GC-MS Spectrum	splash10-0159-0900000000-8e169037bcbe1dcd5de8	Spectrum
GC-MS	L-Serine, 3 TMS, GC-MS Spectrum	splash10-0uxr-0970000000-67271ed235e35c662db5	Spectrum
GC-MS	L-Serine, 3 TMS, GC-MS Spectrum	splash10-00di-9540000000-1297bf302358bcf0f1c0	Spectrum
GC-MS	L-Serine, 3 TMS, GC-MS Spectrum	splash10-0uxr-1790000000-caaa37778f5a4686f5f0	Spectrum
GC-MS	L-Serine, non-derivatized, GC-MS Spectrum	splash10-0159-0900000000-ae4f860052c41e9ba734	Spectrum
GC-MS	L-Serine, non-derivatized, GC-MS Spectrum	splash10-0uxr-0590000000-ce32a8bfb64d16590b52	Spectrum
GC-MS	L-Serine, non-derivatized, GC-MS Spectrum	splash10-0udi-0940000000-59d5e0f76fd204be8110	Spectrum
GC-MS	L-Serine, non-derivatized, GC-MS Spectrum	splash10-0udi-0980000000-ab49fc3ee88db87d1a16	Spectrum
GC-MS	L-Serine, non-derivatized, GC-MS Spectrum	splash10-0159-0900000000-8e169037bcbe1dcd5de8	Spectrum
GC-MS	L-Serine, non-derivatized, GC-MS Spectrum	splash10-0uxr-0970000000-67271ed235e35c662db5	Spectrum
GC-MS	L-Serine, non-derivatized, GC-MS Spectrum	splash10-00dr-7966000000-7b5b37fd4ac885548172	Spectrum
GC-MS	L-Serine, non-derivatized, GC-MS Spectrum	splash10-00di-9540000000-1297bf302358bcf0f1c0	Spectrum
GC-MS	L-Serine, non-derivatized, GC-MS Spectrum	splash10-0uxr-1790000000-caaa37778f5a4686f5f0	Spectrum
Predicted GC-MS	L-Serine, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	splash10-06sl-9000000000-033631650075b940e0e2	Spectrum
Predicted GC-MS	L-Serine, 2 TMS, Predicted GC-MS Spectrum - 70eV, Positive	splash10-0fkl-9420000000-ed7a327e1f071802a4dd	Spectrum
Predicted GC-MS	L-Serine, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	L-Serine, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	L-Serine, TMS_1_1, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	L-Serine, TMS_1_2, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	L-Serine, TMS_1_3, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	L-Serine, TMS_2_2, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	L-Serine, TMS_2_3, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	L-Serine, TMS_2_4, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum

MS/MS

Type	Description	Splash Key	View
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)	splash10-03di-9100000000-38f84912ebfc7b4e8339	2012-07-24	View Spectrum
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)	splash10-03dl-9000000000-89e57995d3ca765a20e8	2012-07-24	View Spectrum
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)	splash10-01ox-9100000000-f3baf93032cc9f09cf2d	2012-07-24	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-0zfr-0900000000-b6085e53e881cdaa1824	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-000i-9000000000-2e16e9d6f9b3c2688f8a	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-0a4i-9000000000-9857daa028fb3016a7e2	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-0006-0009200000-0617acd25c69bf24ad1f	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-0a4i-0900000000-823dfcf6229956372e31	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-0a4i-9000000000-eec63565f8a9fe4bd336	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-000i-9000000000-008412efd202c202d56a	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-0002-0930000000-932aedc4efb5e1dd5e7b	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-0w29-0951000000-cd0895e475dd50e4934d	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-00di-9000000000-15294ba22b153cf5ab5b	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-014i-9000000000-48c370acff657443f0e6	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-0udi-0190000000-1bad10ba7388ce0c2249	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-0ue9-0792100000-9f2bfe40e4c01044d209	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-00di-9000000000-dfa7aca58cc28303ebc7	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-0udi-0900000000-282f31d8021649afdbe8	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-0udi-0290000000-eeee98e6b0514b08cd63	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Negative	splash10-0udi-1900000000-ed66566e27a94ee99f13	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, Negative	splash10-00di-9100000000-b9f6b4b6ee7c88a9c569	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, Negative	splash10-00di-9000000000-929aea63ace0e20c6d43	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 40V, Negative	splash10-00di-9000000000-ba9cd5b3e37ded5d3764	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Positive	splash10-0a4i-6900000000-5622633ab0a27d2e5360	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, Positive	splash10-03di-9000000000-3e25ca80e2e62be19ac5	2012-08-31	View Spectrum

NMR

Type	Description	View
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, experimental)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Spectrum
2D NMR	[¹H, ¹H]-TOCSY. Unexported temporarily by An Chi on Oct 15, 2021 until json or nmrML file is generated. 2D NMR Spectrum (experimental)	Spectrum
2D NMR	[¹H, ¹³C]-HSQC NMR Spectrum (2D, 600 MHz, H₂O, experimental)	Spectrum

Pathways

Name	SMPDB/Pathwhiz	KEGG
Ammonia Recycling
Sphingolipid Metabolism
Glycine and Serine Metabolism
Methionine Metabolism
Homocysteine Degradation		Not Available

Protein Targets

Enzymes

Protein Name	Gene Name	Locus	Uniprot ID	Details
Serine--tRNA ligase, mitochondrial	SARS2	19q13.2	Q9NP81	details
Serine--tRNA ligase, cytoplasmic	SARS	1p13.3	P49591	details
L-serine dehydratase/L-threonine deaminase	SDS	12q24.13	P20132	details
Cystathionine beta-synthase	CBS	21q22.3	P35520	details
Serine--pyruvate aminotransferase	AGXT	2q37.3	P21549	details
Serine hydroxymethyltransferase, mitochondrial	SHMT2	12q12-q14	P34897	details
Serine hydroxymethyltransferase, cytosolic	SHMT1	17p11.2	P34896	details
Serine palmitoyltransferase 1	SPTLC1	9q22.2	O15269	details
Phosphoserine phosphatase	PSPH	7p11.2	P78330	details
Serine palmitoyltransferase 2	SPTLC2	14q24.3	O15270	details
Phosphatidylserine synthase 1	PTDSS1	8q22	P48651	details
Phosphatidylserine synthase 2	PTDSS2	11p15.5	Q9BVG9	details
Serine dehydratase-like	SDSL	12q24.13	Q96GA7	details
Serine palmitoyltransferase 3	SPTLC3	20p12.1	Q9NUV7	details
Serine racemase	SRR	17p13	Q9GZT4	details
Serine hydroxymethyltransferase	SHMT1	17p11.2	A8MYA6	details

Transporters

Protein Name	Gene Name	Locus	Uniprot ID	Details
Neutral amino acid transporter A	SLC1A4	2p15-p13	P43007	details
Monocarboxylate transporter 10	SLC16A10	6q21-q22	Q8TF71	details

Metal Bindings

Protein Name	Gene Name	Locus	Uniprot ID	Details
Cystathionine beta-synthase	CBS	21q22.3	P35520	details

Receptors

Not Available

Transcriptional Factors

Not Available

Concentrations Data

Cannabis Cultivar	Status	Value	Reference	Details
Alien Dawg	Detected and Quantified	0.637 mg/g dry wt	David S. Wishart,...	details
Gabriola	Detected and Quantified	0.372 mg/g dry wt	David S. Wishart,...	details
Island Honey	Detected and Quantified	0.511 mg/g dry wt	David S. Wishart,...	details
Quadra	Detected and Quantified	0.404 mg/g dry wt	David S. Wishart,...	details
Sensi Star	Detected and Quantified	0.386 mg/g dry wt	David S. Wishart,...	details
Tangerine Dream	Detected and Quantified	0.587 mg/g dry wt	David S. Wishart,...	details

External Links

HMDB ID

HMDB0000187

DrugBank ID

DB00133

Phenol Explorer Compound ID

Not Available

FoodDB ID

KNApSAcK ID

Chemspider ID

KEGG Compound ID

BioCyc ID

BiGG ID

Wikipedia Link

METLIN ID

PubChem Compound

PDB ID

Not Available

ChEBI ID

17115

References

General References

Turner CE, Elsohly MA, Boeren EG: Constituents of Cannabis sativa L. XVII. A review of the natural constituents. J Nat Prod. 1980 Mar-Apr;43(2):169-234. doi: 10.1021/np50008a001. [PubMed:6991645 ]
de Koning TJ, Snell K, Duran M, Berger R, Poll-The BT, Surtees R: L-serine in disease and development. Biochem J. 2003 May 1;371(Pt 3):653-61. doi: 10.1042/BJ20021785. [PubMed:12534373 ]

Only showing the first 10 proteins. There are 19 proteins in total.

Show All

Enzymes

Enzyme Details

1. Serine--tRNA ligase, mitochondrial

General function:: Involved in nucleotide binding
Specific function:: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity).
Gene Name:: SARS2
Uniprot ID:: Q9NP81
Molecular weight:: 58029.805

Enzyme Details

2. Serine--tRNA ligase, cytoplasmic

General function:: Involved in nucleotide binding
Specific function:: Catalyzes the attachment of serine to tRNA(Ser). Is also probably able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).
Gene Name:: SARS
Uniprot ID:: P49591
Molecular weight:: 58776.785

Enzyme Details

3. L-serine dehydratase/L-threonine deaminase

General function:: Involved in catalytic activity
Specific function:: Not Available
Gene Name:: SDS
Uniprot ID:: P20132
Molecular weight:: 34625.105

Enzyme Details

4. Cystathionine beta-synthase

General function:: Involved in cysteine biosynthetic process from serine
Specific function:: Only known pyridoxal phosphate-dependent enzyme that contains heme. Important regulator of hydrogen sulfide, especially in the brain, utilizing cysteine instead of serine to catalyze the formation of hydrogen sulfide. Hydrogen sulfide is a gastratransmitter with signaling and cytoprotective effects such as acting as a neuromodulator in the brain to protect neurons against hypoxic injury (By similarity).
Gene Name:: CBS
Uniprot ID:: P35520
Molecular weight:: 60586.05

Enzyme Details

5. Serine--pyruvate aminotransferase

General function:: Involved in metabolic process
Specific function:: Not Available
Gene Name:: AGXT
Uniprot ID:: P21549
Molecular weight:: 43009.535

Enzyme Details

6. Serine hydroxymethyltransferase, mitochondrial

General function:: Involved in catalytic activity
Specific function:: Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Interconversion of serine and glycine. Associates with mitochondrial DNA.
Gene Name:: SHMT2
Uniprot ID:: P34897
Molecular weight:: 54862.125

Enzyme Details

7. Serine hydroxymethyltransferase, cytosolic

General function:: Involved in catalytic activity
Specific function:: Interconversion of serine and glycine.
Gene Name:: SHMT1
Uniprot ID:: P34896
Molecular weight:: 53082.18

Enzyme Details

8. Serine palmitoyltransferase 1

General function:: Involved in transferase activity, transferring nitrogenous groups
Specific function:: Serine palmitoyltransferase (SPT). The heterodimer formed with SPTLC2 or SPTLC3 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference.
Gene Name:: SPTLC1
Uniprot ID:: O15269
Molecular weight:: 52743.41

Enzyme Details

9. Phosphoserine phosphatase

General function:: Involved in catalytic activity
Specific function:: Catalyzes the last step in the biosynthesis of serine from carbohydrates. The reaction mechanism proceeds via the formation of a phosphoryl-enzyme intermediates.
Gene Name:: PSPH
Uniprot ID:: P78330
Molecular weight:: 25007.49

Enzyme Details

10. Serine palmitoyltransferase 2

General function:: Involved in transferase activity
Specific function:: Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC2-SPTSSB complex displays a preference for C18-CoA substrate.
Gene Name:: SPTLC2
Uniprot ID:: O15270
Molecular weight:: 62923.765

Transporters

Enzyme Details

1. Neutral amino acid transporter A

General function:: Involved in sodium:dicarboxylate symporter activity
Specific function:: Transporter for alanine, serine, cysteine, and threonine. Exhibits sodium dependence
Gene Name:: SLC1A4
Uniprot ID:: P43007
Molecular weight:: 55722.5

Enzyme Details

2. Monocarboxylate transporter 10

General function:: Involved in transmembrane transport
Specific function:: Sodium-independent transporter that mediates the update of aromatic acid. Can function as a net efflux pathway for aromatic amino acids in the basosolateral epithelial cells
Gene Name:: SLC16A10
Uniprot ID:: Q8TF71
Molecular weight:: 55492.1

Only showing the first 10 proteins. There are 19 proteins in total.

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Showing Compound Card for L-Serine (CDB000131)

Structure for CDB000131 (L-Serine)

Enzymes

Transporters