Identification |
HMDB Protein ID
| CDBP02250 |
Secondary Accession Numbers
| Not Available |
Name
| Neutral amino acid transporter A |
Description
| Not Available |
Synonyms
|
- ASCT-1
- Alanine/serine/cysteine/threonine transporter 1
- SATT
- Solute carrier family 1 member 4
|
Gene Name
| SLC1A4 |
Protein Type
| Transporter |
Biological Properties |
General Function
| Involved in sodium:dicarboxylate symporter activity |
Specific Function
| Transporter for alanine, serine, cysteine, and threonine. Exhibits sodium dependence |
GO Classification
|
Component |
membrane |
cell part |
Function |
transmembrane transporter activity |
substrate-specific transmembrane transporter activity |
transporter activity |
organic acid transmembrane transporter activity |
carboxylic acid transmembrane transporter activity |
dicarboxylic acid transmembrane transporter activity |
sodium:dicarboxylate symporter activity |
Process |
transport |
organic acid transport |
carboxylic acid transport |
dicarboxylic acid transport |
establishment of localization |
|
Cellular Location
|
- Melanosome
- Membrane
- Multi-pass membrane protein
|
Pathways
|
Name | SMPDB/Pathwhiz | KEGG | Glucose-Alanine Cycle | | Not Available | Urea Cycle | | | Argininemia | | Not Available | Argininosuccinic Aciduria | | Not Available | Citrullinemia Type I | | Not Available |
|
Gene Properties |
Chromosome Location
| Chromosome:2 |
Locus
| 2p15-p13 |
SNPs
| SLC1A4 |
Gene Sequence
|
>1596 bp
ATGGCCCTGGGTGAAGAAAAGGCAGAAGCGGAAGCATCTGAAGACACAAAGGCCCAGTCC
TATGGGAGAGGGAGCTGCAGGGAGCGGGAGCTGGACATCCCAGGGCCCATGAGTGGGGAG
CAGCCCCCACGCCTGGAAGCTGAGGGAGGGCTCATCTCCCCTGTATGGGGGGCAGAAGGG
ATACCTGCCCCTACTTGCTGGATTGGGACTGACCCTGGCGGCCCCTCTAGAGCCCACCAG
CCACAGGCCAGTGATGCCAACAGAGAGCCCGTAGCTGAGAGGTCTGAGCCTGCACTCAGT
GGCCTGCCTCCTGCCACCATGGGGTCTGGAGACCTTCTGCTCTCCGGGGAAAGCCAGGTG
GAGAAGACCAAGCTTTCTTCCTCCGAGGAGTTCCCTCAGACTCTGAGCCTTCCCAGAACA
ACAACTATTTGCTCAGGACATGATGCTGATACCGAAGATGATCCATCCCTAGCAGATTTG
CCCCAGGCACTGGACCTCAGCCAGCAGCCTCACAGCTCAGGTCTCTCTTGCCTGTCACAG
TGGAAGTCCGTGCTGAGCCCAGGTTCCGCAGCTCAGCCTTCCAGCTGCAGCATCTCTGCT
TCCTCCACAGGCAGCAGTCTCCAGGGTCACCAGGAGAGGGCGGAGCCTCGTGGTGGTTCT
CTGGCCAAGGTCTCCTCCTCCCTGGAGCCGGTCGTCCCCCAGGAACCTTCCTCTGTGGTG
GGGCTAGGACCTCGGCCCCAGTGGTCACCACAGCCTGTGTTCTCTGGGGGTGATGCTTCT
GGGCTAGGCAGGAGACGCCTCTCCTTCCAGGCTGAGTACTGGGCCTGTGTGCTGCCAGAT
TCCCTGCCTCCATCACCCGACCGCCACTCCCCTCTCTGGAACCCAAATAAAGAGTATGAA
GATCTGCTTGACTATACTTACCCACTGAGGCCCGGGCCTCAGCTCCCAAAGCACCTTGAT
AGCCGTGTGCCAGCTGACCCTGTCCTGCAGGACTCCGGGGTAGACCTGGATAGCTTCTCT
GTCTCTCCAGCAAGCACCCTCAAATCACCTACTAATGTCTCCCCCAACTGCCCACCAGCA
GAGGCCACTGCCCTGCCATTTTCTGGGCCCAGAGAGCCAAGCCTTAAGCAGTGGCCCTCC
AGAGTACCCCAGAAACAGGGTGGCATGGGCTTGGCATCTTGGAGCCAACTTGCATCTACC
CCCAGAGCCCCAGGCAGTAGGGATGCTCGTTGGGAGCGCAGAGAGCCAGCCCTGAGGGGT
GCGAAGGACCGGCTGACTATAGGCAAGCACCTTGATATGGGCTCTCCCCAGCTAAGGACA
CGGGACAGAGGGTGGCCCTCGCCCAGGCCAGAGAGGGAGAAGAGGACCAGCCAGAGTGCC
CGGCGCCCTACCTGCACAGAGTCTAGGTGGAAATCAGAAGAGGAAGTGGAAAGTGATGAC
GAGTATCTTGCCCTCCCCGCTCGGCTGACACAGACATTTTGCTGTCAGCTGGAAGAGCTG
ATCTGCTGGCTGTATAATGTTGCAGATGTTACTGACCACGGGACTGCAGCCAGGTCCAAT
CTTACAAGTCTCAAGTCTTCTCTGCAGCTTTACCGG
|
Protein Properties |
Number of Residues
| 532 |
Molecular Weight
| 55722.5 |
Theoretical pI
| 6.18 |
Pfam Domain Function
|
|
Signals
|
|
Transmembrane Regions
|
- ["42-62", "88-108", "119-139", "217-237", "257-277", "298-318", "328-348", "373-393", "418-438"]
|
Protein Sequence
|
>Neutral amino acid transporter A
MEKSNETNGYLDSAQAGPAAGPGAPGTAAGRARRCAGFLRRQALVLLTVSGVLAGAGLGA
ALRGLSLSRTQVTYLAFPGEMLLRMLRMIILPLVVCSLVSGAASLDASCLGRLGGIAVAY
FGLTTLSASALAVALAFIIKPGSGAQTLQSSDLGLEDSGPPPVPKETVDSFLDLARNLFP
SNLVVAAFRTYATDYKVVTQNSSSGNVTHEKIPIGTEIEGMNILGLVLFALVLGVALKKL
GSEGEDLIRFFNSLNEATMVLVSWIMWYVPVGIMFLVGSKIVEMKDIIVLVTSLGKYIFA
SILGHVIHGGIVLPLIYFVFTRKNPFRFLLGLLAPFATAFATCSSSATLPSMMKCIEENN
GVDKRISRFILPIGATVNMDGAAIFQCVAAVFIAQLNNVELNAGQIFTILVTATASSVGA
AGVPAGGVLTIAIILEAIGLPTHDLPLILAVDWIVDRTTTVVNVEGDALGAGILHHLNQK
ATKKGEQELAEVKVEAIPNCKSEEETSPLVTHQNPAGPVASAPELESKESVL
|
External Links |
GenBank ID Protein
| 62822396 |
UniProtKB/Swiss-Prot ID
| P43007 |
UniProtKB/Swiss-Prot Entry Name
| SATT_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| AC007386 |
GeneCard ID
| SLC1A4 |
GenAtlas ID
| SLC1A4 |
HGNC ID
| HGNC:10942 |
References |
General References
| Not Available |