Cannabis Compound Database: Showing Compound Card for Salicylic acid (CDB004930)

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Identification Taxonomy Ontology Physical properties Spectra Protein target Pathways Concentrations Links References enzymes (5)transporters (8) Show 17 proteins XML

Record Information

Version

1.0

Created at

2020-04-17 18:51:39 UTC

Updated at

2022-12-13 23:36:28 UTC

CannabisDB ID

CDB004930

Secondary Accession Numbers

Not Available

Cannabis Compound Identification

Common Name

Salicylic acid

Description

Salicylic acid, also known as 2-carboxyphenol or 2-hydroxybenzoate, belongs to the class of organic compounds known as salicylic acids. These are ortho-hydroxylated benzoic acids. Salicylic acid is also classified as a beta hydroxy acid (BHA). Salicylic acid is a weak acid and exists as a white powder and has no detectable odor. It is readily soluble in water. Salicylic acid was originally isolated from willow trees and is found in many other plants where it functions as a plant hormone or phytohormone to facilitate plant defenses against pathogens (PMID: 31489905 ). Salicylic acid also helps plants cope with other abiotic stressors such a chilling, freezing, heat, heavy metals, salt and drought (PMID: 31489905 ). Salicylic acid also plays a role in the regulation or stomatal closure and seed germination. Industrially, salicylic acid is used as a food preservative, a bactericidal and an antiseptic. It is also used in the production of various pharmaceuticals, including 4-aminosalicylic acid, sandulpiride, landetimide and most notably acetylsalicylic acid or ASA (aspirin). Medically, salicylic acid is used most commonly to help remove the outer layer of the skin. As such, it is used to treat warts, psoriasis, acne, ringworm, dandruff, and ichthyosis. Salicylic acid modulates COX2 gene expression to decrease the formation of pro-inflammatory prostaglandins. Salicylic acid also inhibits the oxidation of uridine-5-diphosphoglucose (UDPG) competitively with nicotinamide adenosine dinucleotide (NAD). In humans, salicylic acid is involved in salicylic acid action pathway. Salicylic acid has been detected, but not quantified in, several different foods and plants, such as canola, cocoa beans, rowanberries, yautia, and ucuhuba. This could make salicylic acid a potential biomarker for the consumption of these foods. Salicylic acid is also found in cannabis smoke and is formed during the combustion of cannabis ( Ref:DOI ).

Structure

MOL SDF 3D-SDF PDB SMILES InChI View 3D Structure

Synonyms

Value	Source
2-Carboxyphenol	ChEBI
2-HYDROXYBENZOIC ACID	ChEBI
O-Carboxyphenol	ChEBI
O-Hydroxybenzoic acid	ChEBI
2-HYDROXYBENZOate	Generator
O-Hydroxybenzoate	Generator
Salicylate	Generator
2 Hydroxybenzoic acid	MeSH
Acid, 2-hydroxybenzoic	MeSH
Acid, salicylic	MeSH
Acid, O-hydroxybenzoic	MeSH
Acid, ortho-hydroxybenzoic	MeSH
O Hydroxybenzoic acid	MeSH
Ortho hydroxybenzoic acid	MeSH
Ortho-hydroxybenzoic acid	MeSH
2-Hydroxybenzenecarboxylate	HMDB
2-Hydroxybenzenecarboxylic acid	HMDB
Advanced pain relief callus removers	HMDB
Advanced pain relief corn removers	HMDB
Clear away wart remover	HMDB
Compound W	HMDB
Dr. scholl's callus removers	HMDB
Dr. scholl's corn removers	HMDB
Dr. scholl's wart remover kit	HMDB
Duofil wart remover	HMDB
Duoplant	HMDB
Freezone	HMDB
Ionil	HMDB
Ionil plus	HMDB
K 537	HMDB
K 557	HMDB
Phenol-2-carboxylate	HMDB
Phenol-2-carboxylic acid	HMDB
Psoriacid-S-stift	HMDB
Retarder W	HMDB
Rutranex	HMDB
Salicylic acid collodion	HMDB
Salicylic acid soap	HMDB
Saligel	HMDB
Salonil	HMDB
Stri-dex	HMDB
trans-Ver-sal	HMDB
SA	PhytoBank

Chemical Formula

C₇H₆O₃

Average Molecular Weight

138.12

Monoisotopic Molecular Weight

138.0317

IUPAC Name

2-hydroxybenzoic acid

Traditional Name

salicylic

CAS Registry Number

69-72-7

SMILES

OC(=O)C1=CC=CC=C1O

InChI Identifier

InChI=1S/C7H6O3/c8-6-4-2-1-3-5(6)7(9)10/h1-4,8H,(H,9,10)

InChI Key

YGSDEFSMJLZEOE-UHFFFAOYSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as salicylic acids. These are ortho-hydroxylated benzoic acids.

Kingdom

Organic compounds

Super Class

Benzenoids

Class

Benzene and substituted derivatives

Sub Class

Benzoic acids and derivatives

Direct Parent

Salicylic acids

Alternative Parents

Substituents

Salicylic acid
Benzoic acid
Benzoyl
1-hydroxy-4-unsubstituted benzenoid
1-hydroxy-2-unsubstituted benzenoid
Phenol
Vinylogous acid
Monocarboxylic acid or derivatives
Carboxylic acid
Carboxylic acid derivative
Organic oxygen compound
Organic oxide
Hydrocarbon derivative
Organooxygen compound
Aromatic homomonocyclic compound

Molecular Framework

Aromatic homomonocyclic compounds

External Descriptors

monohydroxybenzoic acid (CHEBI:16914 )

Ontology

Disposition

Route of exposure:

Enteral:

Ingestion

Source:

Food

Synthetic:

Personal care product

Biological:

Plant:

Biological location:

Tissue and substructures:

Placenta

Biofluid and excreta:

Organ and components:

Role

Industrial application:

Pharmaceutical industry:

Pharmaceutical

Physical Properties

State

Solid

Experimental Properties

Property	Value	Reference
Melting Point	158 °C	Not Available
Boiling Point	200 °C	Wikipedia
Water Solubility	2.24 mg/mL at 25 °C	Not Available
logP	2.26	HANSCH,C ET AL. (1995)

Predicted Properties

Property	Value	Source
logP	1.96	ALOGPS
logP	1.98	ChemAxon
logS	-1.1	ALOGPS
pKa (Strongest Acidic)	2.79	ChemAxon
pKa (Strongest Basic)	-6.3	ChemAxon
Physiological Charge	-1	ChemAxon
Hydrogen Acceptor Count	3	ChemAxon
Hydrogen Donor Count	2	ChemAxon
Polar Surface Area	57.53 Å²	ChemAxon
Rotatable Bond Count	1	ChemAxon
Refractivity	35.3 m³·mol⁻¹	ChemAxon
Polarizability	12.81 Å³	ChemAxon
Number of Rings	1	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

EI-MS/GC-MS

Type	Description	Splash Key	View
EI-MS	Mass Spectrum (Electron Ionization)	splash10-00du-9600000000-6d4a0ff2d48d814b5c54	2014-09-20	View Spectrum
GC-MS	Salicylic acid, 2 TMS, GC-MS Spectrum	splash10-014i-3890000000-62eae168a9d7ab3ada6f	Spectrum
GC-MS	Salicylic acid, non-derivatized, GC-MS Spectrum	splash10-00du-9700000000-e1e2ee6b61d86c596403	Spectrum
GC-MS	Salicylic acid, non-derivatized, GC-MS Spectrum	splash10-014i-3890000000-62eae168a9d7ab3ada6f	Spectrum
GC-MS	Salicylic acid, non-derivatized, GC-MS Spectrum	splash10-014i-2960000000-1b6b46cbb2b643b71448	Spectrum
Predicted GC-MS	Salicylic acid, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	splash10-0079-8900000000-e8ee46d81fcc1ce3766e	Spectrum
Predicted GC-MS	Salicylic acid, 2 TMS, Predicted GC-MS Spectrum - 70eV, Positive	splash10-006x-8950000000-9ed3a56f2b2654ba281f	Spectrum
Predicted GC-MS	Salicylic acid, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Salicylic acid, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum

MS/MS

Type	Description	Splash Key	View
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 10V, Negative (Annotated)	splash10-059j-9600000000-54545731fceee84be340	2012-07-24	View Spectrum
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 25V, Negative (Annotated)	splash10-00xu-9500000000-2f1c989b672669aaf083	2012-07-24	View Spectrum
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 40V, Negative (Annotated)	splash10-0gb9-9000000000-a0049e982e8ecd7ab730	2012-07-24	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Negative	splash10-000i-0900000000-f1e71df6894bcc8dda74	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, Negative	splash10-0006-9200000000-f9fd317c182ec7ca90dc	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, Negative	splash10-0006-9000000000-2b17aea4ee0ddd6321cf	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 40V, Negative	splash10-0006-9000000000-320b7cd879b61439cf42	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 50V, Negative	splash10-0006-9000000000-7d1b96d60026076a7ecc	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - ESI-TOF , Negative	splash10-002b-0496100000-97708001d2a6d031beff	2017-08-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - ESI-TOF 10V, Negative	splash10-002b-0496100000-97708001d2a6d031beff	2017-08-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - ESI-TOF , Negative	splash10-002b-0496100000-97708001d2a6d031beff	2017-09-12	View Spectrum
MS/MS	LC-MS/MS Spectrum - ESI-TOF 10V, Negative	splash10-000i-0900000000-f88c693bac9b89416a52	2017-09-12	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QFT , negative	splash10-0006-9400000000-b0fb5458dfa73429b976	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QFT , negative	splash10-0006-9400000000-b0fb5458dfa73429b976	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QFT , negative	splash10-0006-9100000000-237ee14e8af5262c0dab	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QFT , negative	splash10-0006-9000000000-3ec5d7a9114e37b8af2a	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QFT , negative	splash10-0006-9000000000-d8fdab29114453b10280	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QFT , negative	splash10-0006-9000000000-4a337e3639c9f42a9000	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QFT , negative	splash10-0006-9000000000-2deb0e843e099fdcea99	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QFT , negative	splash10-00kf-9000000000-951b374b351c5534628a	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QFT , negative	splash10-014l-9000000000-4ea52d5aa4344a40c007	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ , negative	splash10-000i-0900000000-f1e71df6894bcc8dda74	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ , negative	splash10-0006-9200000000-65f3f297188dc07b53be	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ , negative	splash10-0006-9000000000-2b17aea4ee0ddd6321cf	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ , negative	splash10-0006-9000000000-320b7cd879b61439cf42	2017-09-14	View Spectrum

NMR

Type	Description	View
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, experimental)	Spectrum
1D NMR	¹H NMR Spectrum (1D, D₂O, experimental)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, D₂O, experimental)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Spectrum
2D NMR	[¹H, ¹H]-TOCSY. Unexported temporarily by An Chi on Oct 15, 2021 until json or nmrML file is generated. 2D NMR Spectrum (experimental)	Spectrum
2D NMR	[¹H, ¹³C]-HSQC NMR Spectrum (2D, 600 MHz, H₂O, experimental)	Spectrum

Pathways

Name	SMPDB/Pathwhiz	KEGG
Salicylic Acid Action Pathway		Not Available

Protein Targets

Enzymes

Protein Name	Gene Name	Locus	Uniprot ID	Details
Aldo-keto reductase family 1 member C1	AKR1C1	10p15-p14	Q04828	details
UDP-glucuronosyltransferase 1-1	UGT1A1	2q37	P22309	details
Prostaglandin G/H synthase 2	PTGS2	1q25.2-q25.3	P35354	details
Prostaglandin G/H synthase 1	PTGS1	9q32-q33.3	P23219	details
Glycine N-acyltransferase	GLYAT	11q12.1	Q6IB77	details

Transporters

Protein Name	Gene Name	Locus	Uniprot ID	Details
Monocarboxylate transporter 1	SLC16A1	1p12	P53985	details
Solute carrier organic anion transporter family member 2B1	SLCO2B1	11q13	O94956	details
Multidrug resistance protein 1	ABCB1	7q21.12	P08183	details
Solute carrier family 22 member 11	SLC22A11	11q13.1	Q9NSA0	details
Solute carrier family 22 member 6	SLC22A6	11q12.3	Q4U2R8	details
Amiloride-sensitive cation channel 2, neuronal	ACCN2	12q12	P78348	details
Amiloride-sensitive cation channel 3	ACCN3	7q35	Q9UHC3	details
Solute carrier family 22 member 7	SLC22A7	6p21.1	Q9Y694	details

Metal Bindings

Protein Name	Gene Name	Locus	Uniprot ID	Details
Prostaglandin G/H synthase 2	PTGS2	1q25.2-q25.3	P35354	details
Prostaglandin G/H synthase 1	PTGS1	9q32-q33.3	P23219	details
Cytochrome P450 2C9	CYP2C9	10q24	P11712	details

Receptors

Protein Name	Gene Name	Locus	Uniprot ID	Details
Prostaglandin G/H synthase 1	PTGS1	9q32-q33.3	P23219	details

Transcriptional Factors

Not Available

Concentrations Data

Cannabis Cultivar	Status	Value	Reference	Details
Alien Dawg	Detected and Quantified	0.0231 mg/g dry wt	David S. Wishart,...	details
Gabriola	Detected and Quantified	0.0236 mg/g dry wt	David S. Wishart,...	details
Island Honey	Detected and Quantified	0.0103 mg/g dry wt	David S. Wishart,...	details
Quadra	Detected and Quantified	0.0214 mg/g dry wt	David S. Wishart,...	details
Sensi Star	Detected and Quantified	0.0104 mg/g dry wt	David S. Wishart,...	details
Tangerine Dream	Detected and Quantified	0.00854 mg/g dry wt	David S. Wishart,...	details

External Links

HMDB ID

HMDB0001895

DrugBank ID

DB00936

Phenol Explorer Compound ID

FoodDB ID

KNApSAcK ID

Chemspider ID

KEGG Compound ID

BioCyc ID

BiGG ID

Not Available

Wikipedia Link

Salicylic_Acid

METLIN ID

616

PubChem Compound

338

PDB ID

Not Available

ChEBI ID

16914

References

General References

Pokotylo I, Kravets V, Ruelland E: Salicylic Acid Binding Proteins (SABPs): The Hidden Forefront of Salicylic Acid Signalling. Int J Mol Sci. 2019 Sep 6;20(18). pii: ijms20184377. doi: 10.3390/ijms20184377. [PubMed:31489905 ]

Only showing the first 10 proteins. There are 17 proteins in total.

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Enzymes

Enzyme Details

1. Aldo-keto reductase family 1 member C1

General function:: Involved in oxidoreductase activity
Specific function:: Converts progesterone to its inactive form, 20-alpha-dihydroxyprogesterone (20-alpha-OHP). In the liver and intestine, may have a role in the transport of bile. May have a role in monitoring the intrahepatic bile acid concentration. Has a low bile-binding ability. May play a role in myelin formation.
Gene Name:: AKR1C1
Uniprot ID:: Q04828
Molecular weight:: 36788.02

Enzyme Details

2. UDP-glucuronosyltransferase 1-1

General function:: Involved in transferase activity, transferring hexosyl groups
Specific function:: UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX-alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate. Is also able to catalyze the glucuronidation of 17beta-estradiol, 17alpha-ethinylestradiol, 1-hydroxypyrene, 4-methylumbelliferone, 1-naphthol, paranitrophenol, scopoletin, and umbelliferone.
Gene Name:: UGT1A1
Uniprot ID:: P22309
Molecular weight:: 59590.91

Enzyme Details

3. Prostaglandin G/H synthase 2

General function:: Involved in peroxidase activity
Specific function:: Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity.
Gene Name:: PTGS2
Uniprot ID:: P35354
Molecular weight:: 68995.625

Enzyme Details

4. Prostaglandin G/H synthase 1

General function:: Involved in peroxidase activity
Specific function:: May play an important role in regulating or promoting cell proliferation in some normal and neoplastically transformed cells.
Gene Name:: PTGS1
Uniprot ID:: P23219
Molecular weight:: 68685.82

Enzyme Details

5. Glycine N-acyltransferase

General function:: Involved in glycine N-acyltransferase activity
Specific function:: Mitochondrial acyltransferase which transfers an acyl group to the N-terminus of glycine and glutamine, although much less efficiently. Can conjugate numerous substrates to form a variety of N-acylglycines, with a preference for benzoyl-CoA over phenylacetyl-CoA as acyl donors. Thereby detoxify xenobiotics, such as benzoic acid or salicylic acid, and endogenous organic acids, such as isovaleric acid.
Gene Name:: GLYAT
Uniprot ID:: Q6IB77
Molecular weight:: 18506.33

Transporters

Enzyme Details

1. Monocarboxylate transporter 1

General function:: Involved in transmembrane transport
Specific function:: Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate
Gene Name:: SLC16A1
Uniprot ID:: P53985
Molecular weight:: 53957.7

Enzyme Details

2. Solute carrier organic anion transporter family member 2B1

General function:: Involved in transporter activity
Specific function:: Mediates the Na(+)-independent transport of organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost
Gene Name:: SLCO2B1
Uniprot ID:: O94956
Molecular weight:: 76697.9

Enzyme Details

3. Multidrug resistance protein 1

General function:: Involved in ATP binding
Specific function:: Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells
Gene Name:: ABCB1
Uniprot ID:: P08183
Molecular weight:: 141477.3

Enzyme Details

4. Solute carrier family 22 member 11

General function:: Involved in transporter activity
Specific function:: Mediates saturable uptake of estrone sulfate, dehydroepiandrosterone sulfate and related compounds
Gene Name:: SLC22A11
Uniprot ID:: Q9NSA0
Molecular weight:: 59970.9

Enzyme Details

5. Solute carrier family 22 member 6

General function:: Involved in ion transmembrane transporter activity
Specific function:: Involved in the renal elimination of endogenous and exogenous organic anions. Functions as organic anion exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one molecule of endogenous dicarboxylic acid (glutarate, ketoglutarate, etc). Mediates the sodium-independent uptake of 2,3-dimercapto-1-propanesulfonic acid (DMPS). Mediates the sodium-independent uptake of p- aminohippurate (PAH), ochratoxin (OTA), acyclovir (ACV), 3'-azido- 3-'deoxythymidine (AZT), cimetidine (CMD), 2,4-dichloro- phenoxyacetate (2,4-D), hippurate (HA), indoleacetate (IA), indoxyl sulfate (IS) and 3-carboxy-4-methyl-5-propyl-2- furanpropionate (CMPF), cidofovir, adefovir, 9-(2- phosphonylmethoxyethyl) guanine (PMEG), 9-(2- phosphonylmethoxyethyl) diaminopurine (PMEDAP) and edaravone sulfate. PAH uptake is inhibited by p- chloromercuribenzenesulphonate (PCMBS), diethyl pyrocarbonate (DEPC), sulindac, diclofenac, carprofen, glutarate and okadaic acid. PAH uptake is inhibited by benzothiazolylcysteine (BTC), S-chlorotrifluoroethylcysteine (CTFC), cysteine S-conjugates S-dichlorovinylcysteine (DCVC), furosemide, steviol, phorbol 12-myristate 13-acetate (PMA), calcium ionophore A23187, benzylpenicillin, furosemide, indomethacin, bumetamide, losartan, probenecid, phenol red, urate, and alpha-ketoglutarate
Gene Name:: SLC22A6
Uniprot ID:: Q4U2R8
Molecular weight:: 61815.8

Enzyme Details

6. Amiloride-sensitive cation channel 2, neuronal

General function:: Involved in ligand-gated sodium channel activity
Specific function:: Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Ca(2+), Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Mediates glutamate-independent Ca(2+) entry into neurons upon acidosis. This Ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor that influences intracellular Ca(2+) concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Modulates activity in the circuits underlying innate fear
Gene Name:: ACCN2
Uniprot ID:: P78348
Molecular weight:: 59908.9

Enzyme Details

7. Amiloride-sensitive cation channel 3

General function:: Involved in ligand-gated sodium channel activity
Specific function:: Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties
Gene Name:: ACCN3
Uniprot ID:: Q9UHC3
Molecular weight:: 58904.7

Enzyme Details

8. Solute carrier family 22 member 7

General function:: Involved in transmembrane transport
Specific function:: Mediates sodium-independent multispecific organic anion transport. Transport of prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha- ketoglutarate
Gene Name:: SLC22A7
Uniprot ID:: Q9Y694
Molecular weight:: 60025.0

Only showing the first 10 proteins. There are 17 proteins in total.

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Showing Compound Card for Salicylic acid (CDB004930)

Structure for CDB004930 (Salicylic acid)

Enzymes

Transporters