Identification |
HMDB Protein ID
| CDBP03200 |
Secondary Accession Numbers
| Not Available |
Name
| Solute carrier family 22 member 6 |
Description
| Not Available |
Synonyms
|
- Organic anion transporter 1
- PAH transporter
- Renal organic anion transporter 1
- hOAT1
- hPAHT
- hROAT1
|
Gene Name
| SLC22A6 |
Protein Type
| Transporter |
Biological Properties |
General Function
| Involved in ion transmembrane transporter activity |
Specific Function
| Involved in the renal elimination of endogenous and exogenous organic anions. Functions as organic anion exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one molecule of endogenous dicarboxylic acid (glutarate, ketoglutarate, etc). Mediates the sodium-independent uptake of 2,3-dimercapto-1-propanesulfonic acid (DMPS). Mediates the sodium-independent uptake of p- aminohippurate (PAH), ochratoxin (OTA), acyclovir (ACV), 3'-azido- 3-'deoxythymidine (AZT), cimetidine (CMD), 2,4-dichloro- phenoxyacetate (2,4-D), hippurate (HA), indoleacetate (IA), indoxyl sulfate (IS) and 3-carboxy-4-methyl-5-propyl-2- furanpropionate (CMPF), cidofovir, adefovir, 9-(2- phosphonylmethoxyethyl) guanine (PMEG), 9-(2- phosphonylmethoxyethyl) diaminopurine (PMEDAP) and edaravone sulfate. PAH uptake is inhibited by p- chloromercuribenzenesulphonate (PCMBS), diethyl pyrocarbonate (DEPC), sulindac, diclofenac, carprofen, glutarate and okadaic acid. PAH uptake is inhibited by benzothiazolylcysteine (BTC), S-chlorotrifluoroethylcysteine (CTFC), cysteine S-conjugates S-dichlorovinylcysteine (DCVC), furosemide, steviol, phorbol 12-myristate 13-acetate (PMA), calcium ionophore A23187, benzylpenicillin, furosemide, indomethacin, bumetamide, losartan, probenecid, phenol red, urate, and alpha-ketoglutarate |
GO Classification
|
Component |
cell part |
membrane part |
intrinsic to membrane |
integral to membrane |
Function |
transmembrane transporter activity |
substrate-specific transmembrane transporter activity |
ion transmembrane transporter activity |
transporter activity |
Process |
transmembrane transport |
ion transport |
establishment of localization |
transport |
|
Cellular Location
|
- Cell membrane
- Multi-pass membrane protein (Potential)
|
Pathways
|
Name | SMPDB/Pathwhiz | KEGG | Kidney Function | ![Thumb](https://smpdb.ca/super_pathway_visualizations/PW000147/thumb) ![Thumb?image type=greyscale](https://smpdb.ca/super_pathway_visualizations/PW000147/thumb?image_type=greyscale) ![Thumb?image type=simple](https://smpdb.ca/super_pathway_visualizations/PW000147/thumb?image_type=simple) | Not Available | Glucose Transporter Defect (SGLT2) | ![Thumb](https://smpdb.ca/super_pathway_visualizations/PW000216/thumb) ![Thumb?image type=greyscale](https://smpdb.ca/super_pathway_visualizations/PW000216/thumb?image_type=greyscale) ![Thumb?image type=simple](https://smpdb.ca/super_pathway_visualizations/PW000216/thumb?image_type=simple) | Not Available | Hartnup Disorder | ![Thumb](https://smpdb.ca/super_pathway_visualizations/PW000218/thumb) ![Thumb?image type=greyscale](https://smpdb.ca/super_pathway_visualizations/PW000218/thumb?image_type=greyscale) ![Thumb?image type=simple](https://smpdb.ca/super_pathway_visualizations/PW000218/thumb?image_type=simple) | Not Available | Iminoglycinuria | ![Thumb](https://smpdb.ca/super_pathway_visualizations/PW000219/thumb) ![Thumb?image type=greyscale](https://smpdb.ca/super_pathway_visualizations/PW000219/thumb?image_type=greyscale) ![Thumb?image type=simple](https://smpdb.ca/super_pathway_visualizations/PW000219/thumb?image_type=simple) | Not Available | Lysinuric Protein Intolerance | ![Thumb](https://smpdb.ca/super_pathway_visualizations/PW000220/thumb) ![Thumb?image type=greyscale](https://smpdb.ca/super_pathway_visualizations/PW000220/thumb?image_type=greyscale) ![Thumb?image type=simple](https://smpdb.ca/super_pathway_visualizations/PW000220/thumb?image_type=simple) | Not Available |
|
Gene Properties |
Chromosome Location
| Chromosome:1 |
Locus
| 11q12.3 |
SNPs
| SLC22A6 |
Gene Sequence
|
>1692 bp
ATGGCCTTTAATGACCTCCTGCAGCAGGTGGGGGGTGTCGGCCGCTTCCAGCAGATCCAG
GTCACCCTGGTGGTCCTCCCCCTGCTCCTGATGGCTTCTCACAACACCCTGCAGAACTTC
ACTGCTGCCATCCCTACCCACCACTGCCGCCCGCCTGCCGATGCCAACCTCAGCAAGAAC
GGGGGGCTGGAGGTCTGGCTGCCCCGGGACAGGCAGGGGCAGCCTGAGTCCTGCCTCCGC
TTCACCTCCCCGCAGTGGGGACTGCCCTTTCTCAATGGCACAGAAGCCAATGGCACAGGG
GCCACAGAGCCCTGCACCGATGGCTGGATCTATGACAACAGCACCTTCCCATCTACCATC
GTGACTGAGTGGGACCTTGTGTGCTCTCACAGGGCCCTACGCCAGCTGGCCCAGTCCTTG
TACATGGTGGGGGTGCTGCTCGGAGCCATGGTGTTCGGCTACCTTGCAGACAGGCTAGGC
CGCCGGAAGGTACTCATCTTGAACTACCTGCAGACAGCTGTGTCAGGGACCTGCGCAGCC
TTCGCACCCAACTTCCCCATCTACTGCGCCTTCCGGCTCCTCTCGGGCATGGCTCTGGCT
GGCATCTCCCTCAACTGCATGACACTGAATGTGGAGTGGATGCCCATTCACACACGGGCC
TGCGTGGGCACCTTGATTGGCTATGTCTACAGCCTGGGCCAGTTCCTCCTGGCTGGTGTG
GCCTACGCTGTGCCCCACTGGCGCCACCTGCAGCTACTGGTCTCTGCGCCTTTTTTTGCC
TTCTTCATCTACTCCTGGTTCTTCATTGAGTCGGCCCGCTGGCACTCCTCCTCCGGGAGG
CTGGACCTCACCCTGAGGGCCCTGCAGAGAGTCGCCCGGATCAATGGGAAGCGGGAAGAA
GGAGCCAAATTGAGTATGGAGGTACTCCGGGCCAGTCTGCAGAAGGAGCTGACCATGGGC
AAAGGCCAGGCATCGGCCATGGAGCTGCTGCGCTGCCCCACCCTCCGCCACCTCTTCCTC
TGCCTCTCCATGCTGTGGTTTGCCACTAGCTTTGCATACTATGGGCTGGTCATGGACCTG
CAGGGCTTTGGAGTCAGCATCTACCTAATCCAGGTGATCTTTGGTGCTGTGGACCTGCCT
GCCAAGCTTGTGGGCTTCCTTGTCATCAACTCCCTGGGTCGCCGGCCTGCCCAGATGGCT
GCACTGCTGCTGGCAGGCATCTGCATCCTGCTCAATGGGGTGATACCCCAGGACCAGTCC
ATTGTCCGAACCTCTCTTGCTGTGCTGGGGAAGGGTTGTCTGGCTGCCTCCTTCAACTGC
ATCTTCCTGTATACTGGGGAACTGTATCCCACAATGATCCGGCAGACAGGCATGGGAATG
GGCAGCACCATGGCCCGAGTGGGCAGCATCGTGAGCCCACTGGTGAGCATGACTGCCGAG
CTCTACCCCTCCATGCCTCTCTTCATCTACGGTGCTGTTCCTGTGGCCGCCAGCGCTGTC
ACTGTCCTCCTGCCAGAGACCCTGGGCCAGCCACTGCCAGACACGGTGCAGGACCTGGAG
AGCAGGTGGGCCCCCACTCAGAAAGAAGCAGGGATATATCCCAGGAAAGGGAAACAGACG
CGACAGCAACAAGAGCACCAGAAGTATATGGTCCCACTGCAGGCCTCAGCACAAGAGAAG
AATGGACTCTGA
|
Protein Properties |
Number of Residues
| 563 |
Molecular Weight
| 61815.8 |
Theoretical pI
| 8.88 |
Pfam Domain Function
|
|
Signals
|
|
Transmembrane Regions
|
- ["10-30", "136-156", "165-187", "191-213", "225-245", "249-269", "338-358", "369-389", "396-416", "426-446", "456-475", "485-505"]
|
Protein Sequence
|
>Solute carrier family 22 member 6
MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLSKN
GGLEVWLPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTGATEPCTDGWIYDNSTFPSTI
VTEWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCAA
FAPNFPIYCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLAGV
AYAVPHWRHLQLLVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGKREE
GAKLSMEVLRASLQKELTMGKGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVMDL
QGFGVSIYLIQVIFGAVDLPAKLVGFLVINSLGRRPAQMAALLLAGICILLNGVIPQDQS
IVRTSLAVLGKGCLAASFNCIFLYTGELYPTMIRQTGMGMGSTMARVGSIVSPLVSMTAE
LYPSMPLFIYGAVPVAASAVTVLLPETLGQPLPDTVQDLESRWAPTQKEAGIYPRKGKQT
RQQQEHQKYMVPLQASAQEKNGL
|
External Links |
GenBank ID Protein
| 4579723 |
UniProtKB/Swiss-Prot ID
| Q4U2R8 |
UniProtKB/Swiss-Prot Entry Name
| S22A6_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| AB009697 |
GeneCard ID
| SLC22A6 |
GenAtlas ID
| SLC22A6 |
HGNC ID
| HGNC:10970 |
References |
General References
| Not Available |