Cannabis Compound Database: Showing Compound Card for L-Tyrosine (CDB004812)

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Record Information

Version

1.0

Created at

2020-04-17 18:39:18 UTC

Updated at

2020-12-07 19:11:00 UTC

CannabisDB ID

CDB004812

Secondary Accession Numbers

Not Available

Cannabis Compound Identification

Common Name

L-Tyrosine

Description

Tyrosine or L-tyrosine abbreviated Tyr or Y, is a non-essential, hydrophobic amino acid synthesized from phenylalanine, which is derived from food. In humans, the¬†enzyme¬†phenylalanine hydroxylase catalyzes the conversion of phenylalanine to tyrosine. Tyrosine is strong basic compound with an odorless taste. Tyrosine is found in highest concentrations in protein rich foods such as caseins (cheese, yogurt), milk (cow), chicken, turkey, peanuts, almonds, sesame seeds, lima beans and soy products and in lower concentrations in avocado, bananas, semolina, crayfish, and crabs. Tyrosine has also been detected in annual wild rices, lovages, corianders, lumpsuckers, and sugars making tyrosine a potential biomarker for the consumption of these foods. Tyrosine is also found in cannabis plants (PMID: 6991645 ). It is not found in high concentrations in the body as it is rapidly metabolized. Valine and other branched amino acids, and possibly tryptophan and phenylalanine may reduce tyrosine absorption. Tyrosine readily passes the blood-brain barrier where it is converted to L-dopamine (L-dopa) by tyrosine hydroxylase. L-dopa is a precursor of the catecholamines, norepinephrine and epinephrine. L-dopa is used to treat Parkinson's (PMID: 29503325 ) and tyrosine, in large doses, can be used as an adjunct in the treatment of Parkinson's. Tyrosine is also the precursor for the thyroid hormones (PMID: 29892819 ) and for the human pigment, melanin. Tyrosine is an important amino acid in many proteins, peptides and even enkephalins, the body's natural pain reliever. The hydroxyl of tyrosine can be phosphorylated by protein kinases (PMID: 10966463 ), creating phosphotyrosine. This phosphorylation is an important part of signal transduction within the cell and also alters the enzymatic activity of target proteins. There are several genetic errors of tyrosine metabolism such as hawkinsinuria and tyrosinemia I (PMID: 30740402 ) where there is an increased amount of tyrosine in the blood of premature infants. This causes decreased motor activity, lethargy, poor feeding, infection and intellectual deficits. Vitamin C supplements may reverse the disease as increasing amounts of vitamin C improved performance in chicks supplemented with excess tyrosine (PMID: 7104784 ). Some adults also develop elevated tyrosine in their blood signaling a need for more vitamin C. More tyrosine is needed under stress, and tyrosine supplements may prevent the stress-induced depletion of norepinephrine and can cure biochemical depression. However, excess, tyrosine may lead to psychosis. Indeed, many antipsychotic medications apparently function by inhibiting tyrosine metabolism. L-Tyrosine is expected to be in Cannabis as all living plants are known to produce and metabolize it.

Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
(-)-alpha-Amino-p-hydroxyhydrocinnamic acid	ChEBI
(2S)-2-Amino-3-(4-hydroxyphenyl)propanoic acid	ChEBI
(S)-(-)-Tyrosine	ChEBI
(S)-2-Amino-3-(p-hydroxyphenyl)propionic acid	ChEBI
(S)-3-(p-Hydroxyphenyl)alanine	ChEBI
(S)-alpha-Amino-4-hydroxybenzenepropanoic acid	ChEBI
(S)-Tyrosine	ChEBI
4-Hydroxy-L-phenylalanine	ChEBI
L-Tyrosin	ChEBI
Tyr	ChEBI
TYROSINE	ChEBI
Y	ChEBI
(-)-a-Amino-p-hydroxyhydrocinnamate	Generator
(-)-a-Amino-p-hydroxyhydrocinnamic acid	Generator
(-)-alpha-Amino-p-hydroxyhydrocinnamate	Generator
(-)-Α-amino-p-hydroxyhydrocinnamate	Generator
(-)-Α-amino-p-hydroxyhydrocinnamic acid	Generator
(2S)-2-Amino-3-(4-hydroxyphenyl)propanoate	Generator
(S)-2-Amino-3-(p-hydroxyphenyl)propionate	Generator
(S)-a-Amino-4-hydroxybenzenepropanoate	Generator
(S)-a-Amino-4-hydroxybenzenepropanoic acid	Generator
(S)-alpha-Amino-4-hydroxybenzenepropanoate	Generator
(S)-Α-amino-4-hydroxybenzenepropanoate	Generator
(S)-Α-amino-4-hydroxybenzenepropanoic acid	Generator
(S)-a-Amino-4-hydroxy-benzenepropanoate	HMDB
(S)-a-Amino-4-hydroxy-benzenepropanoic acid	HMDB
(S)-alpha-Amino-4-hydroxy-benzenepropanoate	HMDB
(S)-alpha-Amino-4-hydroxy-benzenepropanoic acid	HMDB
2-Amino-3-(4-hydroxyphen yl)-2-amino-3-(4-hydroxyphenyl)-propanoate	HMDB
2-Amino-3-(4-hydroxyphen yl)-2-amino-3-(4-hydroxyphenyl)-propanoic acid	HMDB
3-(4-Hydroxyphenyl)-L-alanine	HMDB
Benzenepropanoate	HMDB
Benzenepropanoic acid	HMDB
L-p-Tyrosine	HMDB
p-Tyrosine	HMDB
L Tyrosine	HMDB
Tyrosine, L-isomer	HMDB
Tyrosine, L isomer	HMDB
Para tyrosine	HMDB
Para-tyrosine	HMDB

Chemical Formula

C₉H₁₁NO₃

Average Molecular Weight

181.19

Monoisotopic Molecular Weight

181.0739

IUPAC Name

(2S)-2-amino-3-(4-hydroxyphenyl)propanoic acid

Traditional Name

L-tyrosine

CAS Registry Number

140-43-2

SMILES

N[C@@H](CC1=CC=C(O)C=C1)C(O)=O

InChI Identifier

InChI=1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1

InChI Key

OUYCCCASQSFEME-QMMMGPOBSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as tyrosine and derivatives. Tyrosine and derivatives are compounds containing tyrosine or a derivative thereof resulting from reaction of tyrosine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom.

Kingdom

Organic compounds

Super Class

Organic acids and derivatives

Class

Carboxylic acids and derivatives

Sub Class

Amino acids, peptides, and analogues

Direct Parent

Tyrosine and derivatives

Alternative Parents

Substituents

Tyrosine or derivatives
Phenylalanine or derivatives
3-phenylpropanoic-acid
Alpha-amino acid
Amphetamine or derivatives
L-alpha-amino acid
1-hydroxy-2-unsubstituted benzenoid
Phenol
Aralkylamine
Monocyclic benzene moiety
Benzenoid
Amino acid
Carboxylic acid
Monocarboxylic acid or derivatives
Organic oxide
Organooxygen compound
Organonitrogen compound
Amine
Primary aliphatic amine
Organic nitrogen compound
Carbonyl group
Organopnictogen compound
Organic oxygen compound
Hydrocarbon derivative
Primary amine
Aromatic homomonocyclic compound

Molecular Framework

Aromatic homomonocyclic compounds

External Descriptors

proteinogenic amino acid (CHEBI:17895 )
L-alpha-amino acid (CHEBI:17895 )
tyrosine (CHEBI:17895 )
erythrose 4-phosphate/phosphoenolpyruvate family amino acid (CHEBI:17895 )
Common amino acids (C00082 )

Ontology

Myocardial infarction

Endocrine disorders:

Hypothyroidism

Cancer:

Leukemia

Disposition

Route of exposure:

Enteral:

Ingestion

Source:

Synthetic:

Personal care product

Biological:

Animal

Plant:

Biological location:

Tissue and substructures:

Organ and components:

Prostate

Biofluid and excreta:

Subcellular:

Cell and elements:

Extracellular

Role

Biological role:

Trace element

Industrial application:

Personal care products

Food and nutrition:

Nutritional supplement

Pharmaceutical industry:

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	343 °C	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	0.48 mg/mL	Not Available
logP	-2.26	HANSCH,C ET AL. (1995)

Predicted Properties

Property	Value	Source
logP	-2.4	ALOGPS
logP	-1.5	ChemAxon
logS	-1.4	ALOGPS
pKa (Strongest Acidic)	2	ChemAxon
pKa (Strongest Basic)	9.19	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	4	ChemAxon
Hydrogen Donor Count	3	ChemAxon
Polar Surface Area	83.55 Å²	ChemAxon
Rotatable Bond Count	3	ChemAxon
Refractivity	47.1 m³·mol⁻¹	ChemAxon
Polarizability	18.01 Å³	ChemAxon
Number of Rings	1	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

EI-MS/GC-MS

Type	Description	Splash Key	View
EI-MS	Mass Spectrum (Electron Ionization)	splash10-0a4i-3900000000-7a26097fda66f2f445b5	2018-05-25	View Spectrum
GC-MS	L-Tyrosine, 3 TMS, GC-MS Spectrum	splash10-014i-0690000000-cbbf40bb26fc84f2aead	Spectrum
GC-MS	L-Tyrosine, 3 TMS, GC-MS Spectrum	splash10-014i-0890000000-ca45f993f95c8b0cee44	Spectrum
GC-MS	L-Tyrosine, 3 TMS, GC-MS Spectrum	splash10-014i-0890000000-5749069211ba15d713ef	Spectrum
GC-MS	L-Tyrosine, 3 TMS, GC-MS Spectrum	splash10-00xr-9240000000-2c87373c0d964e0edef5	Spectrum
GC-MS	L-Tyrosine, non-derivatized, GC-MS Spectrum	splash10-014i-0890000000-848b2a4f247a0b3f14e8	Spectrum
GC-MS	L-Tyrosine, 3 TMS, GC-MS Spectrum	splash10-00xr-9450000000-6d4550940f4dde6f18ff	Spectrum
GC-MS	L-Tyrosine, 2 TMS, GC-MS Spectrum	splash10-004i-1910000000-5cc19cad5dc24b3b9b11	Spectrum
GC-MS	L-Tyrosine, 3 TMS, GC-MS Spectrum	splash10-014i-1790000000-de22041357aadf60a06b	Spectrum
GC-MS	L-Tyrosine, non-derivatized, GC-MS Spectrum	splash10-014i-0690000000-cbbf40bb26fc84f2aead	Spectrum
GC-MS	L-Tyrosine, non-derivatized, GC-MS Spectrum	splash10-014i-0890000000-ca45f993f95c8b0cee44	Spectrum
GC-MS	L-Tyrosine, non-derivatized, GC-MS Spectrum	splash10-014i-0890000000-5749069211ba15d713ef	Spectrum
GC-MS	L-Tyrosine, non-derivatized, GC-MS Spectrum	splash10-00xr-9240000000-2c87373c0d964e0edef5	Spectrum
GC-MS	L-Tyrosine, non-derivatized, GC-MS Spectrum	splash10-014i-0890000000-848b2a4f247a0b3f14e8	Spectrum
GC-MS	L-Tyrosine, non-derivatized, GC-MS Spectrum	splash10-0udi-3319000000-1d3d28a67f82366fff22	Spectrum
GC-MS	L-Tyrosine, non-derivatized, GC-MS Spectrum	splash10-00xr-9450000000-6d4550940f4dde6f18ff	Spectrum
GC-MS	L-Tyrosine, non-derivatized, GC-MS Spectrum	splash10-004i-1910000000-5cc19cad5dc24b3b9b11	Spectrum
GC-MS	L-Tyrosine, non-derivatized, GC-MS Spectrum	splash10-014i-1790000000-de22041357aadf60a06b	Spectrum
Predicted GC-MS	L-Tyrosine, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	splash10-052r-4900000000-9be1412408207db5df4e	Spectrum
Predicted GC-MS	L-Tyrosine, 2 TMS, Predicted GC-MS Spectrum - 70eV, Positive	splash10-05fr-9750000000-937b6ee7a745865ee7ee	Spectrum
Predicted GC-MS	L-Tyrosine, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	L-Tyrosine, TMS_1_1, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	L-Tyrosine, TMS_1_2, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	L-Tyrosine, TMS_1_3, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	L-Tyrosine, TMS_2_2, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	L-Tyrosine, TMS_2_3, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum

MS/MS

Type	Description	Splash Key	View
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)	splash10-01p9-0900000000-580de2c16cd24559cd5c	2012-07-24	View Spectrum
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)	splash10-0006-9400000000-f233fbc6c58236ee4aeb	2012-07-24	View Spectrum
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)	splash10-002f-9100000000-8b5e12eba034bcfdf8a1	2012-07-24	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-001i-0920000000-b43356ad3da227b488cb	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-014i-0900000000-c04f0be6515621dda5ac	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-000i-0900000000-3ed8b68bfade9194763b	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-0udi-0900000000-fe6a1ce69851a8c5db00	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-001i-0900000000-aafdcea07be221817fd4	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-0002-0900000000-66a5b9a0a48bdc0a2b47	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-014i-0900000000-13eb4252ca23455a58da	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-014i-0900000000-fb85798746829bac3f3d	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-03e9-0839226000-5504e667281c746669ec	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-03di-0900000000-f65cb3ad2fa730c922f7	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-001i-0900000000-a9276fe43ef61b4693e6	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-0a59-0039210000-21b4bd9870bf4965a6d1	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-001i-0848491200-aae99eb0b66dd1c7036d	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-03di-0900000000-4104a2ca5d5ef5f22f6d	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-001i-0900000000-f309996d57a95c719deb	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-03di-0013090000-112cd9c2eea42dbc079b	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Negative	splash10-001i-0900000000-c7f95918d936586f633d	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, Negative	splash10-03yi-1900000000-d1682546c1e0893c71e4	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, Negative	splash10-014i-2900000000-a0cc78ed35e56dd812a5	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 40V, Negative	splash10-00kf-9500000000-d3f399f5dd10e338e25a	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 50V, Negative	splash10-0006-9200000000-8acd8d370f194bfe28ed	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Positive	splash10-001i-0900000000-6b26ce2f5b326ace12a4	2012-08-31	View Spectrum

NMR

Type	Description	View
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, experimental)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 125 MHz, H₂O, experimental)	Spectrum
1D NMR	¹H NMR Spectrum (1D, D₂O, experimental)	Spectrum
1D NMR	¹H NMR Spectrum (1D, D₂O, experimental)	Spectrum
1D NMR	¹H NMR Spectrum (1D, D₂O, experimental)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, D₂O, experimental)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Spectrum
2D NMR	[¹H, ¹H]-TOCSY. Unexported temporarily by An Chi on Oct 15, 2021 until json or nmrML file is generated. 2D NMR Spectrum (experimental)	Spectrum
2D NMR	[¹H, ¹³C]-HSQC NMR Spectrum (2D, 400 MHz, H₂O, experimental)	Spectrum

Pathways

Name	SMPDB/Pathwhiz	KEGG
Tyrosine Metabolism
Transcription/Translation	Not Available	Not Available
Phenylalanine and Tyrosine Metabolism
Catecholamine Biosynthesis
Aromatic L-Aminoacid Decarboxylase Deficiency		Not Available

Protein Targets

Enzymes

Protein Name	Gene Name	Locus	Uniprot ID	Details
Tyrosinase	TYR	11q14-q21	P14679	details
Tyrosine 3-monooxygenase	TH	11p15.5	P07101	details
Thyroid peroxidase	TPO	2p25	P07202	details
Tyrosine aminotransferase	TAT	16q22.1	P17735	details
Aromatic-L-amino-acid decarboxylase	DDC	7p12.2	P20711	details
Phenylalanine-4-hydroxylase	PAH	12q22-q24.2	P00439	details
Aspartate aminotransferase, cytoplasmic	GOT1	10q24.1-q25.1	P17174	details
Aspartate aminotransferase, mitochondrial	GOT2	16q21	P00505	details
Tyrosine--tRNA ligase, cytoplasmic	YARS	1p35.1	P54577	details
Tyrosine--tRNA ligase, mitochondrial	YARS2	12p11.21	Q9Y2Z4	details
Basic fibroblast growth factor receptor 1	FGFR1	8p12	P11362	details
Epidermal growth factor receptor	EGFR	7p12	P00533	details
L-amino-acid oxidase	IL4I1	19q13.3-q13.4	Q96RQ9	details
Iodotyrosine dehalogenase 1	IYD	6q25.1	Q6PHW0	details
Tubulin--tyrosine ligase	TTL	2q13	Q8NG68	details

Transporters

Protein Name	Gene Name	Locus	Uniprot ID	Details
Monocarboxylate transporter 8	SLC16A2		P36021	details
Monocarboxylate transporter 10	SLC16A10	6q21-q22	Q8TF71	details

Metal Bindings

Protein Name	Gene Name	Locus	Uniprot ID	Details
Tyrosine 3-monooxygenase	TH	11p15.5	P07101	details
Thyroid peroxidase	TPO	2p25	P07202	details
Phenylalanine-4-hydroxylase	PAH	12q22-q24.2	P00439	details

Receptors

Protein Name	Gene Name	Locus	Uniprot ID	Details
Tyrosine 3-monooxygenase	TH	11p15.5	P07101	details
Tyrosine--tRNA ligase, cytoplasmic	YARS	1p35.1	P54577	details
Basic fibroblast growth factor receptor 1	FGFR1	8p12	P11362	details
Epidermal growth factor receptor	EGFR	7p12	P00533	details

Transcriptional Factors

Not Available

Concentrations Data

Not Available

External Links

HMDB ID

HMDB0000158

DrugBank ID

DB00135

Phenol Explorer Compound ID

Not Available

FoodDB ID

KNApSAcK ID

Chemspider ID

KEGG Compound ID

BioCyc ID

BiGG ID

Wikipedia Link

METLIN ID

PubChem Compound

6057

PDB ID

Not Available

ChEBI ID

17895

References

General References

Turner CE, Elsohly MA, Boeren EG: Constituents of Cannabis sativa L. XVII. A review of the natural constituents. J Nat Prod. 1980 Mar-Apr;43(2):169-234. doi: 10.1021/np50008a001. [PubMed:6991645 ]
Radhakrishnan DM, Goyal V: Parkinson's disease: A review. Neurol India. 2018 Mar-Apr;66(Supplement):S26-S35. doi: 10.4103/0028-3886.226451. [PubMed:29503325 ]
Kohrle J: Thyroid Hormones and Derivatives: Endogenous Thyroid Hormones and Their Targets. Methods Mol Biol. 2018;1801:85-104. doi: 10.1007/978-1-4939-7902-8_9. [PubMed:29892819 ]
Hubbard SR, Till JH: Protein tyrosine kinase structure and function. Annu Rev Biochem. 2000;69:373-98. doi: 10.1146/annurev.biochem.69.1.373. [PubMed:10966463 ]
Aliu E, Kanungo S, Arnold GL: Amino acid disorders. Ann Transl Med. 2018 Dec;6(24):471. doi: 10.21037/atm.2018.12.12. [PubMed:30740402 ]
Yanaka M, Okumura J: Influence of ascorbic acid on the adverse effect of feeding a diet containing excess tyrosine to chicks. Br Poult Sci. 1982 May;23(3):239-45. doi: 10.1080/00071688208447952. [PubMed:7104784 ]

Only showing the first 10 proteins. There are 24 proteins in total.

Show All

Enzymes

Enzyme Details

1. Tyrosinase

General function:: Involved in oxidoreductase activity
Specific function:: This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the rate-limiting conversions of tyrosine to DOPA, DOPA to DOPA-quinone and possibly 5,6-dihydroxyindole to indole-5,6 quinone.
Gene Name:: TYR
Uniprot ID:: P14679
Molecular weight:: 60392.69

Enzyme Details

2. Tyrosine 3-monooxygenase

General function:: Involved in monooxygenase activity
Specific function:: Plays an important role in the physiology of adrenergic neurons.
Gene Name:: TH
Uniprot ID:: P07101
Molecular weight:: 55611.26

Enzyme Details

3. Thyroid peroxidase

General function:: Involved in calcium ion binding
Specific function:: Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4).
Gene Name:: TPO
Uniprot ID:: P07202
Molecular weight:: 102961.63

Enzyme Details

4. Tyrosine aminotransferase

General function:: Involved in 1-aminocyclopropane-1-carboxylate synthase activity
Specific function:: Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. Can catalyze the reverse reaction, using glutamic acid, with 2-oxoglutarate as cosubstrate (in vitro). Has much lower affinity and transaminase activity towards phenylalanine.
Gene Name:: TAT
Uniprot ID:: P17735
Molecular weight:: 50398.895

Enzyme Details

5. Aromatic-L-amino-acid decarboxylase

General function:: Involved in carboxy-lyase activity
Specific function:: Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine.
Gene Name:: DDC
Uniprot ID:: P20711
Molecular weight:: 53893.755

Enzyme Details

6. Phenylalanine-4-hydroxylase

General function:: Involved in amino acid binding
Specific function:: Not Available
Gene Name:: PAH
Uniprot ID:: P00439
Molecular weight:: 51861.565

Enzyme Details

7. Aspartate aminotransferase, cytoplasmic

General function:: Involved in transferase activity, transferring nitrogenous groups
Specific function:: Plays a key role in amino acid metabolism (By similarity).
Gene Name:: GOT1
Uniprot ID:: P17174
Molecular weight:: 46247.14

Enzyme Details

8. Aspartate aminotransferase, mitochondrial

General function:: Involved in transferase activity, transferring nitrogenous groups
Specific function:: Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids.
Gene Name:: GOT2
Uniprot ID:: P00505
Molecular weight:: 47517.285

Enzyme Details

9. Tyrosine--tRNA ligase, cytoplasmic

General function:: Involved in nucleotide binding
Specific function:: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity).
Gene Name:: YARS
Uniprot ID:: P54577
Molecular weight:: 59143.025

Enzyme Details

10. Tyrosine--tRNA ligase, mitochondrial

General function:: Involved in nucleotide binding
Specific function:: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity).
Gene Name:: YARS2
Uniprot ID:: Q9Y2Z4
Molecular weight:: 53198.56

Transporters

Enzyme Details

1. Monocarboxylate transporter 8

General function:: Involved in transmembrane transport
Specific function:: Very active and specific thyroid hormone transporter. Stimulates cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine. Does not transport Leu, Phe, Trp or Tyr
Gene Name:: SLC16A2
Uniprot ID:: P36021
Molecular weight:: 59510.9

Enzyme Details

2. Monocarboxylate transporter 10

General function:: Involved in transmembrane transport
Specific function:: Sodium-independent transporter that mediates the update of aromatic acid. Can function as a net efflux pathway for aromatic amino acids in the basosolateral epithelial cells
Gene Name:: SLC16A10
Uniprot ID:: Q8TF71
Molecular weight:: 55492.1

Only showing the first 10 proteins. There are 24 proteins in total.

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Showing Compound Card for L-Tyrosine (CDB004812)

Structure for CDB004812 (L-Tyrosine)

Enzymes

Transporters