Cannabis Compound Database: Showing Compound Card for Aspartic acid (CDB000235)

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Identification Taxonomy Ontology Physical properties Spectra Protein target Pathways Concentrations Links References enzymes (26)transporters (4) Show 39 proteins XML

Record Information

Version

1.0

Created at

2020-03-19 00:26:05 UTC

Updated at

2022-12-13 23:36:24 UTC

CannabisDB ID

CDB000235

Secondary Accession Numbers

Not Available

Cannabis Compound Identification

Common Name

Aspartic acid

Description

Aspartic acid (Asp, D), also known as aspartate, the name of its anion, is one of the 20 natural proteinogenic amino acids which are the building blocks of proteins. As such, it is also present in Cannabis sativa (PMID: 6991645 ). As its name indicates, aspartic acid is the carboxylic acid analog of asparagine. As a neurotransmitter, aspartic acid may provide resistance to fatigue and thus lead to endurance, although the evidence to support this idea is not strong. Aspartic acid is a nonessential amino acid, since it can be made from glutamic acid by enzymes using vitamin B6. The amino acid has important roles in the urea cycle and DNA metabolism. Aspartic acid is a major excitatory neurotransmitter, which is sometimes found to be increased in epileptic and stroke patients. It is decreased in depressed patients and in patients with brain atrophy. Aspartic acid supplements are being evaluated. Five grams can raise blood levels. Magnesium and zinc may be natural inhibitors of some of the actions of aspartic acid. Aspartic acid, with the amino acid phenylalanine, is a part of the natural sweetener, aspartame. This sweetener is an advance in artificial sweeteners and is probably safe in normal doses to all except phenylketonurics. The jury is still out on the long-term effects it has on many brain neurohormones. Aspartic acid may be a significant immunostimulant of the thymus and can protect against some of the damaging effects of radiation. Many claims have been made for the special value of administering aspartic acid in the form of potassium and magnesium salts. Since aspartic acid is relatively nontoxic, studies are now in progress to elucidate its pharmacological and therapeutic roles.

Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
(S)-2-Aminobutanedioic acid	ChEBI
(S)-2-Aminosuccinic acid	ChEBI
2-Aminosuccinic acid	ChEBI
Asp	ChEBI
ASPARTIC ACID	ChEBI
D	ChEBI
L-Asparaginsaeure	ChEBI
L-Asp	Kegg
(S)-2-Aminobutanedioate	Generator
(S)-2-Aminosuccinate	Generator
2-Aminosuccinate	Generator
ASPARTate	Generator
L-Aspartate	Generator
(+)-Aspartate	HMDB
(+)-Aspartic acid	HMDB
(2S)-Aspartate	HMDB
(2S)-Aspartic acid	HMDB
(L)-Aspartate	HMDB
(L)-Aspartic acid	HMDB
(R)-2-Aminosuccinate	HMDB
(S)-(+)-Aspartate	HMDB
(S)-(+)-Aspartic acid	HMDB
(S)-Amino-butanedioate	HMDB
(S)-Amino-butanedioic acid	HMDB
(S)-Aminobutanedioate	HMDB
(S)-Aminobutanedioic acid	HMDB
(S)-Aspartate	HMDB
(S)-Aspartic acid	HMDB
2-Amino-3-methylsuccinate	HMDB
2-Amino-3-methylsuccinic acid	HMDB
alpha-Aminosuccinate	HMDB
alpha-Aminosuccinic acid	HMDB
Aminosuccinate	HMDB
Asparagate	HMDB
Asparagic acid	HMDB
Asparaginate	HMDB
Asparaginic acid	HMDB
Asparatate	HMDB
H-Asp-OH	HMDB
L-(+)-Aspartate	HMDB
L-(+)-Aspartic acid	HMDB
L-Aminosuccinate	HMDB
L-Aminosuccinic acid	HMDB
L-Asparagate	HMDB
L-Asparagic acid	HMDB
L-Asparaginate	HMDB
L-Asparaginic acid	HMDB
(+-)-Aspartic acid	HMDB
(R,S)-Aspartic acid	HMDB
Aspartate, disodium	HMDB
Aspartate, magnesium	HMDB
Aspartate, monopotassium	HMDB
Aspartic acid, dipotassium salt	HMDB
Aspartic acid, hydrobromide	HMDB
Aspartic acid, monopotassium salt	HMDB
Aspartic acid, monosodium salt	HMDB
Aspartic acid, potassium salt	HMDB
L Aspartate	HMDB
MG5Longoral	HMDB
Potassium aspartate	HMDB
Polysuccinimide	HMDB
Ammonium aspartate	HMDB
Aspartate, ammonium	HMDB
Aspartate, calcium	HMDB
Aspartate, monosodium	HMDB
Aspartic acid, calcium salt	HMDB
Aspartic acid, disodium salt	HMDB
Aspartic acid, magnesium (1:1) salt, hydrochloride, trihydrate	HMDB
Dipotassium aspartate	HMDB
Disodium aspartate	HMDB
Hydrochloride, aspartate magnesium	HMDB
Monopotassium aspartate	HMDB
Sodium aspartate	HMDB
Aspartate, dipotassium	HMDB
Aspartic acid, magnesium (2:1) salt	HMDB
Aspartic acid, sodium salt	HMDB
Hydrobromide aspartic acid	HMDB
Magnesium aspartate	HMDB
MG 5 Longoral	HMDB
Monosodium aspartate	HMDB
Aspartate magnesium hydrochloride	HMDB
Aspartate, potassium	HMDB
Aspartate, sodium	HMDB
Aspartic acid, ammonium salt	HMDB
Aspartic acid, hydrochloride	HMDB
Aspartic acid, magnesium-potassium (2:1:2) salt	HMDB
Calcium aspartate	HMDB
Hydrochloride aspartic acid	HMDB
L Aspartic acid	HMDB
Magnesiocard	HMDB
MG-5-Longoral	HMDB
Poly-DL-succinimide	HMDB

Chemical Formula

C₄H₇NO₄

Average Molecular Weight

133.1

Monoisotopic Molecular Weight

133.0375

IUPAC Name

(2S)-2-aminobutanedioic acid

Traditional Name

L-aspartic acid

CAS Registry Number

56-84-8

SMILES

N[C@@H](CC(O)=O)C(O)=O

InChI Identifier

InChI=1S/C4H7NO4/c5-2(4(8)9)1-3(6)7/h2H,1,5H2,(H,6,7)(H,8,9)/t2-/m0/s1

InChI Key

CKLJMWTZIZZHCS-REOHCLBHSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as aspartic acid and derivatives. Aspartic acid and derivatives are compounds containing an aspartic acid or a derivative thereof resulting from reaction of aspartic acid at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom.

Kingdom

Organic compounds

Super Class

Organic acids and derivatives

Class

Carboxylic acids and derivatives

Sub Class

Amino acids, peptides, and analogues

Direct Parent

Aspartic acid and derivatives

Alternative Parents

Substituents

Aspartic acid or derivatives
Alpha-amino acid
L-alpha-amino acid
Dicarboxylic acid or derivatives
Fatty acid
Amino acid
Carboxylic acid
Organic oxide
Organopnictogen compound
Primary amine
Organooxygen compound
Organonitrogen compound
Primary aliphatic amine
Organic oxygen compound
Carbonyl group
Amine
Organic nitrogen compound
Hydrocarbon derivative
Aliphatic acyclic compound

Molecular Framework

Aliphatic acyclic compounds

External Descriptors

aspartate family amino acid (CHEBI:17053 )
proteinogenic amino acid (CHEBI:17053 )
L-alpha-amino acid (CHEBI:17053 )
aspartic acid (CHEBI:17053 )
Common amino acids (C00049 )
Amino acids (C00049 )

Ontology

Ingestion

Source:

Biological:

Animal

Plant:

Biological location:

Tissue and substructures:

Organ and components:

Prostate

Biofluid and excreta:

Subcellular:

Cell and elements:

Extracellular

Role

Industrial application:

Pharmaceutical industry:

Pharmaceutical

Biological role:

Essential amino acid

Physical Properties

State

Solid

Experimental Properties

Property	Value	Reference
Melting Point	270 °C	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	5.39 mg/mL	YALKOWSKY,SH & DANNENFELSER,RM (1992)
logP	-3.89	CHMELIK,J ET AL. (1991)

Predicted Properties

Property	Value	Source
logP	-3.5	ALOGPS
logP	-3.5	ChemAxon
logS	0.03	ALOGPS
pKa (Strongest Acidic)	1.7	ChemAxon
pKa (Strongest Basic)	9.61	ChemAxon
Physiological Charge	-1	ChemAxon
Hydrogen Acceptor Count	5	ChemAxon
Hydrogen Donor Count	3	ChemAxon
Polar Surface Area	100.62 Å²	ChemAxon
Rotatable Bond Count	3	ChemAxon
Refractivity	26.53 m³·mol⁻¹	ChemAxon
Polarizability	11.28 Å³	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

EI-MS/GC-MS

Type	Description	Splash Key	View
GC-MS	Aspartic acid, 3 TMS, GC-MS Spectrum	splash10-0f89-0960000000-5a6a6cb21e9fc0875f84	Spectrum
GC-MS	Aspartic acid, 3 TMS, GC-MS Spectrum	splash10-0f89-0950000000-51399a8446c394459765	Spectrum
GC-MS	Aspartic acid, 3 TMS, GC-MS Spectrum	splash10-0f89-0950000000-f07e7f52b3c31fd119f5	Spectrum
GC-MS	Aspartic acid, 3 TMS, GC-MS Spectrum	splash10-0f89-0950000000-9e175dfa17a8b17a72d2	Spectrum
GC-MS	Aspartic acid, non-derivatized, GC-MS Spectrum	splash10-0f89-0950000000-f4475587d5a3b20bfc58	Spectrum
GC-MS	Aspartic acid, 3 TMS, GC-MS Spectrum	splash10-00di-9430000000-0cac9a97e698db1672b5	Spectrum
GC-MS	Aspartic acid, 2 TMS, GC-MS Spectrum	splash10-03yi-1900000000-ea61b8526ee02ae79b66	Spectrum
GC-MS	Aspartic acid, 3 TMS, GC-MS Spectrum	splash10-0f89-1890000000-7da576c8129142b71a1b	Spectrum
GC-MS	Aspartic acid, 4 TMS, GC-MS Spectrum	splash10-0pb9-0981000000-ad23d55e348f55115f00	Spectrum
GC-MS	Aspartic acid, non-derivatized, GC-MS Spectrum	splash10-001i-0590000000-13cc5a7841854e97f68b	Spectrum
GC-MS	Aspartic acid, non-derivatized, GC-MS Spectrum	splash10-0f89-0960000000-5a6a6cb21e9fc0875f84	Spectrum
GC-MS	Aspartic acid, non-derivatized, GC-MS Spectrum	splash10-0f89-0950000000-51399a8446c394459765	Spectrum
GC-MS	Aspartic acid, non-derivatized, GC-MS Spectrum	splash10-0f89-0950000000-f07e7f52b3c31fd119f5	Spectrum
GC-MS	Aspartic acid, non-derivatized, GC-MS Spectrum	splash10-0f89-0950000000-9e175dfa17a8b17a72d2	Spectrum
GC-MS	Aspartic acid, non-derivatized, GC-MS Spectrum	splash10-0f89-0950000000-f4475587d5a3b20bfc58	Spectrum
GC-MS	Aspartic acid, non-derivatized, GC-MS Spectrum	splash10-0g4i-6946100000-0ae49e3be0f2f1f92065	Spectrum
GC-MS	Aspartic acid, non-derivatized, GC-MS Spectrum	splash10-00di-9430000000-0cac9a97e698db1672b5	Spectrum
GC-MS	Aspartic acid, non-derivatized, GC-MS Spectrum	splash10-03yi-1900000000-ea61b8526ee02ae79b66	Spectrum
GC-MS	Aspartic acid, non-derivatized, GC-MS Spectrum	splash10-0f89-1890000000-7da576c8129142b71a1b	Spectrum
GC-MS	Aspartic acid, non-derivatized, GC-MS Spectrum	splash10-0pb9-0981000000-ad23d55e348f55115f00	Spectrum
Predicted GC-MS	Aspartic acid, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	splash10-000f-9100000000-b7db3377089f4c95001b	Spectrum
Predicted GC-MS	Aspartic acid, 2 TMS, Predicted GC-MS Spectrum - 70eV, Positive	splash10-01w4-9610000000-0f1463c6395830708e12	Spectrum
Predicted GC-MS	Aspartic acid, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Aspartic acid, TMS_1_1, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Aspartic acid, TMS_1_2, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum

MS/MS

Type	Description	Splash Key	View
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)	splash10-0079-9300000000-92f9914d94078d96f5cf	2012-07-24	View Spectrum
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)	splash10-00di-9000000000-c467d10f2b7e21ed1734	2012-07-24	View Spectrum
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)	splash10-00dl-9000000000-87f0c58226f5a2f3ac8a	2012-07-24	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-00di-0900000000-fde7ef1951fddff4b817	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-0uk9-8900000000-2d7e5609618437e59272	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-000i-9000000000-4b43567f4a446aed0828	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-014i-4900000000-45382d9abd25be948e5b	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-001i-0900000000-3f39a9b758e282358ac0	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-014i-3900000000-44d361ad09ff9a30dd14	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-000i-9000000000-18e1dba62e6b803e17b8	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-0002-0930000000-d97f9518a2d516d830c5	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-02ai-0962100000-909bb894b2c1318afee4	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-00di-9000000000-f2059dd438fcf62f62e1	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-03dr-7900000000-8b7b89ed34530e331024	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-014i-0190000000-58a78949f4b93de22aab	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-001i-0921000000-214b6b969fdc4216ca71	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-03dr-6900000000-4918748927dd097d2879	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-001i-0900000000-88dc2f1093f261e76201	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-004i-0290000000-a8856f56645a2961baac	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Negative	splash10-001i-0900000000-8cf9870557ca9adc3374	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, Negative	splash10-000i-9400000000-81b2804a712625a2d9c4	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, Negative	splash10-000i-9000000000-9bf77ba12ad952f84ac0	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 40V, Negative	splash10-00di-9000000000-e08bfb96c5fd8c9b9db7	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 50V, Negative	splash10-0006-9000000000-876e30f6c9ed061091fe	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Positive	splash10-00dl-9000000000-6c0d44d4e3853e5701a3	2012-08-31	View Spectrum

NMR

Type	Description	View
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, experimental)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 125 MHz, H₂O, experimental)	Spectrum
1D NMR	¹H NMR Spectrum (1D, D₂O, experimental)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 400 MHz, H₂O, experimental)	Spectrum
2D NMR	[¹H, ¹H]-TOCSY. Unexported temporarily by An Chi on Oct 15, 2021 until json or nmrML file is generated. 2D NMR Spectrum (experimental)	Spectrum
2D NMR	[¹H, ¹³C]-HSQC NMR Spectrum (2D, 400 MHz, H₂O, experimental)	Spectrum

Pathways

Name	SMPDB/Pathwhiz	KEGG
Transcription/Translation	Not Available	Not Available
Arginine and Proline Metabolism
Aspartate Metabolism
Urea Cycle
Beta-Alanine Metabolism

Protein Targets

Enzymes

Protein Name	Gene Name	Locus	Uniprot ID	Details
Aspartate aminotransferase, cytoplasmic	GOT1	10q24.1-q25.1	P17174	details
Aspartate aminotransferase, mitochondrial	GOT2	16q21	P00505	details
Ribonuclease pancreatic	RNASE1	14q11.2	P07998	details
Aminoacylase-1	ACY1	3p21.1	Q03154	details
Aspartoacylase	ASPA	17p13.3	P45381	details
Aspartoacylase-2	ACY3		Q96HD9	details
Asparagine synthetase [glutamine-hydrolyzing]	ASNS	7q21.3	P08243	details
Aspartate--tRNA ligase, cytoplasmic	DARS	2q21.3	P14868	details
Argininosuccinate synthase	ASS1	9q34.1	P00966	details
Glutamate dehydrogenase 1, mitochondrial	GLUD1	10q23.3	P00367	details
Glutamate decarboxylase 2	GAD2	10p11.23	Q05329	details
Glutamate decarboxylase 1	GAD1	2q31	Q99259	details
Adenylosuccinate synthetase isozyme 2	ADSS	1q44	P30520	details
Adenylosuccinate synthetase isozyme 1	ADSSL1	14q32.33	Q8N142	details
Multifunctional protein ADE2	PAICS	4q12	P22234	details
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase	AGA	4q34.3	P20933	details
Aspartyl/asparaginyl beta-hydroxylase	ASPH	8q12.1	Q12797	details
Lysozyme C	LYZ	12q15	P61626	details
Isoaspartyl peptidase/L-asparaginase	ASRGL1	11q12.3	Q7L266	details
60 kDa lysophospholipase	ASPG	14q32.33	Q86U10	details
L-amino-acid oxidase	IL4I1	19q13.3-q13.4	Q96RQ9	details
Putative L-aspartate dehydrogenase	ASPDH	19q13.33	A6ND91	details
Putative aspartate aminotransferase, cytoplasmic 2	GOT1L1	8p11.23	Q8NHS2	details
Aspartate aminotransferase	GIG18		Q2TU84	details
Aspartate--tRNA ligase, mitochondrial	DARS2	1q25.1	Q6PI48	details
N-acetylaspartate synthetase	NAT8L	4p16.3	Q8N9F0	details

Transporters

Protein Name	Gene Name	Locus	Uniprot ID	Details
Calcium-binding mitochondrial carrier protein Aralar2	SLC25A13	7q21.3	Q9UJS0	details
Excitatory amino acid transporter 3	SLC1A1	9p24	P43005	details
Calcium-binding mitochondrial carrier protein Aralar1	SLC25A12	2q24	O75746	details
Monocarboxylate transporter 10	SLC16A10	6q21-q22	Q8TF71	details

Metal Bindings

Protein Name	Gene Name	Locus	Uniprot ID	Details
Aminoacylase-1	ACY1	3p21.1	Q03154	details
Aspartoacylase	ASPA	17p13.3	P45381	details
Aspartoacylase-2	ACY3		Q96HD9	details
Adenylosuccinate synthetase isozyme 2	ADSS	1q44	P30520	details
Adenylosuccinate synthetase isozyme 1	ADSSL1	14q32.33	Q8N142	details
Calcium-binding mitochondrial carrier protein Aralar2	SLC25A13	7q21.3	Q9UJS0	details
Calcium-binding mitochondrial carrier protein Aralar1	SLC25A12	2q24	O75746	details
CAD protein	CAD	2p22-p21	P27708	details

Receptors

Not Available

Transcriptional Factors

Protein Name	Gene Name	Locus	Uniprot ID	Details
Aspartyl/asparaginyl beta-hydroxylase	ASPH	8q12.1	Q12797	details

Concentrations Data

Cannabis Cultivar	Status	Value	Reference	Details
Alien Dawg	Detected and Quantified	1.446 mg/g dry wt	David S. Wishart,...	details
Gabriola	Detected and Quantified	1.278 mg/g dry wt	David S. Wishart,...	details
Island Honey	Detected and Quantified	0.827 mg/g dry wt	David S. Wishart,...	details
Quadra	Detected and Quantified	0.391 mg/g dry wt	David S. Wishart,...	details
Sensi Star	Detected and Quantified	1.609 mg/g dry wt	David S. Wishart,...	details
Tangerine Dream	Detected and Quantified	0.675 mg/g dry wt	David S. Wishart,...	details

External Links

HMDB ID

HMDB0000191

DrugBank ID

DB00128

Phenol Explorer Compound ID

Not Available

FoodDB ID

KNApSAcK ID

Chemspider ID

KEGG Compound ID

BioCyc ID

BiGG ID

Wikipedia Link

METLIN ID

PubChem Compound

PDB ID

Not Available

ChEBI ID

17053

References

General References

Turner CE, Elsohly MA, Boeren EG: Constituents of Cannabis sativa L. XVII. A review of the natural constituents. J Nat Prod. 1980 Mar-Apr;43(2):169-234. doi: 10.1021/np50008a001. [PubMed:6991645 ]

Only showing the first 10 proteins. There are 39 proteins in total.

Show All

Enzymes

Enzyme Details

1. Aspartate aminotransferase, cytoplasmic

General function:: Involved in transferase activity, transferring nitrogenous groups
Specific function:: Plays a key role in amino acid metabolism (By similarity).
Gene Name:: GOT1
Uniprot ID:: P17174
Molecular weight:: 46247.14

Enzyme Details

2. Aspartate aminotransferase, mitochondrial

General function:: Involved in transferase activity, transferring nitrogenous groups
Specific function:: Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids.
Gene Name:: GOT2
Uniprot ID:: P00505
Molecular weight:: 47517.285

Enzyme Details

3. Ribonuclease pancreatic

General function:: Involved in nucleic acid binding
Specific function:: Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single stranded and double stranded RNA
Gene Name:: RNASE1
Uniprot ID:: P07998
Molecular weight:: 17644.1

Enzyme Details

4. Aminoacylase-1

General function:: Involved in metallopeptidase activity
Specific function:: Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate).
Gene Name:: ACY1
Uniprot ID:: Q03154
Molecular weight:: 45884.705

Enzyme Details

5. Aspartoacylase

General function:: Involved in hydrolase activity, acting on ester bonds
Specific function:: Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter. In other tissues it act as a scavenger of NAA from body fluids.
Gene Name:: ASPA
Uniprot ID:: P45381
Molecular weight:: 35734.79

Enzyme Details

6. Aspartoacylase-2

General function:: Involved in hydrolase activity, acting on ester bonds
Specific function:: Plays an important role in deacetylating mercapturic acids in kidney proximal tubules (By similarity).
Gene Name:: ACY3
Uniprot ID:: Q96HD9
Molecular weight:: Not Available

Enzyme Details

7. Asparagine synthetase [glutamine-hydrolyzing]

General function:: Involved in asparagine synthase (glutamine-hydrolyzing) activity
Specific function:: Not Available
Gene Name:: ASNS
Uniprot ID:: P08243
Molecular weight:: 62167.855

Enzyme Details

8. Aspartate--tRNA ligase, cytoplasmic

General function:: Involved in nucleotide binding
Specific function:: Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA.
Gene Name:: DARS
Uniprot ID:: P14868
Molecular weight:: 57135.8

Enzyme Details

9. Argininosuccinate synthase

General function:: Involved in argininosuccinate synthase activity
Specific function:: Not Available
Gene Name:: ASS1
Uniprot ID:: P00966
Molecular weight:: 46530.055

Enzyme Details

10. Glutamate dehydrogenase 1, mitochondrial

General function:: Involved in oxidoreductase activity
Specific function:: May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (By similarity).
Gene Name:: GLUD1
Uniprot ID:: P00367
Molecular weight:: 61397.315

Transporters

Enzyme Details

1. Calcium-binding mitochondrial carrier protein Aralar2

General function:: Involved in transporter activity
Specific function:: Catalyzes the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartate across the mitochondrial inner membrane. May have a function in the urea cycle.
Gene Name:: SLC25A13
Uniprot ID:: Q9UJS0
Molecular weight:: 74303.085

Enzyme Details

2. Excitatory amino acid transporter 3

General function:: Involved in sodium:dicarboxylate symporter activity
Specific function:: Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Negatively regulated by ARL6IP5
Gene Name:: SLC1A1
Uniprot ID:: P43005
Molecular weight:: 57099.8

Enzyme Details

3. Calcium-binding mitochondrial carrier protein Aralar1

General function:: Involved in transporter activity
Specific function:: Catalyzes the calcium-dependent exchange of cytoplasmic glutamate with mitochondrial aspartate across the mitochondrial inner membrane. May have a function in the urea cycle.
Gene Name:: SLC25A12
Uniprot ID:: O75746
Molecular weight:: 74761.225

Enzyme Details

4. Monocarboxylate transporter 10

General function:: Involved in transmembrane transport
Specific function:: Sodium-independent transporter that mediates the update of aromatic acid. Can function as a net efflux pathway for aromatic amino acids in the basosolateral epithelial cells
Gene Name:: SLC16A10
Uniprot ID:: Q8TF71
Molecular weight:: 55492.1

Only showing the first 10 proteins. There are 39 proteins in total.

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Showing Compound Card for Aspartic acid (CDB000235)

Structure for CDB000235 (Aspartic acid)

Enzymes

Transporters