Identification
HMDB Protein ID CDBP00838
Secondary Accession Numbers Not Available
Name N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase
Description Not Available
Synonyms
  1. Aspartylglucosaminidase
  2. Glycosylasparaginase
  3. Glycosylasparaginase alpha chain
  4. Glycosylasparaginase beta chain
  5. N4-(N-acetyl-beta-glucosaminyl)-L-asparagine amidase
Gene Name AGA
Protein Type Enzyme
Biological Properties
General Function Involved in hydrolase activity
Specific Function Cleaves the GlcNAc-Asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins.
GO Classification
Biological Process
protein deglycosylation
protein maturation
proteolysis
Cellular Component
endoplasmic reticulum
lysosome
Function
catalytic activity
hydrolase activity
Molecular Function
N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity
peptidase activity
Cellular Location
  1. Lysosome
Pathways
Gene Properties
Chromosome Location 4
Locus 4q34.3
SNPs AGA
Gene Sequence
>1041 bp
ATGGCGCGGAAGTCGAACTTGCCTGTGCTTCTCGTGCCGTTTCTGCTCTGCCAGGCCCTA
GTGCGCTGCTCCAGCCCTCTGCCCCTGGTCGTCAACACTTGGCCCTTTAAGAATGCAACC
GAAGCAGCGTGGAGGGCATTAGCATCTGGAGGCTCTGCCCTGGATGCAGTGGAGAGCGGC
TGTGCCATGTGTGAGAGAGAGCAGTGTGACGGCTCTGTAGGCTTTGGAGGAAGTCCTGAT
GAACTTGGAGAAACCACACTAGATGCCATGATCATGGATGGCACTACTATGGATGTAGGA
GCAGTAGGAGATCTCAGACGAATTAAAAATGCTATTGGTGTGGCACGGAAAGTACTGGAA
CATACAACACACACACTTTTAGTAGGAGAGTCAGCCACCACATTTGCTCAAAGTATGGGG
TTTATCAATGAAGACTTATCTACCAGTGCTTCTCAAGCTCTTCATTCAGATTGGCTTGCT
CGGAATTGCCAGCCAAATTATTGGAGGAATGTTATACCAGATCCCTCAAAATACTGCGGA
CCCTACAAACCACCTGGTATCTTAAAGCAGGATATTCCTATCCATAAAGAAACAGAAGAT
GATCGTGGTCATGACACTATTGGCATGGTTGTAATCCATAAGACAGGACATATTGCTGCT
GGTACATCTACAAATGGTATAAAATTCAAAATACATGGCCGTGTAGGAGACTCACCAATA
CCTGGAGCTGGAGCCTATGCTGACGATACTGCAGGGGCAGCCGCAGCCACTGGGAATGGT
GATATATTGATGCGCTTCCTGCCAAGCTACCAAGCTGTAGAATACATGAGAAGAGGAGAA
GATCCAACCATAGCTTGCCAAAAAGTGATTTCAAGAATCCAGAAGCATTTTCCAGAATTC
TTTGGGGCTGTTATATGTGCCAATGTGACTGGAAGTTACGGTGCTGCTTGCAATAAACTT
TCAACATTTACTCAGTTTAGTTTCATGGTTTATAATTCCGAAAAAAATCAGCCAACTGAG
GAAAAAGTGGACTGCATCTAA
Protein Properties
Number of Residues 346
Molecular Weight 37207.955
Theoretical pI 6.281
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase
MARKSNLPVLLVPFLLCQALVRCSSPLPLVVNTWPFKNATEAAWRALASGGSALDAVESG
CAMCEREQCDGSVGFGGSPDELGETTLDAMIMDGTTMDVGAVGDLRRIKNAIGVARKVLE
HTTHTLLVGESATTFAQSMGFINEDLSTTASQALHSDWLARNCQPNYWRNVIPDPSKYCG
PYKPPGILKQDIPIHKETEDDRGHDTIGMVVIHKTGHIAAGTSTNGIKFKIHGRVGDSPI
PGAGAYADDTAGAAAATGNGDILMRFLPSYQAVEYMRRGEDPTIACQKVISRIQKHFPEF
FGAVICANVTGSYGAACNKLSTFTQFSFMVYNSEKNQPTEEKVDCI
GenBank ID Protein 34760
UniProtKB/Swiss-Prot ID P20933
UniProtKB/Swiss-Prot Entry Name ASPG_HUMAN
PDB IDs
GenBank Gene ID X55762
GeneCard ID AGA
GenAtlas ID AGA
HGNC ID HGNC:318
References
General References Not Available