Identification |
HMDB Protein ID
| CDBP00838 |
Secondary Accession Numbers
| Not Available |
Name
| N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase |
Description
| Not Available |
Synonyms
|
- Aspartylglucosaminidase
- Glycosylasparaginase
- Glycosylasparaginase alpha chain
- Glycosylasparaginase beta chain
- N4-(N-acetyl-beta-glucosaminyl)-L-asparagine amidase
|
Gene Name
| AGA |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in hydrolase activity |
Specific Function
| Cleaves the GlcNAc-Asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins.
|
GO Classification
|
Biological Process |
protein deglycosylation |
protein maturation |
proteolysis |
Cellular Component |
endoplasmic reticulum |
lysosome |
Function |
catalytic activity |
hydrolase activity |
Molecular Function |
N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity |
peptidase activity |
|
Cellular Location
|
- Lysosome
|
Pathways
|
Name | SMPDB/Pathwhiz | KEGG | Other glycan degradation | Not Available | | Lysosome | Not Available | |
|
Gene Properties |
Chromosome Location
| 4 |
Locus
| 4q34.3 |
SNPs
| AGA |
Gene Sequence
|
>1041 bp
ATGGCGCGGAAGTCGAACTTGCCTGTGCTTCTCGTGCCGTTTCTGCTCTGCCAGGCCCTA
GTGCGCTGCTCCAGCCCTCTGCCCCTGGTCGTCAACACTTGGCCCTTTAAGAATGCAACC
GAAGCAGCGTGGAGGGCATTAGCATCTGGAGGCTCTGCCCTGGATGCAGTGGAGAGCGGC
TGTGCCATGTGTGAGAGAGAGCAGTGTGACGGCTCTGTAGGCTTTGGAGGAAGTCCTGAT
GAACTTGGAGAAACCACACTAGATGCCATGATCATGGATGGCACTACTATGGATGTAGGA
GCAGTAGGAGATCTCAGACGAATTAAAAATGCTATTGGTGTGGCACGGAAAGTACTGGAA
CATACAACACACACACTTTTAGTAGGAGAGTCAGCCACCACATTTGCTCAAAGTATGGGG
TTTATCAATGAAGACTTATCTACCAGTGCTTCTCAAGCTCTTCATTCAGATTGGCTTGCT
CGGAATTGCCAGCCAAATTATTGGAGGAATGTTATACCAGATCCCTCAAAATACTGCGGA
CCCTACAAACCACCTGGTATCTTAAAGCAGGATATTCCTATCCATAAAGAAACAGAAGAT
GATCGTGGTCATGACACTATTGGCATGGTTGTAATCCATAAGACAGGACATATTGCTGCT
GGTACATCTACAAATGGTATAAAATTCAAAATACATGGCCGTGTAGGAGACTCACCAATA
CCTGGAGCTGGAGCCTATGCTGACGATACTGCAGGGGCAGCCGCAGCCACTGGGAATGGT
GATATATTGATGCGCTTCCTGCCAAGCTACCAAGCTGTAGAATACATGAGAAGAGGAGAA
GATCCAACCATAGCTTGCCAAAAAGTGATTTCAAGAATCCAGAAGCATTTTCCAGAATTC
TTTGGGGCTGTTATATGTGCCAATGTGACTGGAAGTTACGGTGCTGCTTGCAATAAACTT
TCAACATTTACTCAGTTTAGTTTCATGGTTTATAATTCCGAAAAAAATCAGCCAACTGAG
GAAAAAGTGGACTGCATCTAA
|
Protein Properties |
Number of Residues
| 346 |
Molecular Weight
| 37207.955 |
Theoretical pI
| 6.281 |
Pfam Domain Function
|
|
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase
MARKSNLPVLLVPFLLCQALVRCSSPLPLVVNTWPFKNATEAAWRALASGGSALDAVESG
CAMCEREQCDGSVGFGGSPDELGETTLDAMIMDGTTMDVGAVGDLRRIKNAIGVARKVLE
HTTHTLLVGESATTFAQSMGFINEDLSTTASQALHSDWLARNCQPNYWRNVIPDPSKYCG
PYKPPGILKQDIPIHKETEDDRGHDTIGMVVIHKTGHIAAGTSTNGIKFKIHGRVGDSPI
PGAGAYADDTAGAAAATGNGDILMRFLPSYQAVEYMRRGEDPTIACQKVISRIQKHFPEF
FGAVICANVTGSYGAACNKLSTFTQFSFMVYNSEKNQPTEEKVDCI
|
External Links |
GenBank ID Protein
| 34760 |
UniProtKB/Swiss-Prot ID
| P20933 |
UniProtKB/Swiss-Prot Entry Name
| ASPG_HUMAN |
PDB IDs
|
|
GenBank Gene ID
| X55762 |
GeneCard ID
| AGA |
GenAtlas ID
| AGA |
HGNC ID
| HGNC:318 |
References |
General References
| Not Available |