| Identification |
|---|
| HMDB Protein ID
| CDBP00838 |
| Secondary Accession Numbers
| Not Available |
| Name
| N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase |
| Description
| Not Available |
| Synonyms
|
- Aspartylglucosaminidase
- Glycosylasparaginase
- Glycosylasparaginase alpha chain
- Glycosylasparaginase beta chain
- N4-(N-acetyl-beta-glucosaminyl)-L-asparagine amidase
|
| Gene Name
| AGA |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in hydrolase activity |
| Specific Function
| Cleaves the GlcNAc-Asn bond which joins oligosaccharides to the peptide of asparagine-linked glycoproteins.
|
| GO Classification
|
| Biological Process |
| protein deglycosylation |
| protein maturation |
| proteolysis |
| Cellular Component |
| endoplasmic reticulum |
| lysosome |
| Function |
| catalytic activity |
| hydrolase activity |
| Molecular Function |
| N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity |
| peptidase activity |
|
| Cellular Location
|
- Lysosome
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Other glycan degradation | Not Available |  | | Lysosome | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 4 |
| Locus
| 4q34.3 |
| SNPs
| AGA |
| Gene Sequence
|
>1041 bp
ATGGCGCGGAAGTCGAACTTGCCTGTGCTTCTCGTGCCGTTTCTGCTCTGCCAGGCCCTA
GTGCGCTGCTCCAGCCCTCTGCCCCTGGTCGTCAACACTTGGCCCTTTAAGAATGCAACC
GAAGCAGCGTGGAGGGCATTAGCATCTGGAGGCTCTGCCCTGGATGCAGTGGAGAGCGGC
TGTGCCATGTGTGAGAGAGAGCAGTGTGACGGCTCTGTAGGCTTTGGAGGAAGTCCTGAT
GAACTTGGAGAAACCACACTAGATGCCATGATCATGGATGGCACTACTATGGATGTAGGA
GCAGTAGGAGATCTCAGACGAATTAAAAATGCTATTGGTGTGGCACGGAAAGTACTGGAA
CATACAACACACACACTTTTAGTAGGAGAGTCAGCCACCACATTTGCTCAAAGTATGGGG
TTTATCAATGAAGACTTATCTACCAGTGCTTCTCAAGCTCTTCATTCAGATTGGCTTGCT
CGGAATTGCCAGCCAAATTATTGGAGGAATGTTATACCAGATCCCTCAAAATACTGCGGA
CCCTACAAACCACCTGGTATCTTAAAGCAGGATATTCCTATCCATAAAGAAACAGAAGAT
GATCGTGGTCATGACACTATTGGCATGGTTGTAATCCATAAGACAGGACATATTGCTGCT
GGTACATCTACAAATGGTATAAAATTCAAAATACATGGCCGTGTAGGAGACTCACCAATA
CCTGGAGCTGGAGCCTATGCTGACGATACTGCAGGGGCAGCCGCAGCCACTGGGAATGGT
GATATATTGATGCGCTTCCTGCCAAGCTACCAAGCTGTAGAATACATGAGAAGAGGAGAA
GATCCAACCATAGCTTGCCAAAAAGTGATTTCAAGAATCCAGAAGCATTTTCCAGAATTC
TTTGGGGCTGTTATATGTGCCAATGTGACTGGAAGTTACGGTGCTGCTTGCAATAAACTT
TCAACATTTACTCAGTTTAGTTTCATGGTTTATAATTCCGAAAAAAATCAGCCAACTGAG
GAAAAAGTGGACTGCATCTAA
|
| Protein Properties |
|---|
| Number of Residues
| 346 |
| Molecular Weight
| 37207.955 |
| Theoretical pI
| 6.281 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase
MARKSNLPVLLVPFLLCQALVRCSSPLPLVVNTWPFKNATEAAWRALASGGSALDAVESG
CAMCEREQCDGSVGFGGSPDELGETTLDAMIMDGTTMDVGAVGDLRRIKNAIGVARKVLE
HTTHTLLVGESATTFAQSMGFINEDLSTTASQALHSDWLARNCQPNYWRNVIPDPSKYCG
PYKPPGILKQDIPIHKETEDDRGHDTIGMVVIHKTGHIAAGTSTNGIKFKIHGRVGDSPI
PGAGAYADDTAGAAAATGNGDILMRFLPSYQAVEYMRRGEDPTIACQKVISRIQKHFPEF
FGAVICANVTGSYGAACNKLSTFTQFSFMVYNSEKNQPTEEKVDCI
|
| External Links |
|---|
| GenBank ID Protein
| 34760 |
| UniProtKB/Swiss-Prot ID
| P20933 |
| UniProtKB/Swiss-Prot Entry Name
| ASPG_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| X55762 |
| GeneCard ID
| AGA |
| GenAtlas ID
| AGA |
| HGNC ID
| HGNC:318 |
| References |
|---|
| General References
| Not Available |