| Identification |
|---|
| HMDB Protein ID
| CDBP02345 |
| Secondary Accession Numbers
| Not Available |
| Name
| Isoaspartyl peptidase/L-asparaginase |
| Description
| Not Available |
| Synonyms
|
- Asparaginase-like protein 1
- L-asparagine amidohydrolase
- Beta-aspartyl-peptidase
- Isoaspartyl dipeptidase
|
| Gene Name
| ASRGL1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in hydrolase activity |
| Specific Function
| Has both L-asparaginase and beta-aspartyl peptidase activity. May be involved in the production of L-aspartate, which can act as an excitatory neurotransmitter in some brain regions. Is highly active with L-Asp beta-methyl ester. Besides, has catalytic activity toward beta-aspartyl dipeptides and their methyl esters, including beta-L-Asp-L-Phe, beta-L-Asp-L-Phe methyl ester (aspartame), beta-L-Asp-L-Ala, beta-L-Asp-L-Leu and beta-L-Asp-L-Lys. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activity toward glutamine.
|
| GO Classification
|
| Biological Process |
| asparagine catabolic process via L-aspartate |
| proteolysis |
| Cellular Component |
| microtubule cytoskeleton |
| cytoplasm |
| nucleus |
| Function |
| catalytic activity |
| hydrolase activity |
| Molecular Function |
| asparaginase activity |
| beta-aspartyl-peptidase activity |
|
| Cellular Location
|
- Cytoplasm
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG |
|---|
| Aspartate Metabolism |    |  | | Ammonia Recycling |    |  | | Canavan Disease |    | Not Available | | Hypoacetylaspartia |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 11 |
| Locus
| 11q12.3 |
| SNPs
| ASRGL1 |
| Gene Sequence
|
>927 bp
ATGAATCCCATCGTAGTGGTCCACGGCGGCGGAGCCGGTCCCATCTCCAAGGATCGGAAG
GAGCGAGTGCACCAGGGCATGGTCAGAGCCGCCACCGTGGGCTACGGCATCCTCCGGGAG
GGCGGGAGCGCCGTGGATGCCGTAGAGGGAGCTGTCGTCGCCCTGGAAGACGATCCCGAG
TTCAACGCAGGTTGTGGGTCTGTCTTGAACACAAATGGTGAGGTTGAAATGGATGCTAGT
ATCATGGATGGAAAAGACCTGTCTGCAGGAGCAGTGTCCGCAGTCCAGTGTATAGCAAAT
CCCATTAAACTTGCTCGGCTTGTCATGGAAAAGACACCTCATTGCTTTCTGACTGACCAA
GGCGCAGCGCAGTTTGCAGCAGCTATGGGGGTTCCAGAGATTCCTGGAGAAAAACTGGTG
ACAGAGAGAAACAAAAAGCGCCTGGAAAAAGAGAAGCATGAAAAAGGTGCTCAGAAAACA
GATTGTCAAAAAAACTTGGGAACCGTGGGTGCTGTTGCCTTGGACTGCAAAGGGAATGTA
ACCTACGCAACCTCCACAGGCGGTATCGTTAATAAAATGGTCGGCCGCGTTGGGGACTCA
CCGTGTCTAGGAGCTGGAGGTTATGCCGACAATGACATCGGAGCCGTCTCAACCACAGGG
CATGGGGAAAGCATCCTGAAGGTGAACCTGGCTAGACTCACCCTGTTCCACATAGAACAA
GGAAAGACGGTAGAAGAGGCTGCGGACCTATCGTTGGGTTATATGAAGTCAAGGGTTAAA
GGTTTAGGTGGCCTCATCGTGGTTAGCAAAACAGGAGACTGGGTGGCAAAGTGGACCTCC
ACCTCCATGCCCTGGGCAGCCGCCAAGGACGGCAAGCTGCACTTTGGAATTGATCCTGAC
GATACTACTATCACCGACCTTCCCTAA
|
| Protein Properties |
|---|
| Number of Residues
| 308 |
| Molecular Weight
| 32054.325 |
| Theoretical pI
| 6.241 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>L-asparaginase
MNPIVVVHGGGAGPISKDRKERVHQGMVRAATVGYGILREGGSAVDAVEGAVVALEDDPE
FNAGCGSVLNTNGEVEMDASIMDGKDLSAGAVSAVQCIANPIKLARLVMEKTPHCFLTDQ
GAAQFAAAMGVPEIPGEKLVTERNKKRLEKEKHEKGAQKTDCQKNLGTVGAVALDCKGNV
AYATSTGGIVNKMVGRVGDSPCLGAGGYADNDIGAVSTTGHGESILKVNLARLTLFHIEQ
GKTVEEAADLSLGYMKSRVKGLGGLIVVSKTGDWVAKWTSTSMPWAAAKDGKLHFGIDPD
DTTITDLP
|
| External Links |
|---|
| GenBank ID Protein
| 20799290 |
| UniProtKB/Swiss-Prot ID
| Q7L266 |
| UniProtKB/Swiss-Prot Entry Name
| ASGL1_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AF411076 |
| GeneCard ID
| ASRGL1 |
| GenAtlas ID
| ASRGL1 |
| HGNC ID
| HGNC:16448 |
| References |
|---|
| General References
| Not Available |