Cannabis Compound Database: Showing Compound Card for Delta-9-tetrahydrocannabinol (CDB000001)

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Identification Taxonomy Ontology Physical properties Spectra Protein target Pathways Concentrations Links References enzymes (1)transporters (2) Show 12 proteins XML

Record Information

Version

1.0

Created at

2020-03-19 00:35:40 UTC

Updated at

2022-12-13 21:44:20 UTC

CannabisDB ID

CDB000001

Secondary Accession Numbers

Not Available

Cannabis Compound Identification

Common Name

Delta-9-tetrahydrocannabinol

Description

Delta-9-Tetrahydrocannabinol, also known as tetrahydrocannabinol or THC, belongs to the class of organic compounds known as 2,2-dimethyl-1-benzopyrans. These are organic compounds containing a 1-benzopyran moiety that carries two methyl groups at the 2-position. THC is also chemically or biochemically classified as a diterpenoid. Formally it can be described as a 6a,7,8,10a-tetrahydro-6H-benzo[c]chromene substituted at position 1 by a hydroxy group, positions 6, 6 and 9 by methyl groups and at position 3 by a pentyl group. Tetrahydrocannabinol (THC) is one of at least 113 cannabinoids identified in cannabis (PMID: 26836472 ). In the cannabis plant THC (like most plant terpenes) is used in self-defense, mostly to protect itself against insect predation, ultraviolet light, and other environmental stressors. THC is the principal psychoactive constituent of cannabis, responsible for the ‚Äúhigh‚Äù that users experience ( Ref:DOI ). The psychoactivity of THC results from its partial agonist activity of the cannabinoid receptor CB1 (Ki = 10 nM), located mainly in the central nervous system, and the CB2 receptor (Ki = 24 nM), mainly found in cells of the immune system. THC activation of these cannabinoid receptors, especially the CB1 receptor, leads to a decrease in the concentration of the second messenger molecule cAMP in synaptosomes and brain synapses through inhibition of adenylate cyclase (PMID: 9260875 ; PMID: 1848340 ). In cannabis plants, THC occurs mainly as tetrahydrocannabinolic acid (THCA). THCA is produced via the following pathway: Geranyl pyrophosphate and olivetolic acid react, catalysed by an enzyme Geranyl-pyrophosphate‚Äîolivetolic acid geranyltransferase to produce cannabigerolic acid which is then cyclized by the enzyme THC acid synthase to give THCA. Over time, or when heated (via vaping or smoking), THCA is decarboxylated, producing THC. THC (either as a pure drug or through ingestion/inhalation via medical marijuana) is used for the treatment of anorexia associated with AIDS as well as nausea and vomiting associated with cancer chemotherapy in patients who have failed to respond adequately to conventional antiemetic treatments. THC has been formulated into several commercially available oral drugs. Dronabinol is the generic name for the oral form of synthetic THC and is marketed in the U.S. as Marinol. It is indicated for the treatment of severe CINV (chemotherapy-induced nausea and vomiting) in cancer patients, and for AIDS-related anorexia associated with weight loss. Nabilone is the generic name for an orally administered synthetic structural analogue of THC, which is marketed in Canada as Cesamet but also now available in generic forms (e.g. RAN-nabilone, PMS-nabilone, TEVA-nabilone, CO- nabilone, ACT-nabilone). It is indicated for severe CINV in cancer patients. THC is an active ingredient in another drug called Nabiximols, a specific extract of Cannabis that was approved as a botanical drug in the United Kingdom in 2010 as a mouth spray for people with multiple sclerosis to alleviate neuropathic pain, spasticity, overactive bladder, and other symptoms.

Structure

MOL SDF 3D-SDF PDB SMILES InChI View 3D Structure

Synonyms

Value	Source
(-)-delta9-trans-Tetrahydrocannabinol	ChEBI
1-trans-delta-9-Tetrahydrocannabinol	ChEBI
3-Pentyl-6,6,9-trimethyl-6a,7,8,10a-tetrahydro-6H-dibenzo(b,D)pyran-1-ol	ChEBI
6,6,9-Trimethyl-3-pentyl-6a,7,8,10a-tetrahydro-6H-benzo[c]chromen-1-ol	ChEBI
Delta(1)-Tetrahydrocannabinol	ChEBI
delta9-Tetrahydrocannabinol	ChEBI
Delta(9)-THC	ChEBI
Dronabinol	ChEBI
Dronabinolum	ChEBI
Syndros	ChEBI
THC	Kegg
Marinol	Kegg
(-)-Δ9-trans-tetrahydrocannabinol	Generator
1-trans-Δ-9-tetrahydrocannabinol	Generator
Δ(1)-tetrahydrocannabinol	Generator
Δ9-tetrahydrocannabinol	Generator
Δ(9)-THC	Generator
DELTA-9-THC	HMDB
DELTA-9-TETRAHYDROCANNABINOL	HMDB
Δ-9-THC	HMDB
Δ-9-tetrahydrocannabinol	HMDB
Tetrahydrocannabinol, (6a-trans)-isomer	HMDB
9-Ene-tetrahydrocannabinol	HMDB
Tetrahydrocannabinol, (6ar-cis)-isomer	HMDB
Tetrahydrocannabinol, (6as-cis)-isomer	HMDB
Tetrahydrocannabinol, trans isomer	HMDB
delta(9)-Tetrahydrocannabinol	HMDB
delta(1)-THC	HMDB
9 Ene tetrahydrocannabinol	HMDB
Solvay brand OF tetrahydrocannabinol	HMDB
Tetrahydrocannabinol, trans-(+-)-isomer	HMDB
Tetrahydrocannabinol, trans-isomer	HMDB
delta 1-Tetrahydrocannabinol	HMDB
(-)- delta 9-Tetrahydrocannabinol	HMDB
(-)-delta 1-Tetrahydrocannabinol	HMDB
(-)-delta 9-THC	HMDB
(-)-delta 9-trans-Tetrahydrocannabinol	HMDB
(-)-trans-delta 1-Tetrahydrocannabinol	HMDB
(-)-trans-delta 9-Tetrahydrocannabinol	HMDB
(-)-trans-delta 9-THC	HMDB
(L)-delta 1-Tetrahydrocannabinol	HMDB
1-trans-delta 9-Tetrahydrocannabinol	HMDB
14C-delta 1-Tetrahydrocannabinol	HMDB
delta 1-THC	HMDB
delta 9-Tetrahydrocannabinol	HMDB
delta 9-THC	HMDB
delta 9-trans-Tetrahydrocannabinol	HMDB
Exocyclic delta (9)(11)-tetrahydrocannabiol	HMDB
L-delta 1-trans-Tetrahydrocannabinol	HMDB
L-trans-delta 9-Tetrahydrocannabinol	HMDB
Primolut	HMDB
trans-delta (-)-9-Tetrahydrocannabinol	HMDB
trans-delta 9-Tetrahydrocannabinol	HMDB
Tetrahydrocannabinol	ChEBI
(-)-3,4-trans-delta1-Tetrahydrocannabinol	PhytoBank
(-)-3,4-trans-Δ1-Tetrahydrocannabinol	PhytoBank
(-)-delta1-Tetrahydrocannabinol	PhytoBank
(-)-delta9-THC	PhytoBank
(-)-delta9-Tetrahydrocannabinol	PhytoBank
(-)-trans-delta1-Tetrahydrocannabinol	PhytoBank
(-)-trans-delta9-THC	PhytoBank
(-)-trans-delta9-Tetrahydrocannabinol	PhytoBank
(-)-trans-Δ1-Tetrahydrocannabinol	PhytoBank
(-)-trans-Δ9-THC	PhytoBank
(-)-trans-Δ9-Tetrahydrocannabinol	PhytoBank
(-)-Δ1-Tetrahydrocannabinol	PhytoBank
(-)-Δ9-THC	PhytoBank
(-)-Δ9-Tetrahydrocannabinol	PhytoBank
(l)-delta1-Tetrahydrocannabinol	PhytoBank
(l)-Δ1-Tetrahydrocannabinol	PhytoBank
delta1-THC	PhytoBank
delta1-Tetrahydrocannabinol	PhytoBank
delta9-THC	PhytoBank
delta9-trans-Tetrahydrocannabinol	PhytoBank
l-delta1-trans-Tetrahydrocannabinol	PhytoBank
l-trans-delta9-Tetrahydrocannabinol	PhytoBank
l-trans-Δ9-Tetrahydrocannabinol	PhytoBank
l-Δ1-trans-Tetrahydrocannabinol	PhytoBank
trans-(-)-delta9-Tetrahydrocannabinol	PhytoBank
trans-(-)-Δ9-Tetrahydrocannabinol	PhytoBank
trans-delta9-Tetrahydrocannabinol	PhytoBank
trans-Δ9-Tetrahydrocannabinol	PhytoBank
Δ1-THC	PhytoBank
Δ1-Tetrahydrocannabinol	PhytoBank
Δ9-THC	PhytoBank
Δ9-trans-Tetrahydrocannabinol	PhytoBank

Chemical Formula

C₂₁H₃₀O₂

Average Molecular Weight

314.46

Monoisotopic Molecular Weight

314.2246

IUPAC Name

(6aR,10aR)-6,6,9-trimethyl-3-pentyl-6H,6aH,7H,8H,10aH-benzo[c]isochromen-1-ol

Traditional Name

THC

CAS Registry Number

1972-08-3

SMILES

CCCCCC1=CC(O)=C2[C@@H]3C=C(C)CC[C@H]3C(C)(C)OC2=C1

InChI Identifier

InChI=1S/C21H30O2/c1-5-6-7-8-15-12-18(22)20-16-11-14(2)9-10-17(16)21(3,4)23-19(20)13-15/h11-13,16-17,22H,5-10H2,1-4H3/t16-,17-/m1/s1

InChI Key

CYQFCXCEBYINGO-IAGOWNOFSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as 2,2-dimethyl-1-benzopyrans. These are organic compounds containing a 1-benzopyran moiety that carries two methyl groups at the 2-position.

Kingdom

Organic compounds

Super Class

Organoheterocyclic compounds

Class

Benzopyrans

Sub Class

1-benzopyrans

Direct Parent

2,2-dimethyl-1-benzopyrans

Alternative Parents

Substituents

2,2-dimethyl-1-benzopyran
1-hydroxy-4-unsubstituted benzenoid
1-hydroxy-2-unsubstituted benzenoid
Alkyl aryl ether
Benzenoid
Oxacycle
Ether
Organic oxygen compound
Hydrocarbon derivative
Organooxygen compound
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

polyketide (CHEBI:66964 )
diterpenoid (CHEBI:66964 )
phytocannabinoid (CHEBI:66964 )
benzochromene (CHEBI:66964 )
Cannabinoids (C06972 )

Ontology

Physiological effect

Health effect:

Health condition:

Psychiatric disorders:

Insomnia

Disposition

Route of exposure:

Enteral:

Ingestion

Biological location:

Subcellular:

Biofluid and excreta:

Role

Biological role:

Nutrient

Industrial application:

Drug

Pharmaceutical industry:

Physical Properties

State

Solid

Experimental Properties

Property	Value	Reference
Melting Point	200 °C	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	0.0026 g/L	Not Available
logP	5.648	Not Available

Predicted Properties

Property	Value	Source
logP	7.29	ALOGPS
logP	5.94	ChemAxon
logS	-5.1	ALOGPS
pKa (Strongest Acidic)	9.34	ChemAxon
pKa (Strongest Basic)	-4.9	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	2	ChemAxon
Hydrogen Donor Count	1	ChemAxon
Polar Surface Area	29.46 Å²	ChemAxon
Rotatable Bond Count	4	ChemAxon
Refractivity	96.73 m³·mol⁻¹	ChemAxon
Polarizability	38.96 Å³	ChemAxon
Number of Rings	3	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	Yes	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

EI-MS/GC-MS

Type	Description	Splash Key	View
EI-MS	Mass Spectrum (Electron Ionization)	splash10-01pp-4792000000-06532e533cb7794b7c37	2014-09-20	View Spectrum
Predicted GC-MS	Delta-9-tetrahydrocannabinol, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	splash10-0597-4090000000-670e40c1592b93325e44	Spectrum
Predicted GC-MS	Delta-9-tetrahydrocannabinol, 1 TMS, Predicted GC-MS Spectrum - 70eV, Positive	splash10-00dl-6009000000-735bce5abc1be2637810	Spectrum
Predicted GC-MS	Delta-9-tetrahydrocannabinol, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Delta-9-tetrahydrocannabinol, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum

MS/MS

Type	Description	Splash Key	View
MS/MS	LC-MS/MS Spectrum - Orbitrap 11V, positive	splash10-014i-0219000000-1916f155ea706f1bfd78	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - Orbitrap 15V, positive	splash10-05mx-3943000000-9b0e61162051930e030f	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - Orbitrap 19V, positive	splash10-052f-3920000000-06615e927292d6b78f04	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - Orbitrap 25V, positive	splash10-006x-5900000000-c44a1196b35ae31ac75c	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - Orbitrap 31V, positive	splash10-00xu-7900000000-d06351b5900dfe483bd6	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - Orbitrap 37V, positive	splash10-00tf-9600000000-14d6a1649ef828de05e3	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - Orbitrap 43V, positive	splash10-00mo-9400000000-c1c5f46aa3925b6b440f	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - Orbitrap 50V, positive	splash10-00ou-9300000000-fec356cc420b4d525c37	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - Orbitrap 59V, positive	splash10-016u-9200000000-295f54d67e0fa9512778	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - Orbitrap 71V, positive	splash10-0fvl-9200000000-92620f75edee11220267	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - n/a 21V, positive	splash10-053f-0980000000-c5e3986b120b13bf6cad	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - n/a 21V, positive	splash10-00dr-0900000000-71e91d90ab20dda21879	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - n/a 21V, positive	splash10-0002-9000000000-0c6530b23f4594b0199d	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - n/a 21V, positive	splash10-03di-0910000000-13e75d88a02fafe0bbe2	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - n/a 21V, positive	splash10-000j-0900000000-ae7ab2b9c0db456ba4d4	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - n/a 21V, positive	splash10-00lr-0490000000-aebf4a983943679cba93	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - n/a 21V, positive	splash10-004i-0910000000-13eb5c07bf46dbbbc6c3	2020-07-22	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-014i-1239000000-dd0a437774bcd5f12cd9	2016-08-03	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-0600-6291000000-48cdeee605af2033e358	2016-08-03	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-0aou-9140000000-f6fc10c62a978b5bb9b0	2016-08-03	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-03di-0009000000-1a8c2415357935328858	2016-08-03	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-03di-0429000000-d0c2b14e825c4f547980	2016-08-03	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-01re-3930000000-3f6ef979ec17030832a8	2016-08-03	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-03di-0009000000-2514638890974c4f71f3	2021-09-23	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-03di-0009000000-f9f1dddf06624032e0de	2021-09-23	View Spectrum

NMR

Type	Description		View

Pathways

Not Available

Protein Targets

Enzymes

Protein Name	Gene Name	Locus	Uniprot ID	Details
Prostaglandin G/H synthase 1	PTGS1	9q32-q33.3	P23219	details

Transporters

Protein Name	Gene Name	Locus	Uniprot ID	Details
Multidrug resistance protein 1	ABCB1	7q21.12	P08183	details
ATP-binding cassette sub-family G member 2	ABCG2	4q22	Q9UNQ0	details

Metal Bindings

Protein Name	Gene Name	Locus	Uniprot ID	Details
Prostaglandin G/H synthase 1	PTGS1	9q32-q33.3	P23219	details
Cytochrome P450 3A4	CYP3A4	7q21.1	P08684	details
Cytochrome P450 2C9	CYP2C9	10q24	P11712	details
Cytochrome P450 2C19	CYP2C19	10q24	P33261	details
Cytochrome P450 1A1	CYP1A1	15q24.1	P04798	details
Cytochrome P450 2A6	CYP2A6	19q13.2	P11509	details

Receptors

Protein Name	Gene Name	Locus	Uniprot ID	Details
Prostaglandin G/H synthase 1	PTGS1	9q32-q33.3	P23219	details
Cannabinoid receptor 1	CNR1	6q14-q15	P21554	details
Cannabinoid receptor 2	CNR2	1p36.11	P34972	details

Transcriptional Factors

Not Available

Concentrations Data

Cannabis Cultivar	Status	Value	Reference	Details
Alien Blues	Detected and Quantified	86.6 +/- 11.6 mg/g dry wt	PMID: 30036388	details
Alien Dawg	Detected and Quantified	1.029 mg/g dry wt	David S. Wishart,...	details
Blue Cherry Pie	Detected and Quantified	98 +/- 22.5 mg/g dry wt	PMID: 30036388	details
Blue Dream	Detected and Quantified	109.9 +/- 24.1 mg/g dry wt	PMID: 30036388	details
Bohdi Tree	Detected and Quantified	38.3 +/- 15.5 mg/g dry wt	PMID: 30036388	details
Cold Creek Kush	Detected and Quantified	88.8 +/- 42.8 mg/g dry wt	PMID: 30036388	details
Crystal Cookies	Detected and Quantified	170.7 +/- 18.5 mg/g dry wt	PMID: 30036388	details
Double Royal Kush	Detected and Quantified	119.7 +/- 3.5 mg/g dry wt	PMID: 30036388	details
FLO	Detected and Quantified	153 +/- 15.2 mg/g dry wt	PMID: 30036388	details
Gabriola	Detected and Quantified	0.951 mg/g dry wt	David S. Wishart,...	details
Grandaddy Purple	Detected and Quantified	143 +/- 7.9 mg/g dry wt	PMID: 30036388	details
Green Crack	Detected and Quantified	203 +/- 23.3 mg/g dry wt	PMID: 30036388	details
Green Crack 2015	Detected and Quantified	171.7 +/- 13.3 mg/g dry wt	PMID: 30036388	details
Holy Power	Detected and Quantified	215.3 +/- 20.4 mg/g dry wt	PMID: 30036388	details
Island Honey	Detected and Quantified	0.703 mg/g dry wt	David S. Wishart,...	details
Juanita	Detected and Quantified	30.3 +/- 3.7 mg/g dry wt	PMID: 30036388	details
Lavendar	Detected and Quantified	119.1 +/- 39.1 mg/g dry wt	PMID: 30036388	details
Lavendar	Detected and Quantified	162.7 +/- 12.1 mg/g dry wt	PMID: 30036388	details
Lavendar Jones 2015	Detected and Quantified	165.3 +/- 28 mg/g dry wt	PMID: 30036388	details
Love Lace	Detected and Quantified	42 +/- 5.3 mg/g dry wt	PMID: 30036388	details
Oracle	Detected and Quantified	170.2 +/- 4 mg/g dry wt	PMID: 30036388	details
Platinum Buffalo	Detected and Quantified	139 +/- 7.5 mg/g dry wt	PMID: 30036388	details
Platinum Gorilla	Detected and Quantified	158 +/- 6 mg/g dry wt	PMID: 30036388	details
Platinum Scout	Detected and Quantified	187 +/- 2.6 mg/g dry wt	PMID: 30036388	details
Purple Fat Pie	Detected and Quantified	108.5 +/- 10.7 mg/g dry wt	PMID: 30036388	details
Quadra	Detected and Quantified	1.043 mg/g dry wt	David S. Wishart,...	details
Romulin	Detected and Quantified	102.1 +/- 25.5 mg/g dry wt	PMID: 30036388	details
RX	Detected and Quantified	127.3 +/- 4.5 mg/g dry wt	PMID: 30036388	details
Sensi Star	Detected and Quantified	1.133 mg/g dry wt	David S. Wishart,...	details
Skywalker	Detected and Quantified	117.4 +/- 20.9 mg/g dry wt	PMID: 30036388	details
Sour Willie	Detected and Quantified	57.3 +/- 22.6 mg/g dry wt	PMID: 30036388	details
Tangerine Dream	Detected and Quantified	0.743 mg/g dry wt	David S. Wishart,...	details
Thunderstruck	Detected and Quantified	59.4 +/- 6.3 mg/g dry wt	PMID: 30036388	details
Twisted Velvet	Detected and Quantified	124.7 +/- 12.9 mg/g dry wt	PMID: 30036388	details
Walker Kush	Detected and Quantified	160.7 +/- 8.5 mg/g dry wt	PMID: 30036388	details
White Widow	Detected and Quantified	156.3 +/- 9.1 mg/g dry wt	PMID: 30036388	details

External Links

HMDB ID

HMDB0014613

DrugBank ID

DB00470

Phenol Explorer Compound ID

Not Available

FoodDB ID

KNApSAcK ID

Chemspider ID

KEGG Compound ID

BioCyc ID

BiGG ID

Not Available

Wikipedia Link

Tetrahydrocannabinol

METLIN ID

Not Available

PubChem Compound

16078

PDB ID

Not Available

ChEBI ID

66964

References

General References

Aizpurua-Olaizola O, Soydaner U, Ozturk E, Schibano D, Simsir Y, Navarro P, Etxebarria N, Usobiaga A: Evolution of the Cannabinoid and Terpene Content during the Growth of Cannabis sativa Plants from Different Chemotypes. J Nat Prod. 2016 Feb 26;79(2):324-31. doi: 10.1021/acs.jnatprod.5b00949. Epub 2016 Feb 2. [PubMed:26836472 ]
Koh WS, Crawford RB, Kaminski NE: Inhibition of protein kinase A and cyclic AMP response element (CRE)-specific transcription factor binding by delta9-tetrahydrocannabinol (delta9-THC): a putative mechanism of cannabinoid-induced immune modulation. Biochem Pharmacol. 1997 May 15;53(10):1477-84. doi: 10.1016/s0006-2952(97)82441-0. [PubMed:9260875 ]
Little PJ, Martin BR: The effects of delta 9-tetrahydrocannabinol and other cannabinoids on cAMP accumulation in synaptosomes. Life Sci. 1991;48(12):1133-41. doi: 10.1016/0024-3205(91)90450-p. [PubMed:1848340 ]

Only showing the first 10 proteins. There are 12 proteins in total.

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Enzymes

Enzyme Details

1. Prostaglandin G/H synthase 1

General function:: Involved in peroxidase activity
Specific function:: May play an important role in regulating or promoting cell proliferation in some normal and neoplastically transformed cells.
Gene Name:: PTGS1
Uniprot ID:: P23219
Molecular weight:: 68685.82

Transporters

Enzyme Details

1. Multidrug resistance protein 1

General function:: Involved in ATP binding
Specific function:: Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells
Gene Name:: ABCB1
Uniprot ID:: P08183
Molecular weight:: 141477.3

Enzyme Details

2. ATP-binding cassette sub-family G member 2

General function:: Involved in ATP binding
Specific function:: Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. May be involved in brain-to-blood efflux. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. When overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin and doxorubicin, display diminished intracellular accumulation of daunorubicin, and manifest an ATP- dependent increase in the efflux of rhodamine 123
Gene Name:: ABCG2
Uniprot ID:: Q9UNQ0
Molecular weight:: 72313.5

Only showing the first 10 proteins. There are 12 proteins in total.

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Showing Compound Card for Delta-9-tetrahydrocannabinol (CDB000001)

Structure for CDB000001 (Delta-9-tetrahydrocannabinol)

Enzymes

Transporters