Showing Protein Cannabinoid receptor 2 (CDBP05641)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 17 compounds
Identification
HMDB Protein ID CDBP05641
Secondary Accession Numbers Not Available
Name Cannabinoid receptor 2
Description Not Available
Synonyms Not Available
Gene Name CNR2
Protein Type Receptor
Biological Properties
General Function cannabinoid receptor activity
Specific Function Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis.
GO Classification
Biological Process
G-protein coupled receptor signaling pathway
negative regulation of action potential
inflammatory response
negative regulation of mast cell activation
negative regulation of nitric-oxide synthase activity
response to amphetamine
sensory perception of pain
negative regulation of synaptic transmission, GABAergic
immune response
leukocyte chemotaxis
negative regulation of inflammatory response
response to lipopolysaccharide
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
Cellular Component
endoplasmic reticulum
plasma membrane
dendrite
perikaryon
extrinsic to internal side of plasma membrane
integral to plasma membrane
Molecular Function
cannabinoid receptor activity
Cellular Location
  1. Cell membrane
  2. Cell projection
  3. dendrite
  4. Perikaryon
Pathways
Gene Properties
Chromosome Location 1
Locus 1p36.11
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 360
Molecular Weight 39680.275
Theoretical pI Not Available
Pfam Domain Function
Signals Not Available
Transmembrane Regions
  • ["34-59", "72-92", "105-129", "150-172", "189-214", "247-267", "280-301"]
Protein Sequence 
>Cannabinoid receptor 2
MEECWVTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILS
SHQLRRKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTAS
VGSLLLTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCPRPCS
ELFPLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLD
VRLAKTLGLVLAVLLICWFPVLALMAHSLATTLSDQVKKAFAFCSMLCLINSMVNPVIYA
LRSGEIRSSAHHCLAHWKKCVRGLGSEAKEEAPRSSVTETEADGKITPWPDSRDLDLSDC
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P34972
UniProtKB/Swiss-Prot Entry Name CNR2_HUMAN
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID HGNC:2160
References
General References Not Available