Cannabis Compound Database: Showing Compound Card for PE(18:1(9Z)/18:1(9Z)) (CDB001082)

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Identification Taxonomy Ontology Physical properties Spectra Protein target Pathways Concentrations Links References enzymes (42)transporters (13) Show 82 proteins XML

Record Information

Version

1.0

Created at

2020-03-30 18:02:24 UTC

Updated at

2020-12-07 19:07:56 UTC

CannabisDB ID

CDB001082

Secondary Accession Numbers

Not Available

Cannabis Compound Identification

Common Name

PE(18:1(9Z)/18:1(9Z))

Description

PE(18:1(9Z)/18:1(9Z)) is a phosphatidylethanolamine. It is a glycerophospholipid in which a phosphorylethanolamine moiety occupies a glycerol substitution site. As is the case with diacylglycerols, glycerophosphoethanolamines can have many different combinations of fatty acids of varying lengths and saturation attached to the C-1 and C-2 positions. PE(18:1(9Z)/18:1(9Z)), in particular, consists of two 9Z-octadecenoyl chains at positions C-1 and C-2. While most phospholipids have a saturated fatty acid on C-1 and an unsaturated fatty acid on C-2 of the glycerol backbone, the fatty acid distribution at the C-1 and C-2 positions of glycerol within phospholipids is continually in flux, owing to phospholipid degradation and the continuous phospholipid remodeling that occurs while these molecules are in membranes. PEs are neutral zwitterions at physiological pH. They mostly have palmitic or stearic acid on carbon 1 and a long chain unsaturated fatty acid (e.g. 18:2, 20:4 and 22:6) on carbon 2. PE synthesis can occur via two pathways. The first requires that ethanolamine be activated by phosphorylation and then coupled to CDP. The ethanolamine is then transferred from CDP-ethanolamine to phosphatidic acid to yield PE. The second involves the decarboxylation of PS. This compound is expected to be in Cannabis as all living plants are known to produce and metabolize it.

Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
1,2-Di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine	ChEBI
1-(9Z)-Octadecenoyl-2-(9Z)-octadecenoyl-sn-glycero-3-phosphoethanolamine zwitterion	ChEBI
1-C18:1(Omega-9)-2-C18:1(omega-9)-phosphatidylethanolamine zwitterion	ChEBI
1,2-Dioleoylphosphatidylethanolamine	HMDB
1,2-DOPE	HMDB
1,2-Dielaidoylphosphatidylethanolamine	HMDB
1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine	HMDB
1-2-DOPE	HMDB
Lipofectin	HMDB
Dioleoyl cephalin	HMDB
1,2-Dioleoylglycero-3-phosphoethanolamine	HMDB
1-2-Di-(9-octadecenoyl)-sn-glycero-3-phosphoethethanolamine	HMDB
1,2-Dioleoyl-rac-glycero-3-phosphoethanolamine	HMDB
PE(18:1/18:1)	HMDB
GPEtn(18:1/18:1)	HMDB
Phophatidylethanolamine(36:2)	HMDB
Phophatidylethanolamine(18:1/18:1)	HMDB
GPEtn(36:2)	HMDB
1,2-Di(9Z-octadecenoyl)-rac-glycero-3-phosphoethanolamine	HMDB
PE(36:2)	HMDB
PE(18:1(9Z)/18:1(9Z))	Lipid Annotator

Chemical Formula

C₄₁H₇₈NO₈P

Average Molecular Weight

744.05

Monoisotopic Molecular Weight

743.5465

IUPAC Name

(2-aminoethoxy)[(2R)-2,3-bis[(9Z)-octadec-9-enoyloxy]propoxy]phosphinic acid

Traditional Name

1,2-dioleoyl-sn-gl

CAS Registry Number

Not Available

SMILES

[H][C@@](COC(=O)CCCCCCC\C=C/CCCCCCCC)(COP(O)(=O)OCCN)OC(=O)CCCCCCC\C=C/CCCCCCCC

InChI Identifier

InChI=1S/C41H78NO8P/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-40(43)47-37-39(38-49-51(45,46)48-36-35-42)50-41(44)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h17-20,39H,3-16,21-38,42H2,1-2H3,(H,45,46)/b19-17-,20-18-/t39-/m1/s1

InChI Key

MWRBNPKJOOWZPW-NYVOMTAGSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as phosphatidylethanolamines. These are glycerophosphoetahnolamines in which two fatty acids are bonded to the glycerol moiety through ester linkages.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Glycerophospholipids

Sub Class

Glycerophosphoethanolamines

Direct Parent

Phosphatidylethanolamines

Alternative Parents

Substituents

Diacylglycero-3-phosphoethanolamine
Phosphoethanolamine
Fatty acid ester
Dialkyl phosphate
Dicarboxylic acid or derivatives
Organic phosphoric acid derivative
Phosphoric acid ester
Alkyl phosphate
Fatty acyl
Amino acid or derivatives
Carboxylic acid ester
Carboxylic acid derivative
Organopnictogen compound
Organic oxygen compound
Organooxygen compound
Organonitrogen compound
Amine
Primary aliphatic amine
Organic nitrogen compound
Primary amine
Carbonyl group
Organic oxide
Hydrocarbon derivative
Aliphatic acyclic compound

Molecular Framework

Aliphatic acyclic compounds

External Descriptors

1,2-diacyl-sn-glycero-3-phosphoethanolamine (CHEBI:84839 )
Diacylglycerophosphoethanolamines (LMGP02010052 )

Ontology

Physiological effect

Organoleptic effect:

Touch:

Smooth

Disposition

Route of exposure:

Enteral:

Ingestion

Source:

Biological:

Animal

Biological location:

System:

Nervous system

Biofluid and excreta:

Blood

Tissue and substructures:

All tissues

Organ and components:

Brain

Cell and elements:

Extracellular

Subcellular:

Role

Industrial application:

Food and nutrition:

Biological role:

Physical Properties

State

Solid

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
logP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	8.81	ALOGPS
logP	11.51	ChemAxon
logS	-7.1	ALOGPS
pKa (Strongest Acidic)	1.87	ChemAxon
pKa (Strongest Basic)	10	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	5	ChemAxon
Hydrogen Donor Count	2	ChemAxon
Polar Surface Area	134.38 Å²	ChemAxon
Rotatable Bond Count	41	ChemAxon
Refractivity	211.64 m³·mol⁻¹	ChemAxon
Polarizability	90.54 Å³	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	No	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

EI-MS/GC-MS

Type	Description	Splash Key	View
Predicted GC-MS	PE(18:1(9Z)/18:1(9Z)), non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum

MS/MS

Type	Description	Splash Key	View
MS/MS	LC-MS/MS Spectrum - IT 40V, negative	splash10-001l-0090100400-2e505f9bbb1be20750d0	2020-07-21	View Spectrum
MS/MS	LC-MS/MS Spectrum - QTOF 2V, positive	splash10-0006-0000001900-5c8d87e0015e6e5d1cb9	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - QTOF 4V, positive	splash10-0006-0000003900-f9393f34f408d3df66f5	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - QTOF 6V, positive	splash10-0f6x-0000005900-0c0762234af9b7f2c3b8	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - QTOF 8V, positive	splash10-0f6x-0001007900-cadb26b1db0ca86589e5	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - QTOF 14V, positive	splash10-0udi-0101009200-7fcb84a56ede0e704634	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - QTOF 16V, positive	splash10-0udi-0001009100-5aeac3a5eb6fed78d9a2	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - IT 30V, positive	splash10-0udi-0000009200-86abb6550ab0e0c580fb	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - Orbitrap 20V, positive	splash10-0006-0000002900-af4784d2becf4f36e733	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - Orbitrap 32V, positive	splash10-0udi-0000009200-240a0652b33b213f4a7e	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - Orbitrap 43V, positive	splash10-0udi-0000009000-fcccd79c5013049d21a8	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - Orbitrap 55V, positive	splash10-0udi-1111009000-a46540873bbf27bb32fb	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - Orbitrap 65V, positive	splash10-0uxs-9831005000-b52b90c60bc5216ef312	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - Orbitrap 77V, positive	splash10-015a-9600000000-d5b92aa6c5d21aff830a	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - Orbitrap 87V, positive	splash10-00ls-9500000000-aa5703b09a2b4982f7e1	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - Orbitrap 99V, positive	splash10-015a-9300000000-c887c51891d1740cd6f1	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - Orbitrap 110V, positive	splash10-015a-9200000000-97aea4999fbe0d5dd12a	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - Orbitrap 132V, positive	splash10-067i-9100000000-4ba5915c8412373ceb4a	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - n/a 52V, positive	splash10-0udi-0000009000-90677bb4d4cb194d7bb8	2020-07-22	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-0006-0010000900-994357b6692ae6b01544	2017-10-04	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-0006-0010000900-994357b6692ae6b01544	2017-10-04	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-001l-0390300600-ac1e6f12f1f2dd8e7274	2017-10-04	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-0006-0000001900-cbb310d334ec991a7d65	2017-10-04	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-0udl-0001309700-eeb33a57ed592ba6ec54	2017-10-04	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-0udi-0001309300-02a1479ca6e84ae12d27	2017-10-04	View Spectrum

NMR

Not Available

Pathways

Name	SMPDB/Pathwhiz	KEGG
Phosphatidylcholine Biosynthesis PC(18:1(9Z)/18:1(9Z))		Not Available
Phosphatidylethanolamine Biosynthesis PE(18:1(9Z)/18:1(9Z))		Not Available

Protein Targets

Enzymes

Protein Name	Gene Name	Locus	Uniprot ID	Details
Calcium-dependent phospholipase A2	PLA2G5	1p36-p34	P39877	details
Group IIF secretory phospholipase A2	PLA2G2F	1p35	Q9BZM2	details
Cytosolic phospholipase A2	PLA2G4A	1q25	P47712	details
Phospholipase A2	PLA2G1B	12q23-q24.1	P04054	details
Group XIIB secretory phospholipase A2-like protein	PLA2G12B		Q9BX93	details
Group 10 secretory phospholipase A2	PLA2G10	16p13.1-p12	O15496	details
Group IIE secretory phospholipase A2	PLA2G2E	1p36.13	Q9NZK7	details
85/88 kDa calcium-independent phospholipase A2	PLA2G6	22q13.1	O60733	details
Group IID secretory phospholipase A2	PLA2G2D	1p36.12	Q9UNK4	details
Phospholipase D2	PLD2	17p13.1	O14939	details
Phosphatidylethanolamine N-methyltransferase	PEMT	17p11.2	Q9UBM1	details
Phospholipase D1	PLD1	3q26	Q13393	details
Group 3 secretory phospholipase A2	PLA2G3	22q12.2	Q9NZ20	details
Probable phospholipid-transporting ATPase IG	ATP11C		Q8NB49	details
Probable phospholipid-transporting ATPase IH	ATP11A	13q34	P98196	details
Probable phospholipid-transporting ATPase VA	ATP10A	15q11.2	O60312	details
Probable phospholipid-transporting ATPase IC	ATP8B1	18q21-q22\|18q21.31	O43520	details
Probable phospholipid-transporting ATPase IIA	ATP9A	20q13.2	O75110	details
Probable phospholipid-transporting ATPase VD	ATP10D	4p12	Q9P241	details
Probable phospholipid-transporting ATPase IB	ATP8A2	13q12	Q9NTI2	details
Probable phospholipid-transporting ATPase IA	ATP8A1	4p13	Q9Y2Q0	details
Probable phospholipid-transporting ATPase IM	ATP8B4	15q21.2	Q8TF62	details
Probable phospholipid-transporting ATPase IF	ATP11B	3q27	Q9Y2G3	details
Probable phospholipid-transporting ATPase IK	ATP8B3	19p13.3	O60423	details
Phospholipid scramblase 1	PLSCR1	3q23	O15162	details
Phosphatidylserine decarboxylase proenzyme	PISD	22q12.2	Q9UG56	details
Choline/ethanolaminephosphotransferase 1	CEPT1	1p13.3	Q9Y6K0	details
Phospholipase D3	PLD3	19q13.2	Q8IV08	details
Phospholipase D4	PLD4	14q32.33	Q96BZ4	details
Phospholipid scramblase 2	PLSCR2	3q24	Q9NRY7	details
Phospholipid scramblase 3	PLSCR3	17p13.1	Q9NRY6	details
Phospholipid scramblase 4	PLSCR4	3q24	Q9NRQ2	details
Phospholipid scramblase family member 5	PLSCR5	3q24	A0PG75	details
Probable phospholipid-transporting ATPase VB	ATP10B	5q34	O94823	details
Probable phospholipid-transporting ATPase ID	ATP8B2	1q21.3	P98198	details
Abhydrolase domain-containing protein 4	ABHD4	14q11.2	Q8TB40	details
N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D	NAPEPLD	7q22.1	Q6IQ20	details
Phosphatidylethanolamine-binding protein 1	PEBP1	12q24.23	P30086	details
Phosphatidylethanolamine-binding protein 4	PEBP4	8p21.3	Q96S96	details
Ethanolaminephosphotransferase 1	EPT1	2p23.3	Q9C0D9	details
Cytosolic phospholipase A2 beta	PLA2G4B	15q11.2-q21.3	P0C869	details
Phospholipase D1 variant			Q59EA4	details

Transporters

Protein Name	Gene Name	Locus	Uniprot ID	Details
Probable phospholipid-transporting ATPase IG	ATP11C		Q8NB49	details
Probable phospholipid-transporting ATPase IH	ATP11A	13q34	P98196	details
Probable phospholipid-transporting ATPase VA	ATP10A	15q11.2	O60312	details
Probable phospholipid-transporting ATPase IC	ATP8B1	18q21-q22\|18q21.31	O43520	details
Probable phospholipid-transporting ATPase IIA	ATP9A	20q13.2	O75110	details
Probable phospholipid-transporting ATPase VD	ATP10D	4p12	Q9P241	details
Probable phospholipid-transporting ATPase IB	ATP8A2	13q12	Q9NTI2	details
Probable phospholipid-transporting ATPase IA	ATP8A1	4p13	Q9Y2Q0	details
Probable phospholipid-transporting ATPase IM	ATP8B4	15q21.2	Q8TF62	details
Probable phospholipid-transporting ATPase IF	ATP11B	3q27	Q9Y2G3	details
Probable phospholipid-transporting ATPase IK	ATP8B3	19p13.3	O60423	details
Probable phospholipid-transporting ATPase VB	ATP10B	5q34	O94823	details
Probable phospholipid-transporting ATPase ID	ATP8B2	1q21.3	P98198	details

Metal Bindings

Protein Name	Gene Name	Locus	Uniprot ID	Details
Calcium-dependent phospholipase A2	PLA2G5	1p36-p34	P39877	details
Group IIF secretory phospholipase A2	PLA2G2F	1p35	Q9BZM2	details
Phospholipase A2	PLA2G1B	12q23-q24.1	P04054	details
Group XIIB secretory phospholipase A2-like protein	PLA2G12B		Q9BX93	details
Group 10 secretory phospholipase A2	PLA2G10	16p13.1-p12	O15496	details
Group IIE secretory phospholipase A2	PLA2G2E	1p36.13	Q9NZK7	details
Group IID secretory phospholipase A2	PLA2G2D	1p36.12	Q9UNK4	details
Probable phospholipid-transporting ATPase IG	ATP11C		Q8NB49	details
Probable phospholipid-transporting ATPase IH	ATP11A	13q34	P98196	details
Probable phospholipid-transporting ATPase VA	ATP10A	15q11.2	O60312	details
Probable phospholipid-transporting ATPase IC	ATP8B1	18q21-q22\|18q21.31	O43520	details
Probable phospholipid-transporting ATPase IIA	ATP9A	20q13.2	O75110	details
Probable phospholipid-transporting ATPase VD	ATP10D	4p12	Q9P241	details
Probable phospholipid-transporting ATPase IB	ATP8A2	13q12	Q9NTI2	details
Probable phospholipid-transporting ATPase IA	ATP8A1	4p13	Q9Y2Q0	details
Probable phospholipid-transporting ATPase IM	ATP8B4	15q21.2	Q8TF62	details
Probable phospholipid-transporting ATPase IF	ATP11B	3q27	Q9Y2G3	details
Probable phospholipid-transporting ATPase IK	ATP8B3	19p13.3	O60423	details
Choline/ethanolaminephosphotransferase 1	CEPT1	1p13.3	Q9Y6K0	details
Probable phospholipid-transporting ATPase VB	ATP10B	5q34	O94823	details
Probable phospholipid-transporting ATPase ID	ATP8B2	1q21.3	P98198	details
N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D	NAPEPLD	7q22.1	Q6IQ20	details
Ethanolaminephosphotransferase 1	EPT1	2p23.3	Q9C0D9	details

Receptors

Protein Name	Gene Name	Locus	Uniprot ID	Details
Phospholipase A2	PLA2G1B	12q23-q24.1	P04054	details
Phospholipase D2	PLD2	17p13.1	O14939	details

Transcriptional Factors

Protein Name	Gene Name	Locus	Uniprot ID	Details
Phospholipase A2	PLA2G1B	12q23-q24.1	P04054	details
Group 10 secretory phospholipase A2	PLA2G10	16p13.1-p12	O15496	details

Concentrations Data

Not Available

External Links

HMDB ID

HMDB0009059

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

FDB026249

KNApSAcK ID

Not Available

Chemspider ID

Not Available

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

9546757

PDB ID

Not Available

ChEBI ID

74986

References

General References

Not Available

Only showing the first 10 proteins. There are 82 proteins in total.

Show All

Enzymes

Enzyme Details

1. Calcium-dependent phospholipase A2

General function:: Involved in phospholipase A2 activity
Specific function:: PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. This isozyme hydrolyzes more efficiently L-alpha-1-palmitoyl-2-oleoyl phosphatidylcholine than L-alpha-1-palmitoyl-2-arachidonyl phosphatidylcholine, L-alpha-1-palmitoyl-2-arachidonyl phosphatidylethanolamine, or L-alpha-1-stearoyl-2-arachidonyl phosphatidylinositol. May be involved in the production of lung surfactant, the remodeling or regulation of cardiac muscle.
Gene Name:: PLA2G5
Uniprot ID:: P39877
Molecular weight:: 15674.065

Enzyme Details

2. Group IIF secretory phospholipase A2

General function:: Involved in phospholipase A2 activity
Specific function:: PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Hydrolyzes phosphatidylglycerol versus phosphatidylcholine with a 15-fold preference.
Gene Name:: PLA2G2F
Uniprot ID:: Q9BZM2
Molecular weight:: 23256.29

Enzyme Details

3. Cytosolic phospholipase A2

General function:: Involved in metabolic process
Specific function:: Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response.
Gene Name:: PLA2G4A
Uniprot ID:: P47712
Molecular weight:: 85210.19

Enzyme Details

4. Phospholipase A2

General function:: Involved in phospholipase A2 activity
Specific function:: PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
Gene Name:: PLA2G1B
Uniprot ID:: P04054
Molecular weight:: 16359.535

Enzyme Details

5. Group XIIB secretory phospholipase A2-like protein

General function:: Involved in phospholipase A2 activity
Specific function:: Not known; does not seem to have catalytic activity.
Gene Name:: PLA2G12B
Uniprot ID:: Q9BX93
Molecular weight:: Not Available

Enzyme Details

6. Group 10 secretory phospholipase A2

General function:: Involved in phospholipase A2 activity
Specific function:: PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Has a powerful potency for releasing arachidonic acid from cell membrane phospholipids. Prefers phosphatidylethanolamine and phosphatidylcholine liposomes to those of phosphatidylserine.
Gene Name:: PLA2G10
Uniprot ID:: O15496
Molecular weight:: 18153.04

Enzyme Details

7. Group IIE secretory phospholipase A2

General function:: Involved in phospholipase A2 activity
Specific function:: PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Has a preference for arachidonic-containing phospholipids.
Gene Name:: PLA2G2E
Uniprot ID:: Q9NZK7
Molecular weight:: 15988.525

Enzyme Details

8. 85/88 kDa calcium-independent phospholipase A2

General function:: Involved in metabolic process
Specific function:: Catalyzes the release of fatty acids from phospholipids. It has been implicated in normal phospholipid remodeling, nitric oxide-induced or vasopressin-induced arachidonic acid release and in leukotriene and prostaglandin production. May participate in fas mediated apoptosis and in regulating transmembrane ion flux in glucose-stimulated B-cells. Has a role in cardiolipin (CL) deacylation. Required for both speed and directionality of monocyte MCP1/CCL2-induced chemotaxis through regulation of F-actin polymerization at the pseudopods. Isoform ankyrin-iPLA2-1 and isoform ankyrin-iPLA2-2, which lack the catalytic domain, are probably involved in the negative regulation of iPLA2 activity.
Gene Name:: PLA2G6
Uniprot ID:: O60733
Molecular weight:: 84092.635

Enzyme Details

9. Group IID secretory phospholipase A2

General function:: Involved in phospholipase A2 activity
Specific function:: PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. L-alpha-1-palmitoyl-2-linoleoyl phosphatidylethanolamine is more efficiently hydrolyzed than the other phospholipids examined.
Gene Name:: PLA2G2D
Uniprot ID:: Q9UNK4
Molecular weight:: 16546.1

Enzyme Details

10. Phospholipase D2

General function:: Involved in protein binding
Specific function:: May have a role in signal-induced cytoskeletal regulation and/or endocytosis (By similarity).
Gene Name:: PLD2
Uniprot ID:: O14939
Molecular weight:: 104656.485

Transporters

Enzyme Details

1. Probable phospholipid-transporting ATPase IG

General function:: Involved in ATP binding
Specific function:: ATP + H(2)O + phospholipid(In) = ADP + phosphate + phospholipid(Out)
Gene Name:: ATP11C
Uniprot ID:: Q8NB49
Molecular weight:: 129476.0

Enzyme Details

2. Probable phospholipid-transporting ATPase IH

General function:: Involved in ATP binding
Specific function:: ATP + H(2)O + phospholipid(In) = ADP + phosphate + phospholipid(Out)
Gene Name:: ATP11A
Uniprot ID:: P98196
Molecular weight:: 129754.6

Enzyme Details

3. Probable phospholipid-transporting ATPase VA

General function:: Involved in ATP binding
Specific function:: ATP + H(2)O + phospholipid(In) = ADP + phosphate + phospholipid(Out)
Gene Name:: ATP10A
Uniprot ID:: O60312
Molecular weight:: 167686.6

Enzyme Details

4. Probable phospholipid-transporting ATPase IC

General function:: Involved in ATP binding
Specific function:: May play a role in the transport of aminophospholipids from the outer to the inner leaflet of various membranes and the maintenance of asymmetric distribution of phospholipids in the canicular membrane. May have a role in transport of bile acids into the canaliculus, uptake of bile acids from intestinal contents into intestinal mucosa or both
Gene Name:: ATP8B1
Uniprot ID:: O43520
Molecular weight:: 143694.1

Enzyme Details

5. Probable phospholipid-transporting ATPase IIA

General function:: Involved in ATP binding
Specific function:: ATP + H(2)O + phospholipid(In) = ADP + phosphate + phospholipid(Out)
Gene Name:: ATP9A
Uniprot ID:: O75110
Molecular weight:: 118581.5

Enzyme Details

6. Probable phospholipid-transporting ATPase VD

General function:: Involved in ATP binding
Specific function:: ATP + H(2)O + phospholipid(In) = ADP + phosphate + phospholipid(Out)
Gene Name:: ATP10D
Uniprot ID:: Q9P241
Molecular weight:: 160272.3

Enzyme Details

7. Probable phospholipid-transporting ATPase IB

General function:: Involved in ATP binding
Specific function:: ATP + H(2)O + phospholipid(In) = ADP + phosphate + phospholipid(Out)
Gene Name:: ATP8A2
Uniprot ID:: Q9NTI2
Molecular weight:: 129240.4

Enzyme Details

8. Probable phospholipid-transporting ATPase IA

General function:: Involved in ATP binding
Specific function:: May play a role in the transport of aminophospholipids from the outer to the inner leaflet of various membranes and the maintenance of asymmetric distribution of phospholipids, mainly in secretory vesicles
Gene Name:: ATP8A1
Uniprot ID:: Q9Y2Q0
Molecular weight:: 131368.2

Enzyme Details

9. Probable phospholipid-transporting ATPase IM

General function:: Involved in ATP binding
Specific function:: ATP + H(2)O + phospholipid(In) = ADP + phosphate + phospholipid(Out)
Gene Name:: ATP8B4
Uniprot ID:: Q8TF62
Molecular weight:: 135867.0

Enzyme Details

10. Probable phospholipid-transporting ATPase IF

General function:: Involved in ATP binding
Specific function:: ATP + H(2)O + phospholipid(In) = ADP + phosphate + phospholipid(Out)
Gene Name:: ATP11B
Uniprot ID:: Q9Y2G3
Molecular weight:: 134188.6

Only showing the first 10 proteins. There are 82 proteins in total.

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Showing Compound Card for PE(18:1(9Z)/18:1(9Z)) (CDB001082)

Structure for CDB001082 (PE(18:1(9Z)/18:1(9Z)))

Enzymes

Transporters