Cannabis Compound Database: Showing Compound Card for L-Alanine (CDB000128)

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Identification Taxonomy Ontology Physical properties Spectra Protein target Pathways Concentrations Links References enzymes (16)transporters (5) Show 29 proteins XML

Record Information

Version

1.0

Created at

2020-03-18 23:25:49 UTC

Updated at

2022-12-13 23:36:22 UTC

CannabisDB ID

CDB000128

Secondary Accession Numbers

Not Available

Cannabis Compound Identification

Common Name

L-Alanine

Description

L-Alanine or Alanine, abbreviated Ala or A, is a non-essential amino acid made in the body from either the conversion of the carbohydrate pyruvate or the breakdown of DNA and the dipeptides carnosine and anserine. Normal alanine metabolism, like that of other amino acids, is highly dependent upon enzymes that contain vitamin B6. Alanine is an important participant as well as a regulator of glucose metabolism. Alanine levels parallel blood sugar levels in both diabetes and hypoglycemia, and alanine reduces both severe hypoglycemia and the ketosis of diabetes. It is highly concentrated in muscle and is one of the most important amino acids released by muscle, functioning as a major energy source. Plasma alanine is often decreased when the BCAA (branched-chain amino acids) are deficient. This finding may relate to muscle metabolism. It is an important amino acid for lymphocyte reproduction and immunity. Alanine therapy has helped dissolve kidney stones in experimental animals. L-Alanine has been found to be associated with glucagon deficiency, which is an inborn error of metabolism. Alanine is highly concentrated in meat products and other high-protein foods like wheat germ and cottage cheese. L-alanine is also found in Cannabis plants (PMID: 6991645 ).

Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
(2S)-2-Aminopropanoic acid	ChEBI
(S)-2-Aminopropanoic acid	ChEBI
(S)-Alanine	ChEBI
A	ChEBI
Ala	ChEBI
ALANINE	ChEBI
L-2-Aminopropionic acid	ChEBI
L-Alanin	ChEBI
L-alpha-Alanine	ChEBI
(2S)-2-Aminopropanoate	Generator
(S)-2-Aminopropanoate	Generator
L-2-Aminopropionate	Generator
L-a-Alanine	Generator
L-Α-alanine	Generator
(S)-(+)-Alanine	HMDB
(S)-2-Amino-propanoate	HMDB
(S)-2-Amino-propanoic acid	HMDB
2-Aminopropanoate	HMDB
2-Aminopropanoic acid	HMDB
2-Aminopropionate	HMDB
2-Aminopropionic acid	HMDB
2-Ammoniopropanoate	HMDB
2-Ammoniopropanoic acid	HMDB
a-Alanine	HMDB
a-Aminopropionate	HMDB
a-Aminopropionic acid	HMDB
alpha-Alanine	HMDB
alpha-Aminopropanoate	HMDB
alpha-Aminopropanoic acid	HMDB
alpha-Aminopropionate	HMDB
alpha-Aminopropionic acid	HMDB
L-(+)-Alanine	HMDB
L-2-Aminopropanoate	HMDB
L-2-Aminopropanoic acid	HMDB
L-a-Aminopropionate	HMDB
L-a-Aminopropionic acid	HMDB
L-alpha-Aminopropionate	HMDB
L-alpha-Aminopropionic acid	HMDB
Abufène	HMDB
Alanine doms-adrian brand	HMDB
Alanine, L-isomer	HMDB
Doms-adrian brand OF alanine	HMDB
Doms adrian brand OF alanine	HMDB
L-Isomer alanine	HMDB
Alanine, L isomer	HMDB
L Alanine	HMDB

Chemical Formula

C₃H₇NO₂

Average Molecular Weight

89.09

Monoisotopic Molecular Weight

89.0477

IUPAC Name

(2S)-2-aminopropanoic acid

Traditional Name

L-alanine

CAS Registry Number

115967-49-2

SMILES

C[C@H](N)C(O)=O

InChI Identifier

InChI=1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1

InChI Key

QNAYBMKLOCPYGJ-REOHCLBHSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as alanine and derivatives. Alanine and derivatives are compounds containing alanine or a derivative thereof resulting from reaction of alanine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom.

Kingdom

Organic compounds

Super Class

Organic acids and derivatives

Class

Carboxylic acids and derivatives

Sub Class

Amino acids, peptides, and analogues

Direct Parent

Alanine and derivatives

Alternative Parents

Substituents

Alanine or derivatives
Alpha-amino acid
L-alpha-amino acid
Amino acid
Carboxylic acid
Monocarboxylic acid or derivatives
Hydrocarbon derivative
Organic oxygen compound
Primary amine
Organooxygen compound
Organonitrogen compound
Organic nitrogen compound
Primary aliphatic amine
Carbonyl group
Amine
Organopnictogen compound
Organic oxide
Aliphatic acyclic compound

Molecular Framework

Aliphatic acyclic compounds

External Descriptors

proteinogenic amino acid (CHEBI:16977 )
L-alpha-amino acid (CHEBI:16977 )
alanine (CHEBI:16977 )
pyruvate family amino acid (CHEBI:16977 )
Common amino acids (C00041 )

Ontology

Infections and infestations:

Meningitis

Cardiac disorders:

Heart failure

Disposition

Route of exposure:

Enteral:

Ingestion

Source:

Synthetic:

Personal care product

Biological:

Animal

Plant:

Biological location:

Role

Industrial application:

Physical Properties

State

Solid

Experimental Properties

Property	Value	Reference
Melting Point	300 °C	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	204 mg/mL	Human Metabolome Project
logP	-2.85	SANGSTER (1994)

Predicted Properties

Property	Value	Source
logP	-3	ALOGPS
logP	-2.8	ChemAxon
logS	0.7	ALOGPS
pKa (Strongest Acidic)	2.47	ChemAxon
pKa (Strongest Basic)	9.48	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	3	ChemAxon
Hydrogen Donor Count	2	ChemAxon
Polar Surface Area	63.32 Å²	ChemAxon
Rotatable Bond Count	1	ChemAxon
Refractivity	20.5 m³·mol⁻¹	ChemAxon
Polarizability	8.49 Å³	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

EI-MS/GC-MS

Type	Description	Splash Key	View
GC-MS	L-Alanine, 1 TMS, GC-MS Spectrum	splash10-014i-0900000000-c7f6dbace291e8305a4e	Spectrum
GC-MS	L-Alanine, non-derivatized, GC-MS Spectrum	splash10-014i-0900000000-381ddf4d9ea77be0b8a5	Spectrum
GC-MS	L-Alanine, 3 TMS, GC-MS Spectrum	splash10-01b9-6900000000-6a7c1bb2915e5dd0791f	Spectrum
GC-MS	L-Alanine, 2 TMS, GC-MS Spectrum	splash10-014i-1900000000-84b389f82562c29a8148	Spectrum
GC-MS	L-Alanine, non-derivatized, GC-MS Spectrum	splash10-00kf-9000000000-b2f7507be509a85d821b	Spectrum
GC-MS	L-Alanine, non-derivatized, GC-MS Spectrum	splash10-014i-0900000000-941672891ab94cf5015d	Spectrum
GC-MS	L-Alanine, non-derivatized, GC-MS Spectrum	splash10-0f79-0910000000-47bd3e3aa274a653a64e	Spectrum
GC-MS	L-Alanine, non-derivatized, GC-MS Spectrum	splash10-014i-0900000000-c7f6dbace291e8305a4e	Spectrum
GC-MS	L-Alanine, non-derivatized, GC-MS Spectrum	splash10-014i-0900000000-381ddf4d9ea77be0b8a5	Spectrum
GC-MS	L-Alanine, non-derivatized, GC-MS Spectrum	splash10-0a4i-1940000000-5def9f7c902aaf1ef607	Spectrum
GC-MS	L-Alanine, non-derivatized, GC-MS Spectrum	splash10-01b9-6900000000-6a7c1bb2915e5dd0791f	Spectrum
GC-MS	L-Alanine, non-derivatized, GC-MS Spectrum	splash10-014i-1900000000-84b389f82562c29a8148	Spectrum
Predicted GC-MS	L-Alanine, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	splash10-0006-9000000000-d31f7a2ed8284a740b59	Spectrum
Predicted GC-MS	L-Alanine, 1 TMS, Predicted GC-MS Spectrum - 70eV, Positive	splash10-0006-9100000000-ab365202f52df8e6d401	Spectrum
Predicted GC-MS	L-Alanine, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	L-Alanine, TMS_1_2, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	L-Alanine, TBDMS_1_1, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	L-Alanine, TBDMS_1_2, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum

MS/MS

Type	Description	Splash Key	View
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Negative	splash10-000i-9000000000-55d0139f513946f76461	Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, Negative	splash10-000i-9000000000-5b0dff13a98daf782205	Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, Negative	splash10-000i-9000000000-37db595fcf7364600bc9	Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ , negative	splash10-000i-9000000000-55d0139f513946f76461	Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ , negative	splash10-000i-9000000000-5b0dff13a98daf782205	Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ , negative	splash10-000i-9000000000-37db595fcf7364600bc9	Spectrum
MS/MS	LC-MS/MS Spectrum - 40V, Negative	splash10-000i-9000000000-9ca90486c916f938450b	Spectrum
MS/MS	LC-MS/MS Spectrum - 20V, Negative	splash10-000i-9000000000-e9e9900761fdd599ee3f	Spectrum
MS/MS	LC-MS/MS Spectrum - 10V, Negative	splash10-000i-9000000000-17dcfdd88dc79713c4b7	Spectrum
MS/MS	LC-MS/MS Spectrum - 10V, Negative	splash10-000i-9000000000-8cc23f8c1455fdf68df5	Spectrum
MS/MS	LC-MS/MS Spectrum - 35V, Negative	splash10-000i-9000000000-7b5177095a55ce689565	Spectrum
MS/MS	LC-MS/MS Spectrum - 33V, Negative	splash10-0uxr-9400000000-b26be1c8f3385f90fcc3	Spectrum
MS/MS	LC-MS/MS Spectrum - 33V, Negative	splash10-02ti-9000000000-41eecbbaba19b8b0b536	Spectrum
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)	splash10-0006-9000000000-96b54b269c91ab21be08	Spectrum
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)	splash10-0006-9000000000-a8008305399aa1097e1a	Spectrum
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)	splash10-0006-9000000000-7253c912562200edc231	Spectrum
MS/MS	LC-MS/MS Spectrum - EI-B (HITACHI RMU-6M) , Positive	splash10-00kf-9000000000-72694f3a1a5de3b49790	Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Positive	splash10-0006-9000000000-5129e160acf979ac549e	Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, Positive	splash10-0006-9000000000-11c20eba8c5ad41d806c	Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, Positive	splash10-0006-9000000000-df7c7d6a6ae2d6bccefe	Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 40V, Positive	splash10-0006-9000000000-32477244247613182214	Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 50V, Positive	splash10-000f-9002000000-4873ce0cdcac54d68186	Spectrum
MS/MS	LC-MS/MS Spectrum - CE-ESI-TOF (CE-system connected to 6210 Time-of-Flight MS, Agilent) , Positive	splash10-0006-9000000000-8193842b36c819ca3ec6	Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ , positive	splash10-0006-9000000000-fefc31c264a2f0fcf6d0	Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ , positive	splash10-0006-9000000000-ba42bcd60aa9182a780e	Spectrum

NMR

Type	Description	View
1D NMR	1H NMR Spectrum	Spectrum
1D NMR	13C NMR Spectrum	Spectrum
1D NMR	13C NMR Spectrum	Spectrum
1D NMR	1H NMR Spectrum	Spectrum
1D NMR	13C NMR Spectrum	Spectrum
1D NMR	1H NMR Spectrum	Spectrum
1D NMR	13C NMR Spectrum	Spectrum
1D NMR	1H NMR Spectrum	Spectrum
1D NMR	13C NMR Spectrum	Spectrum
1D NMR	1H NMR Spectrum	Spectrum
1D NMR	13C NMR Spectrum	Spectrum
1D NMR	1H NMR Spectrum	Spectrum
1D NMR	13C NMR Spectrum	Spectrum
1D NMR	1H NMR Spectrum	Spectrum
1D NMR	13C NMR Spectrum	Spectrum
1D NMR	1H NMR Spectrum	Spectrum
1D NMR	13C NMR Spectrum	Spectrum
1D NMR	1H NMR Spectrum	Spectrum
1D NMR	13C NMR Spectrum	Spectrum
1D NMR	1H NMR Spectrum	Spectrum
1D NMR	13C NMR Spectrum	Spectrum
1D NMR	1H NMR Spectrum	Spectrum
2D NMR	[1H,1H] 2D NMR Spectrum	Spectrum
2D NMR	[1H,13C] 2D NMR Spectrum	Spectrum

Pathways

Name	SMPDB/Pathwhiz	KEGG
Transcription/Translation	Not Available	Not Available
Urea Cycle
Glucose-Alanine Cycle		Not Available
Selenoamino Acid Metabolism
Alanine Metabolism

Protein Targets

Enzymes

Protein Name	Gene Name	Locus	Uniprot ID	Details
4-aminobutyrate aminotransferase, mitochondrial	ABAT	16p13.2	P80404	details
Kynureninase	KYNU	2q22.2	Q16719	details
Alanine--glyoxylate aminotransferase 2, mitochondrial	AGXT2	5p13	Q9BYV1	details
Alanine--tRNA ligase, cytoplasmic	AARS	16q22	P49588	details
Serine--pyruvate aminotransferase	AGXT	2q37.3	P21549	details
Alanine aminotransferase 1	GPT	8q24.3	P24298	details
Peptidoglycan recognition protein 1	PGLYRP1		O75594	details
Cysteine desulfurase, mitochondrial	NFS1	20q11.22	Q9Y697	details
Alanine aminotransferase 2	GPT2	16q12.1	Q8TD30	details
Selenocysteine lyase	SCLY	2q37.3	Q96I15	details
5-phosphohydroxy-L-lysine phospho-lyase	AGXT2L2	5q35.3	Q8IUZ5	details
Molybdenum cofactor sulfurase	MOCOS	18q12	Q96EN8	details
Peptidoglycan recognition protein 3	PGLYRP3		Q96LB9	details
Peptidoglycan recognition protein 4	PGLYRP4		Q96LB8	details
Alanine--tRNA ligase, mitochondrial	AARS2	6p21.1	Q5JTZ9	details
N-acetylmuramoyl-L-alanine amidase	PGLYRP2		Q96PD5	details

Transporters

Protein Name	Gene Name	Locus	Uniprot ID	Details
Large neutral amino acids transporter small subunit 2	SLC7A8	14q11.2	Q9UHI5	details
Sodium-coupled neutral amino acid transporter 3	SLC38A3	3p21.3	Q99624	details
Neutral amino acid transporter A	SLC1A4	2p15-p13	P43007	details
Proton-coupled amino acid transporter 1	SLC36A1	5q33.1	Q7Z2H8	details
Monocarboxylate transporter 10	SLC16A10	6q21-q22	Q8TF71	details

Metal Bindings

Protein Name	Gene Name	Locus	Uniprot ID	Details
Alanine--tRNA ligase, cytoplasmic	AARS	16q22	P49588	details
Molybdenum cofactor sulfurase	MOCOS	18q12	Q96EN8	details
Alanine--tRNA ligase, mitochondrial	AARS2	6p21.1	Q5JTZ9	details
N-acetylmuramoyl-L-alanine amidase	PGLYRP2		Q96PD5	details

Receptors

Protein Name	Gene Name	Uniprot ID	Details
Peptidoglycan recognition protein 1	PGLYRP1	O75594	details
Peptidoglycan recognition protein 3	PGLYRP3	Q96LB9	details
Peptidoglycan recognition protein 4	PGLYRP4	Q96LB8	details
N-acetylmuramoyl-L-alanine amidase	PGLYRP2	Q96PD5	details

Transcriptional Factors

Not Available

Concentrations Data

Cannabis Cultivar	Status	Value	Reference	Details
Alien Dawg	Detected and Quantified	0.284 mg/g dry wt	Jiamin Zheng, Yil...	details
Gabriola	Detected and Quantified	0.337 mg/g dry wt	Jiamin Zheng, Yil...	details
Island Honey	Detected and Quantified	0.462 mg/g dry wt	Jiamin Zheng, Yil...	details
Quadra	Detected and Quantified	0.315 mg/g dry wt	Jiamin Zheng, Yil...	details
Sensi Star	Detected and Quantified	0.452 mg/g dry wt	Jiamin Zheng, Yil...	details
Tangerine Dream	Detected and Quantified	0.432 mg/g dry wt	Jiamin Zheng, Yil...	details

External Links

HMDB ID

HMDB0000161

DrugBank ID

DB00160

Phenol Explorer Compound ID

Not Available

FoodDB ID

KNApSAcK ID

Chemspider ID

KEGG Compound ID

BioCyc ID

BiGG ID

Wikipedia Link

METLIN ID

Not Available

PubChem Compound

5950

PDB ID

Not Available

ChEBI ID

16977

References

General References

Turner CE, Elsohly MA, Boeren EG: Constituents of Cannabis sativa L. XVII. A review of the natural constituents. J Nat Prod. 1980 Mar-Apr;43(2):169-234. doi: 10.1021/np50008a001. [PubMed:6991645 ]

Only showing the first 10 proteins. There are 29 proteins in total.

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Enzymes

Enzyme Details

1. 4-aminobutyrate aminotransferase, mitochondrial

General function:: Involved in 4-aminobutyrate transaminase activity
Specific function:: Catalyzes the conversion of gamma-aminobutyrate and L-beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine.
Gene Name:: ABAT
Uniprot ID:: P80404
Molecular weight:: 56438.405

Enzyme Details

2. Kynureninase

General function:: Involved in metabolic process
Specific function:: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity.
Gene Name:: KYNU
Uniprot ID:: Q16719
Molecular weight:: 34634.47

Enzyme Details

3. Alanine--glyoxylate aminotransferase 2, mitochondrial

General function:: Involved in transaminase activity
Specific function:: Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure.
Gene Name:: AGXT2
Uniprot ID:: Q9BYV1
Molecular weight:: 57155.905

Enzyme Details

4. Alanine--tRNA ligase, cytoplasmic

General function:: Involved in nucleotide binding
Specific function:: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain (By similarity).
Gene Name:: AARS
Uniprot ID:: P49588
Molecular weight:: 106809.525

Enzyme Details

5. Serine--pyruvate aminotransferase

General function:: Involved in metabolic process
Specific function:: Not Available
Gene Name:: AGXT
Uniprot ID:: P21549
Molecular weight:: 43009.535

Enzyme Details

6. Alanine aminotransferase 1

General function:: Involved in 1-aminocyclopropane-1-carboxylate synthase activity
Specific function:: Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate. Participates in cellular nitrogen metabolism and also in liver gluconeogenesis starting with precursors transported from skeletal muscles (By similarity).
Gene Name:: GPT
Uniprot ID:: P24298
Molecular weight:: 54636.415

Enzyme Details

7. Peptidoglycan recognition protein 1

General function:: Involved in N-acetylmuramoyl-L-alanine amidase activity
Specific function:: Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. Has bactericidal activity towards Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Binds also to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Plays a role in innate immunity.
Gene Name:: PGLYRP1
Uniprot ID:: O75594
Molecular weight:: Not Available

Enzyme Details

8. Cysteine desulfurase, mitochondrial

General function:: Involved in metabolic process
Specific function:: Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron-sulfur (Fe-S) clusters. May be involved in the biosynthesis of molybdenum cofactor.
Gene Name:: NFS1
Uniprot ID:: Q9Y697
Molecular weight:: 44361.485

Enzyme Details

9. Alanine aminotransferase 2

General function:: Involved in transferase activity, transferring nitrogenous groups
Specific function:: Catalyzes the reversible transamination between alanine and 2-oxoglutarate to form pyruvate and glutamate.
Gene Name:: GPT2
Uniprot ID:: Q8TD30
Molecular weight:: 46982.6

Enzyme Details

10. Selenocysteine lyase

General function:: Involved in metabolic process
Specific function:: Catalyzes the decomposition of L-selenocysteine to L-alanine and elemental selenium (By similarity).
Gene Name:: SCLY
Uniprot ID:: Q96I15
Molecular weight:: 48793.15

Transporters

Enzyme Details

1. Large neutral amino acids transporter small subunit 2

General function:: Involved in transport
Specific function:: Sodium-independent, high-affinity transport of small and large neutral amino acids such as alanine, serine, threonine, cysteine, phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Acts as an amino acid exchanger. Has higher affinity for L-phenylalanine than LAT1 but lower affinity for glutamine and serine. L-alanine is transported at physiological concentrations. Plays a role in basolateral (re)absorption of neutral amino acids. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Plays an essential role in the reabsorption of neutral amino acids from the epithelial cells to the bloodstream in the kidney
Gene Name:: SLC7A8
Uniprot ID:: Q9UHI5
Molecular weight:: 58381.1

Enzyme Details

2. Sodium-coupled neutral amino acid transporter 3

General function:: Amino acid transport and metabolism
Specific function:: Sodium-dependent amino acid/proton antiporter. Mediates electrogenic cotransport of glutamine and sodium ions in exchange for protons. Also recognizes histidine, asparagine and alanine. May mediate amino acid transport in either direction under physiological conditions. May play a role in nitrogen metabolism and synaptic transmission
Gene Name:: SLC38A3
Uniprot ID:: Q99624
Molecular weight:: 55772.4

Enzyme Details

3. Neutral amino acid transporter A

General function:: Involved in sodium:dicarboxylate symporter activity
Specific function:: Transporter for alanine, serine, cysteine, and threonine. Exhibits sodium dependence
Gene Name:: SLC1A4
Uniprot ID:: P43007
Molecular weight:: 55722.5

Enzyme Details

4. Proton-coupled amino acid transporter 1

General function:: Amino acid transport and metabolism
Specific function:: Neutral amino acid/proton symporter. Has a pH-dependent electrogenic transport activity for small amino acids such as glycine, alanine and proline. Besides small apolar L-amino acids, it also recognize their D-enantiomers and selected amino acid derivatives such as gamma-aminobutyric acid
Gene Name:: SLC36A1
Uniprot ID:: Q7Z2H8
Molecular weight:: 53075.0

Enzyme Details

5. Monocarboxylate transporter 10

General function:: Involved in transmembrane transport
Specific function:: Sodium-independent transporter that mediates the update of aromatic acid. Can function as a net efflux pathway for aromatic amino acids in the basosolateral epithelial cells
Gene Name:: SLC16A10
Uniprot ID:: Q8TF71
Molecular weight:: 55492.1

Only showing the first 10 proteins. There are 29 proteins in total.

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Showing Compound Card for L-Alanine (CDB000128)

Structure for CDB000128 (L-Alanine)

Enzymes

Transporters