Cannabis Compound Database: Showing Compound Card for alpha-Ketoisovaleric acid (CDB004783)

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Identification Taxonomy Ontology Physical properties Spectra Protein target Pathways Concentrations Links References enzymes (8)transporters (3) Show 12 proteins XML

Record Information

Version

1.0

Created at

2020-04-17 18:36:19 UTC

Updated at

2020-12-07 19:10:55 UTC

CannabisDB ID

CDB004783

Secondary Accession Numbers

Not Available

Cannabis Compound Identification

Common Name

alpha-Ketoisovaleric acid

Description

alpha-Ketoisovaleric acid, also known as a-keto-isovalerate or 3-methyl-2-oxobutanoate, belongs to the class of organic compounds known as short-chain keto acids and derivatives. These are keto acids with an alkyl chain the contains less than 6 carbon atoms. alpha-Ketoisovaleric acid is a very hydrophobic molecule, practically insoluble (in water), and relatively neutral. alpha-Ketoisovaleric acid exists in all living species, ranging from bacteria to humans. alpha-Ketoisovaleric acid is a fruity tasting compound. Outside of the human body, alpha-Ketoisovaleric acid has been detected, but not quantified in, several different foods, such as root vegetables, jerusalem artichokes, rapinis, chia, and cowpea. This could make alpha-ketoisovaleric acid a potential biomarker for the consumption of these foods. alpha-Ketoisovaleric acid is a potentially toxic compound. alpha-Ketoisovaleric acid, with regard to humans, has been found to be associated with the diseases such as colorectal cancer; alpha-ketoisovaleric acid has also been linked to the inborn metabolic disorder maple syrup urine disease. A 2-oxo monocarboxylic acid that is the 2-oxo derivative of isovaleric acid. alpha-Ketoisovaleric acid is expected to be in Cannabis as all living plants are known to produce and metabolize it.

Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
2-Keto-3-methylbutyric acid	ChEBI
2-Ketoisovaleric acid	ChEBI
2-Ketovaline	ChEBI
2-oxo-3-Methylbutanoic acid	ChEBI
2-oxo-3-Methylbutyric acid	ChEBI
2-Oxoisovaleric acid	ChEBI
3-Methyl-2-oxobutanoate	ChEBI
3-Methyl-2-oxobutyric acid	ChEBI
alpha-Keto-isovaleric acid	ChEBI
alpha-Ketovaline	ChEBI
alpha-oxo-beta-Methylbutyricacid	ChEBI
alpha-Oxoisovaleric acid	ChEBI
Dimethylpyruvic acid	ChEBI
Isopropylglyoxylic acid	ChEBI
2-oxo-3-Methylbutanoate	Kegg
2-Oxoisovalerate	Kegg
2-Oxoisopentanoate	Kegg
2-Keto-3-methylbutyrate	Generator
2-Ketoisovalerate	Generator
2-oxo-3-Methylbutyrate	Generator
3-Methyl-2-oxobutanoic acid	Generator
3-Methyl-2-oxobutyrate	Generator
a-Keto-isovalerate	Generator
a-Keto-isovaleric acid	Generator
alpha-Keto-isovalerate	Generator
Α-keto-isovalerate	Generator
Α-keto-isovaleric acid	Generator
a-Ketovaline	Generator
Α-ketovaline	Generator
a-oxo-b-Methylbutyricacid	Generator
Α-oxo-β-methylbutyricacid	Generator
a-Oxoisovalerate	Generator
a-Oxoisovaleric acid	Generator
alpha-Oxoisovalerate	Generator
Α-oxoisovalerate	Generator
Α-oxoisovaleric acid	Generator
Dimethylpyruvate	Generator
Isopropylglyoxylate	Generator
2-Oxoisopentanoic acid	Generator
a-Ketoisovalerate	Generator
a-Ketoisovaleric acid	Generator
alpha-Ketoisovalerate	Generator
Α-ketoisovalerate	Generator
Α-ketoisovaleric acid	Generator
2-Ketoisvaleric acid	HMDB
2-oxo-3-Methyl-butyrate	HMDB
3-Methyl-2-oxo-butanoate	HMDB
3-Methyl-2-oxo-butanoic acid	HMDB
3-Methyl-2-oxo-butyrate	HMDB
3-Methyl-2-oxo-butyric acid	HMDB
3-Methyl-2-oxobutinoate	HMDB
3-Methyl-2-oxobutinoic acid	HMDB
a-Keto-b-methylbutyrate	HMDB
a-Keto-b-methylbutyric acid	HMDB
a-oxo-b-Methylbutyrate	HMDB
a-oxo-b-Methylbutyric acid	HMDB
alpha-Keto-beta-methylbutyrate	HMDB
alpha-Keto-beta-methylbutyric acid	HMDB
alpha-oxo-beta-Methylbutyrate	HMDB
alpha-oxo-beta-Methylbutyric acid	HMDB
Ketovaline	HMDB
alpha-Ketoisopentanoic acid	HMDB
alpha-Ketoisovaleric acid	Generator, MeSH

Chemical Formula

C₅H₈O₃

Average Molecular Weight

116.12

Monoisotopic Molecular Weight

116.0473

IUPAC Name

3-methyl-2-oxobutanoic acid

Traditional Name

α-ketoisovalerate

CAS Registry Number

759-05-7

SMILES

CC(C)C(=O)C(O)=O

InChI Identifier

InChI=1S/C5H8O3/c1-3(2)4(6)5(7)8/h3H,1-2H3,(H,7,8)

InChI Key

QHKABHOOEWYVLI-UHFFFAOYSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as short-chain keto acids and derivatives. These are keto acids with an alkyl chain the contains less than 6 carbon atoms.

Kingdom

Organic compounds

Super Class

Organic acids and derivatives

Class

Keto acids and derivatives

Sub Class

Short-chain keto acids and derivatives

Direct Parent

Short-chain keto acids and derivatives

Alternative Parents

Substituents

Branched fatty acid
Methyl-branched fatty acid
Short-chain keto acid
Alpha-keto acid
Fatty acyl
Alpha-hydroxy ketone
Ketone
Carboxylic acid derivative
Carboxylic acid
Monocarboxylic acid or derivatives
Carbonyl group
Hydrocarbon derivative
Organic oxygen compound
Organooxygen compound
Organic oxide
Aliphatic acyclic compound

Molecular Framework

Aliphatic acyclic compounds

External Descriptors

2-oxo monocarboxylic acid (CHEBI:16530 )
Branched fatty acids (C00141 )
Branched fatty acids (LMFA01020274 )

Ontology

Disposition

Route of exposure:

Enteral:

Ingestion

Source:

Biological:

Animal

Plant:

Biological location:

Tissue and substructures:

Placenta

Biofluid and excreta:

Subcellular:

Cell and elements:

Extracellular

Role

Indirect biological role:

Biological role:

Industrial application:

Pharmaceutical industry:

Pharmaceutical

Physical Properties

State

Solid

Experimental Properties

Property	Value	Reference
Melting Point	31.5 °C	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
logP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	0.49	ALOGPS
logP	1.31	ChemAxon
logS	-0.59	ALOGPS
pKa (Strongest Acidic)	3.37	ChemAxon
pKa (Strongest Basic)	-9.7	ChemAxon
Physiological Charge	-1	ChemAxon
Hydrogen Acceptor Count	3	ChemAxon
Hydrogen Donor Count	1	ChemAxon
Polar Surface Area	54.37 Å²	ChemAxon
Rotatable Bond Count	2	ChemAxon
Refractivity	27.19 m³·mol⁻¹	ChemAxon
Polarizability	11.04 Å³	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

EI-MS/GC-MS

Type	Description	Splash Key	View
GC-MS	alpha-Ketoisovaleric acid, non-derivatized, GC-MS Spectrum	splash10-000i-9500000000-ff936b879a69b5d118f8	Spectrum
GC-MS	alpha-Ketoisovaleric acid, non-derivatized, GC-MS Spectrum	splash10-000i-8920000000-e37b37d64d43dcf763f0	Spectrum
GC-MS	alpha-Ketoisovaleric acid, 1 MEOX; 1 TMS, GC-MS Spectrum	splash10-000i-9400000000-e3995acc4818a98d0f48	Spectrum
GC-MS	alpha-Ketoisovaleric acid, 1 MEOX; 1 TMS, GC-MS Spectrum	splash10-0f79-9720000000-5d89487273e44ea61a68	Spectrum
GC-MS	alpha-Ketoisovaleric acid, non-derivatized, GC-MS Spectrum	splash10-000i-9700000000-209c737dcac7df2b198c	Spectrum
GC-MS	alpha-Ketoisovaleric acid, non-derivatized, GC-MS Spectrum	splash10-0f79-5920000000-759a2f01b4f52767ade2	Spectrum
GC-MS	alpha-Ketoisovaleric acid, non-derivatized, GC-MS Spectrum	splash10-000i-9500000000-ff936b879a69b5d118f8	Spectrum
GC-MS	alpha-Ketoisovaleric acid, non-derivatized, GC-MS Spectrum	splash10-000i-8920000000-e37b37d64d43dcf763f0	Spectrum
GC-MS	alpha-Ketoisovaleric acid, non-derivatized, GC-MS Spectrum	splash10-000i-9400000000-e3995acc4818a98d0f48	Spectrum
GC-MS	alpha-Ketoisovaleric acid, non-derivatized, GC-MS Spectrum	splash10-0f79-9720000000-5d89487273e44ea61a68	Spectrum
GC-MS	alpha-Ketoisovaleric acid, non-derivatized, GC-MS Spectrum	splash10-000i-7900000000-7e325567183fb56996d5	Spectrum
GC-MS	alpha-Ketoisovaleric acid, non-derivatized, GC-MS Spectrum	splash10-0ufr-0930000000-be90b06add7135b4a539	Spectrum
Predicted GC-MS	alpha-Ketoisovaleric acid, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	splash10-00dl-9000000000-52f9d8fc8386e4c512fe	Spectrum
Predicted GC-MS	alpha-Ketoisovaleric acid, 1 TMS, Predicted GC-MS Spectrum - 70eV, Positive	splash10-006x-9600000000-52aefdc997dac92c8459	Spectrum
Predicted GC-MS	alpha-Ketoisovaleric acid, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	alpha-Ketoisovaleric acid, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	alpha-Ketoisovaleric acid, TMS_1_2, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	alpha-Ketoisovaleric acid, TBDMS_1_1, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	alpha-Ketoisovaleric acid, TBDMS_1_2, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum

MS/MS

Type	Description	Splash Key	View
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)	splash10-000i-9000000000-10ab58a33e9ca7dbace0	2012-07-24	View Spectrum
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)	splash10-000i-9000000000-ad51ff01c94b6046ad64	2012-07-24	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Negative	splash10-014i-0900000000-9993174a7b1801b90ddb	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, Negative	splash10-00xr-9500000000-293818b81e0879b6feb2	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, Negative	splash10-00di-9000000000-75058f27a2178b9cf121	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 40V, Negative	splash10-0006-9000000000-4c20af39e8ee009d5278	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ , negative	splash10-014i-0900000000-9993174a7b1801b90ddb	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ , negative	splash10-00xr-9500000000-1a58c6a6b4f5477dabdd	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ , negative	splash10-00di-9000000000-75058f27a2178b9cf121	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ , negative	splash10-0006-9000000000-cc4465a47e663be66df5	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-IT , negative	splash10-00di-9100000000-19511890852fce513a02	2017-09-14	View Spectrum
MS/MS	LC-MS/MS Spectrum - 20V, Positive	splash10-00kf-9300000000-30d3bdfb6d38dbb8e101	2021-09-20	View Spectrum
MS/MS	LC-MS/MS Spectrum - 40V, Positive	splash10-000l-9000000000-879b6502ff380673b776	2021-09-20	View Spectrum
MS/MS	LC-MS/MS Spectrum - 10V, Positive	splash10-0159-9800000000-0cf4d3a0e7b3356995c6	2021-09-20	View Spectrum
MS/MS	LC-MS/MS Spectrum - 35V, Positive	splash10-014o-9900000000-f35430a2eaea0d81df32	2021-09-20	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-00r2-9400000000-21f8c3fae79161c82099	2015-04-24	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-00dl-9000000000-5f25e41413738bb6b5d7	2015-04-24	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-0006-9000000000-801af00dea93fcfd637d	2015-04-24	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-01b9-8900000000-5185c7dfc72c25069904	2015-04-25	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-00xs-9200000000-7e2a275a65197f96f5d7	2015-04-25	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-0600-9000000000-0013e0ff06f9896a1337	2015-04-25	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-01b9-6900000000-7f00871b074cbd9a42e6	2021-09-25	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-06di-9400000000-6d56778068e11e4f8e85	2021-09-25	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-0a4i-9000000000-b445e7fc67a8ff2bd3ba	2021-09-25	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-006x-9000000000-733fb7227d2d053b112f	2021-09-25	View Spectrum

NMR

Type	Description	View
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, experimental)	Spectrum
1D NMR	¹H NMR Spectrum (1D, D₂O, experimental)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, D₂O, experimental)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, experimental)	Spectrum
2D NMR	[¹H, ¹³C]-HSQC NMR Spectrum (2D, 600 MHz, H₂O, experimental)	Spectrum
2D NMR	[¹H, ¹H]-TOCSY. Unexported temporarily by An Chi on Oct 15, 2021 until json or nmrML file is generated. 2D NMR Spectrum (experimental)	Spectrum

Pathways

Name	SMPDB/Pathwhiz	KEGG
Valine, Leucine and Isoleucine Degradation
Beta-Ketothiolase Deficiency		Not Available
2-Methyl-3-Hydroxybutryl CoA Dehydrogenase Deficiency		Not Available
Propionic Acidemia		Not Available
3-Hydroxy-3-Methylglutaryl-CoA Lyase Deficiency		Not Available

Protein Targets

Enzymes

Protein Name	Gene Name	Locus	Uniprot ID	Details
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial	PDHB	3p21.1-p14.2	P11177	details
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial	PDHA1	Xp22.1	P08559	details
Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial	PDHA2	4q22-q23	P29803	details
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial	DLAT	11q23.1	P10515	details
2-oxoisovalerate dehydrogenase subunit beta, mitochondrial	BCKDHB	6q14.1	P21953	details
2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial	BCKDHA	19q13.1-q13.2	P12694	details
Branched-chain-amino-acid aminotransferase, cytosolic	BCAT1	12p12.1	P54687	details
Branched-chain-amino-acid aminotransferase, mitochondrial	BCAT2	19q13	O15382	details

Transporters

Protein Name	Gene Name	Locus	Uniprot ID	Details
Monocarboxylate transporter 4	SLC16A3	17q25	O15427	details
Monocarboxylate transporter 1	SLC16A1	1p12	P53985	details
Monocarboxylate transporter 2	SLC16A7	12q13	O60669	details

Metal Bindings

Protein Name	Gene Name	Locus	Uniprot ID	Details
2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial	BCKDHA	19q13.1-q13.2	P12694	details

Receptors

Not Available

Transcriptional Factors

Not Available

Concentrations Data

Not Available

External Links

HMDB ID

HMDB0000019

DrugBank ID

DB04074

Phenol Explorer Compound ID

Not Available

FoodDB ID

FDB012250

KNApSAcK ID

C00007623

Chemspider ID

KEGG Compound ID

C00141

BioCyc ID

2-KETO-ISOVALERATE

BiGG ID

34011

Wikipedia Link

Alpha-Ketoisovaleric acid

METLIN ID

5091

PubChem Compound

PDB ID

Not Available

ChEBI ID

16530

References

General References

Not Available

Only showing the first 10 proteins. There are 12 proteins in total.

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Enzymes

Enzyme Details

1. Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

General function:: Involved in catalytic activity
Specific function:: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.
Gene Name:: PDHB
Uniprot ID:: P11177
Molecular weight:: 39233.1

Enzyme Details

2. Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

General function:: Involved in oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Specific function:: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.
Gene Name:: PDHA1
Uniprot ID:: P08559
Molecular weight:: 43295.255

Enzyme Details

3. Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial

General function:: Involved in oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Specific function:: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.
Gene Name:: PDHA2
Uniprot ID:: P29803
Molecular weight:: 42932.855

Enzyme Details

4. Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

General function:: Involved in acyltransferase activity
Specific function:: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.
Gene Name:: DLAT
Uniprot ID:: P10515
Molecular weight:: 68996.03

Enzyme Details

5. 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial

General function:: Involved in catalytic activity
Specific function:: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).
Gene Name:: BCKDHB
Uniprot ID:: P21953
Molecular weight:: 43122.065

Enzyme Details

6. 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial

General function:: Involved in oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Specific function:: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).
Gene Name:: BCKDHA
Uniprot ID:: P12694
Molecular weight:: 50470.58

Enzyme Details

7. Branched-chain-amino-acid aminotransferase, cytosolic

General function:: Involved in catalytic activity
Specific function:: Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine.
Gene Name:: BCAT1
Uniprot ID:: P54687
Molecular weight:: 38644.77

Enzyme Details

8. Branched-chain-amino-acid aminotransferase, mitochondrial

General function:: Involved in catalytic activity
Specific function:: Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. May also function as a transporter of branched chain alpha-keto acids.
Gene Name:: BCAT2
Uniprot ID:: O15382
Molecular weight:: 33776.315

Transporters

Enzyme Details

1. Monocarboxylate transporter 4

General function:: Involved in transmembrane transport
Specific function:: Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate
Gene Name:: SLC16A3
Uniprot ID:: O15427
Molecular weight:: 49468.9

Enzyme Details

2. Monocarboxylate transporter 1

General function:: Involved in transmembrane transport
Specific function:: Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate
Gene Name:: SLC16A1
Uniprot ID:: P53985
Molecular weight:: 53957.7

Enzyme Details

3. Monocarboxylate transporter 2

General function:: Involved in transmembrane transport
Specific function:: Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. MCT2 is a high affinity pyruvate transporter
Gene Name:: SLC16A7
Uniprot ID:: O60669
Molecular weight:: 52185.7

Only showing the first 10 proteins. There are 12 proteins in total.

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Showing Compound Card for alpha-Ketoisovaleric acid (CDB004783)

Structure for CDB004783 (alpha-Ketoisovaleric acid)

Enzymes

Transporters