Cannabis Compound Database: Showing Compound Card for Ornithine (CDB005105)

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Identification Taxonomy Ontology Physical properties Spectra Protein target Pathways Concentrations Links References enzymes (17)transporters (7) Show 27 proteins XML

Record Information

Version

1.0

Created at

2020-04-17 19:09:49 UTC

Updated at

2022-12-13 23:36:25 UTC

CannabisDB ID

CDB005105

Secondary Accession Numbers

Not Available

Cannabis Compound Identification

Common Name

Ornithine

Description

Ornithine, also known as (S)-ornithine, belongs to the class of organic compounds known as l-alpha-amino acids. These are alpha amino acids which have the L-configuration of the alpha-carbon atom. Ornithine is a drug which is used for nutritional supplementation, also for treating dietary shortage or imbalance. it has been claimed that ornithine improves athletic performance, has anabolic effects, has wound-healing effects, and is immuno-enhancing. Ornithine is a very strong basic compound (based on its pKa). Ornithine exists in all living species, ranging from bacteria to humans. Within humans, ornithine participates in a number of enzymatic reactions. In particular, carbamoyl phosphate and ornithine can be converted into citrulline; which is mediated by the enzyme ornithine carbamoyltransferase, mitochondrial. In addition, ornithine and urea can be biosynthesized from L-arginine; which is mediated by the enzyme arginase-1. In humans, ornithine is involved in the metabolic disorder called argininemia. Outside of the human body, Ornithine has been detected, but not quantified in, several different foods, such as lemon thymes, black elderberries, tronchuda cabbages, black mulberries, and bilberries. This could make ornithine a potential biomarker for the consumption of these foods. Ornithine is a potentially toxic compound. Ornithine, with regard to humans, has been found to be associated with several diseases such as ulcerative colitis, myopathy, lactic acidosis, and sideroblastic anemia 1, and perillyl alcohol administration for cancer treatment; ornithine has also been linked to several inborn metabolic disorders including hyperdibasic aminoaciduria I and ornithine transcarbamylase deficiency. An optically active form of ornithine having L-configuration. Ornithine is expected to be in Cannabis as all living plants are known to produce and metabolize it.

Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
(S)-2,5-Diaminopentanoate	ChEBI
(S)-2,5-Diaminopentanoic acid	ChEBI
(S)-2,5-Diaminovaleric acid	ChEBI
(S)-alpha,delta-Diaminovaleric acid	ChEBI
(S)-Ornithine	ChEBI
(S)-2,5-Diaminovalerate	Generator
(S)-a,delta-Diaminovalerate	Generator
(S)-a,delta-Diaminovaleric acid	Generator
(S)-alpha,delta-Diaminovalerate	Generator
(S)-Α,δ-diaminovalerate	Generator
(S)-Α,δ-diaminovaleric acid	Generator
(S)-a,Δ-diaminovalerate	HMDB
(S)-a,Δ-diaminovaleric acid	HMDB
(+)-S-Ornithine	HMDB
(S)-a,D-Diaminovalerate	HMDB
(S)-a,D-Diaminovaleric acid	HMDB
5-Amino-L-norvaline	HMDB
L-(-)-Ornithine	HMDB
L-Ornithine	HMDB
2,5-Diaminopentanoic acid	HMDB
Ornithine dihydrochloride, (L)-isomer	HMDB
Ornithine hydrochloride, (D)-isomer	HMDB
Ornithine, (D)-isomer	HMDB
Ornithine, (L)-isomer	HMDB
2,5 Diaminopentanoic acid	HMDB
Ornithine monoacetate, (L)-isomer	HMDB
Ornithine monohydrochloride, (D)-isomer	HMDB
Ornithine monohydrochloride, (DL)-isomer	HMDB
Ornithine phosphate (1:1), (L)-isomer	HMDB
Ornithine sulfate (1:1), (L)-isomer	HMDB
Ornithine hydrochloride, (DL)-isomer	HMDB
Ornithine hydrochloride, (L)-isomer	HMDB
Ornithine monohydrobromide, (L)-isomer	HMDB
Ornithine, (DL)-isomer	HMDB

Chemical Formula

C₅H₁₂N₂O₂

Average Molecular Weight

132.16

Monoisotopic Molecular Weight

132.0899

IUPAC Name

(2S)-2,5-diaminopentanoic acid

Traditional Name

ornithine

CAS Registry Number

25104-12-5

SMILES

NCCC[C@H](N)C(O)=O

InChI Identifier

InChI=1S/C5H12N2O2/c6-3-1-2-4(7)5(8)9/h4H,1-3,6-7H2,(H,8,9)/t4-/m0/s1

InChI Key

AHLPHDHHMVZTML-BYPYZUCNSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as l-alpha-amino acids. These are alpha amino acids which have the L-configuration of the alpha-carbon atom.

Kingdom

Organic compounds

Super Class

Organic acids and derivatives

Class

Carboxylic acids and derivatives

Sub Class

Amino acids, peptides, and analogues

Direct Parent

L-alpha-amino acids

Alternative Parents

Substituents

L-alpha-amino acid
Fatty acid
Amino acid
Carboxylic acid
Monocarboxylic acid or derivatives
Amine
Hydrocarbon derivative
Organic oxide
Organopnictogen compound
Primary amine
Organooxygen compound
Organonitrogen compound
Organic oxygen compound
Primary aliphatic amine
Organic nitrogen compound
Carbonyl group
Aliphatic acyclic compound

Molecular Framework

Aliphatic acyclic compounds

External Descriptors

non-proteinogenic L-alpha-amino acid (CHEBI:15729 )
ornithine (CHEBI:15729 )
Other amino acids (C00077 )

Ontology

Leukemia

Disposition

Route of exposure:

Enteral:

Ingestion

Organ and components:

Biofluid and excreta:

Cell and elements:

Extracellular

Subcellular:

Role

Industrial application:

Pharmaceutical industry:

Pharmaceutical

Physical Properties

State

Not Available

Experimental Properties

Property	Value	Reference
Melting Point	140 °C	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	620 mg/mL	Not Available
logP	-4.22	SANGSTER (1994)

Predicted Properties

Property	Value	Source
logP	-3.6	ALOGPS
logP	-3.7	ChemAxon
logS	0.11	ALOGPS
pKa (Strongest Acidic)	2.67	ChemAxon
pKa (Strongest Basic)	10.29	ChemAxon
Physiological Charge	1	ChemAxon
Hydrogen Acceptor Count	4	ChemAxon
Hydrogen Donor Count	3	ChemAxon
Polar Surface Area	89.34 Å²	ChemAxon
Rotatable Bond Count	4	ChemAxon
Refractivity	33.21 m³·mol⁻¹	ChemAxon
Polarizability	13.85 Å³	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

EI-MS/GC-MS

Type	Description	Splash Key	View
GC-MS	Ornithine, 2 TMS, GC-MS Spectrum	splash10-0006-1920000000-b0357b8c9888abda7d80	Spectrum
GC-MS	Ornithine, non-derivatized, GC-MS Spectrum	splash10-0006-0910000000-8aaa0faabf1429b90611	Spectrum
GC-MS	Ornithine, 2 TMS, GC-MS Spectrum	splash10-00di-7910000000-5fa118444ceb45204aa3	Spectrum
GC-MS	Ornithine, 3 TMS, GC-MS Spectrum	splash10-006x-3910000000-f6d0c6492f2cab33a392	Spectrum
GC-MS	Ornithine, 3 TMS, GC-MS Spectrum	splash10-00dr-2900000000-77222ff2d0118d3d3b57	Spectrum
GC-MS	Ornithine, 4 TMS, GC-MS Spectrum	splash10-0006-1910000000-53c73c4fa3665c44d3b9	Spectrum
GC-MS	Ornithine, 5 TMS, GC-MS Spectrum	splash10-03di-1691000000-dc14976cfee86cc828b9	Spectrum
GC-MS	Ornithine, non-derivatized, GC-MS Spectrum	splash10-0006-0920000000-f65f61e4a3739eabb1d1	Spectrum
GC-MS	Ornithine, non-derivatized, GC-MS Spectrum	splash10-0006-1920000000-b0357b8c9888abda7d80	Spectrum
GC-MS	Ornithine, non-derivatized, GC-MS Spectrum	splash10-0006-0910000000-8aaa0faabf1429b90611	Spectrum
GC-MS	Ornithine, non-derivatized, GC-MS Spectrum	splash10-00di-7910000000-5fa118444ceb45204aa3	Spectrum
GC-MS	Ornithine, non-derivatized, GC-MS Spectrum	splash10-006x-3910000000-f6d0c6492f2cab33a392	Spectrum
GC-MS	Ornithine, non-derivatized, GC-MS Spectrum	splash10-00dr-2900000000-77222ff2d0118d3d3b57	Spectrum
GC-MS	Ornithine, non-derivatized, GC-MS Spectrum	splash10-0006-1910000000-53c73c4fa3665c44d3b9	Spectrum
GC-MS	Ornithine, non-derivatized, GC-MS Spectrum	splash10-03di-1691000000-dc14976cfee86cc828b9	Spectrum
GC-MS	Ornithine, non-derivatized, GC-MS Spectrum	splash10-0006-0900000000-f59681b9f46f1b738487	Spectrum
GC-MS	Ornithine, non-derivatized, GC-MS Spectrum	splash10-0006-0900000000-3048477975b51ae176af	Spectrum
GC-MS	Ornithine, non-derivatized, GC-MS Spectrum	splash10-00dr-2900000000-8d1a2cc0a88f7d9216e1	Spectrum
GC-MS	Ornithine, non-derivatized, GC-MS Spectrum	splash10-0udi-1900000000-bc40b76e8b03ef7a08f0	Spectrum
Predicted GC-MS	Ornithine, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	splash10-001l-9000000000-50fe14c2cb68fd09e32f	Spectrum
Predicted GC-MS	Ornithine, 1 TMS, Predicted GC-MS Spectrum - 70eV, Positive	splash10-0089-9300000000-bbfdea03043e52ad8a15	Spectrum
Predicted GC-MS	Ornithine, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Ornithine, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Ornithine, TMS_1_2, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Ornithine, TMS_1_3, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum

MS/MS

Type	Description	Splash Key	View
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)	splash10-01b9-6900000000-8fe592b77d2d8e4ae704	2012-07-24	View Spectrum
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)	splash10-00di-9000000000-462b84db532c33527580	2012-07-24	View Spectrum
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)	splash10-00di-9000000000-9c9c28d2e40d5eadacd2	2012-07-24	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-001i-0900000000-e44e06092c06bb4791af	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-014i-9000000000-4d6ccc429f5155b24654	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-014i-0900000000-dcad699e8ed7e1b19860	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-001i-0900000000-7b130437d4e1ceea277b	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-001i-0900000000-0fae230bc6b21623a4bf	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-014i-9000000000-5a350a8e7c607a8b9a60	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-014i-0900000000-516054b6c2f3cd4a1d02	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-000i-0793321000-9fef988b5ce019f84642	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-03di-0900000000-a612df8df5f8ba1ff7f3	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-001i-0910000000-97fad20414656e2b7b93	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-01di-0490000000-1b137b937beb110d2e4b	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Negative	splash10-001i-0900000000-e3fc95eb909e45d8e648	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, Negative	splash10-001i-1900000000-cdd9aac89a5a71814ff3	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, Negative	splash10-001r-9500000000-f1cc3eccf3f5ab734222	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Positive	splash10-0159-0900000000-93ce7b142d1f82f17e95	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, Positive	splash10-00di-9200000000-186f270471bdec40f804	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, Positive	splash10-00di-9000000000-ebbdf0ab6d3180cba1a5	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 40V, Positive	splash10-00di-9000000000-207bcc826fb2238c2cc5	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 50V, Positive	splash10-00di-9000000000-a2f9a950fb23a6b18857	2012-08-31	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-01c9-9700000000-0364d35bb1a7c10a09c7	2016-09-12	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-00dr-9100000000-9c4015733140885b4957	2016-09-12	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-00dl-9000000000-b32e7180e30a835008bb	2016-09-12	View Spectrum

NMR

Type	Description	View
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, experimental)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 125 MHz, H₂O, experimental)	Spectrum
1D NMR	¹H NMR Spectrum (1D, D₂O, experimental)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 400 MHz, H₂O, experimental)	Spectrum
2D NMR	[¹H, ¹H]-TOCSY. Unexported temporarily by An Chi on Oct 15, 2021 until json or nmrML file is generated. 2D NMR Spectrum (experimental)	Spectrum
2D NMR	[¹H, ¹³C]-HSQC NMR Spectrum (2D, 600 MHz, H₂O, experimental)	Spectrum

Pathways

Name	SMPDB/Pathwhiz	KEGG
Arginine and Proline Metabolism
Urea Cycle
Spermidine and Spermine Biosynthesis		Not Available
Glycine and Serine Metabolism
Prolidase Deficiency (PD)		Not Available

Protein Targets

Enzymes

Protein Name	Gene Name	Locus	Uniprot ID	Details
Arginase-1	ARG1	6q23	P05089	details
Ornithine aminotransferase, mitochondrial	OAT	10q26	P04181	details
Glycine amidinotransferase, mitochondrial	GATM	15q21.1	P50440	details
Aminoacylase-1	ACY1	3p21.1	Q03154	details
Delta-1-pyrroline-5-carboxylate synthase	ALDH18A1	10q24.3	P54886	details
Ornithine carbamoyltransferase, mitochondrial	OTC	Xp21.1	P00480	details
Ornithine decarboxylase	ODC1	2p25	P11926	details
Arginase-2, mitochondrial	ARG2	14q24.1	P78540	details
Cationic amino acid transporter 4	SLC7A4	22q11.21	O43246	details
Mitochondrial ornithine transporter 1	SLC25A15	13q14	Q9Y619	details
Mitochondrial ornithine transporter 2	SLC25A2	5q31	Q9BXI2	details
High affinity cationic amino acid transporter 1	SLC7A1	13q12-q14	P30825	details
Low affinity cationic amino acid transporter 2	SLC7A2	8p22-p21.3	P52569	details
Ornithine decarboxylase antizyme 1	OAZ1	19p13.3	P54368	details
Ornithine decarboxylase antizyme 2	OAZ2	15q22.31	O95190	details
Ornithine decarboxylase antizyme 3	OAZ3	1q21.3	Q9UMX2	details
Antizyme inhibitor 1	AZIN1	8q22.3	O14977	details

Transporters

Protein Name	Gene Name	Locus	Uniprot ID	Details
Cationic amino acid transporter 4	SLC7A4	22q11.21	O43246	details
Mitochondrial ornithine transporter 1	SLC25A15	13q14	Q9Y619	details
Mitochondrial ornithine transporter 2	SLC25A2	5q31	Q9BXI2	details
Cationic amino acid transporter 3	SLC7A3		Q8WY07	details
High affinity cationic amino acid transporter 1	SLC7A1	13q12-q14	P30825	details
Low affinity cationic amino acid transporter 2	SLC7A2	8p22-p21.3	P52569	details
Y+L amino acid transporter 2	SLC7A6	16q22.1	Q92536	details

Metal Bindings

Protein Name	Gene Name	Locus	Uniprot ID	Details
Arginase-1	ARG1	6q23	P05089	details
Aminoacylase-1	ACY1	3p21.1	Q03154	details
Arginase-2, mitochondrial	ARG2	14q24.1	P78540	details

Receptors

Not Available

Transcriptional Factors

Not Available

Concentrations Data

Cannabis Cultivar	Status	Value	Reference	Details
Alien Dawg	Detected and Quantified	0.0936 mg/g dry wt	David S. Wishart,...	details
Gabriola	Detected and Quantified	0.0107 mg/g dry wt	David S. Wishart,...	details
Island Honey	Detected and Quantified	0.0351 mg/g dry wt	David S. Wishart,...	details
Quadra	Detected and Quantified	0.0155 mg/g dry wt	David S. Wishart,...	details
Sensi Star	Detected and Quantified	0.00585 mg/g dry wt	David S. Wishart,...	details
Tangerine Dream	Detected and Quantified	0.0374 mg/g dry wt	David S. Wishart,...	details

External Links

HMDB ID

HMDB0000214

DrugBank ID

DB00129

Phenol Explorer Compound ID

Not Available

FoodDB ID

KNApSAcK ID

Chemspider ID

KEGG Compound ID

BioCyc ID

BiGG ID

Wikipedia Link

METLIN ID

PubChem Compound

6262

PDB ID

Not Available

ChEBI ID

15729

References

General References

Not Available

Only showing the first 10 proteins. There are 27 proteins in total.

Show All

Enzymes

Enzyme Details

1. Arginase-1

General function:: Involved in arginase activity
Specific function:: Not Available
Gene Name:: ARG1
Uniprot ID:: P05089
Molecular weight:: 34734.655

Enzyme Details

2. Ornithine aminotransferase, mitochondrial

General function:: Involved in transaminase activity
Specific function:: Not Available
Gene Name:: OAT
Uniprot ID:: P04181
Molecular weight:: 48534.39

Enzyme Details

3. Glycine amidinotransferase, mitochondrial

General function:: Amino acid transport and metabolism
Specific function:: Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine. Creatine plays a vital role in energy metabolism in muscle tissues. May play a role in embryonic and central nervous system development. May be involved in the response to heart failure by elevating local creatine synthesis.
Gene Name:: GATM
Uniprot ID:: P50440
Molecular weight:: 48455.01

Enzyme Details

4. Aminoacylase-1

General function:: Involved in metallopeptidase activity
Specific function:: Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate).
Gene Name:: ACY1
Uniprot ID:: Q03154
Molecular weight:: 45884.705

Enzyme Details

5. Delta-1-pyrroline-5-carboxylate synthase

General function:: Involved in oxidoreductase activity
Specific function:: Bifunctional enzyme that converts glutamate to glutamate 5-semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine.
Gene Name:: ALDH18A1
Uniprot ID:: P54886
Molecular weight:: 87088.29

Enzyme Details

6. Ornithine carbamoyltransferase, mitochondrial

General function:: Involved in carboxyl- or carbamoyltransferase activity
Specific function:: Not Available
Gene Name:: OTC
Uniprot ID:: P00480
Molecular weight:: 39934.775

Enzyme Details

7. Ornithine decarboxylase

General function:: Involved in catalytic activity
Specific function:: Not Available
Gene Name:: ODC1
Uniprot ID:: P11926
Molecular weight:: 51147.73

Enzyme Details

8. Arginase-2, mitochondrial

General function:: Involved in arginase activity
Specific function:: May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders.
Gene Name:: ARG2
Uniprot ID:: P78540
Molecular weight:: 38577.515

Enzyme Details

9. Cationic amino acid transporter 4

General function:: Involved in transport
Specific function:: Involved in the transport of the cationic amino acids (arginine, lysine and ornithine)
Gene Name:: SLC7A4
Uniprot ID:: O43246
Molecular weight:: 68267.2

Enzyme Details

10. Mitochondrial ornithine transporter 1

General function:: Involved in transporter activity
Specific function:: Ornithine transport across inner mitochondrial membrane, from the cytoplasm to the matrix.
Gene Name:: SLC25A15
Uniprot ID:: Q9Y619
Molecular weight:: 32735.96

Transporters

Enzyme Details

1. Cationic amino acid transporter 4

General function:: Involved in transport
Specific function:: Involved in the transport of the cationic amino acids (arginine, lysine and ornithine)
Gene Name:: SLC7A4
Uniprot ID:: O43246
Molecular weight:: 68267.2

Enzyme Details

2. Mitochondrial ornithine transporter 1

General function:: Involved in transporter activity
Specific function:: Ornithine transport across inner mitochondrial membrane, from the cytoplasm to the matrix.
Gene Name:: SLC25A15
Uniprot ID:: Q9Y619
Molecular weight:: 32735.96

Enzyme Details

3. Mitochondrial ornithine transporter 2

General function:: Involved in transporter activity
Specific function:: Ornithine transport across inner mitochondrial membrane, from the cytoplasm to the matrix.
Gene Name:: SLC25A2
Uniprot ID:: Q9BXI2
Molecular weight:: 32580.07

Enzyme Details

4. Cationic amino acid transporter 3

General function:: Involved in transport
Specific function:: Mediates the uptake of the cationic amino acids arginine, lysine and ornithine in a sodium-independent manner
Gene Name:: SLC7A3
Uniprot ID:: Q8WY07
Molecular weight:: 67168.3

Enzyme Details

5. High affinity cationic amino acid transporter 1

General function:: Involved in transport
Specific function:: High-affinity, low capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) in non-hepatic tissues. May also function as an ecotropic retroviral leukemia receptor
Gene Name:: SLC7A1
Uniprot ID:: P30825
Molecular weight:: 67637.6

Enzyme Details

6. Low affinity cationic amino acid transporter 2

General function:: Involved in transport
Specific function:: Low-affinity, high capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine). Plays a regulatory role in classical or alternative activation of macrophages
Gene Name:: SLC7A2
Uniprot ID:: P52569
Molecular weight:: 71672.2

Enzyme Details

7. Y+L amino acid transporter 2

General function:: Involved in transport
Specific function:: Involved in the sodium-independent uptake of dibasic amino acids and sodium-dependent uptake of some neutral amino acids. Requires co-expression with SLC3A2/4F2hc to mediate the uptake of arginine, leucine and glutamine. Also acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Involved in the transport of L-arginine in monocytes. Reduces uptake of ornithine in retinal pigment epithelial (RPE) cells
Gene Name:: SLC7A6
Uniprot ID:: Q92536
Molecular weight:: 56826.9

Only showing the first 10 proteins. There are 27 proteins in total.

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Showing Compound Card for Ornithine (CDB005105)

Structure for CDB005105 (Ornithine)

Enzymes

Transporters