| Identification |
|---|
| HMDB Protein ID
| CDBP04722 |
| Secondary Accession Numbers
| Not Available |
| Name
| Antizyme inhibitor 1 |
| Description
| Not Available |
| Synonyms
|
- AZI
- Ornithine decarboxylase antizyme inhibitor
|
| Gene Name
| AZIN1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in catalytic activity |
| Specific Function
| Regulates cellular polyamine homeostasis. Inhibits antizyme-dependent ornithine decarboxylase degradation by binding to antizyme |
| GO Classification
|
| Function |
| catalytic activity |
| Process |
| polyamine metabolic process |
| polyamine biosynthetic process |
| cellular amino acid and derivative metabolic process |
| metabolic process |
| cellular metabolic process |
| cellular amino acid derivative metabolic process |
| cellular biogenic amine metabolic process |
|
| Cellular Location
|
Not Available
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:8 |
| Locus
| 8q22.3 |
| SNPs
| AZIN1 |
| Gene Sequence
|
>1347 bp
ATGAAAGGATTTATTGATGATGCAAACTACTCCGTTGGCCTGTTGGATGAAGGAACAAAC
CTTGGAAATGTTATTGATAACTATGTTTATGAACATACCCTGACAGGGAAAAATGCATTT
TTTGTGGGAGATCTTGGAAAGATTGTGAAGAAACACAGTCAATGGCAGAATGTAGTGGCT
CAGATAAAGCCATTCTACACAGTGAAGTGCAACTCTGCTCCAGCTGTACTTGAGATTTTG
GCAGCTCTTGGAACCGGATTTGCTTGTTCCAGTAAAAATGAAATGGCTTTAGTGCAAGAG
TTGGGTGTACCTCCAGAAAACATTATTTACATAAGTCCTTGCAAGCAAGTGTCTCAGATA
AAGTATGCAGCAAAAGTTGGAGTGAATATCCTGACATGTGACAATGAAATTGAATTGAAG
AAAATTGCACGTAATCACCCAAATGCCAAGGTCTTACTACATATTGCAACAGAAGATAAT
ATTGGAGGTGAAGAGGGTAACATGAAGTTTGGCACTACCCTGAAGAACTGTAGGCATCTC
TTGGAATGTGCTAAGGAACTTGATGTCCAAATAATTGGGGTTAAATTTCATGTTTCGAGT
GCTTGCAAAGAATCTCAAGTATATGTACATGCTCTATCTGATGCTCGATGTGTGTTTGAC
ATGGCTGGAGAAATTGGCTTTACGATGAACATGTTAGACATTGGTGGAGGATTCACGGGA
ACTGAATTTCAATTGGAAGAGGTTAATCATGTTATCAGCCCTCTGTTGGATATCTACTTT
CCTGAAGGATCTGGTGTTAAGATAATTTCAGAACCCGGAAGCTACTATGTGTCTTCTGCA
TTTACACTCGCAGTTAATATCATAGCAAAGAAAGTTGTTGAAAATGATAAATTTCCCTCT
GGAGTAGAAAAAACCGGAAGTGATGAACCAGCCTTCATGTATTATATGAATGATGGTGTT
TATGGTTCTTTTGCAAGTAAACTGTCTGAGGACTTAAATACCATTCCAGAGGTTCACAAG
AAATACAAGGAAGATGAGCCTCTGTTTACAAGCAGCCTTTGGGGTCCATCCTGTGATGAG
CTTGATCAAATTGTGGAAAGCTGTCTTCTTCCTGAGCTGAATGTGGGAGATTGGCTTATC
TTTGATAACATGGGAGCAGATTCTTTCCATGAACCATCTGCTTTTAATGATTTTCAGAGG
CCAGCCATTTATTACATGATGTCATTCAGTGATTGGTATGAGATGCAAGATGCTGGAATT
ACTTCAGACTCAATGATGAAGAACTTCTTCTTTGTGCCTTCTTGCATTCAGCTGAGCCAA
GAAGACAGCTTTTCCGCTGAAGCTTAA
|
| Protein Properties |
|---|
| Number of Residues
| 448 |
| Molecular Weight
| 49534.8 |
| Theoretical pI
| 4.4 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Antizyme inhibitor 1
MKGFIDDANYSVGLLDEGTNLGNVIDNYVYEHTLTGKNAFFVGDLGKIVKKHSQWQNVVA
QIKPFYTVKCNSAPAVLEILAALGTGFACSSKNEMALVQELGVPPENIIYISPCKQVSQI
KYAAKVGVNILTCDNEIELKKIARNHPNAKVLLHIATEDNIGGEEGNMKFGTTLKNCRHL
LECAKELDVQIIGVKFHVSSACKESQVYVHALSDARCVFDMAGEIGFTMNMLDIGGGFTG
TEFQLEEVNHVISPLLDIYFPEGSGVKIISEPGSYYVSSAFTLAVNIIAKKVVENDKFPS
GVEKTGSDEPAFMYYMNDGVYGSFASKLSEDLNTIPEVHKKYKEDEPLFTSSLWGPSCDE
LDQIVESCLLPELNVGDWLIFDNMGADSFHEPSAFNDFQRPAIYYMMSFSDWYEMQDAGI
TSDSMMKNFFFVPSCIQLSQEDSFSAEA
|
| External Links |
|---|
| GenBank ID Protein
| 21361583 |
| UniProtKB/Swiss-Prot ID
| O14977 |
| UniProtKB/Swiss-Prot Entry Name
| AZIN1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_015878.4 |
| GeneCard ID
| AZIN1 |
| GenAtlas ID
| AZIN1 |
| HGNC ID
| HGNC:16432 |
| References |
|---|
| General References
| Not Available |