Showing Compound Card for Carbon monoxide (CDB004907)

Jump To Section:
IdentificationTaxonomyOntologyPhysical propertiesSpectraProtein targetPathwaysConcentrationsLinksReferencesenzymes (5)transporters (1) Show 11 proteinsXML
Record Information
Version1.0
Created at2020-04-17 18:49:12 UTC
Updated at2020-12-07 19:11:14 UTC
CannabisDB IDCDB004907
Secondary Accession NumbersNot Available
Cannabis Compound Identification
Common NameCarbon monoxide
DescriptionCarbon monoxide, also known as [CO] or C#O, belongs to the class of inorganic compounds known as homogeneous other non-metal compounds. These are inorganic non-metallic compounds in which the largest atom belongs to the class of 'other non-metals'. Carbon monoxide is a drug which is used as a marker of respiratory status in spirometry tests [l2557], [f4]. food additive for pigment fixation in meat [l2531]. Carbon monoxide is possibly neutral. Carbon monoxide exists in all living species, ranging from bacteria to humans. In humans, carbon monoxide is involved in the metabolic disorder called congenital erythropoietic porphyria (cep) or gunther disease pathway. Outside of the human body, Carbon monoxide has been detected, but not quantified in, several different foods, such as garland chrysanthemums, alfalfa, japanese walnuts, lemon grass, and chinese chives. This could make carbon monoxide a potential biomarker for the consumption of these foods. Carbon monoxide is a potentially toxic compound. Carbon monoxide is expected to be in Cannabis as all living plants are known to produce and metabolize it.
Structure
Thumb
MOLSDFPDBSMILESInChI
Synonyms
ValueSource
[CO]ChEBI
C#OChEBI
COChEBI
Monoxide, carbonHMDB
Chemical FormulaCO
Average Molecular Weight28.01
Monoisotopic Molecular Weight27.9949
IUPAC NameNot Available
Traditional NameNot Available
CAS Registry Number630-08-0
SMILES
[C-]#[O+]
InChI Identifier
InChI=1S/CO/c1-2
InChI KeyUGFAIRIUMAVXCW-UHFFFAOYSA-N
Chemical Taxonomy
Description Belongs to the class of inorganic compounds known as homogeneous other non-metal compounds. These are inorganic non-metallic compounds in which the largest atom belongs to the class of 'other non-metals'.
KingdomInorganic compounds
Super ClassHomogeneous non-metal compounds
ClassHomogeneous other non-metal compounds
Sub ClassNot Available
Direct ParentHomogeneous other non-metal compounds
Alternative ParentsNot Available
Substituents
  • Homogeneous other non metal
Molecular FrameworkNot Available
External Descriptors
Ontology
Physiological effect

Health effect:

Disposition

Route of exposure:

Source:

Biological location:

Role

Indirect biological role:

Biological role:

Industrial application:

Physical Properties
StateLiquid
Experimental Properties
PropertyValueReference
Melting Point-56.5 °CNot Available
Boiling PointNot AvailableNot Available
Water Solubility1.48 mg/mL at 25 °CNot Available
logP0.83HANSCH,C ET AL. (1995)
Predicted Properties
PropertyValueSource
logP-0.06ALOGPS
logS-1.1ALOGPS
Hydrogen Acceptor Count0ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area0 ŲChemAxon
Rotatable Bond Count0ChemAxon
Refractivity26.23 m³·mol⁻¹ChemAxon
Polarizability1.94 ųChemAxon
Number of Rings0ChemAxon
BioavailabilityYesChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Spectra
EI-MS/GC-MS
TypeDescriptionSplash KeyView
EI-MSMass Spectrum (Electron Ionization)splash10-004i-9000000000-dfbb2bd73fc3d527a3402014-09-20View Spectrum
MS/MS
TypeDescriptionSplash KeyView
Predicted MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-004i-9000000000-5ea4ad4bdb0565b737bb2016-08-03View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-004i-9000000000-5ea4ad4bdb0565b737bb2016-08-03View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-004i-9000000000-5ea4ad4bdb0565b737bb2016-08-03View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-004i-9000000000-b175ec2a41978516a72e2016-08-03View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-004i-9000000000-b175ec2a41978516a72e2016-08-03View Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-004i-9000000000-b175ec2a41978516a72e2016-08-03View Spectrum
NMR
TypeDescriptionView
Pathways
Pathways
Protein Targets
Enzymes
Protein NameGene NameLocusUniprot IDDetails
Heme oxygenase 2HMOX216p13.3P30519 details
Heme oxygenase 1HMOX122q13.1P09601 details
Leukotriene-B(4) omega-hydroxylase 2CYP4F319p13.2Q08477 details
Eukaryotic translation initiation factor 2-alpha kinase 1EIF2AK17p22Q9BQI3 details
1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenaseADI12p25.3Q9BV57 details
Transporters
Protein NameGene NameLocusUniprot IDDetails
Calcium-activated potassium channel subunit alpha-1KCNMA110q22.3Q12791 details
Metal Bindings
Protein NameGene NameLocusUniprot IDDetails
Heme oxygenase 2HMOX216p13.3P30519 details
Heme oxygenase 1HMOX122q13.1P09601 details
Leukotriene-B(4) omega-hydroxylase 2CYP4F319p13.2Q08477 details
1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenaseADI12p25.3Q9BV57 details
ReceptorsNot Available
Transcriptional Factors
Protein NameGene NameLocusUniprot IDDetails
Heme oxygenase 1HMOX122q13.1P09601 details
Concentrations Data
Not Available
HMDB IDHMDB0001361
DrugBank IDDB11588
Phenol Explorer Compound IDNot Available
FoodDB IDFDB022578
KNApSAcK IDNot Available
Chemspider ID275
KEGG Compound IDC00237
BioCyc IDCARBON-MONOXIDE
BiGG ID1749973
Wikipedia LinkCarbon_monoxide
METLIN IDNot Available
PubChem Compound281
PDB IDNot Available
ChEBI ID17245
References
General ReferencesNot Available

Only showing the first 10 proteins. There are 11 proteins in total.

Show All

Enzymes

Enzyme Details
1. Heme oxygenase 2
General function:
Involved in heme oxygenase (decyclizing) activity
Specific function:
Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme oxygenase 2 could be implicated in the production of carbon monoxide in brain where it could act as a neurotransmitter.
Gene Name:
HMOX2
Uniprot ID:
P30519
Molecular weight:
36032.615
Enzyme Details
2. Heme oxygenase 1
General function:
Involved in heme oxygenase (decyclizing) activity
Specific function:
Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed.
Gene Name:
HMOX1
Uniprot ID:
P09601
Molecular weight:
32818.345
Enzyme Details
3. Leukotriene-B(4) omega-hydroxylase 2
General function:
Involved in monooxygenase activity
Specific function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. This enzyme requires molecular oxygen and NADPH for the omega-hydroxylation of LTB4, a potent chemoattractant for polymorphonuclear leukocytes.
Gene Name:
CYP4F3
Uniprot ID:
Q08477
Molecular weight:
59846.085
Enzyme Details
4. Eukaryotic translation initiation factor 2-alpha kinase 1
General function:
Involved in protein serine/threonine kinase activity
Specific function:
Mediates down-regulation of protein synthesis in response to various stress conditions by the phosphorylation of EIF2S1 at 'Ser-48' and 'Ser-51'. Protein synthesis is inhibited at the level of initiation
Gene Name:
EIF2AK1
Uniprot ID:
Q9BQI3
Molecular weight:
71105.9
Enzyme Details
5. 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase
General function:
Involved in metal ion binding
Specific function:
Catalyzes the formation of formate and 2-keto-4-methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14. Necessary for hepatitis C virus replication in an otherwise non-permissive cell line.
Gene Name:
ADI1
Uniprot ID:
Q9BV57
Molecular weight:
21498.23

Transporters

Enzyme Details
1. Calcium-activated potassium channel subunit alpha-1
General function:
Involved in ion channel activity
Specific function:
Potassium channel activated by both membrane depolarization or increase in cytosolic Ca(2+) that mediates export of K(+). It is also activated by the concentration of cytosolic Mg(2+). Its activation dampens the excitatory events that elevate the cytosolic Ca(2+) concentration and/or depolarize the cell membrane. It therefore contributes to repolarization of the membrane potential. Plays a key role in controlling excitability in a number of systems, such as regulation of the contraction of smooth muscle, the tuning of hair cells in the cochlea, regulation of transmitter release, and innate immunity. In smooth muscles, its activation by high level of Ca(2+), caused by ryanodine receptors in the sarcoplasmic reticulum, regulates the membrane potential. In cochlea cells, its number and kinetic properties partly determine the characteristic frequency of each hair cell and thereby helps to establish a tonotopic map. Kinetics of KCNMA1 channels are determined by alternative splicing, phosphorylation status and its combination with modulating beta subunits. Highly sensitive to both iberiotoxin (IbTx) and charybdotoxin (CTX)
Gene Name:
KCNMA1
Uniprot ID:
Q12791
Molecular weight:
137558.1

Only showing the first 10 proteins. There are 11 proteins in total.

Show All