Record Information
Version1.0
Created at2020-04-17 18:38:16 UTC
Updated at2020-12-07 19:10:58 UTC
CannabisDB IDCDB004802
Secondary Accession NumbersNot Available
Cannabis Compound Identification
Common Namegamma-Aminobutyric acid
Descriptiongamma-Aminobutyric acid, also known as GABA or g-amino-butanoate, belongs to the class of organic compounds known as gamma amino acids and derivatives. These are amino acids having a (-NH2) group attached to the gamma carbon atom. gamma-Aminobutyric acid is a very hydrophobic molecule, practically insoluble (in water), and relatively neutral. gamma-Aminobutyric acid exists in all living species, ranging from bacteria to humans. Outside of the human body, gamma-Aminobutyric acid has been detected, but not quantified in, several different foods, such as fox grapes, oxheart cabbages, garden onion (var.), yellow zucchinis, and chinese mustards. This could make gamma-aminobutyric acid a potential biomarker for the consumption of these foods. gamma-Aminobutyric acid is a potentially toxic compound. A gamma-amino acid that is butanoic acid with the amino substituent located at C-4. gamma-Aminobutyric acid is expected to be in Cannabis as all living plants are known to produce and metabolize it.
Structure
Thumb
Synonyms
ValueSource
4-Aminobutanoic acidChEBI
4-Aminobutyric acidChEBI
4AbuChEBI
GABAChEBI
GAMMA-AMINO-butanoIC ACIDChEBI
gamma-Amino-N-butyric acidChEBI
gamma-Aminobutanoic acidChEBI
gamma-AminobuttersaeureChEBI
Omega-aminobutyric acidChEBI
Piperidic acidChEBI
Piperidinic acidChEBI
4-AminobutyrateKegg
GammalonKegg
4-AminobutanoateGenerator
g-AMINO-butanoateGenerator
g-AMINO-butanoic acidGenerator
gamma-AMINO-butanoateGenerator
Γ-amino-butanoateGenerator
Γ-amino-butanoic acidGenerator
g-Amino-N-butyrateGenerator
g-Amino-N-butyric acidGenerator
gamma-Amino-N-butyrateGenerator
Γ-amino-N-butyrateGenerator
Γ-amino-N-butyric acidGenerator
g-AminobutanoateGenerator
g-Aminobutanoic acidGenerator
gamma-AminobutanoateGenerator
Γ-aminobutanoateGenerator
Γ-aminobutanoic acidGenerator
g-AminobuttersaeureGenerator
Γ-aminobuttersaeureGenerator
Omega-aminobutyrateGenerator
PiperidateGenerator
PiperidinateGenerator
g-AminobutyrateGenerator
g-Aminobutyric acidGenerator
gamma-AminobutyrateGenerator
Γ-aminobutyrateGenerator
Γ-aminobutyric acidGenerator
3-CarboxypropylamineHMDB
AminalonHMDB
GaballonHMDB
GamarexHMDB
gamma AminobutyrateHMDB
gamma Aminobutyric acidHMDB
GammaloneHMDB
GammarHMDB
GammasolHMDB
MielogenHMDB
MielomadeHMDB
W-AminobutyrateHMDB
W-Aminobutyric acidHMDB
gamma-Aminobutyric acid, calcium salt (2:1)HMDB
gamma-Aminobutyric acid, hydrochlorideHMDB
gamma-Aminobutyric acid, zinc salt (2:1)HMDB
4 Aminobutanoic acidHMDB
4 Aminobutyric acidHMDB
Lithium gabaHMDB
gamma Aminobutyric acid, monolithium saltHMDB
gamma Aminobutyric acid, monosodium saltHMDB
gamma-Aminobutyric acid, monolithium saltHMDB
gamma-Aminobutyric acid, monosodium saltHMDB
Acid, hydrochloride gamma-aminobutyricHMDB
AminaloneHMDB
GABA, lithiumHMDB
Hydrochloride gamma-aminobutyric acidHMDB
gamma Aminobutyric acid, hydrochlorideHMDB
4-Amino-butanoateHMDB
gamma-Aminobutyric acidKEGG
Chemical FormulaC4H9NO2
Average Molecular Weight103.12
Monoisotopic Molecular Weight103.0633
IUPAC Name4-aminobutanoic acid
Traditional Namegamma(amino)-butyric acid
CAS Registry Number56-12-2
SMILES
NCCCC(O)=O
InChI Identifier
InChI=1S/C4H9NO2/c5-3-1-2-4(6)7/h1-3,5H2,(H,6,7)
InChI KeyBTCSSZJGUNDROE-UHFFFAOYSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as gamma amino acids and derivatives. These are amino acids having a (-NH2) group attached to the gamma carbon atom.
KingdomOrganic compounds
Super ClassOrganic acids and derivatives
ClassCarboxylic acids and derivatives
Sub ClassAmino acids, peptides, and analogues
Direct ParentGamma amino acids and derivatives
Alternative Parents
Substituents
  • Gamma amino acid or derivatives
  • Amino fatty acid
  • Straight chain fatty acid
  • Fatty acid
  • Fatty acyl
  • Amino acid
  • Monocarboxylic acid or derivatives
  • Carboxylic acid
  • Organic oxide
  • Organopnictogen compound
  • Primary amine
  • Organooxygen compound
  • Organonitrogen compound
  • Primary aliphatic amine
  • Organic oxygen compound
  • Carbonyl group
  • Organic nitrogen compound
  • Amine
  • Hydrocarbon derivative
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External Descriptors
Ontology
Physiological effect

Health effect:

Disposition

Route of exposure:

Source:

Biological location:

Role

Indirect biological role:

Biological role:

Industrial application:

Physical Properties
StateSolid
Experimental Properties
PropertyValueReference
Melting Point203 °CNot Available
Boiling PointNot AvailableNot Available
Water Solubility1300 mg/mLNot Available
logP-3.17HANSCH,C ET AL. (1995)
Predicted Properties
PropertyValueSource
logP-3ALOGPS
logP-2.9ChemAxon
logS0.55ALOGPS
pKa (Strongest Acidic)4.53ChemAxon
pKa (Strongest Basic)10.22ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area63.32 ŲChemAxon
Rotatable Bond Count3ChemAxon
Refractivity25.46 m³·mol⁻¹ChemAxon
Polarizability10.62 ųChemAxon
Number of Rings0ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Spectra
EI-MS/GC-MS
TypeDescriptionSplash KeyView
EI-MSMass Spectrum (Electron Ionization)splash10-001i-9000000000-dbf4f9e19a35f953a189Spectrum
GC-MSgamma-Aminobutyric acid, 3 TMS, GC-MS Spectrumsplash10-00dj-1900000000-f831f79dfcaeffa8b177Spectrum
GC-MSgamma-Aminobutyric acid, 3 TMS, GC-MS Spectrumsplash10-00di-1900000000-2de9d92a2cfc7bc655f4Spectrum
GC-MSgamma-Aminobutyric acid, 3 TMS, GC-MS Spectrumsplash10-00di-1900000000-73bbf2ee0803f058dbedSpectrum
GC-MSgamma-Aminobutyric acid, 3 TMS, GC-MS Spectrumsplash10-00di-1901000000-85d4bd98af8534428b5aSpectrum
GC-MSgamma-Aminobutyric acid, 3 TMS, GC-MS Spectrumsplash10-00di-0900000000-6be23968e972a414be51Spectrum
GC-MSgamma-Aminobutyric acid, non-derivatized, GC-MS Spectrumsplash10-00di-1900000000-9a224763afd8ca892addSpectrum
GC-MSgamma-Aminobutyric acid, 3 TMS, GC-MS Spectrumsplash10-00di-9800000000-d8906d09ca1872a6391cSpectrum
GC-MSgamma-Aminobutyric acid, 2 TMS, GC-MS Spectrumsplash10-0udi-1900000000-54db7e21790401045519Spectrum
GC-MSgamma-Aminobutyric acid, 3 TMS, GC-MS Spectrumsplash10-00di-1901000000-b047af158215c2b5b8e8Spectrum
GC-MSgamma-Aminobutyric acid, non-derivatized, GC-MS Spectrumsplash10-001i-9000000000-21ea76dfb0da62031f1dSpectrum
GC-MSgamma-Aminobutyric acid, non-derivatized, GC-MS Spectrumsplash10-00di-0901000000-5d60b0a446fd8122f613Spectrum
GC-MSgamma-Aminobutyric acid, non-derivatized, GC-MS Spectrumsplash10-00dj-1900000000-f831f79dfcaeffa8b177Spectrum
GC-MSgamma-Aminobutyric acid, non-derivatized, GC-MS Spectrumsplash10-00di-1900000000-2de9d92a2cfc7bc655f4Spectrum
GC-MSgamma-Aminobutyric acid, non-derivatized, GC-MS Spectrumsplash10-00di-1900000000-73bbf2ee0803f058dbedSpectrum
GC-MSgamma-Aminobutyric acid, non-derivatized, GC-MS Spectrumsplash10-00di-1901000000-85d4bd98af8534428b5aSpectrum
GC-MSgamma-Aminobutyric acid, non-derivatized, GC-MS Spectrumsplash10-00di-0900000000-6be23968e972a414be51Spectrum
GC-MSgamma-Aminobutyric acid, non-derivatized, GC-MS Spectrumsplash10-00di-1900000000-9a224763afd8ca892addSpectrum
GC-MSgamma-Aminobutyric acid, non-derivatized, GC-MS Spectrumsplash10-00di-9800000000-d8906d09ca1872a6391cSpectrum
GC-MSgamma-Aminobutyric acid, non-derivatized, GC-MS Spectrumsplash10-0udi-1900000000-54db7e21790401045519Spectrum
GC-MSgamma-Aminobutyric acid, non-derivatized, GC-MS Spectrumsplash10-00di-1901000000-b047af158215c2b5b8e8Spectrum
GC-MSgamma-Aminobutyric acid, non-derivatized, GC-MS Spectrumsplash10-00dj-1900000000-1219470a0be188da64e6Spectrum
GC-MSgamma-Aminobutyric acid, non-derivatized, GC-MS Spectrumsplash10-0udi-0900000000-f7117dfaf9d856c95919Spectrum
GC-MSgamma-Aminobutyric acid, non-derivatized, GC-MS Spectrumsplash10-0006-1900000000-e35585a985d8128d044eSpectrum
Predicted GC-MSgamma-Aminobutyric acid, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positivesplash10-001i-9000000000-d5f55a414ff1e8c65d9dSpectrum
Predicted GC-MSgamma-Aminobutyric acid, 1 TMS, Predicted GC-MS Spectrum - 70eV, Positivesplash10-0fk9-9700000000-4b2809309587240dd479Spectrum
MS/MS
TypeDescriptionSplash KeyView
MS/MSLC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)splash10-0uxr-8900000000-ce0d8f44422836cd9965Spectrum
MS/MSLC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)splash10-0005-9000000000-8ce5afb97d7c08821da3Spectrum
MS/MSLC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)splash10-0005-9100000000-32c433b2c916697690f8Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positivesplash10-0udi-0900000000-5831aaabdf53f3132ae5Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positivesplash10-0a4i-9000000000-9babfd4a6937ecba7318Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positivesplash10-0a4i-9000000000-e1c0c1485d846e9b123bSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positivesplash10-0udi-0900000000-647d55ecf98850e7a875Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positivesplash10-0udi-0900000000-7c107641a38922c88fcaSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positivesplash10-000i-9000000000-86718b349efad6334e3aSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positivesplash10-000i-9000000000-a1e84e55e4b6c6628d5dSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positivesplash10-0006-0009000000-29c22bf0ed844d09c0afSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Negativesplash10-0udi-0900000000-1d00adad47e42c60c340Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, Negativesplash10-0udi-1900000000-47b195fb74720cc99464Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, Negativesplash10-001i-9000000000-a14a52dc59bf9988bb44Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Positivesplash10-0udi-5900000000-20c55b2809389d5ad83bSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, Positivesplash10-000i-9000000000-eca4c5aefca98751a11eSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, Positivesplash10-014j-9000000000-f0783316e09291749409Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 40V, Positivesplash10-0005-9000000000-81837eb9c0b926cb0e81Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 50V, Positivesplash10-0005-9000000000-8b48126992d7fa242636Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Positivesplash10-000i-9000000000-7d4636efbc4e5d75872eSpectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-000i-9100000000-655f9d93a35bfa537583Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-00ku-9000000000-4a334d5e272576f62403Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-0006-9000000000-4a13b03446b3370ccd43Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-000i-9100000000-655f9d93a35bfa537583Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-00ku-9000000000-4a334d5e272576f62403Spectrum
NMR
TypeDescriptionView
1D NMR1H NMR SpectrumSpectrum
1D NMR13C NMR SpectrumSpectrum
1D NMR1H NMR SpectrumSpectrum
1D NMR13C NMR SpectrumSpectrum
1D NMR1H NMR SpectrumSpectrum
2D NMR[1H,13C] 2D NMR SpectrumSpectrum
Pathways
Pathways
Protein Targets
Enzymes
Protein NameGene NameLocusUniprot IDDetails
4-aminobutyrate aminotransferase, mitochondrialABAT16p13.2P80404 details
4-trimethylaminobutyraldehyde dehydrogenaseALDH9A11q23.1P49189 details
Alpha-aminoadipic semialdehyde dehydrogenaseALDH7A15q31P49419 details
Aldehyde dehydrogenase family 1 member A3ALDH1A315q26.3P47895 details
Aldehyde dehydrogenase, mitochondrialALDH212q24.2P05091 details
Fatty aldehyde dehydrogenaseALDH3A217p11.2P51648 details
Aldehyde dehydrogenase X, mitochondrialALDH1B19p11.1P30837 details
Glycine amidinotransferase, mitochondrialGATM15q21.1P50440 details
Glutamine synthetaseGLUL1q31P15104 details
Glutamate decarboxylase 2GAD210p11.23Q05329 details
Glutamate decarboxylase 1GAD12q31Q99259 details
Arginine decarboxylaseADC1p35.1Q96A70 details
Probable glutamate--tRNA ligase, mitochondrialEARS216p12.2Q5JPH6 details
Carnosine synthase 1CARNS111q13.2A5YM72 details
Gamma-aminobutyric acid receptor-associated protein-like 2GABARAPL216q22.1P60520 details
Transporters
Protein NameGene NameLocusUniprot IDDetails
Gamma-aminobutyric acid receptor subunit gamma-2GABRG25q34P18507 details
Gamma-aminobutyric acid receptor subunit alpha-1GABRA15q34-q35P14867 details
Gamma-aminobutyric acid receptor subunit alpha-2GABRA24p12P47869 details
Gamma-aminobutyric acid receptor subunit alpha-3GABRA3P34903 details
Gamma-aminobutyric acid receptor subunit alpha-4GABRA44p12P48169 details
Gamma-aminobutyric acid receptor subunit alpha-5GABRA515q11.2-q12P31644 details
Gamma-aminobutyric acid receptor subunit alpha-6GABRA65q34Q16445 details
Gamma-aminobutyric acid receptor subunit beta-1GABRB14p12P18505 details
Gamma-aminobutyric acid receptor subunit beta-2GABRB25q34P47870 details
Gamma-aminobutyric acid receptor subunit beta-3GABRB315q11.2-q12P28472 details
Gamma-aminobutyric acid receptor subunit deltaGABRD1p|1p36.3O14764 details
Gamma-aminobutyric acid receptor subunit epsilonGABREP78334 details
Gamma-aminobutyric acid receptor subunit gamma-1GABRG14p12Q8N1C3 details
Gamma-aminobutyric acid receptor subunit gamma-3GABRG315q12Q99928 details
Gamma-aminobutyric acid receptor subunit piGABRP5q33-q34O00591 details
Gamma-aminobutyric acid receptor subunit rho-1GABRR16q14-q21|6q13-q16.3P24046 details
Gamma-aminobutyric acid receptor subunit rho-2GABRR26q14-q21|6q13-q16.3P28476 details
Gamma-aminobutyric acid receptor subunit rho-3GABRR33q11.2A8MPY1 details
Gamma-aminobutyric acid receptor subunit thetaGABRQQ9UN88 details
Metal Bindings
Protein NameGene NameLocusUniprot IDDetails
Carnosine synthase 1CARNS111q13.2A5YM72 details
Receptors
Protein NameGene NameLocusUniprot IDDetails
Gamma-aminobutyric acid receptor subunit gamma-2GABRG25q34P18507 details
Gamma-aminobutyric acid type B receptor subunit 1GABBR16p21.31Q9UBS5 details
Gamma-aminobutyric acid type B receptor subunit 2GABBR29q22.1-q22.3O75899 details
Gamma-aminobutyric acid receptor subunit alpha-1GABRA15q34-q35P14867 details
Gamma-aminobutyric acid receptor subunit alpha-2GABRA24p12P47869 details
Gamma-aminobutyric acid receptor subunit alpha-3GABRA3P34903 details
Gamma-aminobutyric acid receptor subunit alpha-4GABRA44p12P48169 details
Gamma-aminobutyric acid receptor subunit alpha-5GABRA515q11.2-q12P31644 details
Gamma-aminobutyric acid receptor subunit alpha-6GABRA65q34Q16445 details
Gamma-aminobutyric acid receptor subunit beta-1GABRB14p12P18505 details
Gamma-aminobutyric acid receptor subunit beta-2GABRB25q34P47870 details
Gamma-aminobutyric acid receptor subunit beta-3GABRB315q11.2-q12P28472 details
Gamma-aminobutyric acid receptor subunit deltaGABRD1p|1p36.3O14764 details
Gamma-aminobutyric acid receptor subunit epsilonGABREP78334 details
Gamma-aminobutyric acid receptor subunit gamma-1GABRG14p12Q8N1C3 details
Gamma-aminobutyric acid receptor subunit gamma-3GABRG315q12Q99928 details
Gamma-aminobutyric acid receptor subunit piGABRP5q33-q34O00591 details
Gamma-aminobutyric acid receptor subunit rho-1GABRR16q14-q21|6q13-q16.3P24046 details
Gamma-aminobutyric acid receptor subunit rho-2GABRR26q14-q21|6q13-q16.3P28476 details
Gamma-aminobutyric acid receptor subunit rho-3GABRR33q11.2A8MPY1 details
Gamma-aminobutyric acid receptor subunit thetaGABRQQ9UN88 details
Gamma-aminobutyric acid receptor-associated proteinGABARAP17p13.1O95166 details
Gamma-aminobutyric acid receptor-associated protein-like 1GABARAPL112p13.2Q9H0R8 details
Transcriptional FactorsNot Available
Concentrations Data
Not Available
HMDB IDHMDB0000112
DrugBank IDDB02530
Phenol Explorer Compound IDNot Available
FoodDB IDFDB030489
KNApSAcK IDC00001337
Chemspider ID116
KEGG Compound IDC00334
BioCyc ID4-AMINO-BUTYRATE
BiGG ID34652
Wikipedia LinkGamma-Aminobutyric_acid
METLIN IDNot Available
PubChem Compound119
PDB IDNot Available
ChEBI ID16865
References
General ReferencesNot Available

Only showing the first 10 proteins. There are 58 proteins in total.

Enzymes

General function:
Involved in 4-aminobutyrate transaminase activity
Specific function:
Catalyzes the conversion of gamma-aminobutyrate and L-beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine.
Gene Name:
ABAT
Uniprot ID:
P80404
Molecular weight:
56438.405
General function:
Involved in oxidoreductase activity
Specific function:
Converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine. Catalyzes the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction.
Gene Name:
ALDH9A1
Uniprot ID:
P49189
Molecular weight:
56291.485
General function:
Involved in oxidoreductase activity
Specific function:
Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism.
Gene Name:
ALDH7A1
Uniprot ID:
P49419
Molecular weight:
58486.74
General function:
Involved in oxidoreductase activity
Specific function:
Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system (By similarity).
Gene Name:
ALDH1A3
Uniprot ID:
P47895
Molecular weight:
56107.995
General function:
Involved in oxidoreductase activity
Specific function:
Not Available
Gene Name:
ALDH2
Uniprot ID:
P05091
Molecular weight:
56380.93
General function:
Involved in oxidoreductase activity
Specific function:
Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid.
Gene Name:
ALDH3A2
Uniprot ID:
P51648
Molecular weight:
54847.36
General function:
Involved in oxidoreductase activity
Specific function:
ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation.
Gene Name:
ALDH1B1
Uniprot ID:
P30837
Molecular weight:
57248.96
General function:
Amino acid transport and metabolism
Specific function:
Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine. Creatine plays a vital role in energy metabolism in muscle tissues. May play a role in embryonic and central nervous system development. May be involved in the response to heart failure by elevating local creatine synthesis.
Gene Name:
GATM
Uniprot ID:
P50440
Molecular weight:
48455.01
General function:
Involved in glutamate-ammonia ligase activity
Specific function:
This enzyme has 2 functions: it catalyzes the production of glutamine and 4-aminobutanoate (gamma-aminobutyric acid, GABA), the latter in a pyridoxal phosphate-independent manner (By similarity). Essential for proliferation of fetal skin fibroblasts.
Gene Name:
GLUL
Uniprot ID:
P15104
Molecular weight:
42064.15
General function:
Involved in carboxy-lyase activity
Specific function:
Catalyzes the production of GABA.
Gene Name:
GAD2
Uniprot ID:
Q05329
Molecular weight:
65410.77

Transporters

General function:
Involved in ion transport
Specific function:
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel
Gene Name:
GABRG2
Uniprot ID:
P18507
Molecular weight:
54161.8
General function:
Involved in ion transport
Specific function:
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel
Gene Name:
GABRA1
Uniprot ID:
P14867
Molecular weight:
51801.4
General function:
Involved in ion transport
Specific function:
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel
Gene Name:
GABRA2
Uniprot ID:
P47869
Molecular weight:
51325.9
General function:
Involved in ion transport
Specific function:
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel
Gene Name:
GABRA3
Uniprot ID:
P34903
Molecular weight:
55164.1
General function:
Involved in ion transport
Specific function:
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel
Gene Name:
GABRA4
Uniprot ID:
P48169
Molecular weight:
61622.6
General function:
Involved in ion transport
Specific function:
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel
Gene Name:
GABRA5
Uniprot ID:
P31644
Molecular weight:
52145.6
General function:
Involved in ion transport
Specific function:
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel
Gene Name:
GABRA6
Uniprot ID:
Q16445
Molecular weight:
51023.7
General function:
Involved in ion transport
Specific function:
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel
Gene Name:
GABRB1
Uniprot ID:
P18505
Molecular weight:
54234.1
General function:
Involved in ion transport
Specific function:
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel
Gene Name:
GABRB2
Uniprot ID:
P47870
Molecular weight:
59149.9
General function:
Involved in ion transport
Specific function:
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel
Gene Name:
GABRB3
Uniprot ID:
P28472
Molecular weight:
54115.0

Only showing the first 10 proteins. There are 58 proteins in total.