Cannabis Compound Database: Showing Compound Card for gamma-Aminobutyric acid (CDB004802)

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Identification Taxonomy Ontology Physical properties Spectra Protein target Pathways Concentrations Links References enzymes (15)transporters (19) Show 58 proteins XML

Record Information

Version

1.0

Created at

2020-04-17 18:38:16 UTC

Updated at

2020-12-07 19:10:58 UTC

CannabisDB ID

CDB004802

Secondary Accession Numbers

Not Available

Cannabis Compound Identification

Common Name

gamma-Aminobutyric acid

Description

gamma-Aminobutyric acid, also known as GABA or g-amino-butanoate, belongs to the class of organic compounds known as gamma amino acids and derivatives. These are amino acids having a (-NH2) group attached to the gamma carbon atom. gamma-Aminobutyric acid is a very hydrophobic molecule, practically insoluble (in water), and relatively neutral. gamma-Aminobutyric acid exists in all living species, ranging from bacteria to humans. Outside of the human body, gamma-Aminobutyric acid has been detected, but not quantified in, several different foods, such as fox grapes, oxheart cabbages, garden onion (var.), yellow zucchinis, and chinese mustards. This could make gamma-aminobutyric acid a potential biomarker for the consumption of these foods. gamma-Aminobutyric acid is a potentially toxic compound. A gamma-amino acid that is butanoic acid with the amino substituent located at C-4. gamma-Aminobutyric acid is expected to be in Cannabis as all living plants are known to produce and metabolize it.

Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
4-Aminobutanoic acid	ChEBI
4-Aminobutyric acid	ChEBI
4Abu	ChEBI
GABA	ChEBI
GAMMA-AMINO-butanoIC ACID	ChEBI
gamma-Amino-N-butyric acid	ChEBI
gamma-Aminobutanoic acid	ChEBI
gamma-Aminobuttersaeure	ChEBI
Omega-aminobutyric acid	ChEBI
Piperidic acid	ChEBI
Piperidinic acid	ChEBI
4-Aminobutyrate	Kegg
Gammalon	Kegg
4-Aminobutanoate	Generator
g-AMINO-butanoate	Generator
g-AMINO-butanoic acid	Generator
gamma-AMINO-butanoate	Generator
Γ-amino-butanoate	Generator
Γ-amino-butanoic acid	Generator
g-Amino-N-butyrate	Generator
g-Amino-N-butyric acid	Generator
gamma-Amino-N-butyrate	Generator
Γ-amino-N-butyrate	Generator
Γ-amino-N-butyric acid	Generator
g-Aminobutanoate	Generator
g-Aminobutanoic acid	Generator
gamma-Aminobutanoate	Generator
Γ-aminobutanoate	Generator
Γ-aminobutanoic acid	Generator
g-Aminobuttersaeure	Generator
Γ-aminobuttersaeure	Generator
Omega-aminobutyrate	Generator
Piperidate	Generator
Piperidinate	Generator
g-Aminobutyrate	Generator
g-Aminobutyric acid	Generator
gamma-Aminobutyrate	Generator
Γ-aminobutyrate	Generator
Γ-aminobutyric acid	Generator
3-Carboxypropylamine	HMDB
Aminalon	HMDB
Gaballon	HMDB
Gamarex	HMDB
gamma Aminobutyrate	HMDB
gamma Aminobutyric acid	HMDB
Gammalone	HMDB
Gammar	HMDB
Gammasol	HMDB
Mielogen	HMDB
Mielomade	HMDB
W-Aminobutyrate	HMDB
W-Aminobutyric acid	HMDB
gamma-Aminobutyric acid, calcium salt (2:1)	HMDB
gamma-Aminobutyric acid, hydrochloride	HMDB
gamma-Aminobutyric acid, zinc salt (2:1)	HMDB
4 Aminobutanoic acid	HMDB
4 Aminobutyric acid	HMDB
Lithium gaba	HMDB
gamma Aminobutyric acid, monolithium salt	HMDB
gamma Aminobutyric acid, monosodium salt	HMDB
gamma-Aminobutyric acid, monolithium salt	HMDB
gamma-Aminobutyric acid, monosodium salt	HMDB
Acid, hydrochloride gamma-aminobutyric	HMDB
Aminalone	HMDB
GABA, lithium	HMDB
Hydrochloride gamma-aminobutyric acid	HMDB
gamma Aminobutyric acid, hydrochloride	HMDB
4-Amino-butanoate	HMDB
gamma-Aminobutyric acid	KEGG

Chemical Formula

C₄H₉NO₂

Average Molecular Weight

103.12

Monoisotopic Molecular Weight

103.0633

IUPAC Name

4-aminobutanoic acid

Traditional Name

gamma(amino)-butyric acid

CAS Registry Number

56-12-2

SMILES

NCCCC(O)=O

InChI Identifier

InChI=1S/C4H9NO2/c5-3-1-2-4(6)7/h1-3,5H2,(H,6,7)

InChI Key

BTCSSZJGUNDROE-UHFFFAOYSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as gamma amino acids and derivatives. These are amino acids having a (-NH2) group attached to the gamma carbon atom.

Kingdom

Organic compounds

Super Class

Organic acids and derivatives

Class

Carboxylic acids and derivatives

Sub Class

Amino acids, peptides, and analogues

Direct Parent

Gamma amino acids and derivatives

Alternative Parents

Substituents

Gamma amino acid or derivatives
Amino fatty acid
Straight chain fatty acid
Fatty acid
Fatty acyl
Amino acid
Monocarboxylic acid or derivatives
Carboxylic acid
Organic oxide
Organopnictogen compound
Primary amine
Organooxygen compound
Organonitrogen compound
Primary aliphatic amine
Organic oxygen compound
Carbonyl group
Organic nitrogen compound
Amine
Hydrocarbon derivative
Aliphatic acyclic compound

Molecular Framework

Aliphatic acyclic compounds

External Descriptors

monocarboxylic acid (CHEBI:16865 )
gamma-amino acid (CHEBI:16865 )
Amino fatty acids (C00334 )
Other amino acids (C00334 )
Biogenic amines (C00334 )
Amino fatty acids (LMFA01100039 )

Ontology

Physiological effect

Health effect:

Health condition:

Metabolism and nutrition disorders:

2-hydroxyglutaric aciduria

Hepatobiliary disorders:

Hepatic encephalopathy

Infections and infestations:

Meningitis

Disposition

Route of exposure:

Enteral:

Ingestion

Source:

Synthetic:

Personal care product

Biological:

Animal

Indirect biological role:

Biological role:

Molecular messenger:

Industrial application:

Pharmaceutical industry:

Pharmaceutical

Physical Properties

State

Solid

Experimental Properties

Property	Value	Reference
Melting Point	203 °C	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	1300 mg/mL	Not Available
logP	-3.17	HANSCH,C ET AL. (1995)

Predicted Properties

Property	Value	Source
logP	-3	ALOGPS
logP	-2.9	ChemAxon
logS	0.55	ALOGPS
pKa (Strongest Acidic)	4.53	ChemAxon
pKa (Strongest Basic)	10.22	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	3	ChemAxon
Hydrogen Donor Count	2	ChemAxon
Polar Surface Area	63.32 Å²	ChemAxon
Rotatable Bond Count	3	ChemAxon
Refractivity	25.46 m³·mol⁻¹	ChemAxon
Polarizability	10.62 Å³	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

EI-MS/GC-MS

Type	Description	Splash Key	View
EI-MS	Mass Spectrum (Electron Ionization)	splash10-001i-9000000000-dbf4f9e19a35f953a189	2014-09-20	View Spectrum
GC-MS	gamma-Aminobutyric acid, 3 TMS, GC-MS Spectrum	splash10-00dj-1900000000-f831f79dfcaeffa8b177	Spectrum
GC-MS	gamma-Aminobutyric acid, 3 TMS, GC-MS Spectrum	splash10-00di-1900000000-2de9d92a2cfc7bc655f4	Spectrum
GC-MS	gamma-Aminobutyric acid, 3 TMS, GC-MS Spectrum	splash10-00di-1900000000-73bbf2ee0803f058dbed	Spectrum
GC-MS	gamma-Aminobutyric acid, 3 TMS, GC-MS Spectrum	splash10-00di-1901000000-85d4bd98af8534428b5a	Spectrum
GC-MS	gamma-Aminobutyric acid, 3 TMS, GC-MS Spectrum	splash10-00di-0900000000-6be23968e972a414be51	Spectrum
GC-MS	gamma-Aminobutyric acid, non-derivatized, GC-MS Spectrum	splash10-00di-1900000000-9a224763afd8ca892add	Spectrum
GC-MS	gamma-Aminobutyric acid, 3 TMS, GC-MS Spectrum	splash10-00di-9800000000-d8906d09ca1872a6391c	Spectrum
GC-MS	gamma-Aminobutyric acid, 2 TMS, GC-MS Spectrum	splash10-0udi-1900000000-54db7e21790401045519	Spectrum
GC-MS	gamma-Aminobutyric acid, 3 TMS, GC-MS Spectrum	splash10-00di-1901000000-b047af158215c2b5b8e8	Spectrum
GC-MS	gamma-Aminobutyric acid, non-derivatized, GC-MS Spectrum	splash10-001i-9000000000-21ea76dfb0da62031f1d	Spectrum
GC-MS	gamma-Aminobutyric acid, non-derivatized, GC-MS Spectrum	splash10-00di-0901000000-5d60b0a446fd8122f613	Spectrum
GC-MS	gamma-Aminobutyric acid, non-derivatized, GC-MS Spectrum	splash10-00dj-1900000000-f831f79dfcaeffa8b177	Spectrum
GC-MS	gamma-Aminobutyric acid, non-derivatized, GC-MS Spectrum	splash10-00di-1900000000-2de9d92a2cfc7bc655f4	Spectrum
GC-MS	gamma-Aminobutyric acid, non-derivatized, GC-MS Spectrum	splash10-00di-1900000000-73bbf2ee0803f058dbed	Spectrum
GC-MS	gamma-Aminobutyric acid, non-derivatized, GC-MS Spectrum	splash10-00di-1901000000-85d4bd98af8534428b5a	Spectrum
GC-MS	gamma-Aminobutyric acid, non-derivatized, GC-MS Spectrum	splash10-00di-0900000000-6be23968e972a414be51	Spectrum
GC-MS	gamma-Aminobutyric acid, non-derivatized, GC-MS Spectrum	splash10-00di-1900000000-9a224763afd8ca892add	Spectrum
GC-MS	gamma-Aminobutyric acid, non-derivatized, GC-MS Spectrum	splash10-00di-9800000000-d8906d09ca1872a6391c	Spectrum
GC-MS	gamma-Aminobutyric acid, non-derivatized, GC-MS Spectrum	splash10-0udi-1900000000-54db7e21790401045519	Spectrum
GC-MS	gamma-Aminobutyric acid, non-derivatized, GC-MS Spectrum	splash10-00di-1901000000-b047af158215c2b5b8e8	Spectrum
GC-MS	gamma-Aminobutyric acid, non-derivatized, GC-MS Spectrum	splash10-00dj-1900000000-1219470a0be188da64e6	Spectrum
GC-MS	gamma-Aminobutyric acid, non-derivatized, GC-MS Spectrum	splash10-0udi-0900000000-f7117dfaf9d856c95919	Spectrum
GC-MS	gamma-Aminobutyric acid, non-derivatized, GC-MS Spectrum	splash10-0006-1900000000-e35585a985d8128d044e	Spectrum
Predicted GC-MS	gamma-Aminobutyric acid, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	splash10-001i-9000000000-d5f55a414ff1e8c65d9d	Spectrum
Predicted GC-MS	gamma-Aminobutyric acid, 1 TMS, Predicted GC-MS Spectrum - 70eV, Positive	splash10-0fk9-9700000000-4b2809309587240dd479	Spectrum

MS/MS

Type	Description	Splash Key	View
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)	splash10-0uxr-8900000000-ce0d8f44422836cd9965	2012-07-24	View Spectrum
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)	splash10-0005-9000000000-8ce5afb97d7c08821da3	2012-07-24	View Spectrum
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)	splash10-0005-9100000000-32c433b2c916697690f8	2012-07-24	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-0udi-0900000000-5831aaabdf53f3132ae5	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-0a4i-9000000000-9babfd4a6937ecba7318	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-0a4i-9000000000-e1c0c1485d846e9b123b	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-0udi-0900000000-647d55ecf98850e7a875	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-0udi-0900000000-7c107641a38922c88fca	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-000i-9000000000-86718b349efad6334e3a	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-000i-9000000000-a1e84e55e4b6c6628d5d	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-0006-0009000000-29c22bf0ed844d09c0af	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Negative	splash10-0udi-0900000000-1d00adad47e42c60c340	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, Negative	splash10-0udi-1900000000-47b195fb74720cc99464	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, Negative	splash10-001i-9000000000-a14a52dc59bf9988bb44	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Positive	splash10-0udi-5900000000-20c55b2809389d5ad83b	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, Positive	splash10-000i-9000000000-eca4c5aefca98751a11e	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, Positive	splash10-014j-9000000000-f0783316e09291749409	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 40V, Positive	splash10-0005-9000000000-81837eb9c0b926cb0e81	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 50V, Positive	splash10-0005-9000000000-8b48126992d7fa242636	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Positive	splash10-000i-9000000000-7d4636efbc4e5d75872e	2012-08-31	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-000i-9100000000-655f9d93a35bfa537583	2015-05-27	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-00ku-9000000000-4a334d5e272576f62403	2015-05-27	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-0006-9000000000-4a13b03446b3370ccd43	2015-05-27	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-000i-9100000000-655f9d93a35bfa537583	2015-05-27	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-00ku-9000000000-4a334d5e272576f62403	2015-05-27	View Spectrum

NMR

Type	Description	View
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, experimental)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 125 MHz, H₂O, experimental)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 90 MHz, D₂O, experimental)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 25.16 MHz, D₂O, experimental)	Spectrum
1D NMR	¹H NMR Spectrum (1D, D₂O, experimental)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Spectrum
2D NMR	[¹H, ¹³C]-HSQC NMR Spectrum (2D, 600 MHz, H₂O, experimental)	Spectrum

Pathways

Name	SMPDB/Pathwhiz	KEGG
Glutamate Metabolism
4-Hydroxybutyric Aciduria/Succinic Semialdehyde Dehydrogenase Deficiency		Not Available
Homocarnosinosis		Not Available
Hyperinsulinism-Hyperammonemia Syndrome		Not Available
2-Hydroxyglutric Aciduria (D And L Form)		Not Available

Protein Targets

Enzymes

Protein Name	Gene Name	Locus	Uniprot ID	Details
4-aminobutyrate aminotransferase, mitochondrial	ABAT	16p13.2	P80404	details
4-trimethylaminobutyraldehyde dehydrogenase	ALDH9A1	1q23.1	P49189	details
Alpha-aminoadipic semialdehyde dehydrogenase	ALDH7A1	5q31	P49419	details
Aldehyde dehydrogenase family 1 member A3	ALDH1A3	15q26.3	P47895	details
Aldehyde dehydrogenase, mitochondrial	ALDH2	12q24.2	P05091	details
Fatty aldehyde dehydrogenase	ALDH3A2	17p11.2	P51648	details
Aldehyde dehydrogenase X, mitochondrial	ALDH1B1	9p11.1	P30837	details
Glycine amidinotransferase, mitochondrial	GATM	15q21.1	P50440	details
Glutamine synthetase	GLUL	1q31	P15104	details
Glutamate decarboxylase 2	GAD2	10p11.23	Q05329	details
Glutamate decarboxylase 1	GAD1	2q31	Q99259	details
Arginine decarboxylase	ADC	1p35.1	Q96A70	details
Probable glutamate--tRNA ligase, mitochondrial	EARS2	16p12.2	Q5JPH6	details
Carnosine synthase 1	CARNS1	11q13.2	A5YM72	details
Gamma-aminobutyric acid receptor-associated protein-like 2	GABARAPL2	16q22.1	P60520	details

Transporters

Protein Name	Gene Name	Locus	Uniprot ID	Details
Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	5q34	P18507	details
Gamma-aminobutyric acid receptor subunit alpha-1	GABRA1	5q34-q35	P14867	details
Gamma-aminobutyric acid receptor subunit alpha-2	GABRA2	4p12	P47869	details
Gamma-aminobutyric acid receptor subunit alpha-3	GABRA3		P34903	details
Gamma-aminobutyric acid receptor subunit alpha-4	GABRA4	4p12	P48169	details
Gamma-aminobutyric acid receptor subunit alpha-5	GABRA5	15q11.2-q12	P31644	details
Gamma-aminobutyric acid receptor subunit alpha-6	GABRA6	5q34	Q16445	details
Gamma-aminobutyric acid receptor subunit beta-1	GABRB1	4p12	P18505	details
Gamma-aminobutyric acid receptor subunit beta-2	GABRB2	5q34	P47870	details
Gamma-aminobutyric acid receptor subunit beta-3	GABRB3	15q11.2-q12	P28472	details
Gamma-aminobutyric acid receptor subunit delta	GABRD	1p\|1p36.3	O14764	details
Gamma-aminobutyric acid receptor subunit epsilon	GABRE		P78334	details
Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	4p12	Q8N1C3	details
Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	15q12	Q99928	details
Gamma-aminobutyric acid receptor subunit pi	GABRP	5q33-q34	O00591	details
Gamma-aminobutyric acid receptor subunit rho-1	GABRR1	6q14-q21\|6q13-q16.3	P24046	details
Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	6q14-q21\|6q13-q16.3	P28476	details
Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	3q11.2	A8MPY1	details
Gamma-aminobutyric acid receptor subunit theta	GABRQ		Q9UN88	details

Metal Bindings

Protein Name	Gene Name	Locus	Uniprot ID	Details
Carnosine synthase 1	CARNS1	11q13.2	A5YM72	details

Receptors

Protein Name	Gene Name	Locus	Uniprot ID	Details
Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	5q34	P18507	details
Gamma-aminobutyric acid type B receptor subunit 1	GABBR1	6p21.31	Q9UBS5	details
Gamma-aminobutyric acid type B receptor subunit 2	GABBR2	9q22.1-q22.3	O75899	details
Gamma-aminobutyric acid receptor subunit alpha-1	GABRA1	5q34-q35	P14867	details
Gamma-aminobutyric acid receptor subunit alpha-2	GABRA2	4p12	P47869	details
Gamma-aminobutyric acid receptor subunit alpha-3	GABRA3		P34903	details
Gamma-aminobutyric acid receptor subunit alpha-4	GABRA4	4p12	P48169	details
Gamma-aminobutyric acid receptor subunit alpha-5	GABRA5	15q11.2-q12	P31644	details
Gamma-aminobutyric acid receptor subunit alpha-6	GABRA6	5q34	Q16445	details
Gamma-aminobutyric acid receptor subunit beta-1	GABRB1	4p12	P18505	details
Gamma-aminobutyric acid receptor subunit beta-2	GABRB2	5q34	P47870	details
Gamma-aminobutyric acid receptor subunit beta-3	GABRB3	15q11.2-q12	P28472	details
Gamma-aminobutyric acid receptor subunit delta	GABRD	1p\|1p36.3	O14764	details
Gamma-aminobutyric acid receptor subunit epsilon	GABRE		P78334	details
Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	4p12	Q8N1C3	details
Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	15q12	Q99928	details
Gamma-aminobutyric acid receptor subunit pi	GABRP	5q33-q34	O00591	details
Gamma-aminobutyric acid receptor subunit rho-1	GABRR1	6q14-q21\|6q13-q16.3	P24046	details
Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	6q14-q21\|6q13-q16.3	P28476	details
Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	3q11.2	A8MPY1	details
Gamma-aminobutyric acid receptor subunit theta	GABRQ		Q9UN88	details
Gamma-aminobutyric acid receptor-associated protein	GABARAP	17p13.1	O95166	details
Gamma-aminobutyric acid receptor-associated protein-like 1	GABARAPL1	12p13.2	Q9H0R8	details

Transcriptional Factors

Not Available

Concentrations Data

Not Available

External Links

HMDB ID

HMDB0000112

DrugBank ID

DB02530

Phenol Explorer Compound ID

Not Available

FoodDB ID

KNApSAcK ID

Chemspider ID

KEGG Compound ID

BioCyc ID

BiGG ID

Wikipedia Link

Gamma-Aminobutyric_acid

METLIN ID

Not Available

PubChem Compound

119

PDB ID

Not Available

ChEBI ID

16865

References

General References

Not Available

Only showing the first 10 proteins. There are 58 proteins in total.

Show All

Enzymes

Enzyme Details

1. 4-aminobutyrate aminotransferase, mitochondrial

General function:: Involved in 4-aminobutyrate transaminase activity
Specific function:: Catalyzes the conversion of gamma-aminobutyrate and L-beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine.
Gene Name:: ABAT
Uniprot ID:: P80404
Molecular weight:: 56438.405

Enzyme Details

2. 4-trimethylaminobutyraldehyde dehydrogenase

General function:: Involved in oxidoreductase activity
Specific function:: Converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine. Catalyzes the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction.
Gene Name:: ALDH9A1
Uniprot ID:: P49189
Molecular weight:: 56291.485

Enzyme Details

3. Alpha-aminoadipic semialdehyde dehydrogenase

General function:: Involved in oxidoreductase activity
Specific function:: Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism.
Gene Name:: ALDH7A1
Uniprot ID:: P49419
Molecular weight:: 58486.74

Enzyme Details

4. Aldehyde dehydrogenase family 1 member A3

General function:: Involved in oxidoreductase activity
Specific function:: Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system (By similarity).
Gene Name:: ALDH1A3
Uniprot ID:: P47895
Molecular weight:: 56107.995

Enzyme Details

5. Aldehyde dehydrogenase, mitochondrial

General function:: Involved in oxidoreductase activity
Specific function:: Not Available
Gene Name:: ALDH2
Uniprot ID:: P05091
Molecular weight:: 56380.93

Enzyme Details

6. Fatty aldehyde dehydrogenase

General function:: Involved in oxidoreductase activity
Specific function:: Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid.
Gene Name:: ALDH3A2
Uniprot ID:: P51648
Molecular weight:: 54847.36

Enzyme Details

7. Aldehyde dehydrogenase X, mitochondrial

General function:: Involved in oxidoreductase activity
Specific function:: ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation.
Gene Name:: ALDH1B1
Uniprot ID:: P30837
Molecular weight:: 57248.96

Enzyme Details

8. Glycine amidinotransferase, mitochondrial

General function:: Amino acid transport and metabolism
Specific function:: Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine. Creatine plays a vital role in energy metabolism in muscle tissues. May play a role in embryonic and central nervous system development. May be involved in the response to heart failure by elevating local creatine synthesis.
Gene Name:: GATM
Uniprot ID:: P50440
Molecular weight:: 48455.01

Enzyme Details

9. Glutamine synthetase

General function:: Involved in glutamate-ammonia ligase activity
Specific function:: This enzyme has 2 functions: it catalyzes the production of glutamine and 4-aminobutanoate (gamma-aminobutyric acid, GABA), the latter in a pyridoxal phosphate-independent manner (By similarity). Essential for proliferation of fetal skin fibroblasts.
Gene Name:: GLUL
Uniprot ID:: P15104
Molecular weight:: 42064.15

Enzyme Details

10. Glutamate decarboxylase 2

General function:: Involved in carboxy-lyase activity
Specific function:: Catalyzes the production of GABA.
Gene Name:: GAD2
Uniprot ID:: Q05329
Molecular weight:: 65410.77

Transporters

Enzyme Details

1. Gamma-aminobutyric acid receptor subunit gamma-2

General function:: Involved in ion transport
Specific function:: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel
Gene Name:: GABRG2
Uniprot ID:: P18507
Molecular weight:: 54161.8

Enzyme Details

2. Gamma-aminobutyric acid receptor subunit alpha-1

General function:: Involved in ion transport
Specific function:: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel
Gene Name:: GABRA1
Uniprot ID:: P14867
Molecular weight:: 51801.4

Enzyme Details

3. Gamma-aminobutyric acid receptor subunit alpha-2

General function:: Involved in ion transport
Specific function:: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel
Gene Name:: GABRA2
Uniprot ID:: P47869
Molecular weight:: 51325.9

Enzyme Details

4. Gamma-aminobutyric acid receptor subunit alpha-3

General function:: Involved in ion transport
Specific function:: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel
Gene Name:: GABRA3
Uniprot ID:: P34903
Molecular weight:: 55164.1

Enzyme Details

5. Gamma-aminobutyric acid receptor subunit alpha-4

General function:: Involved in ion transport
Specific function:: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel
Gene Name:: GABRA4
Uniprot ID:: P48169
Molecular weight:: 61622.6

Enzyme Details

6. Gamma-aminobutyric acid receptor subunit alpha-5

General function:: Involved in ion transport
Specific function:: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel
Gene Name:: GABRA5
Uniprot ID:: P31644
Molecular weight:: 52145.6

Enzyme Details

7. Gamma-aminobutyric acid receptor subunit alpha-6

General function:: Involved in ion transport
Specific function:: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel
Gene Name:: GABRA6
Uniprot ID:: Q16445
Molecular weight:: 51023.7

Enzyme Details

8. Gamma-aminobutyric acid receptor subunit beta-1

General function:: Involved in ion transport
Specific function:: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel
Gene Name:: GABRB1
Uniprot ID:: P18505
Molecular weight:: 54234.1

Enzyme Details

9. Gamma-aminobutyric acid receptor subunit beta-2

General function:: Involved in ion transport
Specific function:: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel
Gene Name:: GABRB2
Uniprot ID:: P47870
Molecular weight:: 59149.9

Enzyme Details

10. Gamma-aminobutyric acid receptor subunit beta-3

General function:: Involved in ion transport
Specific function:: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel
Gene Name:: GABRB3
Uniprot ID:: P28472
Molecular weight:: 54115.0

Only showing the first 10 proteins. There are 58 proteins in total.

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Showing Compound Card for gamma-Aminobutyric acid (CDB004802)

Structure for CDB004802 (gamma-Aminobutyric acid)

Enzymes

Transporters