Cannabis Compound Database: Showing Compound Card for Citrulline (CDB004869)

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Identification Taxonomy Ontology Physical properties Spectra Protein target Pathways Concentrations Links References enzymes (13)transporters (1) Show 27 proteins XML

Record Information

Version

1.0

Created at

2020-04-17 18:45:11 UTC

Updated at

2022-12-13 23:36:25 UTC

CannabisDB ID

CDB004869

Secondary Accession Numbers

Not Available

Cannabis Compound Identification

Common Name

Citrulline

Description

Citrulline, also known as Cit or δ-ureidonorvaline, belongs to the class of organic compounds known as l-alpha-amino acids. These are alpha amino acids which have the L-configuration of the alpha-carbon atom. Citrulline is a drug which is used for nutritional supplementation, also for treating dietary shortage or imbalance. Citrulline is a very strong basic compound (based on its pKa). Citrulline exists in all living species, ranging from bacteria to humans. Within humans, citrulline participates in a number of enzymatic reactions. In particular, citrulline can be biosynthesized from carbamoyl phosphate and ornithine; which is catalyzed by the enzyme ornithine carbamoyltransferase, mitochondrial. In addition, citrulline and L-aspartic acid can be converted into argininosuccinic acid through the action of the enzyme argininosuccinate synthase. In humans, citrulline is involved in the metabolic disorder called argininemia. Outside of the human body, Citrulline is found, on average, in the highest concentration within a few different foods, such as wheats, oats, and cucumbers and in a lower concentration in garden onions, saskatoon berries, and swiss chards. Citrulline has also been detected, but not quantified in, several different foods, such as sweet bay, white mustards, fennels, hyacinth beans, and limes. This could make citrulline a potential biomarker for the consumption of these foods. The L-enantiomer of citrulline. Citrulline is a potentially toxic compound. Citrulline, with regard to humans, has been found to be associated with several diseases such as frontotemporal dementia, tooth decay, phosphoenolpyruvate carboxykinase deficiency 1, cytosolic, and pancreatic cancer; citrulline has also been linked to the inborn metabolic disorder argininosuccinic aciduria. Citrulline is expected to be in Cannabis as all living plants are known to produce and metabolize it.

Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
(S)-2-Amino-5-ureidopentanoic acid	ChEBI
2-Amino-5-ureidovaleric acid	ChEBI
alpha-Amino-delta-ureidovaleric acid	ChEBI
Cit	ChEBI
delta-Ureidonorvaline	ChEBI
L-2-Amino-5-ureidovaleric acid	ChEBI
N(5)-(Aminocarbonyl)-L-ornithine	ChEBI
N5-(Aminocarbonyl)ornithine	ChEBI
N5-Carbamoylornithine	ChEBI
N(delta)-Carbamylornithine	ChEBI
(S)-2-Amino-5-ureidopentanoate	Generator
2-Amino-5-ureidovalerate	Generator
a-Amino-delta-ureidovalerate	Generator
a-Amino-delta-ureidovaleric acid	Generator
alpha-Amino-delta-ureidovalerate	Generator
Α-amino-δ-ureidovalerate	Generator
Α-amino-δ-ureidovaleric acid	Generator
Δ-ureidonorvaline	Generator
L-2-Amino-5-ureidovalerate	Generator
N(Δ)-carbamylornithine	Generator
a-Amino-δ-ureidovalerate	HMDB
a-Amino-δ-ureidovaleric acid	HMDB
(2S)-2-Amino-5-(carbamoylamino)pentanoate	HMDB
(2S)-2-Amino-5-(carbamoylamino)pentanoic acid	HMDB
(S)-2-Amino-5-(aminocarbonyl)aminopentanoate	HMDB
(S)-2-Amino-5-(aminocarbonyl)aminopentanoic acid	HMDB
2-Amino-5-uredovalerate	HMDB
2-Amino-5-uredovaleric acid	HMDB
a-Amino-D-ureidovalerate	HMDB
a-Amino-D-ureidovaleric acid	HMDB
alpha-Amino-gamma-ureidovalerate	HMDB
alpha-Amino-gamma-ureidovaleric acid	HMDB
Amino-ureidovalerate	HMDB
Amino-ureidovaleric acid	HMDB
CIR	HMDB
Cytrulline	HMDB
D-Ureidonorvaline	HMDB
DL-Citrulline	HMDB
Gammaureidonorvaline	HMDB
H-Cit-OH	HMDB
L(+)-2-Amino-5-ureidovalerate	HMDB
L(+)-2-Amino-5-ureidovaleric acid	HMDB
L(+)-Citrulline	HMDB
L-2-Amino-5-ureido-valerate	HMDB
L-2-Amino-5-ureido-valeric acid	HMDB
L-Citrulline	HMDB
L-Cytrulline	HMDB
L-N5-Carbamoyl-ornithine	HMDB
N()-Carbamylornithine	HMDB
N(5)-(Aminocarbonyl)-DL-ornithine	HMDB
N-Carbamylornithine	HMDB
N5-(Aminocarbonyl)-L-ornithine	HMDB
N5-(Aminocarbonyl)-ornithine	HMDB
N5-Carbamoyl-L-ornithine	HMDB
N5-Carbamylornithine	HMDB
ND-Carbamylornithine	HMDB
Ndelta-carbamy-ornithine	HMDB
Ndelta-carbamylornithine	HMDB
Ngamma-carbamylornithine	HMDB
Sitrulline	HMDB
Ureidonorvaline	HMDB
Ureidovalerate	HMDB
Ureidovaleric acid	HMDB

Chemical Formula

C₆H₁₃N₃O₃

Average Molecular Weight

175.19

Monoisotopic Molecular Weight

175.0957

IUPAC Name

(2S)-2-amino-5-(carbamoylamino)pentanoic acid

Traditional Name

L-citrulline

CAS Registry Number

372-75-8

SMILES

N[C@@H](CCCNC(N)=O)C(O)=O

InChI Identifier

InChI=1S/C6H13N3O3/c7-4(5(10)11)2-1-3-9-6(8)12/h4H,1-3,7H2,(H,10,11)(H3,8,9,12)/t4-/m0/s1

InChI Key

RHGKLRLOHDJJDR-BYPYZUCNSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as l-alpha-amino acids. These are alpha amino acids which have the L-configuration of the alpha-carbon atom.

Kingdom

Organic compounds

Super Class

Organic acids and derivatives

Class

Carboxylic acids and derivatives

Sub Class

Amino acids, peptides, and analogues

Direct Parent

L-alpha-amino acids

Alternative Parents

Substituents

L-alpha-amino acid
Fatty acid
Isourea
Amino acid
Carboximidic acid derivative
Carboxylic acid
Monocarboxylic acid or derivatives
Carboximidamide
Amine
Hydrocarbon derivative
Primary amine
Organooxygen compound
Organonitrogen compound
Organic oxide
Primary aliphatic amine
Organopnictogen compound
Imine
Organic oxygen compound
Organic nitrogen compound
Carbonyl group
Aliphatic acyclic compound

Molecular Framework

Aliphatic acyclic compounds

External Descriptors

citrulline (CHEBI:16349 )
Other amino acids (C00327 )

Ontology

Ingestion

Source:

Biological:

Animal

Industrial application:

Protective agent

Food and nutrition:

Nutritional supplement

Pharmaceutical industry:

Pharmaceutical

Physical Properties

State

Solid

Experimental Properties

Property	Value	Reference
Melting Point	235.5 °C	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	212 mg/mL	Not Available
logP	-3.19	SANGSTER (1994)

Predicted Properties

Property	Value	Source
logP	-3.3	ALOGPS
logP	-3.9	ChemAxon
logS	-0.9	ALOGPS
pKa (Strongest Acidic)	2.27	ChemAxon
pKa (Strongest Basic)	9.23	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	4	ChemAxon
Hydrogen Donor Count	4	ChemAxon
Polar Surface Area	118.44 Å²	ChemAxon
Rotatable Bond Count	5	ChemAxon
Refractivity	41.33 m³·mol⁻¹	ChemAxon
Polarizability	17.35 Å³	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

EI-MS/GC-MS

Type	Description	Splash Key	View
GC-MS	Citrulline, non-derivatized, GC-MS Spectrum	splash10-0a4i-0920000000-2d92b63cd5d9648023b8	Spectrum
GC-MS	Citrulline, 3 TMS, GC-MS Spectrum	splash10-00di-9610000000-2e7cd23afc2adcef35a3	Spectrum
GC-MS	Citrulline, non-derivatized, GC-MS Spectrum	splash10-0a4i-0920000000-2d92b63cd5d9648023b8	Spectrum
GC-MS	Citrulline, non-derivatized, GC-MS Spectrum	splash10-00di-9610000000-2e7cd23afc2adcef35a3	Spectrum
Predicted GC-MS	Citrulline, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	splash10-007o-9100000000-1f8dd2c6648b104639c7	Spectrum
Predicted GC-MS	Citrulline, 1 TMS, Predicted GC-MS Spectrum - 70eV, Positive	splash10-00dl-9410000000-37909012a777213f8566	Spectrum
Predicted GC-MS	Citrulline, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Citrulline, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Citrulline, TMS_1_2, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Citrulline, TMS_1_3, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Citrulline, TMS_1_4, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Citrulline, TBDMS_1_1, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Citrulline, TBDMS_1_2, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Citrulline, TBDMS_1_3, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Citrulline, TBDMS_1_4, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum

MS/MS

Type	Description	Splash Key	View
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)	splash10-0a4i-0900000000-4c1d7af748a47e489949	2012-07-24	View Spectrum
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)	splash10-00di-9000000000-988fced362fc0da157c9	2012-07-24	View Spectrum
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)	splash10-00di-9000000000-0818e0e8bcee12692498	2012-07-24	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-004j-0900000000-5fa8a338dcd2f2a6bdd2	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-004i-0900000000-16763200aa07f7629ad4	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-03di-3900000000-d9cfc5187aa799f6f978	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-0a4i-0900000000-10ee9a593e13550bec1c	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-004i-0900000000-45d272576af34c9512a3	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-014i-3900000000-6177a284fdea5a3f1306	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-0a4i-0900000000-d9456d45e2dbd7a3df10	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-004i-0900000000-ada57cdc73bda93be483	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-008a-0904000000-23fbe48f82e515087d68	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-03di-5900000000-78afcbaf8b8b3eabf174	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-001i-0900000000-8fb191d4c20fd54b9282	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Negative	splash10-00di-0900000000-da484f0362a8dca5127e	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Negative	splash10-00e9-0900000000-46229b4f77feabb3f857	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, Negative	splash10-001i-0900000000-4aca1022c393602a297d	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, Negative	splash10-001i-0900000000-3bc2eff2e907b7734cc8	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 40V, Negative	splash10-001i-3900000000-2613bf40e3be814da86f	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 50V, Negative	splash10-0006-9300000000-e83287bbc060eb9cf6f3	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Positive	splash10-056r-0900000000-694a8872bdfd7eec1f2b	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, Positive	splash10-08fr-2900000000-15b4711991ea9985fb2b	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, Positive	splash10-00di-9300000000-915fbb73e0b728420e4a	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 40V, Positive	splash10-00di-9000000000-67e60567f5c062728350	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 50V, Positive	splash10-00di-9000000000-25140713431edd7c5eea	2012-08-31	View Spectrum

NMR

Type	Description	View
1D NMR	¹³C NMR Spectrum (1D, 125 MHz, H₂O, experimental)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, experimental)	Spectrum
1D NMR	¹H NMR Spectrum (1D, D₂O, experimental)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 400 MHz, H₂O, experimental)	Spectrum
2D NMR	[¹H, ¹H]-TOCSY. Unexported temporarily by An Chi on Oct 15, 2021 until json or nmrML file is generated. 2D NMR Spectrum (experimental)	Spectrum
2D NMR	[¹H, ¹³C]-HSQC NMR Spectrum (2D, 600 MHz, H₂O, experimental)	Spectrum

Pathways

Name	SMPDB/Pathwhiz	KEGG
Arginine and Proline Metabolism
Aspartate Metabolism
Urea Cycle
Canavan Disease		Not Available
Hypoacetylaspartia		Not Available

Protein Targets

Enzymes

Protein Name	Gene Name	Locus	Uniprot ID	Details
Argininosuccinate synthase	ASS1	9q34.1	P00966	details
Protein-arginine deiminase type-6	PADI6	1p36.13	Q6TGC4	details
Protein-arginine deiminase type-4	PADI4	1p36.13	Q9UM07	details
Protein-arginine deiminase type-3	PADI3	1p36.13	Q9ULW8	details
Protein-arginine deiminase type-2	PADI2	1p36.13	Q9Y2J8	details
Protein-arginine deiminase type-1	PADI1	1p36.13	Q9ULC6	details
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	DDAH1	1p22	O94760	details
N(G),N(G)-dimethylarginine dimethylaminohydrolase 2	DDAH2	6p21.3	O95865	details
Nitric oxide synthase, inducible	NOS2	17q11.2-q12	P35228	details
Ornithine carbamoyltransferase, mitochondrial	OTC	Xp21.1	P00480	details
Nitric oxide synthase, brain	NOS1	12q24.2-q24.31	P29475	details
Nitric oxide synthase, endothelial	NOS3	7q36	P29474	details
NOS1 mutant	NOS1	12q24.2-q24.31	B3VK56	details

Transporters

Protein Name	Gene Name	Locus	Uniprot ID	Details
Nitric oxide synthase, inducible	NOS2	17q11.2-q12	P35228	details

Metal Bindings

Protein Name	Gene Name	Locus	Uniprot ID	Details
Protein-arginine deiminase type-6	PADI6	1p36.13	Q6TGC4	details
Protein-arginine deiminase type-4	PADI4	1p36.13	Q9UM07	details
Protein-arginine deiminase type-3	PADI3	1p36.13	Q9ULW8	details
Protein-arginine deiminase type-2	PADI2	1p36.13	Q9Y2J8	details
Protein-arginine deiminase type-1	PADI1	1p36.13	Q9ULC6	details
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1	DDAH1	1p22	O94760	details
Nitric oxide synthase, inducible	NOS2	17q11.2-q12	P35228	details
Nitric oxide synthase, brain	NOS1	12q24.2-q24.31	P29475	details
Nitric oxide synthase, endothelial	NOS3	7q36	P29474	details
NOS1 mutant	NOS1	12q24.2-q24.31	B3VK56	details

Receptors

Protein Name	Gene Name	Locus	Uniprot ID	Details
Nitric oxide synthase, brain	NOS1	12q24.2-q24.31	P29475	details

Transcriptional Factors

Protein Name	Gene Name	Locus	Uniprot ID	Details
Protein-arginine deiminase type-4	PADI4	1p36.13	Q9UM07	details
Nitric oxide synthase, brain	NOS1	12q24.2-q24.31	P29475	details

Concentrations Data

Cannabis Cultivar	Status	Value	Reference	Details
Alien Dawg	Detected and Quantified	0.0731 mg/g dry wt	David S. Wishart,...	details
Gabriola	Detected and Quantified	0.0657 mg/g dry wt	David S. Wishart,...	details
Island Honey	Detected and Quantified	0.0557 mg/g dry wt	David S. Wishart,...	details
Quadra	Detected and Quantified	0.0297 mg/g dry wt	David S. Wishart,...	details
Sensi Star	Detected and Quantified	0.0237 mg/g dry wt	David S. Wishart,...	details
Tangerine Dream	Detected and Quantified	0.0583 mg/g dry wt	David S. Wishart,...	details

External Links

HMDB ID

HMDB0000904

DrugBank ID

DB00155

Phenol Explorer Compound ID

Not Available

FoodDB ID

KNApSAcK ID

Chemspider ID

KEGG Compound ID

BioCyc ID

BiGG ID

Wikipedia Link

METLIN ID

PubChem Compound

9750

PDB ID

Not Available

ChEBI ID

16349

References

General References

Not Available

Only showing the first 10 proteins. There are 27 proteins in total.

Show All

Enzymes

Enzyme Details

1. Argininosuccinate synthase

General function:: Involved in argininosuccinate synthase activity
Specific function:: Not Available
Gene Name:: ASS1
Uniprot ID:: P00966
Molecular weight:: 46530.055

Enzyme Details

2. Protein-arginine deiminase type-6

General function:: Involved in protein-arginine deiminase activity
Specific function:: Catalyzes the deimination of arginine residues of proteins. May be involved in cytoskeletal reorganization in the egg and early embryo (By similarity).
Gene Name:: PADI6
Uniprot ID:: Q6TGC4
Molecular weight:: 77726.735

Enzyme Details

3. Protein-arginine deiminase type-4

General function:: Involved in protein-arginine deiminase activity
Specific function:: Catalyzes the citrullination/deimination of arginine residues of proteins. Citrullinates histone H3 at 'Arg-8' and/or 'Arg-17' and histone H4 at 'Arg-3', which prevents their methylation by CARM1 and HRMT1L2/PRMT1 and represses transcription. Citrullinates EP300/P300 at 'Arg-2142', which favors its interaction with NCOA2/GRIP1.
Gene Name:: PADI4
Uniprot ID:: Q9UM07
Molecular weight:: 74078.65

Enzyme Details

4. Protein-arginine deiminase type-3

General function:: Involved in protein-arginine deiminase activity
Specific function:: Catalyzes the deimination of arginine residues of proteins.
Gene Name:: PADI3
Uniprot ID:: Q9ULW8
Molecular weight:: 74742.705

Enzyme Details

5. Protein-arginine deiminase type-2

General function:: Involved in protein-arginine deiminase activity
Specific function:: Catalyzes the deimination of arginine residues of proteins (By similarity).
Gene Name:: PADI2
Uniprot ID:: Q9Y2J8
Molecular weight:: 75563.35

Enzyme Details

6. Protein-arginine deiminase type-1

General function:: Involved in protein-arginine deiminase activity
Specific function:: Catalyzes the deimination of arginine residues of proteins (By similarity).
Gene Name:: PADI1
Uniprot ID:: Q9ULC6
Molecular weight:: 74664.97

Enzyme Details

7. N(G),N(G)-dimethylarginine dimethylaminohydrolase 1

General function:: Involved in hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
Specific function:: Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation.
Gene Name:: DDAH1
Uniprot ID:: O94760
Molecular weight:: 20189.135

Enzyme Details

8. N(G),N(G)-dimethylarginine dimethylaminohydrolase 2

General function:: Involved in hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
Specific function:: Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation.
Gene Name:: DDAH2
Uniprot ID:: O95865
Molecular weight:: 29643.54

Enzyme Details

9. Nitric oxide synthase, inducible

General function:: Involved in oxidoreductase activity
Specific function:: Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.
Gene Name:: NOS2
Uniprot ID:: P35228
Molecular weight:: 131116.3

Enzyme Details

10. Ornithine carbamoyltransferase, mitochondrial

General function:: Involved in carboxyl- or carbamoyltransferase activity
Specific function:: Not Available
Gene Name:: OTC
Uniprot ID:: P00480
Molecular weight:: 39934.775

Transporters

Enzyme Details

1. Nitric oxide synthase, inducible

General function:: Involved in oxidoreductase activity
Specific function:: Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.
Gene Name:: NOS2
Uniprot ID:: P35228
Molecular weight:: 131116.3

Only showing the first 10 proteins. There are 27 proteins in total.

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Showing Compound Card for Citrulline (CDB004869)

Structure for CDB004869 (Citrulline)

Enzymes

Transporters