Cannabis Compound Database: Showing Compound Card for Cannabidiol (CDB000002)

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Record Information

Version

1.0

Created at

2020-03-19 00:35:16 UTC

Updated at

2022-12-13 20:57:25 UTC

CannabisDB ID

CDB000002

Secondary Accession Numbers

Not Available

Cannabis Compound Identification

Common Name

Cannabidiol

Description

Cannabidiol (CBD) is one of at least 85 active cannabinoids identified within the Cannabis plant. It is a major phytocannabinoid, accounting for up to 40% of the Cannabis plant's extract, that binds to a wide variety of physiological targets of the endocannabinoid system within the body. Although the exact medical implications are currently being investigated, CBD has shown promise as a therapeutic and pharmaceutical drug target as an analgesic, anticonvulsant, muscle relaxant, anxiolytic, antipsychotic and has shown neuroprotective, anti-inflammatory, and antioxidant activity, among other currently investigated uses (PMID: 26218440 ; PMID: 17828291 ). CBD's exact place within medical practice is still currently hotly debated. However as the body of evidence grows and legislation changes to reflect its wide-spread use, public and medical opinion have changed significantly with regards to its usefulness in a number of medical conditions ranging from anxiety to epilepsy. From a pharmacological perspective, Cannabis' (and CBD's) diverse receptor profile explains its potential application for such a wide variety of medical conditions. Cannabis contains more than 400 different chemical compounds, of which 61 are considered cannabinoids (PMID: 23408483 ). Cannabinoid receptors are utilized endogenously by the body through the endocannabinoid system, which includes a group of lipid proteins, enzymes, and receptors that are involved in many physiological processes. Through its modulation of neurotransmitter release, the endocannabinoid system regulates cognition, pain sensation, appetite, memory, sleep, immune function, and mood among many other bodily systems. These effects are largely mediated through two members of the G-protein coupled receptors family, cannabinoid receptors 1 and 2 (CB1 and CB2) (PMID: 26015168 ; PMID: 29533978 ). CB1 receptors are found in both the central and peripheral nervous systems, with most receptors localized to the hippocampus and amygdala of the brain. Physiological effects of using cannabis make sense in the context of its receptor activity as the hippocampus and amygdala are primarily involved with regulation of memory, fear, and emotion. In contrast, CB2 receptors are mainly found peripherally in immune cells, lymphoid tissue, and peripheral nerve terminals (PMID: 27086601 ). Tetrahydrocannabinol (THC) and cannabidiol (CBD) are two types of cannabinoids found naturally in the resin of the marijuana plant, both of which interact with the cannabinoid receptors that are found throughout the body. Although THC and CBD have been the most studied cannabinoids, there are many others identified to date including cannabinol (CBN), cannabigerol (CBG), Cannabidivarin (CBDV), and Tetrahydrocannabivarin (THCV) that can be found within the medical cannabis (PMID: 16199061 ). While both CBD and THC are used for medicinal purposes, they have different receptor activity, function, and physiological effects. If not provided in their activated form (such as through synthetic forms of THC like Dronabinol or Nabilone), THC and CBD are obtained through conversion from their precursors, tetrahydrocannabinolic acid-A (THCA-A) and cannabidiolic acid (CBDA), through decarboxylation reactions. This can be achieved through heating, smoking, vaporization, or baking of dried unfertilized female cannabis flowers. The primary psychoactive component of Cannabis, delta 9-tetrahydrocannabinol (Œî9-THC), demonstrates its effects through weak partial agonist activity at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors. This activity results in the well-known effects of smoking cannabis such as increased appetite, reduced pain, and changes in emotional and cognitive processes. In contrast to THC's weak agonist activity, CBD has been shown to act as a negative allosteric modulator of the CB1 receptor, the most abundant G-Protein Coupled Receptor (GPCR) in the body (PMID: 26218440 ). Allosteric regulation is achieved through the modulation of receptor activity on a functionally distinct site from the agonist or antagonist binding site which is clinically significant as direct agonists (such as THC) are limited by their psychomimetic effects such as changes to mood, memory, and anxiety (PMID: 26218440 ). In addition to the well-known activity on CB1 and CB2 receptors, there is further evidence that CBD also activates serotonin Type 1A, 2A,3A (HT1A/2A/3A) serotonergic and transient receptor potential cation channel subfamily V member 2 receptors (TRPV1‚Äì2) vanilloid receptors, antagonizes alpha-1 adrenergic and ¬µ-opioid receptors, inhibits synaptosomal uptake of noradrenaline, dopamine, serotonin and gamma-aminobutyric acid (GABA), and cellular uptake of anandamide, acts on mitochondria Ca2+ stores, blocks low-voltage-activated (T-type) Ca2+ channels, stimulates activity of the inhibitory glycine-receptor, and inhibits activity of fatty amide hydrolase (FAAH) (PMID: 26264914 ; PMID: 24281562 ). CBD is currently available in Canada within a 1:1 formulation with tetrahydrocannbinol (THC) (as the formulation known as "nabiximols"; as the brand name product Sativex). It is approved for use as adjunctive treatment for symptomatic relief of spasticity in adult patients with multiple sclerosis (MS). Sativex was also given a conditional Notice of Compliance (NOC/c) for use as adjunctive treatment for the symptomatic relief of neuropathic pain in adult patients with multiple sclerosis and as adjunctive analgesic treatment for moderate to severe pain in adult patients with advanced cancer. In April 2018, a Food and Drug Administration advisory panel unanimously recommended approval of Epidiolex (cannabidiol oral solution) for the treatment of two rare forms of epilepsy - Lennox-Gastaut syndrome and Dravet syndrome, which are among the two most difficult types of epilepsy to treat. Epidiolex was granted Orphan Drug designation as well as Fast Track Approval from the FDA for further study in these hard to treat conditions. Notably, phase 3 clinical trials of Epidiolex have demonstrated clinically significant improvement in Lennox-Gastaut syndrome and Dravet syndrome. On June 25th, 2018, Epidiolex was approved by the FDA to be the first CBD-based product available on the US market.

Structure

MOL SDF 3D-SDF PDB SMILES InChI View 3D Structure

Synonyms

Value	Source
(-)-Cannabidiol	ChEBI
(-)-CBD	ChEBI
(-)-trans-2-p-Mentha-1,8-dien-3-yl-5-pentylresorcinol	ChEBI
(-)-trans-Cannabidiol	ChEBI
Cannabidiolum	ChEBI
Delta(1(2))-trans-Cannabidiol	ChEBI
Δ(1(2))-trans-cannabidiol	Generator
CBD	ChEMBL
Cannabidiol	MeSH
Epidiolex	PhytoBank
delta1(2)-trans-Cannabidiol	PhytoBank
Δ1(2)-trans-Cannabidiol	PhytoBank

Chemical Formula

C₂₁H₃₀O₂

Average Molecular Weight

314.47

Monoisotopic Molecular Weight

314.2246

IUPAC Name

2-[(1R,6R)-3-methyl-6-(prop-1-en-2-yl)cyclohex-2-en-1-yl]-5-pentylbenzene-1,3-diol

Traditional Name

cannabidiol

CAS Registry Number

3556-78-3

SMILES

CCCCCC1=CC(O)=C([C@@H]2C=C(C)CC[C@H]2C(C)=C)C(O)=C1

InChI Identifier

InChI=1S/C21H30O2/c1-5-6-7-8-16-12-19(22)21(20(23)13-16)18-11-15(4)9-10-17(18)14(2)3/h11-13,17-18,22-23H,2,5-10H2,1,3-4H3/t17-,18+/m0/s1

InChI Key

QHMBSVQNZZTUGM-ZWKOTPCHSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as aromatic monoterpenoids. These are monoterpenoids containing at least one aromatic ring.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Prenol lipids

Sub Class

Monoterpenoids

Direct Parent

Aromatic monoterpenoids

Alternative Parents

Substituents

P-menthane monoterpenoid
Monocyclic monoterpenoid
Aromatic monoterpenoid
Resorcinol
1-hydroxy-4-unsubstituted benzenoid
1-hydroxy-2-unsubstituted benzenoid
Phenol
Benzenoid
Monocyclic benzene moiety
Organic oxygen compound
Hydrocarbon derivative
Organooxygen compound
Aromatic homomonocyclic compound

Molecular Framework

Aromatic homomonocyclic compounds

External Descriptors

organic molecular entity (CHEBI:69478 )

Ontology

Not Available

Physical Properties

State

Solid

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
logP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	6.1	ALOGPS
logP	6.33	ChemAxon
logS	-4.4	ALOGPS
pKa (Strongest Acidic)	9.13	ChemAxon
pKa (Strongest Basic)	-5.7	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	2	ChemAxon
Hydrogen Donor Count	2	ChemAxon
Polar Surface Area	40.46 Å²	ChemAxon
Rotatable Bond Count	6	ChemAxon
Refractivity	98.53 m³·mol⁻¹	ChemAxon
Polarizability	38.26 Å³	ChemAxon
Number of Rings	2	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

EI-MS/GC-MS

Type	Description	Splash Key	View
Predicted GC-MS	Cannabidiol, 1 TMS, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	Cannabidiol, 2 TMS, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum

MS/MS

Type	Description	Splash Key	View
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-014i-1249000000-71d752347245e1abbbf7	2017-07-25	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-0avi-4492000000-96dfcbc63aaf6e5d98ee	2017-07-25	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-0a4l-9350000000-3aaacce5694ae8710a29	2017-07-25	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-03di-0109000000-aaf2dd315ca5f4b5ecbf	2017-07-26	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-03fr-0829000000-4fc6459d1089253c0fd3	2017-07-26	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-00kr-1910000000-5b5d99e9c4d122cb642f	2017-07-26	View Spectrum

NMR

Not Available

Pathways

Not Available

Protein Targets

Enzymes

Protein Name	Gene Name	Locus	Uniprot ID	Details
5-hydroxytryptamine receptor 1A	HTR1A	5q11.2-q13	P08908	details
Fatty-acid amide hydrolase 1	FAAH	1p35-p34	O00519	details
5-hydroxytryptamine receptor 3A	HTR3A	11q23.1	P46098	details
Fatty-acid amide hydrolase 2	FAAH2	Xp11.21	Q6GMR7	details

Transporters

Protein Name	Gene Name	Locus	Uniprot ID	Details
Transient receptor potential cation channel subfamily V member 1	TRPV1	17p13.2	Q8NER1	details
5-hydroxytryptamine receptor 3A	HTR3A	11q23.1	P46098	details
Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	16p13.3	O95180	details
Transient receptor potential cation channel subfamily V member 2	TRPV2	17p11.2	Q9Y5S1	details
Glycine receptor subunit alpha-1	GLRA1	5q32	P23415	details
Glycine receptor subunit alpha-2	GLRA2		P23416	details
Glycine receptor subunit alpha-3	GLRA3	4q33-q34	O75311	details
Glycine receptor subunit beta	GLRB	4q31.3	P48167	details
Transient receptor potential cation channel subfamily A member 1	TRPA1	8q13	O75762	details

Metal Bindings

Not Available

Receptors

Protein Name	Gene Name	Locus	Uniprot ID	Details
Transient receptor potential cation channel subfamily V member 1	TRPV1	17p13.2	Q8NER1	details
5-hydroxytryptamine receptor 1A	HTR1A	5q11.2-q13	P08908	details
Mu-type opioid receptor	OPRM1	6q24-q25	P35372	details
5-hydroxytryptamine receptor 2A	HTR2A	13q14-q21	P28223	details
Alpha-1A adrenergic receptor	ADRA1A	8p21.2	P35348	details
Alpha-1B adrenergic receptor	ADRA1B	5q33.3	P35368	details
Alpha-1D adrenergic receptor	ADRA1D	20p13	P25100	details
Transient receptor potential cation channel subfamily V member 2	TRPV2	17p11.2	Q9Y5S1	details
Glycine receptor subunit alpha-1	GLRA1	5q32	P23415	details
Glycine receptor subunit alpha-2	GLRA2		P23416	details
Glycine receptor subunit alpha-3	GLRA3	4q33-q34	O75311	details
Glycine receptor subunit beta	GLRB	4q31.3	P48167	details
Cannabinoid receptor 1	CNR1	6q14-q15	P21554	details
Transient receptor potential cation channel subfamily A member 1	TRPA1	8q13	O75762	details
Cannabinoid receptor 2	CNR2	1p36.11	P34972	details

Transcriptional Factors

Not Available

Concentrations Data

Cannabis Cultivar	Status	Value	Reference	Details
8-Ball Kush	Detected and Quantified	0.531 mg/g dry wt	PMID: 30036388	details
9 Lb Hammer	Detected and Quantified	0.468 mg/g dry wt	PMID: 30036388	details
97 Sage	Detected and Quantified	0.755 mg/g dry wt	PMID: 30036388	details
Adonis	Detected and Quantified	0.399 mg/g dry wt	PMID: 30036388	details
Alien Blues	Detected and Quantified	1.1 +/- 0.3 mg/g dry wt	PMID: 30036388	details
Alien Dawg	Detected and Quantified	0.0168 mg/g dry wt	David S. Wishart,...	details
Alien Sour Apple	Detected and Quantified	0.274 mg/g dry wt	PMID: 30036388	details
Black Boss	Detected and Quantified	0.593 mg/g dry wt	PMID: 30036388	details
Blue Cherry Pie	Detected and Quantified	0.6 +/- 0.4 mg/g dry wt	PMID: 30036388	details
Blue Dream	Detected and Quantified	0.5 +/- 0.1 mg/g dry wt	PMID: 30036388	details
Blue Dream	Detected and Quantified	0.417 mg/g dry wt	PMID: 30036388	details
Blue Dream	Detected and Quantified	0.479 mg/g dry wt	PMID: 30036388	details
Blue Dream	Detected and Quantified	0.625 mg/g dry wt	PMID: 30036388	details
Blue Dream	Detected and Quantified	0.856 mg/g dry wt	PMID: 30036388	details
Bob Marley	Detected and Quantified	0.506 mg/g dry wt	PMID: 30036388	details
Bohdi Tree	Detected and Quantified	0.2 +/- 0 mg/g dry wt	PMID: 30036388	details
Chemdawg	Detected and Quantified	0.547 mg/g dry wt	PMID: 30036388	details
Chemdawg #4	Detected and Quantified	0.407 mg/g dry wt	PMID: 30036388	details
Chemdawg #4	Detected and Quantified	0.645 mg/g dry wt	PMID: 30036388	details
Cold Creek Kush	Detected and Quantified	0.4 +/- 0 mg/g dry wt	PMID: 30036388	details
Cookies and Cream	Detected and Quantified	0.162 mg/g dry wt	PMID: 30036388	details
Cosmic Lotus	Detected and Quantified	0.455 mg/g dry wt	PMID: 30036388	details
Crystal Cookies	Detected and Quantified	0.8 +/- 0.1 mg/g dry wt	PMID: 30036388	details
Dairy Queen	Detected and Quantified	0.223 mg/g dry wt	PMID: 30036388	details
Dark Shadow Haze	Detected and Quantified	0.100 mg/g dry wt	PMID: 30036388	details
Double Royal Kush	Detected and Quantified	0.5 +/- 0.1 mg/g dry wt	PMID: 30036388	details
FLO	Detected and Quantified	0.7 +/- 0.1 mg/g dry wt	PMID: 30036388	details
FLO	Detected and Quantified	0.534 mg/g dry wt	PMID: 30036388	details
Gabriola	Detected and Quantified	0.00704 mg/g dry wt	David S. Wishart,...	details
Goji OG	Detected and Quantified	0.475 mg/g dry wt	PMID: 30036388	details
Golden Cobra	Detected and Quantified	0.100 mg/g dry wt	PMID: 30036388	details
Golden Sage	Detected and Quantified	0.473 mg/g dry wt	PMID: 30036388	details
Gorilla Glue	Detected and Quantified	0.615 mg/g dry wt	PMID: 30036388	details
Gorilla Glue #4	Detected and Quantified	0.314 mg/g dry wt	PMID: 30036388	details
Grandaddy Purple	Detected and Quantified	0.6 +/- 0.1 mg/g dry wt	PMID: 30036388	details
Grape Stomper	Detected and Quantified	0.406 mg/g dry wt	PMID: 30036388	details
Grape Stomper	Detected and Quantified	0.420 mg/g dry wt	PMID: 30036388	details
Green Crack	Detected and Quantified	1 +/- 0.1 mg/g dry wt	PMID: 30036388	details
Green Crack 2015	Detected and Quantified	0.7 +/- 0 mg/g dry wt	PMID: 30036388	details
Grizzly Kush	Detected and Quantified	0.100 mg/g dry wt	PMID: 30036388	details
Hash Plant	Detected and Quantified	0.421 mg/g dry wt	PMID: 30036388	details
Hash Plant	Detected and Quantified	0.476 mg/g dry wt	PMID: 30036388	details
Hemlock	Detected and Quantified	0.484 mg/g dry wt	PMID: 30036388	details
Holy Power	Detected and Quantified	0.9 +/- 0.2 mg/g dry wt	PMID: 30036388	details
Island Honey	Detected and Quantified	0.00405 mg/g dry wt	David S. Wishart,...	details
Jabberwocky	Detected and Quantified	0.532 mg/g dry wt	PMID: 30036388	details
Jabberwocky	Detected and Quantified	0.598 mg/g dry wt	PMID: 30036388	details
Jack Herer	Detected and Quantified	0.100 mg/g dry wt	PMID: 30036388	details
Juanita	Detected and Quantified	47.1 +/- 8.1 mg/g dry wt	PMID: 30036388	details
Kandy Kush	Detected and Quantified	0.362 mg/g dry wt	PMID: 30036388	details
Kush Puppy	Detected and Quantified	0.417 mg/g dry wt	PMID: 30036388	details
La Choco	Detected and Quantified	0.447 mg/g dry wt	PMID: 30036388	details
Lavendar	Detected and Quantified	0.4 +/- 0.1 mg/g dry wt	PMID: 30036388	details
Lavendar	Detected and Quantified	0.8 +/- 0.1 mg/g dry wt	PMID: 30036388	details
Lavendar Jones 2015	Detected and Quantified	0.6 +/- 0.1 mg/g dry wt	PMID: 30036388	details
Lemon Balm	Detected and Quantified	0.504 mg/g dry wt	PMID: 30036388	details
Lemon Goji	Detected and Quantified	0.100 mg/g dry wt	PMID: 30036388	details
Lemon OG	Detected and Quantified	1.000 mg/g dry wt	PMID: 30036388	details
Lemon Sherbet	Detected and Quantified	0.100 mg/g dry wt	PMID: 30036388	details
Lemon Skunk	Detected and Quantified	0.100 mg/g dry wt	PMID: 30036388	details
Lemon Skunk	Detected and Quantified	0.516 mg/g dry wt	PMID: 30036388	details
Liberty Haze	Detected and Quantified	0.100 mg/g dry wt	PMID: 30036388	details
Lohan	Detected and Quantified	0.564 mg/g dry wt	PMID: 30036388	details
Love Lace	Detected and Quantified	88.8 +/- 11 mg/g dry wt	PMID: 30036388	details
Lucky Charms	Detected and Quantified	0.100 mg/g dry wt	PMID: 30036388	details
Maui Haze	Detected and Quantified	0.489 mg/g dry wt	PMID: 30036388	details
Moby Dick	Detected and Quantified	1.060 mg/g dry wt	PMID: 30036388	details
Moonshine Ghost Trane Haze	Detected and Quantified	0.100 mg/g dry wt	PMID: 30036388	details
Nightmare Cookie	Detected and Quantified	0.100 mg/g dry wt	PMID: 30036388	details
Oracle	Detected and Quantified	0.7 +/- 0.1 mg/g dry wt	PMID: 30036388	details
Orange Skunk	Detected and Quantified	0.100 mg/g dry wt	PMID: 30036388	details
Pineapple Skunk	Detected and Quantified	0.100 mg/g dry wt	PMID: 30036388	details
Pipe Dream	Detected and Quantified	0.463 mg/g dry wt	PMID: 30036388	details
Platinum Buffalo	Detected and Quantified	0 +/- 0.1 mg/g dry wt	PMID: 30036388	details
Platinum Delight	Detected and Quantified	0.100 mg/g dry wt	PMID: 30036388	details
Platinum Gorilla	Detected and Quantified	0.6 +/- 0 mg/g dry wt	PMID: 30036388	details
Purple Eclipse	Detected and Quantified	0.449 mg/g dry wt	PMID: 30036388	details
Purple Fat Pie	Detected and Quantified	0.7 +/- 0.2 mg/g dry wt	PMID: 30036388	details
Quadra	Detected and Quantified	0.0134 mg/g dry wt	David S. Wishart,...	details
Rocket Fuel	Detected and Quantified	0.652 mg/g dry wt	PMID: 30036388	details
Rollex OG	Detected and Quantified	0.100 mg/g dry wt	PMID: 30036388	details
Romulin	Detected and Quantified	0.5 +/- 0.1 mg/g dry wt	PMID: 30036388	details
Rosetta Stone	Detected and Quantified	0.100 mg/g dry wt	PMID: 30036388	details
RX	Detected and Quantified	0.6 +/- 0 mg/g dry wt	PMID: 30036388	details
Satori	Detected and Quantified	0.100 mg/g dry wt	PMID: 30036388	details
Sensi Star	Detected and Quantified	0.0172 mg/g dry wt	David S. Wishart,...	details
Skunk Haze	Detected and Quantified	0.100 mg/g dry wt	PMID: 30036388	details
Skywalker	Detected and Quantified	0.4 +/- 0 mg/g dry wt	PMID: 30036388	details
Skywalker OG	Detected and Quantified	0.471 mg/g dry wt	PMID: 30036388	details
Sour Willie	Detected and Quantified	0.3 +/- 0 mg/g dry wt	PMID: 30036388	details
Spectrum	Detected and Quantified	85.600 mg/g dry wt	PMID: 30036388	details
Star Bud	Detected and Quantified	0.100 mg/g dry wt	PMID: 30036388	details
Star Killer	Detected and Quantified	0.100 mg/g dry wt	PMID: 30036388	details
Strawberry Fields	Detected and Quantified	0.393 mg/g dry wt	PMID: 30036388	details
Strawberry Fields	Detected and Quantified	0.400 mg/g dry wt	PMID: 30036388	details
Sunset Sherbet	Detected and Quantified	0.382 mg/g dry wt	PMID: 30036388	details
Sunset Sherbet	Detected and Quantified	0.462 mg/g dry wt	PMID: 30036388	details
Tangerine Dream	Detected and Quantified	0.00803 mg/g dry wt	David S. Wishart,...	details
Tangerine Dream	Detected and Quantified	0.100 mg/g dry wt	PMID: 30036388	details
The Sauce	Detected and Quantified	0.100 mg/g dry wt	PMID: 30036388	details
Thunderstruck	Detected and Quantified	98.4 +/- 11.5 mg/g dry wt	PMID: 30036388	details
Twisted Velvet	Detected and Quantified	0.5 +/- 0.1 mg/g dry wt	PMID: 30036388	details
Venom OG	Detected and Quantified	0.211 mg/g dry wt	PMID: 30036388	details
Walker Kush	Detected and Quantified	0.7 +/- 0.2 mg/g dry wt	PMID: 30036388	details
White Widow	Detected and Quantified	0.7 +/- 0 mg/g dry wt	PMID: 30036388	details
White Widow	Detected and Quantified	0.787 mg/g dry wt	PMID: 30036388	details
Wonder Woman	Detected and Quantified	1.100 mg/g dry wt	PMID: 30036388	details

External Links

HMDB ID

Not Available

DrugBank ID

DB09061

Phenol Explorer Compound ID

Not Available

FoodDB ID

Not Available

KNApSAcK ID

C00002641

Chemspider ID

559095

KEGG Compound ID

Not Available

BioCyc ID

CPD-7173

BiGG ID

Not Available

Wikipedia Link

Cannabidiol

METLIN ID

Not Available

PubChem Compound

644019

PDB ID

Not Available

ChEBI ID

69478

References

General References

Laprairie RB, Bagher AM, Kelly ME, Denovan-Wright EM: Cannabidiol is a negative allosteric modulator of the cannabinoid CB1 receptor. Br J Pharmacol. 2015 Oct;172(20):4790-805. doi: 10.1111/bph.13250. Epub 2015 Oct 13. [PubMed:26218440 ]
Pertwee RG: The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: delta9-tetrahydrocannabinol, cannabidiol and delta9-tetrahydrocannabivarin. Br J Pharmacol. 2008 Jan;153(2):199-215. doi: 10.1038/sj.bjp.0707442. Epub 2007 Sep 10. [PubMed:17828291 ]
Sharma P, Murthy P, Bharath MM: Chemistry, metabolism, and toxicology of cannabis: clinical implications. Iran J Psychiatry. 2012 Fall;7(4):149-56. [PubMed:23408483 ]
Baron EP: Comprehensive Review of Medicinal Marijuana, Cannabinoids, and Therapeutic Implications in Medicine and Headache: What a Long Strange Trip It's Been .... Headache. 2015 Jun;55(6):885-916. doi: 10.1111/head.12570. Epub 2015 May 25. [PubMed:26015168 ]
Zou S, Kumar U: Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System. Int J Mol Sci. 2018 Mar 13;19(3). pii: ijms19030833. doi: 10.3390/ijms19030833. [PubMed:29533978 ]
Kaur R, Ambwani SR, Singh S: Endocannabinoid System: A Multi-Facet Therapeutic Target. Curr Clin Pharmacol. 2016;11(2):110-7. doi: 10.2174/1574884711666160418105339. [PubMed:27086601 ]
Elsohly MA, Slade D: Chemical constituents of marijuana: the complex mixture of natural cannabinoids. Life Sci. 2005 Dec 22;78(5):539-48. doi: 10.1016/j.lfs.2005.09.011. Epub 2005 Sep 30. [PubMed:16199061 ]
Ibeas Bih C, Chen T, Nunn AV, Bazelot M, Dallas M, Whalley BJ: Molecular Targets of Cannabidiol in Neurological Disorders. Neurotherapeutics. 2015 Oct;12(4):699-730. doi: 10.1007/s13311-015-0377-3. [PubMed:26264914 ]
Zhornitsky S, Potvin S: Cannabidiol in humans-the quest for therapeutic targets. Pharmaceuticals (Basel). 2012 May 21;5(5):529-52. doi: 10.3390/ph5050529. [PubMed:24281562 ]
Haresaku S, Hanioka T, Tsutsui A, Yamamoto M, Chou T, Gunjishima Y: Long-term effect of xylitol gum use on mutans streptococci in adults. Caries Res. 2007;41(3):198-203. doi: 10.1159/000099318. [PubMed:17426399 ]
Grillaud M, Bandon D, Nancy J, Delbos Y, Vaysse F: [The polyols in pediatric dentistry: advantages of xylitol]. Arch Pediatr. 2005 Jul;12(7):1180-6. doi: 10.1016/j.arcped.2005.01.032. [PubMed:15964535 ]

Only showing the first 10 proteins. There are 28 proteins in total.

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Enzymes

Enzyme Details

1. 5-hydroxytryptamine receptor 1A

General function:: Involved in G-protein coupled receptor protein signaling pathway
Specific function:: This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity
Gene Name:: HTR1A
Uniprot ID:: P08908
Molecular weight:: 46106.3

Enzyme Details

2. Fatty-acid amide hydrolase 1

General function:: Involved in carbon-nitrogen ligase activity, with glutamine as amido-N-donor
Specific function:: Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates.
Gene Name:: FAAH
Uniprot ID:: O00519
Molecular weight:: 63065.28

Enzyme Details

3. 5-hydroxytryptamine receptor 3A

General function:: Involved in extracellular ligand-gated ion channel activity
Specific function:: This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel
Gene Name:: HTR3A
Uniprot ID:: P46098
Molecular weight:: 55279.8

Enzyme Details

4. Fatty-acid amide hydrolase 2

General function:: Involved in carbon-nitrogen ligase activity, with glutamine as amido-N-donor
Specific function:: Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes monounsaturated substrate anandamide preferentially as compared to polyunsaturated substrates.
Gene Name:: FAAH2
Uniprot ID:: Q6GMR7
Molecular weight:: 58303.115

Transporters

Enzyme Details

1. Transient receptor potential cation channel subfamily V member 1

General function:: Involved in ion channel activity
Specific function:: Receptor-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. May be involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL
Gene Name:: TRPV1
Uniprot ID:: Q8NER1
Molecular weight:: 94955.3

Enzyme Details

2. 5-hydroxytryptamine receptor 3A

General function:: Involved in extracellular ligand-gated ion channel activity
Specific function:: This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel
Gene Name:: HTR3A
Uniprot ID:: P46098
Molecular weight:: 55279.8

Enzyme Details

3. Voltage-dependent T-type calcium channel subunit alpha-1H

General function:: Involved in ion channel activity
Specific function:: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1H gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes
Gene Name:: CACNA1H
Uniprot ID:: O95180
Molecular weight:: 259160.2

Enzyme Details

4. Transient receptor potential cation channel subfamily V member 2

General function:: Involved in ion channel activity
Specific function:: Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF-I, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH
Gene Name:: TRPV2
Uniprot ID:: Q9Y5S1
Molecular weight:: 85980.3

Enzyme Details

5. Glycine receptor subunit alpha-1

General function:: Involved in ion transport
Specific function:: The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing)
Gene Name:: GLRA1
Uniprot ID:: P23415
Molecular weight:: 52623.4

Enzyme Details

6. Glycine receptor subunit alpha-2

General function:: Involved in ion transport
Specific function:: The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing)
Gene Name:: GLRA2
Uniprot ID:: P23416
Molecular weight:: 52001.6

Enzyme Details

7. Glycine receptor subunit alpha-3

General function:: Involved in ion transport
Specific function:: The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing)
Gene Name:: GLRA3
Uniprot ID:: O75311
Molecular weight:: 53799.8

Enzyme Details

8. Glycine receptor subunit beta

General function:: Involved in extracellular-glycine-gated chloride channel activity
Specific function:: The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing)
Gene Name:: GLRB
Uniprot ID:: P48167
Molecular weight:: 56121.6

Enzyme Details

9. Transient receptor potential cation channel subfamily A member 1

General function:: Not Available
Specific function:: Receptor-activated non-selective cation channel involved in detection of pain and possibly also in cold perception and inner ear function. Has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of volatile irritants, such as mustard oil, garlic and acrolein, an irritant from tears gas and vehicule exhaust fumes. Acts also as a ionotropic cannabinoid receptor by being activated by delta(9)- tetrahydrocannabinol (THC), the psychoactive component of marijuana. Not involved in menthol sensation. May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system
Gene Name:: TRPA1
Uniprot ID:: O75762
Molecular weight:: 127485.8

Only showing the first 10 proteins. There are 28 proteins in total.

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Showing Compound Card for Cannabidiol (CDB000002)

Structure for CDB000002 (Cannabidiol)

Enzymes

Transporters