Cannabis Compound Database: Showing Compound Card for D-Galactose (CDB005235)

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Identification Taxonomy Ontology Physical properties Spectra Protein target Pathways Concentrations Links References enzymes (14) Show 16 proteins XML

Record Information

Version

1.0

Created at

2020-04-17 19:22:52 UTC

Updated at

2020-11-18 16:39:35 UTC

CannabisDB ID

CDB005235

Secondary Accession Numbers

Not Available

Cannabis Compound Identification

Common Name

D-Galactose

Description

D-galactose, also known as galactopyranose, is an aldohexose is a C4-epimer of glucose. It is as sweet as glucose and only 65% as sweet as sucrose. When D-galactose condenses with glucose, lactose if formed. In humans and other species, galactose is metabolized to glucose largely by the Leloir pathway. D-galactose is converted to UDP-glucose and glucose-1-phosphate by three enzymes (PMID: 1292318 ):¬† 1) Galactokinase (GALK; KEGG enzyme E.C. 2.7.1.6) phosphorylates D-galactose to D-galactose-1-phosphate; 2) Then D-galactose-1-phosphate uridyltransferase (GALT; KEGG enzyme E.C. 2.7.7.12) transfers a UMP from UDP-glucose to D-galactose-1-phosphate to form UDP-galactose and glucose-1-phosphate. Glucose-1-phosphate will then enter the glycolytic pathway for energy production. 3) UDP-galactose epimerase (GALE) then interconverts UDP-galactose to UDP-glucose. Lactose in mammalian milk is the main source of D-galactose. Galactose in the urine is a biomarker for the consumption of milk. Galactose can also be found in some fruits and vegetables such as in banana, orange, papaya, bell pepper, avocado and sugar beets ( Ref:DOI ). It is also found in fig leaves, sesame, carob bean, caraway seeds and beet, cocoa, chive, potato, and cannabis plants (PMID: 6991645 ). In addition to D-Galactose providing energy for the body, it is also a necessary substrate for the biosynthesis of many macromolecules such as cerebrosides, gangliosides, and mucoproteins. Galactose is a component of the antigens of the ABO blood group (PMID: 15373665 ). Metabolic pathways for D-galactose are important not only for the provision of these pathways but also for the prevention of D-galactose accumulation. There are diseases resulting from the deficiencies of the three enzymes of the Leloir pathway. Classic galactosemia, or the accumulation of D-galactose in the blood, is the rare inborn error of D-galactose metabolism, caused by the deficiency of the second enzyme GALT, (from mutations in the GALT gene; PMID: 10408771 ). As galactose accumulation is associated with health problems (PMID: 26001656 ), particularly involving the liver (PMID: 29502917 ), the discovery of alternative metabolic pathways to the Leloir in fungi and bacteria (PMID:15256214 ) could lead to discovery of analogous genes in humans. D-galactose was also be protective against pancreatitis (PMID: 2989374 ) and streptozotocin-induced model of Alzheimer‚Äôs disease in rats (PMID: 29501615 ). D-Galactose is expected to be in Cannabis as all living plants are known to produce and metabolize it.

Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
ALPHA D-GALACTOSE	ChEBI
alpha-D-Gal	ChEBI
Gal-alpha	ChEBI
alpha-D-Galactose	Kegg
a D-GALACTOSE	Generator
Α D-galactose	Generator
a-D-Gal	Generator
Α-D-gal	Generator
Gal-a	Generator
Gal-α	Generator
a-D-Galactose	Generator
Α-D-galactose	Generator
(+)-Galactose	HMDB
5Abp	HMDB
8Abp	HMDB
alpha-D-Galactopyranose	HMDB
D-(+)-Galactose	HMDB
D-Hexose	HMDB
GAL	HMDB
Galactose	HMDB
Galactose (NF)	HMDB
GLA	HMDB
GLC	HMDB
Hexose	HMDB
SHU 508 a	MeSH, HMDB
SH-TA-508	MeSH, HMDB
SHU 508	MeSH, HMDB
Levovist	MeSH, HMDB
SHU-508	MeSH, HMDB

Chemical Formula

C₆H₁₂O₆

Average Molecular Weight

180.16

Monoisotopic Molecular Weight

180.0634

IUPAC Name

(2S,3R,4S,5R,6R)-6-(hydroxymethyl)oxane-2,3,4,5-tetrol

Traditional Name

galactose

CAS Registry Number

3646-73-9

SMILES

OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O

InChI Identifier

InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3+,4+,5-,6+/m1/s1

InChI Key

WQZGKKKJIJFFOK-PHYPRBDBSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as hexoses. These are monosaccharides in which the sugar unit is a is a six-carbon containing moeity.

Kingdom

Organic compounds

Super Class

Organic oxygen compounds

Class

Organooxygen compounds

Sub Class

Carbohydrates and carbohydrate conjugates

Direct Parent

Hexoses

Alternative Parents

Substituents

Hexose monosaccharide
Oxane
Secondary alcohol
Hemiacetal
Oxacycle
Organoheterocyclic compound
Polyol
Hydrocarbon derivative
Primary alcohol
Alcohol
Aliphatic heteromonocyclic compound

Molecular Framework

Aliphatic heteromonocyclic compounds

External Descriptors

D-galactopyranose (CHEBI:28061 )

Ontology

Ingestion

Source:

Biological:

Plant:

Animal

Biological location:

Organ and components:

Biofluid and excreta:

Cell and elements:

Extracellular

Subcellular:

Physical Properties

State

Solid

Experimental Properties

Property	Value	Reference
Melting Point	170 °C	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	683 mg/mL	Not Available
logP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	-2.6	ALOGPS
logP	-2.9	ChemAxon
logS	0.64	ALOGPS
pKa (Strongest Acidic)	11.3	ChemAxon
pKa (Strongest Basic)	-3	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	6	ChemAxon
Hydrogen Donor Count	5	ChemAxon
Polar Surface Area	110.38 Å²	ChemAxon
Rotatable Bond Count	1	ChemAxon
Refractivity	35.92 m³·mol⁻¹	ChemAxon
Polarizability	16.13 Å³	ChemAxon
Number of Rings	1	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

EI-MS/GC-MS

Type	Description	Splash Key	View
GC-MS	D-Galactose, non-derivatized, GC-MS Spectrum	splash10-066s-0941000000-8f1b68655e0a5ed179e3	Spectrum
GC-MS	D-Galactose, non-derivatized, GC-MS Spectrum	splash10-0ldj-0941000000-84c771fab416aa0a40d8	Spectrum
GC-MS	D-Galactose, non-derivatized, GC-MS Spectrum	splash10-0ktb-0931000000-6f37a774d1ab64585c8d	Spectrum
GC-MS	D-Galactose, non-derivatized, GC-MS Spectrum	splash10-066s-0931000000-9945093085ef7b0de618	Spectrum
GC-MS	D-Galactose, non-derivatized, GC-MS Spectrum	splash10-0ldj-0931000000-1ed532d5d2897be775df	Spectrum
GC-MS	D-Galactose, non-derivatized, GC-MS Spectrum	splash10-00di-9731000000-af5bd67ad0bbb2997839	Spectrum
GC-MS	D-Galactose, non-derivatized, GC-MS Spectrum	splash10-00di-9621000000-9dad5bd1760a891ace2a	Spectrum
GC-MS	D-Galactose, non-derivatized, GC-MS Spectrum	splash10-0fr2-0920000000-d0bbaf502997c43971ba	Spectrum
GC-MS	D-Galactose, non-derivatized, GC-MS Spectrum	splash10-0fr2-1920000000-f47f0b66263744db15ba	Spectrum
GC-MS	D-Galactose, non-derivatized, GC-MS Spectrum	splash10-066s-0941000000-8f1b68655e0a5ed179e3	Spectrum
GC-MS	D-Galactose, non-derivatized, GC-MS Spectrum	splash10-0ldj-0941000000-84c771fab416aa0a40d8	Spectrum
GC-MS	D-Galactose, non-derivatized, GC-MS Spectrum	splash10-0ktb-0931000000-6f37a774d1ab64585c8d	Spectrum
GC-MS	D-Galactose, non-derivatized, GC-MS Spectrum	splash10-066s-0931000000-9945093085ef7b0de618	Spectrum
GC-MS	D-Galactose, non-derivatized, GC-MS Spectrum	splash10-0ldj-0931000000-1ed532d5d2897be775df	Spectrum
GC-MS	D-Galactose, non-derivatized, GC-MS Spectrum	splash10-00di-9731000000-af5bd67ad0bbb2997839	Spectrum
GC-MS	D-Galactose, non-derivatized, GC-MS Spectrum	splash10-00di-9621000000-9dad5bd1760a891ace2a	Spectrum
GC-MS	D-Galactose, non-derivatized, GC-MS Spectrum	splash10-0fr2-0920000000-d0bbaf502997c43971ba	Spectrum
GC-MS	D-Galactose, non-derivatized, GC-MS Spectrum	splash10-0fr2-1920000000-f47f0b66263744db15ba	Spectrum
Predicted GC-MS	D-Galactose, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	splash10-0np0-9700000000-e8d638dc817e46b97d7b	Spectrum
Predicted GC-MS	D-Galactose, 5 TMS, Predicted GC-MS Spectrum - 70eV, Positive	splash10-004i-6122690000-eaf6f7adf34ccd0c667b	Spectrum
Predicted GC-MS	D-Galactose, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	D-Galactose, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	D-Galactose, TMS_1_1, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	D-Galactose, TMS_1_2, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	D-Galactose, TMS_1_3, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum

MS/MS

Type	Description	Splash Key	View
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)	splash10-0f6t-0900000000-70d3989fddd34b894c77	2012-07-24	View Spectrum
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)	splash10-00ri-9700000000-d454170b4e3ed18ed2d9	2012-07-24	View Spectrum
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)	splash10-007a-9300000000-81f5f12f84924a34e2c0	2012-07-24	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF 10V, negative	splash10-059i-9100000000-33aacf4c62b17cfa394e	2020-07-21	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF 20V, negative	splash10-0a4i-9000000000-79ea696263aaad168701	2020-07-21	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF 40V, negative	splash10-0a4i-9000000000-480461c1cdd9d138dce2	2020-07-21	View Spectrum
MS/MS	LC-MS/MS Spectrum - 10V, Negative	splash10-059i-9100000000-33aacf4c62b17cfa394e	2021-09-20	View Spectrum
MS/MS	LC-MS/MS Spectrum - 20V, Negative	splash10-0a4i-9000000000-79ea696263aaad168701	2021-09-20	View Spectrum
MS/MS	LC-MS/MS Spectrum - 40V, Negative	splash10-0a4i-9000000000-480461c1cdd9d138dce2	2021-09-20	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-01q9-0900000000-b0bc47623e7b2ca31c02	2016-09-12	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-03ea-3900000000-648e1637af29cf2a3518	2016-09-12	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-0007-9200000000-9e6f46a1cbf52d6e347a	2016-09-12	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-004i-2900000000-a4ec4f0b1e29e360a952	2016-09-12	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-01t9-6900000000-7b3ea9c64ecc8d4ac867	2016-09-12	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-052f-9100000000-ec2bf4918640a0a36398	2016-09-12	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-004i-2900000000-2448926b508622464fe7	2021-09-23	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-056r-8900000000-4c073cb93b78120113e6	2021-09-23	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-0a4l-9000000000-ece70093ab5d3c331ac4	2021-09-23	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-01qa-0900000000-04ceb34d441ff6a75763	2021-09-25	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-03dl-9400000000-a8f1ceab155611f949c1	2021-09-25	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-01ow-9000000000-358f68fc2b7a72c27546	2021-09-25	View Spectrum

NMR

Type	Description	View
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, experimental)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 125 MHz, H₂O, experimental)	Spectrum
1D NMR	¹H NMR Spectrum (1D, D₂O, experimental)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 400 MHz, H₂O, experimental)	Spectrum
2D NMR	[¹H, ¹H]-TOCSY. Unexported temporarily by An Chi on Oct 15, 2021 until json or nmrML file is generated. 2D NMR Spectrum (experimental)	Spectrum
2D NMR	[¹H, ¹³C]-HSQC NMR Spectrum (2D, 400 MHz, H₂O, experimental)	Spectrum

Pathways

Name	SMPDB/Pathwhiz	KEGG
Galactose Metabolism
Nucleotide Sugars Metabolism
Lactose Degradation		Not Available
Galactosemia II (GALK)		Not Available
Galactosemia III		Not Available

Protein Targets

Enzymes

Protein Name	Gene Name	Locus	Uniprot ID	Details
Aldose reductase	AKR1B1	7q35	P15121	details
Hexokinase-3	HK3	5q35.2	P52790	details
Hexokinase-2	HK2	2p13	P52789	details
Hexokinase-1	HK1	10q22	P19367	details
Galactocerebrosidase	GALC	14q31	P54803	details
Lactase-phlorizin hydrolase	LCT	2q21	P09848	details
Alpha-galactosidase A	GLA		P06280	details
Beta-galactosidase	GLB1		P16278	details
N-acetylgalactosamine kinase	GALK2	15q21.1-q21.2	Q01415	details
Galactokinase	GALK1	17q24	P51570	details
N-acetylgalactosamine-6-sulfatase	GALNS		P34059	details
Maltase-glucoamylase, intestinal	MGAM		O43451	details
Neutral alpha-glucosidase C	GANC		Q8TET4	details
Putative hexokinase HKDC1	HKDC1	10q22.1	Q2TB90	details

Transporters

Not Available

Metal Bindings

Protein Name	Gene Name	Locus	Uniprot ID	Details
N-acetylgalactosamine-6-sulfatase	GALNS		P34059	details

Receptors

Protein Name	Gene Name	Locus	Uniprot ID	Details
Alpha-galactosidase A	GLA		P06280	details

Transcriptional Factors

Not Available

Concentrations Data

Not Available

External Links

HMDB ID

HMDB0000143

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

FDB021787

KNApSAcK ID

C00001119

Chemspider ID

Not Available

KEGG Compound ID

C00984

BioCyc ID

ALPHA-D-GALACTOSE

BiGG ID

Not Available

Wikipedia Link

Galactose

METLIN ID

Not Available

PubChem Compound

439357

PDB ID

Not Available

ChEBI ID

28061

References

General References

Turner CE, Elsohly MA, Boeren EG: Constituents of Cannabis sativa L. XVII. A review of the natural constituents. J Nat Prod. 1980 Mar-Apr;43(2):169-234. doi: 10.1021/np50008a001. [PubMed:6991645 ]
Tyfield L, Reichardt J, Fridovich-Keil J, Croke DT, Elsas LJ 2nd, Strobl W, Kozak L, Coskun T, Novelli G, Okano Y, Zekanowski C, Shin Y, Boleda MD: Classical galactosemia and mutations at the galactose-1-phosphate uridyl transferase (GALT) gene. Hum Mutat. 1999;13(6):417-30. doi: 10.1002/(SICI)1098-1004(1999)13:6<417::AID-HUMU1>3.0.CO;2-0. [PubMed:10408771 ]
Lai K, Klapa MI: Alternative pathways of galactose assimilation: could inverse metabolic engineering provide an alternative to galactosemic patients? Metab Eng. 2004 Jul;6(3):239-44. doi: 10.1016/j.ymben.2004.01.001. [PubMed:15256214 ]
Blumenreich GA: The standard of care. AANA J. 1992 Dec;60(6):529-31. [PubMed:1292318 ]
Yamamoto F: Review: ABO blood group system--ABH oligosaccharide antigens, anti-A and anti-B, A and B glycosyltransferases, and ABO genes. Immunohematology. 2004;20(1):3-22. [PubMed:15373665 ]
Coelho AI, Berry GT, Rubio-Gozalbo ME: Galactose metabolism and health. Curr Opin Clin Nutr Metab Care. 2015 Jul;18(4):422-7. doi: 10.1097/MCO.0000000000000189. [PubMed:26001656 ]
Demirbas D, Brucker WJ, Berry GT: Inborn Errors of Metabolism with Hepatopathy: Metabolism Defects of Galactose, Fructose, and Tyrosine. Pediatr Clin North Am. 2018 Apr;65(2):337-352. doi: 10.1016/j.pcl.2017.11.008. [PubMed:29502917 ]
Van Meel FC, Steenbakkers PG, Oomen JC: Human and chimpanzee monoclonal antibodies. J Immunol Methods. 1985 Jun 25;80(2):267-76. doi: 10.1016/0022-1759(85)90027-4. [PubMed:2989374 ]
Knezovic A, Osmanovic Barilar J, Babic A, Bagaric R, Farkas V, Riederer P, Salkovic-Petrisic M: Glucagon-like peptide-1 mediates effects of oral galactose in streptozotocin-induced rat model of sporadic Alzheimer's disease. Neuropharmacology. 2018 Jun;135:48-62. doi: 10.1016/j.neuropharm.2018.02.027. Epub 2018 Feb 28. [PubMed:29501615 ]

Only showing the first 10 proteins. There are 16 proteins in total.

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Enzymes

Enzyme Details

1. Aldose reductase

General function:: Involved in oxidoreductase activity
Specific function:: Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
Gene Name:: AKR1B1
Uniprot ID:: P15121
Molecular weight:: 35853.125

Enzyme Details

2. Hexokinase-3

General function:: Involved in ATP binding
Specific function:: Not Available
Gene Name:: HK3
Uniprot ID:: P52790
Molecular weight:: 99024.56

Enzyme Details

3. Hexokinase-2

General function:: Involved in ATP binding
Specific function:: Not Available
Gene Name:: HK2
Uniprot ID:: P52789
Molecular weight:: 102379.06

Enzyme Details

4. Hexokinase-1

General function:: Involved in ATP binding
Specific function:: Not Available
Gene Name:: HK1
Uniprot ID:: P19367
Molecular weight:: 102485.1

Enzyme Details

5. Galactocerebrosidase

General function:: Involved in galactosylceramidase activity
Specific function:: Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Enzyme with very low activity responsible for the lysosomal catabolism of galactosylceramide, a major lipid in myelin, kidney and epithelial cells of small intestine and colon.
Gene Name:: GALC
Uniprot ID:: P54803
Molecular weight:: 77062.86

Enzyme Details

6. Lactase-phlorizin hydrolase

General function:: Involved in hydrolase activity, hydrolyzing O-glycosyl compounds
Specific function:: LPH splits lactose in the small intestine.
Gene Name:: LCT
Uniprot ID:: P09848
Molecular weight:: 218584.77

Enzyme Details

7. Alpha-galactosidase A

General function:: Involved in catalytic activity
Specific function:: Not Available
Gene Name:: GLA
Uniprot ID:: P06280
Molecular weight:: Not Available

Enzyme Details

8. Beta-galactosidase

General function:: Involved in hydrolase activity, hydrolyzing O-glycosyl compounds
Specific function:: Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans. Isoform 2 has no beta-galactosidase catalytic activity, but plays functional roles in the formation of extracellular elastic fibers (elastogenesis) and in the development of connective tissue. Seems to be identical to the elastin-binding protein (EBP), a major component of the non-integrin cell surface receptor expressed on fibroblasts, smooth muscle cells, chondroblasts, leukocytes, and certain cancer cell types. In elastin producing cells, associates with tropoelastin intracellularly and functions as a recycling molecular chaperone which facilitates the secretions of tropoelastin and its assembly into elastic fibers.
Gene Name:: GLB1
Uniprot ID:: P16278
Molecular weight:: Not Available

Enzyme Details

9. N-acetylgalactosamine kinase

General function:: Involved in galactokinase activity
Specific function:: Acts on GalNAc. Also acts as a galactokinase when galactose is present at high concentrations. May be involved in a salvage pathway for the reutilization of free GalNAc derived from the degradation of complex carbohydrates.
Gene Name:: GALK2
Uniprot ID:: Q01415
Molecular weight:: 49234.57

Enzyme Details

10. Galactokinase

General function:: Involved in galactokinase activity
Specific function:: Major enzyme for galactose metabolism.
Gene Name:: GALK1
Uniprot ID:: P51570
Molecular weight:: 42271.805

Only showing the first 10 proteins. There are 16 proteins in total.

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Showing Compound Card for D-Galactose (CDB005235)

Structure for CDB005235 (D-Galactose)

Enzymes