Record Information
Version1.0
Created at2020-04-17 18:39:43 UTC
Updated at2021-01-22 17:44:17 UTC
CannabisDB IDCDB004816
Secondary Accession NumbersNot Available
Cannabis Compound Identification
Common NameL-Lysine
DescriptionLysin and its bioctive form L-lysine is an essential amino acid. Normal human requirements for lysine have been found to be about 8 g per day or 12 mg/kg in adults. Children and infants need more, 44 mg/kg per day for an eleven to-twelve-year old, and 97 mg/kg per day for three-to six-month old. Lysine is highly concentrated in muscle compared to most other amino acids. Lysine is high in foods such as wheat germ, cottage cheese and chicken. Of meat products, wild game and pork have the highest concentration of lysine. Fruits and vegetables contain little lysine, except avocados. Normal lysine metabolism is dependent upon many nutrients including niacin, vitamin B6, riboflavin, vitamin C, glutamic acid and iron. Excess arginine antagonizes lysine. Several inborn errors of lysine metabolism are known, such as cystinuria, hyperdibasic aminoaciduria I, lysinuric protein intolerance, propionic acidemia, and tyrosinemia I. Most are marked by mental retardation with occasional diverse symptoms such as absence of secondary sex characteristics, undescended testes, abnormal facial structure, anemia, obesity, enlarged liver and spleen, and eye muscle imbalance. Lysine also may be a useful adjunct in the treatment of osteoporosis. Although high protein diets result in loss of large amounts of calcium in urine, so does lysine deficiency. Lysine may be an adjunct therapy because it reduces calcium losses in urine. Lysine deficiency also may result in immunodeficiency. Requirements for this amino acid are probably increased by stress. Lysine toxicity has not occurred with oral doses in humans. Lysine dosages are presently too small and may fail to reach the concentrations necessary to prove potential therapeutic applications. Lysine metabolites, amino caproic acid and carnitine have already shown their therapeutic potential. Thirty grams daily of amino caproic acid has been used as an initial daily dose in treating blood clotting disorders, indicating that the proper doses of lysine, its precursor, have yet to be used in medicine. As a widespread aminoacid in nature, L-lysine is also present in the Cannabis sativa plant (PMID: 6991645 ) and it has also been detected in the smoke produced through the combustion of Cannabis (Ref: Ref:DOI ).
Structure
Thumb
Synonyms
ValueSource
(S)-2,6-Diaminohexanoic acidChEBI
(S)-alpha,epsilon-Diaminocaproic acidChEBI
(S)-LysineChEBI
6-Ammonio-L-norleucineChEBI
KChEBI
L-2,6-Diaminocaproic acidChEBI
L-LysinChEBI
LysChEBI
LysinaChEBI
LysineChEBI
Lysine acidChEBI
LysinumChEBI
2,6-Diaminohexanoic acidKegg
(S)-2,6-DiaminohexanoateGenerator
(S)-a,epsilon-DiaminocaproateGenerator
(S)-a,epsilon-Diaminocaproic acidGenerator
(S)-alpha,epsilon-DiaminocaproateGenerator
(S)-Α,epsilon-diaminocaproateGenerator
(S)-Α,epsilon-diaminocaproic acidGenerator
L-2,6-DiaminocaproateGenerator
2,6-DiaminohexanoateGenerator
(+)-S-LysineHMDB
(S)-2,6-Diamino-hexanoateHMDB
(S)-2,6-Diamino-hexanoic acidHMDB
(S)-a,e-DiaminocaproateHMDB
(S)-a,e-Diaminocaproic acidHMDB
6-Amino-aminutrinHMDB
6-Amino-L-norleucineHMDB
a-LysineHMDB
alpha-LysineHMDB
AminutrinHMDB
H-Lys-OHHMDB
L-(+)-LysineHMDB
L-2,6-DiainohexanoateHMDB
L-2,6-Diainohexanoic acidHMDB
L-LysHMDB
Acetate, lysineHMDB
EnisylHMDB
Lysine hydrochlorideHMDB
L LysineHMDB
Lysine acetateHMDB
Chemical FormulaC6H14N2O2
Average Molecular Weight146.19
Monoisotopic Molecular Weight146.1055
IUPAC Name(2S)-2,6-diaminohexanoic acid
Traditional NameL-lysine
CAS Registry Number56-87-1
SMILES
NCCCC[C@H](N)C(O)=O
InChI Identifier
InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/t5-/m0/s1
InChI KeyKDXKERNSBIXSRK-YFKPBYRVSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as l-alpha-amino acids. These are alpha amino acids which have the L-configuration of the alpha-carbon atom.
KingdomOrganic compounds
Super ClassOrganic acids and derivatives
ClassCarboxylic acids and derivatives
Sub ClassAmino acids, peptides, and analogues
Direct ParentL-alpha-amino acids
Alternative Parents
Substituents
  • L-alpha-amino acid
  • Medium-chain fatty acid
  • Amino fatty acid
  • Fatty acid
  • Fatty acyl
  • Amino acid
  • Monocarboxylic acid or derivatives
  • Carboxylic acid
  • Organic oxide
  • Organopnictogen compound
  • Organic oxygen compound
  • Primary amine
  • Organooxygen compound
  • Organonitrogen compound
  • Primary aliphatic amine
  • Carbonyl group
  • Organic nitrogen compound
  • Amine
  • Hydrocarbon derivative
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External Descriptors
Ontology
Physiological effect

Health effect:

Disposition

Route of exposure:

Source:

Biological location:

Role

Industrial application:

Biological role:

Physical Properties
StateSolid
Experimental Properties
PropertyValueReference
Melting Point224.5 °CNot Available
Boiling PointNot AvailableNot Available
Water Solubility1000 mg/mLNot Available
logP-3.05HANSCH,C ET AL. (1995)
Predicted Properties
PropertyValueSource
logP-3.8ALOGPS
logP-3.2ChemAxon
logS-0.14ALOGPS
pKa (Strongest Acidic)2.74ChemAxon
pKa (Strongest Basic)10.29ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count3ChemAxon
Polar Surface Area89.34 ŲChemAxon
Rotatable Bond Count5ChemAxon
Refractivity37.81 m³·mol⁻¹ChemAxon
Polarizability15.84 ųChemAxon
Number of Rings0ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Spectra
EI-MS/GC-MS
TypeDescriptionSplash KeyView
GC-MSL-Lysine, 3 TMS, GC-MS Spectrumsplash10-00di-3910000000-98c565675de67aa87900Spectrum
GC-MSL-Lysine, non-derivatized, GC-MS Spectrumsplash10-0ab9-1910000000-87ef8534f592041f50f2Spectrum
GC-MSL-Lysine, 4 TMS, GC-MS Spectrumsplash10-0a4i-1921000000-84f7815b0f650fa17444Spectrum
GC-MSL-Lysine, 3 TMS, GC-MS Spectrumsplash10-001i-9600000000-823408dba509cb204acfSpectrum
GC-MSL-Lysine, 3 TMS, GC-MS Spectrumsplash10-00di-3910000000-4f5578af5e7d8b6c49f7Spectrum
GC-MSL-Lysine, 4 TMS, GC-MS Spectrumsplash10-0adi-1921000000-4e56d95e623e792f9e6bSpectrum
GC-MSL-Lysine, non-derivatized, GC-MS Spectrumsplash10-00di-0921000000-eeb49e57bc1a75193058Spectrum
GC-MSL-Lysine, non-derivatized, GC-MS Spectrumsplash10-0ab9-0921000000-ebb902be0f3754225b2fSpectrum
GC-MSL-Lysine, non-derivatized, GC-MS Spectrumsplash10-00di-3910000000-98c565675de67aa87900Spectrum
GC-MSL-Lysine, non-derivatized, GC-MS Spectrumsplash10-0ab9-1910000000-87ef8534f592041f50f2Spectrum
GC-MSL-Lysine, non-derivatized, GC-MS Spectrumsplash10-0fdk-3923000000-15b84c2649c1b0455de1Spectrum
GC-MSL-Lysine, non-derivatized, GC-MS Spectrumsplash10-0a4i-1921000000-84f7815b0f650fa17444Spectrum
GC-MSL-Lysine, non-derivatized, GC-MS Spectrumsplash10-001i-9600000000-823408dba509cb204acfSpectrum
GC-MSL-Lysine, non-derivatized, GC-MS Spectrumsplash10-00di-3910000000-4f5578af5e7d8b6c49f7Spectrum
GC-MSL-Lysine, non-derivatized, GC-MS Spectrumsplash10-0adi-1921000000-4e56d95e623e792f9e6bSpectrum
GC-MSL-Lysine, non-derivatized, GC-MS Spectrumsplash10-0abi-1900000000-9ad174122e4d6e003eb8Spectrum
Predicted GC-MSL-Lysine, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positivesplash10-0089-9100000000-974cc55c9130ed5213ebSpectrum
Predicted GC-MSL-Lysine, 1 TMS, Predicted GC-MS Spectrum - 70eV, Positivesplash10-0ue9-9700000000-57b24ae819b6ec26bfd2Spectrum
MS/MS
TypeDescriptionSplash KeyView
MS/MSLC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)splash10-003r-8900000000-470a0beb4f338ed89bcaSpectrum
MS/MSLC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)splash10-001i-9000000000-74e9193d9d33c2509bfaSpectrum
MS/MSLC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)splash10-0a59-9000000000-822c4e78250fffa56e39Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positivesplash10-0002-0900000000-04f9a62a77fb5a37ca22Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positivesplash10-001i-9000000000-035035ecfa084671479bSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positivesplash10-001i-0900000000-5bb15839f86f4fca0d0bSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positivesplash10-001i-0900000000-6c8ef03aa83eb1cab35bSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positivesplash10-01ot-0910000000-c182a7dcdbc260666978Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positivesplash10-0a4j-0900000000-6c5f378cef2f14204e15Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positivesplash10-001i-0900000000-41e1a6499097748934b0Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positivesplash10-03di-0390000000-7270a0b85b9e3f9f6373Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Negativesplash10-0002-0900000000-a997e809874357908880Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, Negativesplash10-0002-2900000000-f64110414f82c93e1fe8Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, Negativesplash10-014m-9200000000-33a38e6370811c5ddc82Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 40V, Negativesplash10-0006-9000000000-3a8b0b6e62f5c66d3720Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 50V, Negativesplash10-0006-9000000000-d5167570d11d77fd541eSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Positivesplash10-0002-0900000000-a46231bd529176101129Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, Positivesplash10-001i-9200000000-f8b9f01b2a9886c51df9Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, Positivesplash10-001i-9000000000-ace0361476d939043e98Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 40V, Positivesplash10-001i-9000000000-5b06b6e9dcf9faf8e89cSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 50V, Positivesplash10-053r-9000000000-2894ef6d7f72ea71688eSpectrum
MS/MSLC-MS/MS Spectrum - CE-ESI-TOF (CE-system connected to 6210 Time-of-Flight MS, Agilent) , Positivesplash10-0002-0900000000-290902f43cf851e8ef5eSpectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Positivesplash10-001i-9300000000-f81193f6b50235ec8147Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Positivesplash10-001i-9300000000-8931d2193adab166d5e4Spectrum
MS/MSLC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Negativesplash10-0002-0900000000-b4825cc64fcb830c6967Spectrum
NMR
TypeDescriptionView
1D NMR1H NMR SpectrumSpectrum
1D NMR13C NMR SpectrumSpectrum
1D NMR1H NMR SpectrumSpectrum
2D NMR[1H,1H] 2D NMR SpectrumSpectrum
2D NMR[1H,13C] 2D NMR SpectrumSpectrum
Pathways
Pathways
Protein Targets
Enzymes
Protein NameGene NameLocusUniprot IDDetails
Histone-lysine N-methyltransferase, H3 lysine-79 specificDOT1L19p13.3Q8TEK3 details
Histone-lysine N-methyltransferase SETD7SETD74q28Q8WTS6 details
Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specificNSD15q35Q96L73 details
Histone-lysine N-methyltransferase SETDB1SETDB11q21Q15047 details
Histone-lysine N-methyltransferase EHMT2EHMT26p21.31Q96KQ7 details
Histone-lysine N-methyltransferase EHMT1EHMT19q34.3Q9H9B1 details
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1PLOD11p36.22Q02809 details
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2PLOD23q24O00469 details
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3PLOD37q22O60568 details
BiotinidaseBTD3p25P43251 details
Lysine--tRNA ligaseKARS16q23.1Q15046 details
Alpha-aminoadipic semialdehyde synthase, mitochondrialAASS7q31.3Q9UDR5 details
Histone-lysine N-methyltransferase MLLMLL11q23Q03164 details
Histone-lysine N-methyltransferase MLL3MLL37q36.1Q8NEZ4 details
Aminoadipate-semialdehyde synthaseAASS7q31.3A4D0W4 details
Carnosine synthase 1CARNS111q13.2A5YM72 details
Histone-lysine N-methyltransferase EZH2EZH27q35-q36Q15910 details
Histone-lysine N-methyltransferase MLL2MLL212q13.12O14686 details
Histone-lysine N-methyltransferase MLL4WBP719q13.1Q9UMN6 details
Histone-lysine N-methyltransferase NSD2WHSC14p16.3O96028 details
Histone-lysine N-methyltransferase NSD3WHSC1L18p11.2Q9BZ95 details
Histone-lysine N-methyltransferase SETD2SETD23p21.31Q9BYW2 details
Lysine-specific demethylase 2AKDM2A11q13.2Q9Y2K7 details
Lysine-specific demethylase 2BKDM2B12q24.31Q8NHM5 details
Transporters
Protein NameGene NameLocusUniprot IDDetails
Histone-lysine N-methyltransferase MLLMLL11q23Q03164 details
Metal Bindings
Protein NameGene NameLocusUniprot IDDetails
Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specificNSD15q35Q96L73 details
Histone-lysine N-methyltransferase SETDB1SETDB11q21Q15047 details
Histone-lysine N-methyltransferase EHMT2EHMT26p21.31Q96KQ7 details
Histone-lysine N-methyltransferase EHMT1EHMT19q34.3Q9H9B1 details
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1PLOD11p36.22Q02809 details
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2PLOD23q24O00469 details
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3PLOD37q22O60568 details
Lysine--tRNA ligaseKARS16q23.1Q15046 details
PR domain zinc finger protein 2PRDM21p36.21Q13029 details
Histone-lysine N-methyltransferase MLLMLL11q23Q03164 details
Histone-lysine N-methyltransferase MLL3MLL37q36.1Q8NEZ4 details
Carnosine synthase 1CARNS111q13.2A5YM72 details
Histone-lysine N-methyltransferase MLL2MLL212q13.12O14686 details
Histone-lysine N-methyltransferase MLL4WBP719q13.1Q9UMN6 details
Histone-lysine N-methyltransferase NSD2WHSC14p16.3O96028 details
Histone-lysine N-methyltransferase NSD3WHSC1L18p11.2Q9BZ95 details
Histone-lysine N-methyltransferase SETD2SETD23p21.31Q9BYW2 details
Lysine-specific demethylase 2AKDM2A11q13.2Q9Y2K7 details
Lysine-specific demethylase 2BKDM2B12q24.31Q8NHM5 details
Receptors
Protein NameGene NameLocusUniprot IDDetails
Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specificNSD15q35Q96L73 details
Histone-lysine N-methyltransferase EZH2EZH27q35-q36Q15910 details
Histone-lysine N-methyltransferase MLL2MLL212q13.12O14686 details
Transcriptional Factors
Protein NameGene NameLocusUniprot IDDetails
Histone-lysine N-methyltransferase, H3 lysine-79 specificDOT1L19p13.3Q8TEK3 details
Histone-lysine N-methyltransferase SETD7SETD74q28Q8WTS6 details
Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specificNSD15q35Q96L73 details
Histone-lysine N-methyltransferase SETDB1SETDB11q21Q15047 details
Histone-lysine N-methyltransferase EHMT2EHMT26p21.31Q96KQ7 details
Histone-lysine N-methyltransferase EHMT1EHMT19q34.3Q9H9B1 details
PR domain zinc finger protein 2PRDM21p36.21Q13029 details
Histone-lysine N-methyltransferase MLLMLL11q23Q03164 details
Histone-lysine N-methyltransferase MLL3MLL37q36.1Q8NEZ4 details
Histone-lysine N-methyltransferase EZH2EZH27q35-q36Q15910 details
Histone-lysine N-methyltransferase MLL2MLL212q13.12O14686 details
Histone-lysine N-methyltransferase MLL4WBP719q13.1Q9UMN6 details
Histone-lysine N-methyltransferase NSD2WHSC14p16.3O96028 details
Histone-lysine N-methyltransferase NSD3WHSC1L18p11.2Q9BZ95 details
Histone-lysine N-methyltransferase SETD2SETD23p21.31Q9BYW2 details
Lysine-specific demethylase 2AKDM2A11q13.2Q9Y2K7 details
Lysine-specific demethylase 2BKDM2B12q24.31Q8NHM5 details
Concentrations Data
Not Available
HMDB IDHMDB0000182
DrugBank IDDB00123
Phenol Explorer Compound IDNot Available
FoodDB IDFDB000474
KNApSAcK IDC00001378
Chemspider ID5747
KEGG Compound IDC00047
BioCyc IDLYS
BiGG ID33655
Wikipedia LinkLysine
METLIN ID5200
PubChem Compound5962
PDB IDLYS
ChEBI ID18019
References
General References
  1. Turner CE, Elsohly MA, Boeren EG: Constituents of Cannabis sativa L. XVII. A review of the natural constituents. J Nat Prod. 1980 Mar-Apr;43(2):169-234. doi: 10.1021/np50008a001. [PubMed:6991645 ]

Only showing the first 10 proteins. There are 64 proteins in total.

Enzymes

General function:
Involved in DNA binding
Specific function:
Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA.
Gene Name:
DOT1L
Uniprot ID:
Q8TEK3
Molecular weight:
164854.41
General function:
Involved in histone-lysine N-methyltransferase activity
Specific function:
Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.
Gene Name:
SETD7
Uniprot ID:
Q8WTS6
Molecular weight:
40720.595
General function:
Involved in histone-lysine N-methyltransferase activity
Specific function:
Histone methyltransferase. Preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4 (in vitro). Transcriptional intermediary factor capable of both negatively or positively influencing transcription, depending on the cellular context.
Gene Name:
NSD1
Uniprot ID:
Q96L73
Molecular weight:
296649.335
General function:
Involved in DNA binding
Specific function:
Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation. Probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1. SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins.
Gene Name:
SETDB1
Uniprot ID:
Q15047
Molecular weight:
143155.6
General function:
Involved in zinc ion binding
Specific function:
Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. May also methylate histone H1. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Also methylates CDYL, WIZ, ACIN1, DNMT1, HDAC1, ERCC6, KLF12 and itself.
Gene Name:
EHMT2
Uniprot ID:
Q96KQ7
Molecular weight:
132369.205
General function:
Involved in zinc ion binding
Specific function:
Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. During G0 phase, it probably contributes to silencing of MYC- and E2F-responsive genes, suggesting a role in G0/G1 transition in cell cycle. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53.
Gene Name:
EHMT1
Uniprot ID:
Q9H9B1
Molecular weight:
86702.845
General function:
Involved in oxidoreductase activity
Specific function:
Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links.
Gene Name:
PLOD1
Uniprot ID:
Q02809
Molecular weight:
83549.55
General function:
Involved in oxidoreductase activity
Specific function:
Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links.
Gene Name:
PLOD2
Uniprot ID:
O00469
Molecular weight:
84685.07
General function:
Involved in oxidoreductase activity
Specific function:
Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links.
Gene Name:
PLOD3
Uniprot ID:
O60568
Molecular weight:
84784.505
General function:
Involved in hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
Specific function:
Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation.
Gene Name:
BTD
Uniprot ID:
P43251
Molecular weight:
61132.43

Transporters

General function:
Involved in DNA binding
Specific function:
Histone methyltransferase that plays an essential role in early development and hematopoiesis. Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac). In the MLL1/MLL complex, it specifically mediates H3K4me, a specific tag for epigenetic transcriptional activation. Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity. Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9'. Required for transcriptional activation of HOXA9. Promotes PPP1R15A-induced apoptosis.
Gene Name:
MLL
Uniprot ID:
Q03164
Molecular weight:
432047.735

Only showing the first 10 proteins. There are 64 proteins in total.