Cannabis Compound Database: Showing Compound Card for L-Lysine (CDB004816)

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Identification Taxonomy Ontology Physical properties Spectra Protein target Pathways Concentrations Links References enzymes (24)transporters (1) Show 64 proteins XML

Record Information

Version

1.0

Created at

2020-04-17 18:39:43 UTC

Updated at

2021-01-22 17:44:17 UTC

CannabisDB ID

CDB004816

Secondary Accession Numbers

Not Available

Cannabis Compound Identification

Common Name

L-Lysine

Description

Lysin and its bioctive form L-lysine is an essential amino acid. Normal human requirements for lysine have been found to be about 8 g per day or 12 mg/kg in adults. Children and infants need more, 44 mg/kg per day for an eleven to-twelve-year old, and 97 mg/kg per day for three-to six-month old. Lysine is highly concentrated in muscle compared to most other amino acids. Lysine is high in foods such as wheat germ, cottage cheese and chicken. Of meat products, wild game and pork have the highest concentration of lysine. Fruits and vegetables contain little lysine, except avocados. Normal lysine metabolism is dependent upon many nutrients including niacin, vitamin B6, riboflavin, vitamin C, glutamic acid and iron. Excess arginine antagonizes lysine. Several inborn errors of lysine metabolism are known, such as cystinuria, hyperdibasic aminoaciduria I, lysinuric protein intolerance, propionic acidemia, and tyrosinemia I. Most are marked by mental retardation with occasional diverse symptoms such as absence of secondary sex characteristics, undescended testes, abnormal facial structure, anemia, obesity, enlarged liver and spleen, and eye muscle imbalance. Lysine also may be a useful adjunct in the treatment of osteoporosis. Although high protein diets result in loss of large amounts of calcium in urine, so does lysine deficiency. Lysine may be an adjunct therapy because it reduces calcium losses in urine. Lysine deficiency also may result in immunodeficiency. Requirements for this amino acid are probably increased by stress. Lysine toxicity has not occurred with oral doses in humans. Lysine dosages are presently too small and may fail to reach the concentrations necessary to prove potential therapeutic applications. Lysine metabolites, amino caproic acid and carnitine have already shown their therapeutic potential. Thirty grams daily of amino caproic acid has been used as an initial daily dose in treating blood clotting disorders, indicating that the proper doses of lysine, its precursor, have yet to be used in medicine. As a widespread aminoacid in nature, L-lysine is also present in the Cannabis sativa plant (PMID: 6991645 ) and it has also been detected in the smoke produced through the combustion of Cannabis (Ref: Ref:DOI ).

Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
(S)-2,6-Diaminohexanoic acid	ChEBI
(S)-alpha,epsilon-Diaminocaproic acid	ChEBI
(S)-Lysine	ChEBI
6-Ammonio-L-norleucine	ChEBI
K	ChEBI
L-2,6-Diaminocaproic acid	ChEBI
L-Lysin	ChEBI
Lys	ChEBI
Lysina	ChEBI
Lysine	ChEBI
Lysine acid	ChEBI
Lysinum	ChEBI
2,6-Diaminohexanoic acid	Kegg
(S)-2,6-Diaminohexanoate	Generator
(S)-a,epsilon-Diaminocaproate	Generator
(S)-a,epsilon-Diaminocaproic acid	Generator
(S)-alpha,epsilon-Diaminocaproate	Generator
(S)-Α,epsilon-diaminocaproate	Generator
(S)-Α,epsilon-diaminocaproic acid	Generator
L-2,6-Diaminocaproate	Generator
2,6-Diaminohexanoate	Generator
(+)-S-Lysine	HMDB
(S)-2,6-Diamino-hexanoate	HMDB
(S)-2,6-Diamino-hexanoic acid	HMDB
(S)-a,e-Diaminocaproate	HMDB
(S)-a,e-Diaminocaproic acid	HMDB
6-Amino-aminutrin	HMDB
6-Amino-L-norleucine	HMDB
a-Lysine	HMDB
alpha-Lysine	HMDB
Aminutrin	HMDB
H-Lys-OH	HMDB
L-(+)-Lysine	HMDB
L-2,6-Diainohexanoate	HMDB
L-2,6-Diainohexanoic acid	HMDB
L-Lys	HMDB
Acetate, lysine	HMDB
Enisyl	HMDB
Lysine hydrochloride	HMDB
L Lysine	HMDB
Lysine acetate	HMDB

Chemical Formula

C₆H₁₄N₂O₂

Average Molecular Weight

146.19

Monoisotopic Molecular Weight

146.1055

IUPAC Name

(2S)-2,6-diaminohexanoic acid

Traditional Name

L-lysine

CAS Registry Number

56-87-1

SMILES

NCCCC[C@H](N)C(O)=O

InChI Identifier

InChI=1S/C6H14N2O2/c7-4-2-1-3-5(8)6(9)10/h5H,1-4,7-8H2,(H,9,10)/t5-/m0/s1

InChI Key

KDXKERNSBIXSRK-YFKPBYRVSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as l-alpha-amino acids. These are alpha amino acids which have the L-configuration of the alpha-carbon atom.

Kingdom

Organic compounds

Super Class

Organic acids and derivatives

Class

Carboxylic acids and derivatives

Sub Class

Amino acids, peptides, and analogues

Direct Parent

L-alpha-amino acids

Alternative Parents

Substituents

L-alpha-amino acid
Medium-chain fatty acid
Amino fatty acid
Fatty acid
Fatty acyl
Amino acid
Monocarboxylic acid or derivatives
Carboxylic acid
Organic oxide
Organopnictogen compound
Organic oxygen compound
Primary amine
Organooxygen compound
Organonitrogen compound
Primary aliphatic amine
Carbonyl group
Organic nitrogen compound
Amine
Hydrocarbon derivative
Aliphatic acyclic compound

Molecular Framework

Aliphatic acyclic compounds

External Descriptors

lysine (CHEBI:18019 )
aspartate family amino acid (CHEBI:18019 )
proteinogenic amino acid (CHEBI:18019 )
L-alpha-amino acid (CHEBI:18019 )
Common amino acids (C00047 )

Ontology

Leukemia

Disposition

Route of exposure:

Enteral:

Ingestion

Source:

Food

Synthetic:

Personal care product

Biological:

Animal

Plant:

Biological location:

Role

Industrial application:

Food and nutrition:

Nutritional supplement

Pharmaceutical industry:

Anticonvulsant

Biological role:

Physical Properties

State

Solid

Experimental Properties

Property	Value	Reference
Melting Point	224.5 °C	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	1000 mg/mL	Not Available
logP	-3.05	HANSCH,C ET AL. (1995)

Predicted Properties

Property	Value	Source
logP	-3.8	ALOGPS
logP	-3.2	ChemAxon
logS	-0.14	ALOGPS
pKa (Strongest Acidic)	2.74	ChemAxon
pKa (Strongest Basic)	10.29	ChemAxon
Physiological Charge	1	ChemAxon
Hydrogen Acceptor Count	4	ChemAxon
Hydrogen Donor Count	3	ChemAxon
Polar Surface Area	89.34 Å²	ChemAxon
Rotatable Bond Count	5	ChemAxon
Refractivity	37.81 m³·mol⁻¹	ChemAxon
Polarizability	15.84 Å³	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

EI-MS/GC-MS

Type	Description	Splash Key	View
GC-MS	L-Lysine, 3 TMS, GC-MS Spectrum	splash10-00di-3910000000-98c565675de67aa87900	Spectrum
GC-MS	L-Lysine, non-derivatized, GC-MS Spectrum	splash10-0ab9-1910000000-87ef8534f592041f50f2	Spectrum
GC-MS	L-Lysine, 4 TMS, GC-MS Spectrum	splash10-0a4i-1921000000-84f7815b0f650fa17444	Spectrum
GC-MS	L-Lysine, 3 TMS, GC-MS Spectrum	splash10-001i-9600000000-823408dba509cb204acf	Spectrum
GC-MS	L-Lysine, 3 TMS, GC-MS Spectrum	splash10-00di-3910000000-4f5578af5e7d8b6c49f7	Spectrum
GC-MS	L-Lysine, 4 TMS, GC-MS Spectrum	splash10-0adi-1921000000-4e56d95e623e792f9e6b	Spectrum
GC-MS	L-Lysine, non-derivatized, GC-MS Spectrum	splash10-00di-0921000000-eeb49e57bc1a75193058	Spectrum
GC-MS	L-Lysine, non-derivatized, GC-MS Spectrum	splash10-0ab9-0921000000-ebb902be0f3754225b2f	Spectrum
GC-MS	L-Lysine, non-derivatized, GC-MS Spectrum	splash10-00di-3910000000-98c565675de67aa87900	Spectrum
GC-MS	L-Lysine, non-derivatized, GC-MS Spectrum	splash10-0ab9-1910000000-87ef8534f592041f50f2	Spectrum
GC-MS	L-Lysine, non-derivatized, GC-MS Spectrum	splash10-0fdk-3923000000-15b84c2649c1b0455de1	Spectrum
GC-MS	L-Lysine, non-derivatized, GC-MS Spectrum	splash10-0a4i-1921000000-84f7815b0f650fa17444	Spectrum
GC-MS	L-Lysine, non-derivatized, GC-MS Spectrum	splash10-001i-9600000000-823408dba509cb204acf	Spectrum
GC-MS	L-Lysine, non-derivatized, GC-MS Spectrum	splash10-00di-3910000000-4f5578af5e7d8b6c49f7	Spectrum
GC-MS	L-Lysine, non-derivatized, GC-MS Spectrum	splash10-0adi-1921000000-4e56d95e623e792f9e6b	Spectrum
GC-MS	L-Lysine, non-derivatized, GC-MS Spectrum	splash10-0abi-1900000000-9ad174122e4d6e003eb8	Spectrum
Predicted GC-MS	L-Lysine, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	splash10-0089-9100000000-974cc55c9130ed5213eb	Spectrum
Predicted GC-MS	L-Lysine, 1 TMS, Predicted GC-MS Spectrum - 70eV, Positive	splash10-0ue9-9700000000-57b24ae819b6ec26bfd2	Spectrum
Predicted GC-MS	L-Lysine, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	L-Lysine, TMS_1_2, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	L-Lysine, TMS_1_3, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	L-Lysine, TBDMS_1_1, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	L-Lysine, TBDMS_1_2, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum
Predicted GC-MS	L-Lysine, TBDMS_1_3, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum

MS/MS

Type	Description	Splash Key	View
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)	splash10-003r-8900000000-470a0beb4f338ed89bca	2012-07-24	View Spectrum
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)	splash10-001i-9000000000-74e9193d9d33c2509bfa	2012-07-24	View Spectrum
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)	splash10-0a59-9000000000-822c4e78250fffa56e39	2012-07-24	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-0002-0900000000-04f9a62a77fb5a37ca22	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-001i-9000000000-035035ecfa084671479b	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-001i-0900000000-5bb15839f86f4fca0d0b	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-001i-0900000000-6c8ef03aa83eb1cab35b	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-01ot-0910000000-c182a7dcdbc260666978	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-0a4j-0900000000-6c5f378cef2f14204e15	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-001i-0900000000-41e1a6499097748934b0	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-ITFT (LTQ Orbitrap XL, Thermo Scientfic) , Positive	splash10-03di-0390000000-7270a0b85b9e3f9f6373	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Negative	splash10-0002-0900000000-a997e809874357908880	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, Negative	splash10-0002-2900000000-f64110414f82c93e1fe8	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, Negative	splash10-014m-9200000000-33a38e6370811c5ddc82	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 40V, Negative	splash10-0006-9000000000-3a8b0b6e62f5c66d3720	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 50V, Negative	splash10-0006-9000000000-d5167570d11d77fd541e	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Positive	splash10-0002-0900000000-a46231bd529176101129	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, Positive	splash10-001i-9200000000-f8b9f01b2a9886c51df9	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, Positive	splash10-001i-9000000000-ace0361476d939043e98	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 40V, Positive	splash10-001i-9000000000-5b06b6e9dcf9faf8e89c	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 50V, Positive	splash10-053r-9000000000-2894ef6d7f72ea71688e	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - CE-ESI-TOF (CE-system connected to 6210 Time-of-Flight MS, Agilent) , Positive	splash10-0002-0900000000-290902f43cf851e8ef5e	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Positive	splash10-001i-9300000000-f81193f6b50235ec8147	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Positive	splash10-001i-9300000000-8931d2193adab166d5e4	2012-08-31	View Spectrum
MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Negative	splash10-0002-0900000000-b4825cc64fcb830c6967	2012-08-31	View Spectrum

NMR

Type	Description	View
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, experimental)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 125 MHz, H₂O, experimental)	Spectrum
1D NMR	¹H NMR Spectrum (1D, D₂O, experimental)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, H₂O, experimental)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 400 MHz, H₂O, experimental)	Spectrum
2D NMR	[¹H, ¹H]-TOCSY. Unexported temporarily by An Chi on Oct 15, 2021 until json or nmrML file is generated. 2D NMR Spectrum (experimental)	Spectrum
2D NMR	[¹H, ¹³C]-HSQC NMR Spectrum (2D, 600 MHz, H₂O, experimental)	Spectrum

Pathways

Name	SMPDB/Pathwhiz	KEGG
Transcription/Translation	Not Available	Not Available
Lysine Degradation
Biotin Metabolism
Carnitine Synthesis		Not Available
Biotinidase Deficiency		Not Available

Protein Targets

Enzymes

Protein Name	Gene Name	Locus	Uniprot ID	Details
Histone-lysine N-methyltransferase, H3 lysine-79 specific	DOT1L	19p13.3	Q8TEK3	details
Histone-lysine N-methyltransferase SETD7	SETD7	4q28	Q8WTS6	details
Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific	NSD1	5q35	Q96L73	details
Histone-lysine N-methyltransferase SETDB1	SETDB1	1q21	Q15047	details
Histone-lysine N-methyltransferase EHMT2	EHMT2	6p21.31	Q96KQ7	details
Histone-lysine N-methyltransferase EHMT1	EHMT1	9q34.3	Q9H9B1	details
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1	PLOD1	1p36.22	Q02809	details
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2	PLOD2	3q24	O00469	details
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3	PLOD3	7q22	O60568	details
Biotinidase	BTD	3p25	P43251	details
Lysine--tRNA ligase	KARS	16q23.1	Q15046	details
Alpha-aminoadipic semialdehyde synthase, mitochondrial	AASS	7q31.3	Q9UDR5	details
Histone-lysine N-methyltransferase MLL	MLL	11q23	Q03164	details
Histone-lysine N-methyltransferase MLL3	MLL3	7q36.1	Q8NEZ4	details
Aminoadipate-semialdehyde synthase	AASS	7q31.3	A4D0W4	details
Carnosine synthase 1	CARNS1	11q13.2	A5YM72	details
Histone-lysine N-methyltransferase EZH2	EZH2	7q35-q36	Q15910	details
Histone-lysine N-methyltransferase MLL2	MLL2	12q13.12	O14686	details
Histone-lysine N-methyltransferase MLL4	WBP7	19q13.1	Q9UMN6	details
Histone-lysine N-methyltransferase NSD2	WHSC1	4p16.3	O96028	details
Histone-lysine N-methyltransferase NSD3	WHSC1L1	8p11.2	Q9BZ95	details
Histone-lysine N-methyltransferase SETD2	SETD2	3p21.31	Q9BYW2	details
Lysine-specific demethylase 2A	KDM2A	11q13.2	Q9Y2K7	details
Lysine-specific demethylase 2B	KDM2B	12q24.31	Q8NHM5	details

Transporters

Protein Name	Gene Name	Locus	Uniprot ID	Details
Histone-lysine N-methyltransferase MLL	MLL	11q23	Q03164	details

Metal Bindings

Protein Name	Gene Name	Locus	Uniprot ID	Details
Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific	NSD1	5q35	Q96L73	details
Histone-lysine N-methyltransferase SETDB1	SETDB1	1q21	Q15047	details
Histone-lysine N-methyltransferase EHMT2	EHMT2	6p21.31	Q96KQ7	details
Histone-lysine N-methyltransferase EHMT1	EHMT1	9q34.3	Q9H9B1	details
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1	PLOD1	1p36.22	Q02809	details
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2	PLOD2	3q24	O00469	details
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3	PLOD3	7q22	O60568	details
Lysine--tRNA ligase	KARS	16q23.1	Q15046	details
PR domain zinc finger protein 2	PRDM2	1p36.21	Q13029	details
Histone-lysine N-methyltransferase MLL	MLL	11q23	Q03164	details
Histone-lysine N-methyltransferase MLL3	MLL3	7q36.1	Q8NEZ4	details
Carnosine synthase 1	CARNS1	11q13.2	A5YM72	details
Histone-lysine N-methyltransferase MLL2	MLL2	12q13.12	O14686	details
Histone-lysine N-methyltransferase MLL4	WBP7	19q13.1	Q9UMN6	details
Histone-lysine N-methyltransferase NSD2	WHSC1	4p16.3	O96028	details
Histone-lysine N-methyltransferase NSD3	WHSC1L1	8p11.2	Q9BZ95	details
Histone-lysine N-methyltransferase SETD2	SETD2	3p21.31	Q9BYW2	details
Lysine-specific demethylase 2A	KDM2A	11q13.2	Q9Y2K7	details
Lysine-specific demethylase 2B	KDM2B	12q24.31	Q8NHM5	details

Receptors

Protein Name	Gene Name	Locus	Uniprot ID	Details
Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific	NSD1	5q35	Q96L73	details
Histone-lysine N-methyltransferase EZH2	EZH2	7q35-q36	Q15910	details
Histone-lysine N-methyltransferase MLL2	MLL2	12q13.12	O14686	details

Transcriptional Factors

Protein Name	Gene Name	Locus	Uniprot ID	Details
Histone-lysine N-methyltransferase, H3 lysine-79 specific	DOT1L	19p13.3	Q8TEK3	details
Histone-lysine N-methyltransferase SETD7	SETD7	4q28	Q8WTS6	details
Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific	NSD1	5q35	Q96L73	details
Histone-lysine N-methyltransferase SETDB1	SETDB1	1q21	Q15047	details
Histone-lysine N-methyltransferase EHMT2	EHMT2	6p21.31	Q96KQ7	details
Histone-lysine N-methyltransferase EHMT1	EHMT1	9q34.3	Q9H9B1	details
PR domain zinc finger protein 2	PRDM2	1p36.21	Q13029	details
Histone-lysine N-methyltransferase MLL	MLL	11q23	Q03164	details
Histone-lysine N-methyltransferase MLL3	MLL3	7q36.1	Q8NEZ4	details
Histone-lysine N-methyltransferase EZH2	EZH2	7q35-q36	Q15910	details
Histone-lysine N-methyltransferase MLL2	MLL2	12q13.12	O14686	details
Histone-lysine N-methyltransferase MLL4	WBP7	19q13.1	Q9UMN6	details
Histone-lysine N-methyltransferase NSD2	WHSC1	4p16.3	O96028	details
Histone-lysine N-methyltransferase NSD3	WHSC1L1	8p11.2	Q9BZ95	details
Histone-lysine N-methyltransferase SETD2	SETD2	3p21.31	Q9BYW2	details
Lysine-specific demethylase 2A	KDM2A	11q13.2	Q9Y2K7	details
Lysine-specific demethylase 2B	KDM2B	12q24.31	Q8NHM5	details

Concentrations Data

Not Available

External Links

HMDB ID

HMDB0000182

DrugBank ID

DB00123

Phenol Explorer Compound ID

Not Available

FoodDB ID

KNApSAcK ID

Chemspider ID

KEGG Compound ID

BioCyc ID

BiGG ID

Wikipedia Link

METLIN ID

PubChem Compound

PDB ID

ChEBI ID

References

General References

Turner CE, Elsohly MA, Boeren EG: Constituents of Cannabis sativa L. XVII. A review of the natural constituents. J Nat Prod. 1980 Mar-Apr;43(2):169-234. doi: 10.1021/np50008a001. [PubMed:6991645 ]

Only showing the first 10 proteins. There are 64 proteins in total.

Show All

Enzymes

Enzyme Details

1. Histone-lysine N-methyltransferase, H3 lysine-79 specific

General function:: Involved in DNA binding
Specific function:: Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA.
Gene Name:: DOT1L
Uniprot ID:: Q8TEK3
Molecular weight:: 164854.41

Enzyme Details

2. Histone-lysine N-methyltransferase SETD7

General function:: Involved in histone-lysine N-methyltransferase activity
Specific function:: Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation.
Gene Name:: SETD7
Uniprot ID:: Q8WTS6
Molecular weight:: 40720.595

Enzyme Details

3. Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific

General function:: Involved in histone-lysine N-methyltransferase activity
Specific function:: Histone methyltransferase. Preferentially methylates 'Lys-36' of histone H3 and 'Lys-20' of histone H4 (in vitro). Transcriptional intermediary factor capable of both negatively or positively influencing transcription, depending on the cellular context.
Gene Name:: NSD1
Uniprot ID:: Q96L73
Molecular weight:: 296649.335

Enzyme Details

4. Histone-lysine N-methyltransferase SETDB1

General function:: Involved in DNA binding
Specific function:: Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. H3 'Lys-9' trimethylation is coordinated with DNA methylation. Probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1. SETDB1 is targeted to histone H3 by TRIM28/TIF1B, a factor recruited by KRAB zinc-finger proteins.
Gene Name:: SETDB1
Uniprot ID:: Q15047
Molecular weight:: 143155.6

Enzyme Details

5. Histone-lysine N-methyltransferase EHMT2

General function:: Involved in zinc ion binding
Specific function:: Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. May also methylate histone H1. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53. Also methylates CDYL, WIZ, ACIN1, DNMT1, HDAC1, ERCC6, KLF12 and itself.
Gene Name:: EHMT2
Uniprot ID:: Q96KQ7
Molecular weight:: 132369.205

Enzyme Details

6. Histone-lysine N-methyltransferase EHMT1

General function:: Involved in zinc ion binding
Specific function:: Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. During G0 phase, it probably contributes to silencing of MYC- and E2F-responsive genes, suggesting a role in G0/G1 transition in cell cycle. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys-373' of p53/TP53.
Gene Name:: EHMT1
Uniprot ID:: Q9H9B1
Molecular weight:: 86702.845

Enzyme Details

7. Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1

General function:: Involved in oxidoreductase activity
Specific function:: Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links.
Gene Name:: PLOD1
Uniprot ID:: Q02809
Molecular weight:: 83549.55

Enzyme Details

8. Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2

General function:: Involved in oxidoreductase activity
Specific function:: Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links.
Gene Name:: PLOD2
Uniprot ID:: O00469
Molecular weight:: 84685.07

Enzyme Details

9. Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3

General function:: Involved in oxidoreductase activity
Specific function:: Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links.
Gene Name:: PLOD3
Uniprot ID:: O60568
Molecular weight:: 84784.505

Enzyme Details

10. Biotinidase

General function:: Involved in hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
Specific function:: Catalytic release of biotin from biocytin, the product of biotin-dependent carboxylases degradation.
Gene Name:: BTD
Uniprot ID:: P43251
Molecular weight:: 61132.43

Transporters

Enzyme Details

1. Histone-lysine N-methyltransferase MLL

General function:: Involved in DNA binding
Specific function:: Histone methyltransferase that plays an essential role in early development and hematopoiesis. Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac). In the MLL1/MLL complex, it specifically mediates H3K4me, a specific tag for epigenetic transcriptional activation. Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity. Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9'. Required for transcriptional activation of HOXA9. Promotes PPP1R15A-induced apoptosis.
Gene Name:: MLL
Uniprot ID:: Q03164
Molecular weight:: 432047.735

Only showing the first 10 proteins. There are 64 proteins in total.

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Showing Compound Card for L-Lysine (CDB004816)

Structure for CDB004816 (L-Lysine)

Enzymes

Transporters