Cannabis Compound Database: Showing Compound Card for MG(0:0/16:0/0:0) (CDB000797)

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Identification Taxonomy Ontology Physical properties Spectra Protein target Pathways Concentrations Links References enzymes (8) Show 9 proteins XML

Record Information

Version

1.0

Created at

2020-03-30 17:43:25 UTC

Updated at

2020-12-07 19:07:46 UTC

CannabisDB ID

CDB000797

Secondary Accession Numbers

Not Available

Cannabis Compound Identification

Common Name

MG(0:0/16:0/0:0)

Description

MG(0:0/16:0/0:0) belongs to the family of monoradyglycerols, which are glycerolipids lipids containing a common glycerol backbone to which at one fatty acyl group is attached. Their general formula is [R1]OCC(CO[R2])O[R3]. MG(0:0/16:0/0:0) is made up of one hexadecanoyl(R2). This compound is expected to be in Cannabis as all living plants are known to produce and metabolize it.

Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
1,3-Dihydroxypropan-2-yl palmitate	ChEBI
2-Hexadecanoylglycerol	ChEBI
2-Monopalmitin	ChEBI
2-Monopalmitoylglycerol	ChEBI
2-O-Palmitoylglycerol	ChEBI
MG (0:0/16:0/0:0)	ChEBI
1,3-Dihydroxypropan-2-yl palmitic acid	Generator
1-Monoacylglyceride	HMDB
1-Monoacylglycerol	HMDB
2-Hexadecanoyl-rac-glycerol	HMDB
2-Palmitoyl-glycerol	HMDB
b-Monoacylglycerol	HMDB
beta-Monoacylglycerol	HMDB
MAG(0:0/16:0)	HMDB
MAG(16:0)	HMDB
MG(0:0/16:0)	HMDB
MG(16:0)	HMDB
2-Palm-GL	HMDB
2-Palmitoylglycerol	MeSH

Chemical Formula

C₁₉H₃₈O₄

Average Molecular Weight

330.5

Monoisotopic Molecular Weight

330.277

IUPAC Name

1,3-dihydroxypropan-2-yl hexadecanoate

Traditional Name

1,3-dihydroxypropan-2-yl hexadecanoate

CAS Registry Number

Not Available

SMILES

[H]C(CO)(CO)OC(=O)CCCCCCCCCCCCCCC

InChI Identifier

InChI=1S/C19H38O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-19(22)23-18(16-20)17-21/h18,20-21H,2-17H2,1H3

InChI Key

BBNYCLAREVXOSG-UHFFFAOYSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as 2-monoacylglycerols. These are monoacylglycerols containing a glycerol acylated at the 2-position.

Kingdom

Organic compounds

Super Class

Lipids and lipid-like molecules

Class

Glycerolipids

Sub Class

Monoradylglycerols

Direct Parent

2-monoacylglycerols

Alternative Parents

Substituents

2-acyl-sn-glycerol
Fatty acid ester
Fatty acyl
Carboxylic acid ester
Monocarboxylic acid or derivatives
Carboxylic acid derivative
Organic oxygen compound
Organic oxide
Hydrocarbon derivative
Primary alcohol
Organooxygen compound
Carbonyl group
Alcohol
Aliphatic acyclic compound

Molecular Framework

Aliphatic acyclic compounds

External Descriptors

2-monoglyceride (CHEBI:75455 )
Monoacylglycerols (LMGL01010025 )
a monoacylglycerol (CPD66-43 )

Ontology

Disposition

Route of exposure:

Enteral:

Ingestion

Source:

Biological:

Animal

Biological location:

Tissue and substructures:

All tissues

Cell and elements:

Extracellular

Subcellular:

Role

Industrial application:

Biological role:

Physical Properties

State

Solid

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
logP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	5.77	ALOGPS
logP	5.08	ChemAxon
logS	-4.9	ALOGPS
pKa (Strongest Acidic)	14.28	ChemAxon
pKa (Strongest Basic)	-3	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	3	ChemAxon
Hydrogen Donor Count	2	ChemAxon
Polar Surface Area	66.76 Å²	ChemAxon
Rotatable Bond Count	18	ChemAxon
Refractivity	94.11 m³·mol⁻¹	ChemAxon
Polarizability	42.12 Å³	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	No	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	Yes	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Spectra

EI-MS/GC-MS

Type	Description	Splash Key	View
GC-MS	MG(0:0/16:0/0:0), non-derivatized, GC-MS Spectrum	splash10-0fba-1920000000-134607514f54b5fa383a	Spectrum
GC-MS	MG(0:0/16:0/0:0), non-derivatized, GC-MS Spectrum	splash10-0fba-1920000000-134607514f54b5fa383a	Spectrum
Predicted GC-MS	MG(0:0/16:0/0:0), 2 TMS, Predicted GC-MS Spectrum - 70eV, Positive	splash10-0fy9-8690000000-42e670eb7d2b93c2cf13	Spectrum
Predicted GC-MS	MG(0:0/16:0/0:0), non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	Not Available	Spectrum

MS/MS

Type	Description	Splash Key	View
MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF 35V, positive	splash10-0abd-9201000000-13c26a3dfbe9c2c0ee82	2020-07-21	View Spectrum
MS/MS	LC-MS/MS Spectrum - Orbitrap 0V, positive	splash10-001i-0009000000-3fbc80e8b1a6c4769b57	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - n/a 23V, positive	splash10-03di-0009000000-ab66c5fcbc1ccb42abd0	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - n/a 23V, positive	splash10-0a4i-2590000000-fbd516b957b730aa1e61	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - n/a 23V, positive	splash10-014i-9000000000-fb41d95361a6747c1394	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - Orbitrap 9V, positive	splash10-03di-3009000000-1461fc327f550f36fd64	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - Orbitrap 11V, positive	splash10-08fr-9105000000-5ff0ac490f9e9eb2fd3a	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - Orbitrap 13V, positive	splash10-0ab9-9101000000-543e82e44e10c0bafe1b	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - Orbitrap 16V, positive	splash10-0a4i-9000000000-42345c34104efaffa9e5	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - Orbitrap 18V, positive	splash10-0a4i-9000000000-10f9ae2324888d282fe8	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - Orbitrap 20V, positive	splash10-0a4i-9000000000-168d6d9e105e242d5381	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - Orbitrap 24V, positive	splash10-0a4i-9000000000-788ea5a75eccdebbb706	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - Orbitrap 30V, positive	splash10-0a4i-9000000000-f5d8bcb715bb7c4eec96	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - Orbitrap 36V, positive	splash10-0a4i-9000000000-bebf6a01d91a3cefd039	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - Orbitrap 44V, positive	splash10-0a4i-9000000000-158d88e5fdd09f1bfc44	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - Orbitrap 53V, positive	splash10-0a4i-9000000000-e48e57dbfb8d67f5c722	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - n/a 23V, positive	splash10-0a4i-3890000000-dc3e6fa9504ad7732b36	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - n/a 23V, positive	splash10-014i-9000000000-fb41d95361a6747c1394	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - n/a 23V, positive	splash10-0kps-4910000000-366e65362ec66509aff9	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - n/a 23V, positive	splash10-0f79-2910000000-96991d9805c0c30dbaf4	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - n/a 23V, positive	splash10-004i-9000000000-2b3b5490150f8c42c1ef	2020-07-22	View Spectrum
MS/MS	LC-MS/MS Spectrum - 35V, Positive	splash10-0a4m-9201000000-1493642eda69722aa926	2021-09-20	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-0002-0009000000-88db68411e5bedb3a55c	2017-10-04	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-001k-0009000000-3ea7f1cea75ce9907e95	2017-10-04	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-00f2-0049000000-f01e41d62e6fdf3b791b	2017-10-04	View Spectrum

NMR

Not Available

Pathways

Name	SMPDB/Pathwhiz	KEGG
Glycerolipid Metabolism
Glycerol Kinase Deficiency		Not Available
D-glyceric acidura		Not Available
Familial lipoprotein lipase deficiency		Not Available

Protein Targets

Enzymes

Protein Name	Gene Name	Locus	Uniprot ID	Details
Monoglyceride lipase	MGLL		Q99685	details
Hormone-sensitive lipase	LIPE	19q13.2	Q05469	details
2-acylglycerol O-acyltransferase 2	MOGAT2	11q13.5	Q3SYC2	details
2-acylglycerol O-acyltransferase 1	MOGAT1	2q36.1	Q96PD6	details
2-acylglycerol O-acyltransferase 3	MOGAT3	7q22.1	Q86VF5	details
Lysophosphatidic acid phosphatase type 6	ACP6	1q21	Q9NPH0	details
Acylglycerol kinase, mitochondrial	AGK	7q34	Q53H12	details
Ectonucleotide pyrophosphatase/phosphodiesterase family member 6	ENPP6	4q35.1	Q6UWR7	details

Transporters

Not Available

Metal Bindings

Not Available

Receptors

Protein Name	Gene Name	Locus	Uniprot ID	Details
Acylglycerol kinase, mitochondrial	AGK	7q34	Q53H12	details

Transcriptional Factors

Not Available

Concentrations Data

Not Available

External Links

HMDB ID

HMDB0011533

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FoodDB ID

FDB003077

KNApSAcK ID

Not Available

Chemspider ID

110006

KEGG Compound ID

Not Available

BioCyc ID

Not Available

BiGG ID

Not Available

Wikipedia Link

Not Available

METLIN ID

Not Available

PubChem Compound

123409

PDB ID

Not Available

ChEBI ID

75455

References

General References

Not Available

Enzymes

Enzyme Details

1. Monoglyceride lipase

General function:: Lipid transport and metabolism
Specific function:: Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain (By similarity). Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth.
Gene Name:: MGLL
Uniprot ID:: Q99685
Molecular weight:: Not Available

Enzyme Details

2. Hormone-sensitive lipase

General function:: Involved in hydrolase activity
Specific function:: In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production.
Gene Name:: LIPE
Uniprot ID:: Q05469
Molecular weight:: 116596.715

Enzyme Details

3. 2-acylglycerol O-acyltransferase 2

General function:: Involved in transferase activity, transferring acyl groups other than amino-acyl groups
Specific function:: Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Has a preference toward monoacylglycerols containing unsaturated fatty acids in an order of C18:3 > C18:2 > C18:1 > C18:0. Plays a central role in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes. May play a role in diet-induced obesity.
Gene Name:: MOGAT2
Uniprot ID:: Q3SYC2
Molecular weight:: 38195.285

Enzyme Details

4. 2-acylglycerol O-acyltransferase 1

General function:: Involved in transferase activity, transferring acyl groups other than amino-acyl groups
Specific function:: Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Probably not involved in absorption of dietary fat in the small intestine (By similarity).
Gene Name:: MOGAT1
Uniprot ID:: Q96PD6
Molecular weight:: 38812.19

Enzyme Details

5. 2-acylglycerol O-acyltransferase 3

General function:: Involved in transferase activity, transferring acyl groups other than amino-acyl groups
Specific function:: Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Also able to catalyze the terminal step in triacylglycerol synthesis by using diacylglycerol and fatty acyl-CoA as substrates. Has a preference toward palmitoyl-CoA and oleoyl-CoA. May be involved in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes.
Gene Name:: MOGAT3
Uniprot ID:: Q86VF5
Molecular weight:: 38729.84

Enzyme Details

6. Lysophosphatidic acid phosphatase type 6

General function:: Involved in acid phosphatase activity
Specific function:: Hydrolyzes lysophosphatidic acid to monoacylglycerol.
Gene Name:: ACP6
Uniprot ID:: Q9NPH0
Molecular weight:: 48853.955

Enzyme Details

7. Acylglycerol kinase, mitochondrial

General function:: Involved in NAD+ kinase activity
Specific function:: Lipid kinase that can phosphorylate both monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively. Does not phosphorylate sphingosine. Overexpression increases the formation and secretion of LPA, resulting in transactivation of EGFR and activation of the downstream MAPK signaling pathway, leading to increased cell growth
Gene Name:: AGK
Uniprot ID:: Q53H12
Molecular weight:: 47136.8

Enzyme Details

8. Ectonucleotide pyrophosphatase/phosphodiesterase family member 6

General function:: Involved in catalytic activity
Specific function:: Choline-specific glycerophosphodiester phosphodiesterase. The preferred substrate may be lysosphingomyelin (By similarity). Hydrolyzes lysophosphatidylcholine (LPC) to form monoacylglycerol and phosphorylcholine but not lysophosphatidic acid, showing it has a lysophospholipase C activity. Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. Also hydrolyzes glycerophosphorylcholine and sphingosylphosphorylcholine efficiently. Hydrolyzes the classical substrate for phospholipase C, p-nitrophenyl phosphorylcholine in vitro, while it does not hydrolyze the classical nucleotide phosphodiesterase substrate, p-nitrophenyl thymidine 5'-monophosphate. Does not hydrolyze diacyl phospholipids such as phosphatidylethanolamine, phosphatidylinositol, phosphatidylserine, phosphatidylglycerol and phosphatidic acid.
Gene Name:: ENPP6
Uniprot ID:: Q6UWR7
Molecular weight:: 50240.625

Showing Compound Card for MG(0:0/16:0/0:0) (CDB000797)

Structure for CDB000797 (MG(0:0/16:0/0:0))

Enzymes