| Identification |
|---|
| HMDB Protein ID
| CDBP00308 |
| Secondary Accession Numbers
| Not Available |
| Name
| Monoglyceride lipase |
| Description
| Not Available |
| Synonyms
|
- HU-K5
- Lysophospholipase homolog
- Lysophospholipase-like
- MGL
- Monoacylglycerol lipase
- MAGL
|
| Gene Name
| MGLL |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Lipid transport and metabolism |
| Specific Function
| Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain (By similarity). Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth.
|
| GO Classification
|
| Biological Process |
| platelet activation |
| inflammatory response |
| arachidonic acid metabolic process |
| acylglycerol acyl-chain remodeling |
| triglyceride catabolic process |
| long term synaptic depression |
| glycerophospholipid biosynthetic process |
| regulation of endocannabinoid signaling pathway |
| fatty acid biosynthetic process |
| regulation of sensory perception of pain |
| regulation of inflammatory response |
| Cellular Component |
| endoplasmic reticulum membrane |
| plasma membrane |
| synapse |
| Molecular Function |
| acylglycerol lipase activity |
| lysophospholipase activity |
| lipid binding |
| carboxylesterase activity |
|
| Cellular Location
|
Not Available
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | triacylglycerol degradation | Not Available | Not Available | | Retrograde endocannabinoid signaling | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| MGLL |
| Gene Sequence
|
>912 bp
ATGCCAGAGGAAAGTTCCCCCAGGCGGACCCCGCAGAGCATTCCCTACCAGGACCTCCCT
CACCTGGTCAATGCAGACGGACAGTACCTCTTCTGCAGGTACTGGAAACCCACAGGCACA
CCCAAGGCCCTCATCTTTGTGTCCCATGGAGCCGGAGAGCACAGTGGCCGCTATGAAGAG
CTGGCTCGGATGCTGATGGGGCTGGACCTGCTGGTGTTCGCCCACGACCATGTTGGCCAC
GGACAGAGCGAAGGGGAGAGGATGGTAGTGTCTGACTTCCACGTTTTCGTCAGGGATGTG
TTGCAGCATGTGGATTCCATGCAGAAAGACTACCCTGGGCTTCCTGTCTTCCTTCTGGGC
CACTCCATGGGAGGCGCCATCGCCATCCTCACGGCCGCAGAGAGGCCGGGCCACTTCGCC
GGCATGGTACTCATTTCGCCTCTGGTTCTTGCCAATCCTGAATCTGCAACAACTTTCAAG
GTCCTTGCTGCGAAAGTGCTCAACCTTGTGCTGCCAAACTTGTCCCTCGGGCCCATCGAC
TCCAGCGTGCTCTCTCGGAATAAGACAGAGGTCGACATTTATAACTCAGACCCCCTGATC
TGCCGGGCAGGGCTGAAGGTGTGCTTCGGCATCCAACTGCTGAATGCCGTCTCACGGGTG
GAGCGCGCCCTCCCCAAGCTGACTGTGCCCTTCCTGCTGCTCCAGGGCTCTGCCGATCGC
CTATGTGACAGCAAAGGGGCCTACCTGCTCATGGAGTTAGCCAAGAGCCAGGACAAGACT
CTCAAGATTTATGAAGGTGCCTACCATGTTCTCCACAAGGAGCTTCCTGAAGTCACCAAC
TCCGTCTTCCATGAAATAAACATGTGGGTCTCTCAAAGGACAGCCACGGCAGGAACTGCG
TCCCCACCCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 303 |
| Molecular Weight
| Not Available |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Monoglyceride lipase
MPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEE
LARMLMGLDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDVLQHVDSMQKDYPGLPVFLLG
HSMGGAIAILTAAERPGHFAGMVLISPLVLANPESATTFKVLAAKVLNLVLPNLSLGPID
SSVLSRNKTEVDIYNSDPLICRAGLKVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADR
LCDSKGAYLLMELAKSQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWVSQRTATAGTA
SPP
|
| External Links |
|---|
| GenBank ID Protein
| 14594904 |
| UniProtKB/Swiss-Prot ID
| Q99685 |
| UniProtKB/Swiss-Prot Entry Name
| MGLL_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AJ270950 |
| GeneCard ID
| MGLL |
| GenAtlas ID
| MGLL |
| HGNC ID
| HGNC:17038 |
| References |
|---|
| General References
| Not Available |