Identification |
HMDB Protein ID
| CDBP04936 |
Secondary Accession Numbers
| Not Available |
Name
| Ectonucleotide pyrophosphatase/phosphodiesterase family member 6 |
Description
| Not Available |
Synonyms
|
- E-NPP 6
- Ectonucleotide pyrophosphatase/phosphodiesterase family member 6 soluble form
- NPP-6
- Choline-specific glycerophosphodiester phosphodiesterase
- Glycerophosphocholine cholinephosphodiesterase
- GPC-Cpde
|
Gene Name
| ENPP6 |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in catalytic activity |
Specific Function
| Choline-specific glycerophosphodiester phosphodiesterase. The preferred substrate may be lysosphingomyelin (By similarity). Hydrolyzes lysophosphatidylcholine (LPC) to form monoacylglycerol and phosphorylcholine but not lysophosphatidic acid, showing it has a lysophospholipase C activity. Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. Also hydrolyzes glycerophosphorylcholine and sphingosylphosphorylcholine efficiently. Hydrolyzes the classical substrate for phospholipase C, p-nitrophenyl phosphorylcholine in vitro, while it does not hydrolyze the classical nucleotide phosphodiesterase substrate, p-nitrophenyl thymidine 5'-monophosphate. Does not hydrolyze diacyl phospholipids such as phosphatidylethanolamine, phosphatidylinositol, phosphatidylserine, phosphatidylglycerol and phosphatidic acid.
|
GO Classification
|
Biological Process |
choline metabolic process |
lipid catabolic process |
lipid metabolic process |
Cellular Component |
plasma membrane |
extracellular region |
integral to membrane |
Function |
catalytic activity |
Molecular Function |
glycerophosphocholine cholinephosphodiesterase activity |
glycerophosphodiester phosphodiesterase activity |
Process |
metabolic process |
|
Cellular Location
|
- Cell membrane
- Secreted
- Single-pass type I membrane protein (Probable)
|
Pathways
|
Name | SMPDB/Pathwhiz | KEGG | Ether lipid metabolism | Not Available | ![Map00565](https://www.genome.jp/kegg/misc/thumbnail/map00565.gif) |
|
Gene Properties |
Chromosome Location
| 4 |
Locus
| 4q35.1 |
SNPs
| ENPP6 |
Gene Sequence
|
>1323 bp
ATGGCAGTGAAGCTTGGGACCCTCCTGCTGGCCCTTGCCCTGGGCCTGGCCCAGCCAGCC
TCTGCCCGCCGGAAGCTGCTGGTGTTTCTGCTGGATGGTTTTCGCTCAGACTACATCAGT
GATGAGGCGCTGGAGTCATTGCCTGGTTTCAAAGAGATTGTGAGCAGGGGAGTAAAAGTG
GATTACTTGACTCCAGACTTCCCTAGTCTCTCGTATCCCAATTATTATACCCTAATGACT
GGCCGCCATTGTGAAGTCCATCAGATGATCGGGAACTACATGTGGGACCCCACCACCAAC
AAGTCCTTTGACATTGGCGTCAACAAAGACAGCCTAATGCCTCTCTGGTGGAATGGATCA
GAACCTCTGTGGGTCACTCTGACCAAGGCCAAAAGGAAGGTCTACATGTACTACTGGCCA
GGCTGTGAGGTTGAGATTCTGGGTGTCAGACCCACCTACTGCCTAGAATATAAAAATGTC
CCAACGGATATCAATTTTGCCAATGCAGTCAGCGATGCTCTTGACTCCTTCAAGAGTGGC
CGGGCCGACCTGGCAGCCATATACCATGAGCGCATTGACGTGGAAGGCCACCACTACGGG
CCTGCATCTCCGCAGAGGAAAGATGCCCTCAAGGCTGTAGACACTGTCCTGAAGTACATG
ACCAAGTGGATCCAGGAGCGGGGCCTGCAGGACCGCCTGAACGTCATTATTTTCTCGGAT
CACGGAATGACCGACATTTTCTGGATGGACAAAGTGATTGAGCTGAATAAGTACATCAGC
CTGAATGACCTGCAGCAAGTGAAGGACCGCGGGCCTGTTGTGAGCCTTTGGCCGGCCCCT
GGGAAACACTCTGAGATATATAACAAACTGAGCACAGTGGAACACATGACTGTCTACGAG
AAAGAAGCCATCCCAAGCAGGTTCTATTACAAGAAAGGAAAGTTTGTCTCTCCTTTGACT
TTAGTGGCTGATGAAGGCTGGTTCATAACTGAGAATCGAGAGATGCTTCCGTTTTGGATG
AACAGCACCGGCAGGCGGGAAGGTTGGCAGCGTGGATGGCACGGCTACGACAACGAGCTC
ATGGACATGCGGGGCATCTTCCTGGCCTTCGGACCTGATTTCAAATCCAACTTCAGAGCT
GCTCCTATCAGGTCGGTGGACGTCTACAATGTCATGTGCAATGTGGTGGGCATCACCCCG
CTGCCCAACAACGGATCCTGGTCCAGGGTGATGTGCATGCTGAAGGGCCGCGCCAGCACT
GCCCCGCCTGTCTGGCCCAGCCACTGTGCCCTGGCACTGATTCTTCTCTTCCTGCTTGCA
TAA
|
Protein Properties |
Number of Residues
| 440 |
Molecular Weight
| 50240.625 |
Theoretical pI
| 7.981 |
Pfam Domain Function
|
|
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>Ectonucleotide pyrophosphatase/phosphodiesterase family member 6
MAVKLGTLLLALALGLAQPASARRKLLVFLLDGFRSDYISDEALESLPGFKEIVSRGVKV
DYLTPDFPSLSYPNYYTLMTGRHCEVHQMIGNYMWDPTTNKSFDIGVNKDSLMPLWWNGS
EPLWVTLTKAKRKVYMYYWPGCEVEILGVRPTYCLEYKNVPTDINFANAVSDALDSFKSG
RADLAAIYHERIDVEGHHYGPASPQRKDALKAVDTVLKYMTKWIQERGLQDRLNVIIFSD
HGMTDIFWMDKVIELNKYISLNDLQQVKDRGPVVSLWPAPGKHSEIYNKLSTVEHMTVYE
KEAIPSRFYYKKGKFVSPLTLVADEGWFITENREMLPFWMNSTGRREGWQRGWHGYDNEL
MDMRGIFLAFGPDFKSNFRAAPIRSVDVYNVMCNVVGITPLPNNGSWSRVMCMLKGRAST
APPVWPSHCALALILLFLLA
|
External Links |
GenBank ID Protein
| 16553045 |
UniProtKB/Swiss-Prot ID
| Q6UWR7 |
UniProtKB/Swiss-Prot Entry Name
| ENPP6_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| AK057370 |
GeneCard ID
| ENPP6 |
GenAtlas ID
| ENPP6 |
HGNC ID
| HGNC:23409 |
References |
General References
| Not Available |