| Identification |
|---|
| HMDB Protein ID
| CDBP05658 |
| Secondary Accession Numbers
| Not Available |
| Name
| Taste receptor type 2 member 8 |
| Description
| Not Available |
| Synonyms
|
Not Available
|
| Gene Name
| TAS2R8 |
| Protein Type
| Receptor |
| Biological Properties |
|---|
| General Function
| taste receptor activity |
| Specific Function
| Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5. |
| GO Classification
|
| Biological Process |
| G-protein coupled receptor signaling pathway |
| detection of chemical stimulus involved in sensory perception of bitter taste |
| Cellular Component |
| plasma membrane |
| integral to membrane |
| Molecular Function |
| G protein-coupled receptor activity |
| taste receptor activity |
| bitter taste receptor activity |
|
| Cellular Location
|
- Membrane
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 12 |
| Locus
| 12p13.2 |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 309 |
| Molecular Weight
| 35876.93 |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
- ["8-28", "51-71", "83-103", "132-152", "185-205", "240-260", "267-287"]
|
| Protein Sequence
|
>Taste receptor type 2 member 8
MFSPADNIFIILITGEFILGILGNGYIALVNWIDWIKKKKISTVDYILTNLVIARICLIS
VMVVNGIVIVLNPDVYTKNKQQIVIFTFWTFANYLNMWITTCLNVFYFLKIASSSHPLFL
WLKWKIDMVVHWILLGCFAISLLVSLIAAIVLSCDYRFHAIAKHKRNITEMFHVSKIPYF
EPLTLFNLFAIVPFIVSLISFFLLVRSLWRHTKQIKLYATGSRDPSTEVHVRAIKTMTSF
IFFFFLYYISSILMTFSYLMTKYKLAVEFGEIAAILYPLGHSLILIVLNNKLRQTFVRML
TCRKIACMI
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q9NYW2 |
| UniProtKB/Swiss-Prot Entry Name
| TA2R8_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| HGNC:14915 |
| References |
|---|
| General References
| Not Available |