Identification
HMDB Protein ID CDBP05651
Secondary Accession Numbers Not Available
Name Taste receptor type 2 member 46
Description Not Available
Synonyms Not Available
Gene Name TAS2R46
Protein Type Receptor
Biological Properties
General Function G protein-coupled receptor activity
Specific Function Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 (By similarity). In airway epithelial cells, binding of bitter compounds increases the intracellular calcium ion concentration and stimulates ciliary beat frequency (By similarity).
GO Classification
Biological Process
G-protein coupled receptor signaling pathway
detection of chemical stimulus involved in sensory perception of bitter taste
Cellular Component
plasma membrane
integral to membrane
ciliary membrane
Molecular Function
bitter taste receptor activity
G protein-coupled receptor activity
Cellular Location
  1. Membrane
  2. Cell projection
  3. cilium membrane
Pathways
Gene Properties
Chromosome Location 12
Locus 12p13.2
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 309
Molecular Weight 35522.27
Theoretical pI Not Available
Pfam Domain Function
Signals Not Available
Transmembrane Regions
  • ["2-22", "47-67", "87-107", "127-147", "179-199", "230-250", "260-280"]
Protein Sequence
>Taste receptor type 2 member 46
MITFLPIIFSILIVVTFVIGNFANGFIALVNSIEWFKRQKISFADQILTALAVSRVGLLW
VLVLNWYATELNPAFNSIEVRITAYNVWAVINHFSNWLATSLSIFYLLKIANFSNLIFLH
LKRRVKSVVLVILLGPLLFLVCHLFVINMNQIIWTKEYEGNMTWKIKLRSAMYLSNTTVT
ILANLVPFTLTLISFLLLICSLCKHLKKMQLHGKGSQDPSMKVHIKALQTVTSFLLLCAI
YFLSIIMSVWSFESLENKPVFMFCEAIAFSYPSTHPFILIWGNKKLKQTFLSVLWHVRYW
VKGEKPSSS
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P59540
UniProtKB/Swiss-Prot Entry Name T2R46_HUMAN
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID HGNC:18877
References
General References Not Available