| Identification |
|---|
| HMDB Protein ID
| CDBP05622 |
| Secondary Accession Numbers
| Not Available |
| Name
| Microtubule-associated proteins 1A/1B light chain 3B |
| Description
| Not Available |
| Synonyms
|
Not Available
|
| Gene Name
| MAP1LC3B |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| ubiquitin protein ligase binding |
| Specific Function
| Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. While LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway. Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover (PubMed:31006538, PubMed:31006537). |
| GO Classification
|
| Biological Process |
| autophagosome assembly |
| cellular response to starvation |
| autophagosome maturation |
| autophagy |
| autophagy of mitochondrion |
| cellular response to nitrogen starvation |
| macroautophagy |
| Cellular Component |
| intracellular membrane-bounded organelle |
| autophagosome |
| axoneme |
| cytosol |
| intracellular |
| mitochondrion |
| autophagic vacuole membrane |
| organelle membrane |
| endomembrane system |
| cytoplasmic vesicle |
| microtubule |
| Molecular Function |
| microtubule binding |
| ubiquitin protein ligase binding |
|
| Cellular Location
|
- Cytoplasm
- Endomembrane system
- Cytoplasmic vesicle
- cytoskeleton
- autophagosome membrane
- Autophagosome
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 16 |
| Locus
| 16q24.2 |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 125 |
| Molecular Weight
| 14687.94 |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Microtubule-associated proteins 1A/1B light chain 3B
MPSEKTFKQRRTFEQRVEDVRLIREQHPTKIPVIIERYKGEKQLPVLDKTKFLVPDHVNM
SELIKIIRRRLQLNANQAFFLLVNGHSMVSVSTPISEVYESEKDEDGFLYMVYASQETFG
MKLSV
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q9GZQ8 |
| UniProtKB/Swiss-Prot Entry Name
| MLP3B_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| HGNC:13352 |
| References |
|---|
| General References
| Not Available |