| Identification |
|---|
| HMDB Protein ID
| CDBP05610 |
| Secondary Accession Numbers
| Not Available |
| Name
| ER degradation-enhancing alpha-mannosidase-like protein 1 |
| Description
| Not Available |
| Synonyms
|
Not Available
|
| Gene Name
| EDEM1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| misfolded protein binding |
| Specific Function
| Extracts misfolded glycoproteins, but not glycoproteins undergoing productive folding, from the calnexin cycle. It is directly involved in endoplasmic reticulum-associated degradation (ERAD) and targets misfolded glycoproteins for degradation in an N-glycan-independent manner, probably by forming a complex with SEL1L. It has low mannosidase activity, catalyzing mannose trimming from Man8GlcNAc2 to Man7GlcNAc2. |
| GO Classification
|
| Biological Process |
| ubiquitin-dependent glycoprotein ERAD pathway |
| ER-associated protein catabolic process |
| IRE1-mediated unfolded protein response |
| mannose trimming involved in glycoprotein ERAD pathway |
| positive regulation of retrograde protein transport, ER to cytosol |
| trimming of terminal mannose on C branch |
| Cellular Component |
| endoplasmic reticulum |
| integral to endoplasmic reticulum membrane |
| endoplasmic reticulum quality control compartment |
| aggresome |
| Molecular Function |
| mannosyl-oligosaccharide 1,2-alpha-mannosidase activity |
| calcium ion binding |
| misfolded protein binding |
|
| Cellular Location
|
- Endoplasmic reticulum membrane
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 3 |
| Locus
| 3p26.1 |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 657 |
| Molecular Weight
| 73767.5 |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>ER degradation-enhancing alpha-mannosidase-like protein 1
MQWRALVLGLVLLRLGLHGVLWLVFGLGPSMGFYQRFPLSFGFQRLRSPDGPASPTSGPV
GRPGGVSGPSWLQPPGTGAAQSPRKAPRRPGPGMCGPANWGYVLGGRGRGPDEYEKRYSG
AFPPQLRAQMRDLARGMFVFGYDNYMAHAFPQDELNPIHCRGRGPDRGDPSNLNINDVLG
NYSLTLVDALDTLAIMGNSSEFQKAVKLVINTVSFDKDSTVQVFEATIRVLGSLLSAHRI
ITDSKQPFGDMTIKDYDNELLYMAHDLAVRLLPAFENTKTGIPYPRVNLKTGVPPDTNNE
TCTAGAGSLLVEFGILSRLLGDSTFEWVARRAVKALWNLRSNDTGLLGNVVNIQTGHWVG
KQSGLGAGLDSFYEYLLKSYILFGEKEDLEMFNAAYQSIQNYLRRGREACNEGEGDPPLY
VNVNMFSGQLMNTWIDSLQAFFPGLQVLIGDVEDAICLHAFYYAIWKRYGALPERYNWQL
QAPDVLFYPLRPELVESTYLLYQATKNPFYLHVGMDILQSLEKYTKVKCGYATLHHVIDK
STEDRMESFFLSETCKYLYLLFDEDNPVHKSGTRYMFTTEGHIVSVDEHLRELPWKEFFS
EEGGQDQGGKSVHRPKPHELKVINSSSNCNRVPDERRYSLPLKSIYMRQIDQMVGLI
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q92611 |
| UniProtKB/Swiss-Prot Entry Name
| EDEM1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| HGNC:18967 |
| References |
|---|
| General References
| Not Available |