Showing Protein Glycosaminoglycan xylosylkinase (CDBP05561)
| Identification | |||||||||
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| HMDB Protein ID | CDBP05561 | ||||||||
| Secondary Accession Numbers | Not Available | ||||||||
| Name | Glycosaminoglycan xylosylkinase | ||||||||
| Description | Not Available | ||||||||
| Synonyms |
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| Gene Name | FAM20B | ||||||||
| Protein Type | Enzyme | ||||||||
| Biological Properties | |||||||||
| General Function | Not Available | ||||||||
| Specific Function | Responsible for the 2-O-phosphorylation of xylose in the glycosaminoglycan-protein linkage region of proteoglycans thereby regulating the amount of mature GAG chains. Sulfated glycosaminoglycans (GAGs), including heparan sulfate and chondroitin sulfate, are synthesized on the so-called common GAG-protein linkage region (GlcUAbeta1-3Galbeta1-3Galbeta1-4Xylbeta1-O-Ser) of core proteins, which is formed by the stepwise addition of monosaccharide residues by the respective specific glycosyltransferases. Xylose 2-o-phosphorylation may influence the catalytic activity of B3GAT3 (GlcAT-I) which completes the precursor tetrasaccharide of GAG-protein linkage regions on which the repeating disaccharide region is synthesized. | ||||||||
| GO Classification |
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| Cellular Location | Not Available | ||||||||
| Pathways | Not Available | ||||||||
| Gene Properties | |||||||||
| Chromosome Location | 1 | ||||||||
| Locus | 1q25 | ||||||||
| SNPs | Not Available | ||||||||
| Gene Sequence | Not Available | ||||||||
| Protein Properties | |||||||||
| Number of Residues | Not Available | ||||||||
| Molecular Weight | 46432.04 | ||||||||
| Theoretical pI | 6.88 | ||||||||
| Pfam Domain Function |
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| Signals | Not Available | ||||||||
| Transmembrane Regions | Not Available | ||||||||
| Protein Sequence |
>gi|7662150|ref|NP_055679.1| glycosaminoglycan xylosylkinase [Homo sapiens] MKLKQRVVLLAILLVIFIFTKVFLIDNLDTSAANREDQRAFHRMMTGLRVELAPKLDHTL QSPWEIAAQW |
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| External Links | |||||||||
| GenBank ID Protein | Not Available | ||||||||
| UniProtKB/Swiss-Prot ID | O75063 | ||||||||
| UniProtKB/Swiss-Prot Entry Name | Not Available | ||||||||
| PDB IDs | Not Available | ||||||||
| GenBank Gene ID | Not Available | ||||||||
| GeneCard ID | Not Available | ||||||||
| GenAtlas ID | Not Available | ||||||||
| HGNC ID | HGNC:23017 | ||||||||
| References | |||||||||
| General References | Not Available | ||||||||