Cannabis Compound Database: Showing Protein Transitional endoplasmic reticulum ATPase (CDBP05523)

Identification Biological properties Gene properties Protein properties External links References XML Show 3 compounds

Identification

HMDB Protein ID

CDBP05523

Secondary Accession Numbers

Not Available

Name

Transitional endoplasmic reticulum ATPase

Description

Not Available

Synonyms

TER ATPase
15S Mg(2+)-ATPase p97 subunit
Valosin-containing protein
VCP

Gene Name

VCP

Protein Type

Enzyme

Biological Properties

General Function

Not Available

Specific Function

Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1L-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope. Regulates E3 ubiquitin-protein ligase activity of RNF19A (By similarity). Component of the VCP/p97-AMFR/gp78 complex that participates in the final step of the sterol-mediated ubiquitination and endoplasmic reticulum-associated degradation (ERAD) of HMGCR. Also involved in DNA damage response: recruited to double-strand breaks (DSBs) sites in a RNF8- and RNF168-dependent manner and promotes the recruitment of TP53BP1 at DNA damage sites. Recruited to stalled replication forks by SPRTN: may act by mediating extraction of DNA polymerase eta (POLH) to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage.

GO Classification

Biological Process
activation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
ER to Golgi vesicle-mediated transport
double-strand break repair
protein N-linked glycosylation via asparagine
endoplasmic reticulum unfolded protein response
protein homooligomerization
translesion synthesis
ER-associated protein catabolic process
aggresome assembly
positive regulation of protein complex assembly
retrograde protein transport, ER to cytosol
protein ubiquitination
Cellular Component
nucleus
proteasome complex
cytosol
site of double-strand break
endoplasmic reticulum
Molecular Function
lipid binding
ATP binding
ATPase activity
polyubiquitin binding

Cellular Location

Not Available

Pathways

Name	SMPDB/Pathwhiz	KEGG
Protein processing in endoplasmic reticulum	Not Available
Legionellosis	Not Available

Gene Properties

Chromosome Location

Locus

9p13.3

SNPs

Not Available

Gene Sequence

Not Available

Protein Properties

Number of Residues

Not Available

Molecular Weight

89320.885

Theoretical pI

5.267

Pfam Domain Function

Not Available

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>gi|6005942|ref|NP_009057.1| transitional endoplasmic reticulum ATPase [Homo sapiens]
MASGADSKGDDLSTAILKQKNRPNRLIVDEAINEDNSVVSLSQPKMDELQLFRGDTVLLK
GKKRREAVCI

External Links

GenBank ID Protein

Not Available

UniProtKB/Swiss-Prot ID

P55072

UniProtKB/Swiss-Prot Entry Name

Not Available

PDB IDs

GenBank Gene ID

Not Available

GeneCard ID

Not Available

GenAtlas ID

Not Available

HGNC ID

HGNC:12666

References

General References

Not Available