| Identification |
|---|
| HMDB Protein ID
| CDBP05481 |
| Secondary Accession Numbers
| Not Available |
| Name
| RuvB-like 1 |
| Description
| Not Available |
| Synonyms
|
- 49 kDa TATA box-binding protein-interacting protein
- 54 kDa erythrocyte cytosolic protein
- INO80 complex subunit H
- Nuclear matrix protein 238
- Pontin 52
- TIP49a
- TIP60-associated protein 54-alpha
- 49 kDa TBP-interacting protein
- ECP-54
- NMP 238
- TAP54-alpha
|
| Gene Name
| RUVBL1 |
| Protein Type
| Transcription Factor |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity; hexamerization is thought to be critical for ATP hydrolysis and adjacent subunits in the ring-like structure contribute to the ATPase activity.
Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage.
Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.
Plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex. Essential for cell proliferation.
May be able to bind plasminogen at cell surface and enhance plasminogen activation.
|
| GO Classification
|
| Biological Process |
| mitosis |
| DNA recombination |
| spermatogenesis |
| cell division |
| CENP-A containing nucleosome assembly at centromere |
| histone H2A acetylation |
| DNA repair |
| histone H4 acetylation |
| regulation of transcription from RNA polymerase II promoter |
| transcription, DNA-dependent |
| regulation of growth |
| Cellular Component |
| NuA4 histone acetyltransferase complex |
| Golgi apparatus |
| nuclear matrix |
| Ino80 complex |
| MLL1 complex |
| membrane |
| microtubule organizing center |
| Molecular Function |
| ATP binding |
| DNA helicase activity |
|
| Cellular Location
|
Not Available
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Wnt signaling pathway | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 3 |
| Locus
| 3q21 |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 50227.605 |
| Theoretical pI
| 6.418 |
| Pfam Domain Function
|
Not Available |
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>gi|4506753|ref|NP_003698.1| ruvB-like 1 [Homo sapiens]
MKIEEVKSTTKTQRIASHSHVKGLGLDESGLAKQAASGLVGQENAREACGVIVELIKSKK
MAGRAVLLAG
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q9Y265 |
| UniProtKB/Swiss-Prot Entry Name
| Not Available |
| PDB IDs
|
|
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| HGNC:10474 |
| References |
|---|
| General References
| Not Available |