Identification
HMDB Protein ID CDBP05373
Secondary Accession Numbers Not Available
Name DNA helicase MCM9
Description Not Available
Synonyms
  1. hMCM9
  2. Mini-chromosome maintenance deficient domain-containing protein 1
  3. Minichromosome maintenance 9
Gene Name MCM9
Protein Type Enzyme
Biological Properties
General Function Not Available
Specific Function Component of the MCM8-MCM9 complex, a complex involved in homologous recombination repair following DNA interstrand cross-links and plays a key role during gametogenesis. The MCM8-MCM9 complex probably acts as a hexameric helicase downstream of the Fanconi anemia proteins BRCA2 and RAD51 and is required to process aberrant forks into homologous recombination substrates and to orchestrate homologous recombination with resection, fork stabilization and fork restart.
GO Classification
Biological Process
DNA replication
double-strand break repair via homologous recombination
female gamete generation
Cellular Component
nucleus
MCM8-MCM9 complex
Molecular Function
ATP binding
DNA binding
helicase activity
Cellular Location Not Available
Pathways
Gene Properties
Chromosome Location 6
Locus 6q22.31
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues Not Available
Molecular Weight 127311.57
Theoretical pI 7.732
Pfam Domain Function Not Available
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>gi|312284070|ref|NP_060166.2| DNA helicase MCM9 isoform 1 [Homo sapiens]
MNSDQVTLVGQVFESYVSEYHKNDILLILKERDEDAHYPVVVNAMTLFETNMEIGEYFNM
FPSEVLTIFD
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q9NXL9
UniProtKB/Swiss-Prot Entry Name Not Available
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID HGNC:21484
References
General References Not Available