Identification
HMDB Protein ID CDBP05370
Secondary Accession Numbers Not Available
Name DNA replication licensing factor MCM4
Description Not Available
Synonyms
  1. CDC21 homolog
  2. P1-CDC21
Gene Name MCM4
Protein Type Enzyme
Biological Properties
General Function Not Available
Specific Function Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.
GO Classification
Biological Process
DNA strand elongation involved in DNA replication
DNA replication initiation
M/G1 transition of mitotic cell cycle
DNA unwinding involved in replication
S phase of mitotic cell cycle
G1/S transition of mitotic cell cycle
cell cycle checkpoint
Cellular Component
nucleoplasm
MCM complex
Molecular Function
ATP binding
single-stranded DNA binding
DNA helicase activity
Cellular Location Not Available
Pathways
Gene Properties
Chromosome Location 8
Locus 8q11.2
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues Not Available
Molecular Weight 96556.97
Theoretical pI 6.735
Pfam Domain Function Not Available
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>gi|33469919|ref|NP_005905.2| DNA replication licensing factor MCM4 [Homo sapiens]
MSSPASTPSRRGSRRGRATPAQTPRSEDARSSPSQRRRGEDSTSTGELQPMPTSPGVDLQ
SPAAQDVLFS
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P33991
UniProtKB/Swiss-Prot Entry Name Not Available
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID HGNC:6947
References
General References Not Available