| Identification |
|---|
| HMDB Protein ID
| CDBP05339 |
| Secondary Accession Numbers
| Not Available |
| Name
| HRAS-like suppressor 3 |
| Description
| Not Available |
| Synonyms
|
- HRSL3
- Adipose-specific phospholipase A2
- Group XVI phospholipase A1/A2
- H-rev 107 protein homolog
- HRAS-like suppressor 1
- HREV107-1
- HREV107-3
- Renal carcinoma antigen NY-REN-65
- AdPLA
|
| Gene Name
| PLA2G16 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Exhibits PLA1/2 activity, catalyzing the calcium-independent hydrolysis of acyl groups in various phosphotidylcholines (PC) and phosphatidylethanolamine (PE). For most substrates, PLA1 activity is much higher than PLA2 activity. Specifically catalyzes the release of fatty acids from phospholipids in adipose tissue (By similarity). N- and O-acylation activity is hardly detectable. Might decrease protein phosphatase 2A (PP2A) activity.
|
| GO Classification
|
| Biological Process |
| phosphatidylinositol acyl-chain remodeling |
| phosphatidylserine acyl-chain remodeling |
| lipid catabolic process |
| glycerophospholipid biosynthetic process |
| negative regulation of cell cycle |
| phosphatidylcholine acyl-chain remodeling |
| phosphatidylethanolamine acyl-chain remodeling |
| Cellular Component |
| cytosol |
| endoplasmic reticulum |
| perinuclear region of cytoplasm |
| integral to membrane |
| Molecular Function |
| 1-acyl-2-lysophosphatidylserine acylhydrolase activity |
| phosphatidylcholine 1-acylhydrolase activity |
| phosphatidylserine 1-acylhydrolase activity |
| phospholipase A2 activity |
|
| Cellular Location
|
Not Available
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Glycerophospholipid metabolism | Not Available |  | | Ether lipid metabolism | Not Available |  | | Linoleic acid metabolism | Not Available |  | | alpha-Linolenic acid metabolism | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 11 |
| Locus
| 11q12.3 |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 17936.515 |
| Theoretical pI
| 7.98 |
| Pfam Domain Function
|
Not Available |
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>gi|189571621|ref|NP_001121675.1| HRAS-like suppressor 3 [Homo sapiens]
MRAPIPEPKPGDLIEIFRPFYRHWAIYVGDGYVVHLAPPSEVAGAGAASVMSALTDKAIV
KKELLYDVAG
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P53816 |
| UniProtKB/Swiss-Prot Entry Name
| Not Available |
| PDB IDs
|
|
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| HGNC:17825 |
| References |
|---|
| General References
| Not Available |