Identification
HMDB Protein ID CDBP05285
Secondary Accession Numbers Not Available
Name TFIIH basal transcription factor complex helicase XPB subunit
Description Not Available
Synonyms
  1. Basic transcription factor 2 89 kDa subunit
  2. DNA excision repair protein ERCC-3
  3. DNA repair protein complementing XP-B cells
  4. TFIIH basal transcription factor complex 89 kDa subunit
  5. Xeroderma pigmentosum group B-complementing protein
  6. BTF2 p89
  7. TFIIH 89 kDa subunit
  8. TFIIH p89
Gene Name ERCC3
Protein Type Enzyme
Biological Properties
General Function Not Available
Specific Function ATP-dependent 3'-5' DNA helicase, component of the core-TFIIH basal transcription factor, involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. Acts by opening DNA either around the RNA transcription start site or the DNA damage.
GO Classification
Biological Process
induction of apoptosis
virus-host interaction
transcription-coupled nucleotide-excision repair
viral reproduction
response to oxidative stress
positive regulation of transcription from RNA polymerase II promoter
7-methylguanosine mRNA capping
UV protection
cell cycle checkpoint
response to hypoxia
protein localization
positive regulation of viral transcription
hair cell differentiation
transcription elongation from RNA polymerase II promoter
nucleotide-excision repair, DNA damage removal
transcription initiation from RNA polymerase II promoter
nucleotide-excision repair, DNA incision
termination of RNA polymerase I transcription
transcription elongation from RNA polymerase I promoter
transcription initiation from RNA polymerase I promoter
response to UV
DNA topological change
nucleotide-excision repair, DNA duplex unwinding
Cellular Component
holo TFIIH complex
SSL2-core TFIIH complex
Molecular Function
dATP binding
RNA polymerase II carboxy-terminal domain kinase activity
damaged DNA binding
ATPase activity
GTP binding
ATP binding
transcription factor binding
ATP-dependent DNA helicase activity
peptide binding
3'-5' DNA helicase activity
Cellular Location Not Available
Pathways
Gene Properties
Chromosome Location 2
Locus 2q21
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues Not Available
Molecular Weight 89276.985
Theoretical pI 7.227
Pfam Domain Function Not Available
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>gi|4557563|ref|NP_000113.1| TFIIH basal transcription factor complex helicase XPB subunit [Homo sapiens]
MGKRDRADRDKKKSRKRHYEDEEDDEEDAPGNDPQEAVPSAAGKQVDESGTKVDEYGAKD
YRLQMPLKDD
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P19447
UniProtKB/Swiss-Prot Entry Name Not Available
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID HGNC:3435
References
General References Not Available