Showing Protein Dual specificity protein phosphatase 26 (CDBP05275)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 compounds
Identification
HMDB Protein ID CDBP05275
Secondary Accession Numbers Not Available
Name Dual specificity protein phosphatase 26
Description Not Available
Synonyms
  1. Dual specificity phosphatase SKRP3
  2. Low-molecular-mass dual-specificity phosphatase 4
  3. Mitogen-activated protein kinase phosphatase 8
  4. Novel amplified gene in thyroid anaplastic cancer
  5. DSP-4
  6. LDP-4
  7. MAP kinase phosphatase 8
  8. MKP-8
Gene Name DUSP26
Protein Type Enzyme
Biological Properties
General Function Not Available
Specific Function Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK).
GO Classification
Biological Process
peptidyl-tyrosine dephosphorylation
Cellular Component
mitochondrion
Golgi apparatus
nucleus
Molecular Function
protein tyrosine/serine/threonine phosphatase activity
protein tyrosine phosphatase activity
Cellular Location Not Available
Pathways
Gene Properties
Chromosome Location 8
Locus 8p12
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues Not Available
Molecular Weight 23945.38
Theoretical pI 9.607
Pfam Domain Function Not Available
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence 
>gi|13128968|ref|NP_076930.1| dual specificity protein phosphatase 26 [Homo sapiens]
MCPGNWLWASMTFMARFSRSSSRSPVRTRGTLEEMPTVQHPFLNVFELERLLYTGKTACN
HADEVWPGLY
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q9BV47
UniProtKB/Swiss-Prot Entry Name Not Available
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID HGNC:28161
References
General References Not Available