Identification |
HMDB Protein ID
| CDBP05273 |
Secondary Accession Numbers
| Not Available |
Name
| Dual specificity protein phosphatase 22 |
Description
| Not Available |
Synonyms
|
- JNK-stimulatory phosphatase-1
- Low molecular weight dual specificity phosphatase 2
- Mitogen-activated protein kinase phosphatase x
- JSP-1
- LMW-DSP2
- MAP kinase phosphatase x
- MKP-x
|
Gene Name
| DUSP22 |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Not Available |
Specific Function
| Activates the Jnk signaling pathway. Dephosphorylates and deactivates p38 and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) (By similarity).
|
GO Classification
|
Biological Process |
multicellular organismal development |
regulation of cell proliferation |
apoptotic process |
cell proliferation |
negative regulation of transcription from RNA polymerase II promoter |
inactivation of MAPK activity |
positive regulation of JNK cascade |
transforming growth factor beta receptor signaling pathway |
peptidyl-tyrosine dephosphorylation |
Cellular Component |
nucleus |
cytoplasm |
Molecular Function |
protein tyrosine/serine/threonine phosphatase activity |
protein tyrosine phosphatase activity |
|
Cellular Location
|
Not Available
|
Pathways
|
Name | SMPDB/Pathwhiz | KEGG | MAPK signaling pathway | Not Available | ![Map04010](https://www.genome.jp/kegg/misc/thumbnail/map04010.gif) |
|
Gene Properties |
Chromosome Location
| 6 |
Locus
| 6p25.3 |
SNPs
| Not Available |
Gene Sequence
|
Not Available
|
Protein Properties |
Number of Residues
| Not Available |
Molecular Weight
| 20909.845 |
Theoretical pI
| 8.105 |
Pfam Domain Function
|
Not Available |
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>gi|9910432|ref|NP_064570.1| dual specificity protein phosphatase 22 [Homo sapiens]
MGNGMNKILPGLYIGNFKDARDAEQLSKNKVTHILSVHDSARPMLEGVKYLCIPAADSPS
QNLTRHFKES
|
External Links |
GenBank ID Protein
| Not Available |
UniProtKB/Swiss-Prot ID
| Q9NRW4 |
UniProtKB/Swiss-Prot Entry Name
| Not Available |
PDB IDs
|
|
GenBank Gene ID
| Not Available |
GeneCard ID
| Not Available |
GenAtlas ID
| Not Available |
HGNC ID
| HGNC:16077 |
References |
General References
| Not Available |