Identification |
HMDB Protein ID
| CDBP05242 |
Secondary Accession Numbers
| Not Available |
Name
| Probable ATP-dependent RNA helicase DDX5 |
Description
| Not Available |
Synonyms
|
- DEAD box protein 5
- RNA helicase p68
|
Gene Name
| DDX5 |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Not Available |
Specific Function
| Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for estrogen receptor ESR1 and androgen receptor AR. Increases ESR1 AF-1 domain-mediated transactivation and ESR1 AF-1 and AF-2 domains transcriptional synergistic activity. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation. Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis. Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation. Acts as transcriptional repressor in a promoter-specicic manner; the function probbaly involves association with histone deacetylases, such as HDAC1.
|
GO Classification
|
Biological Process |
regulation of viral genome replication |
negative regulation of transcription from RNA polymerase II promoter |
positive regulation of transcription from RNA polymerase II promoter |
transcription, DNA-dependent |
positive regulation of intracellular estrogen receptor signaling pathway |
regulation of skeletal muscle cell differentiation |
in utero embryonic development |
mRNA splicing, via spliceosome |
cell growth |
intrinsic apoptotic signaling pathway by p53 class mediator |
positive regulation of DNA damage response, signal transduction by p53 class mediator |
regulation of alternative mRNA splicing, via spliceosome |
regulation of androgen receptor signaling pathway |
regulation of osteoblast differentiation |
Cellular Component |
nucleolus |
catalytic step 2 spliceosome |
Molecular Function |
RNA helicase activity |
ATP-dependent RNA helicase activity |
ATP binding |
estrogen receptor binding |
transcription coactivator activity |
androgen receptor binding |
pre-mRNA binding |
|
Cellular Location
|
Not Available
|
Pathways
|
Name | SMPDB/Pathwhiz | KEGG | Spliceosome | Not Available | | Transcriptional misregulation in cancer | Not Available | | Proteoglycans in cancer | Not Available | |
|
Gene Properties |
Chromosome Location
| 17 |
Locus
| 17q21 |
SNPs
| Not Available |
Gene Sequence
|
Not Available
|
Protein Properties |
Number of Residues
| Not Available |
Molecular Weight
| 69147.585 |
Theoretical pI
| 8.924 |
Pfam Domain Function
|
|
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>gi|4758138|ref|NP_004387.1| probable ATP-dependent RNA helicase DDX5 [Homo sapiens]
MSGYSSDRDRGRDRGFGAPRFGGSRAGPLSGKKFGNPGEKLVKKKWNLDELPKFEKNFYQ
EHPDLARRTA
|
External Links |
GenBank ID Protein
| Not Available |
UniProtKB/Swiss-Prot ID
| P17844 |
UniProtKB/Swiss-Prot Entry Name
| Not Available |
PDB IDs
|
|
GenBank Gene ID
| Not Available |
GeneCard ID
| Not Available |
GenAtlas ID
| Not Available |
HGNC ID
| HGNC:2746 |
References |
General References
| Not Available |