Identification |
HMDB Protein ID
| CDBP05227 |
Secondary Accession Numbers
| Not Available |
Name
| ATP-dependent RNA helicase DDX42 |
Description
| Not Available |
Synonyms
|
- DEAD box protein 42
- RNA helicase-like protein
- RNA helicase-related protein
- SF3b DEAD box protein
- Splicing factor 3B-associated 125 kDa protein
- RHELP
- RNAHP
- SF3b125
|
Gene Name
| DDX42 |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Not Available |
Specific Function
| ATP-dependent RNA helicase. Binds to partially double-stranded RNAs (dsRNAs) in order to unwind RNA secondary structures. Unwinding is promoted in the presence of single-strand binding proteins. Mediates also RNA duplex formation thereby displacing the single-strand RNA binding protein. ATP and ADP modulate its activity: ATP binding and hydrolysis by DDX42 triggers RNA strand separation, whereas the ADP-bound form of the protein triggers annealing of complementary RNA strands. Involved in the survival of cells by interacting with TP53BP2 and thereby counteracting the apoptosis-stimulating activity of TP53BP2. Relocalizes TP53BP2 to the cytoplasm.
|
GO Classification
|
Biological Process |
protein localization |
Cellular Component |
cytoplasm |
nucleus |
Cajal body |
nuclear speck |
Molecular Function |
ATP binding |
ATP-dependent helicase activity |
RNA binding |
|
Cellular Location
|
Not Available
|
Pathways
|
Name | SMPDB/Pathwhiz | KEGG | Spliceosome | Not Available | |
|
Gene Properties |
Chromosome Location
| 17 |
Locus
| 17q23.3 |
SNPs
| Not Available |
Gene Sequence
|
Not Available
|
Protein Properties |
Number of Residues
| Not Available |
Molecular Weight
| 102974.485 |
Theoretical pI
| 7.015 |
Pfam Domain Function
|
Not Available |
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>gi|45446743|ref|NP_031398.2| ATP-dependent RNA helicase DDX42 [Homo sapiens]
MNWNKGGPGTKRGFGFGGFAISAGKKEEPKLPQQSHSAFGATSSSSGFGKSAPPQLPSFY
KIGSKRANFD
|
External Links |
GenBank ID Protein
| Not Available |
UniProtKB/Swiss-Prot ID
| Q86XP3 |
UniProtKB/Swiss-Prot Entry Name
| Not Available |
PDB IDs
|
Not Available |
GenBank Gene ID
| Not Available |
GeneCard ID
| Not Available |
GenAtlas ID
| Not Available |
HGNC ID
| HGNC:18676 |
References |
General References
| Not Available |