Identification |
HMDB Protein ID
| CDBP05213 |
Secondary Accession Numbers
| Not Available |
Name
| Probable ATP-dependent RNA helicase DDX17 |
Description
| Not Available |
Synonyms
|
- DEAD box protein 17
- DEAD box protein p72
- RNA-dependent helicase p72
|
Gene Name
| DDX17 |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Not Available |
Specific Function
| RNA-dependent ATPase activity. Involved in transcriptional regulation. Transcriptional coactivator for estrogen receptor ESR1. Increases ESR1 AF-1 domain-mediated transactivation. Synergizes with DDX5 and SRA1 RNA to activate MYOD1 transcriptional activity and probably involved in skeletal muscle differentiation. Required for zinc-finger antiviral protein ZC3HAV1-mediated mRNA degradation.
|
GO Classification
|
Biological Process |
positive regulation of intracellular estrogen receptor signaling pathway |
regulation of skeletal muscle cell differentiation |
RNA processing |
positive regulation of transcription from RNA polymerase II promoter |
transcription, DNA-dependent |
Cellular Component |
nucleolus |
nucleus |
Molecular Function |
RNA helicase activity |
RNA-dependent ATPase activity |
ATP binding |
ATP-dependent helicase activity |
estrogen receptor binding |
transcription coactivator activity |
RNA binding |
|
Cellular Location
|
Not Available
|
Pathways
|
Not Available
|
Gene Properties |
Chromosome Location
| 22 |
Locus
| 22q13.1 |
SNPs
| Not Available |
Gene Sequence
|
Not Available
|
Protein Properties |
Number of Residues
| Not Available |
Molecular Weight
| 80271.8 |
Theoretical pI
| 8.269 |
Pfam Domain Function
|
Not Available |
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>gi|38201710|ref|NP_006377.2| probable ATP-dependent RNA helicase DDX17 isoform 1 [Homo sapiens]
MPTGFVAPILCVLLPSPTREAATVASATGDSASERESAAPAAAPTAEAPPPSVVTRPEPQ
ALPSPAIRAP
|
External Links |
GenBank ID Protein
| Not Available |
UniProtKB/Swiss-Prot ID
| Q92841 |
UniProtKB/Swiss-Prot Entry Name
| Not Available |
PDB IDs
|
Not Available |
GenBank Gene ID
| Not Available |
GeneCard ID
| Not Available |
GenAtlas ID
| Not Available |
HGNC ID
| HGNC:2740 |
References |
General References
| Not Available |