Identification |
HMDB Protein ID
| CDBP05171 |
Secondary Accession Numbers
| Not Available |
Name
| Activating signal cointegrator 1 complex subunit 3 |
Description
| Not Available |
Synonyms
|
- ASC-1 complex subunit p200
- Helicase, ATP binding 1
- Trip4 complex subunit p200
- ASC1p200
|
Gene Name
| ASCC3 |
Protein Type
| Transcription Factor |
Biological Properties |
General Function
| Not Available |
Specific Function
| 3'-5' DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3, enabling ALKHB3 to process alkylated N3-methylcytosine (3mC) within double-stranded regions. Enhances NF-kappa-B, SRF and AP1 transactivation.
|
GO Classification
|
Biological Process |
cell proliferation |
DNA dealkylation involved in DNA repair |
regulation of transcription, DNA-dependent |
transcription, DNA-dependent |
Cellular Component |
cytoplasm |
nucleus |
Molecular Function |
ATP-dependent 3'-5' DNA helicase activity |
nucleic acid binding |
ATP binding |
|
Cellular Location
|
Not Available
|
Pathways
|
Not Available
|
Gene Properties |
Chromosome Location
| 6 |
Locus
| 6q16 |
SNPs
| Not Available |
Gene Sequence
|
Not Available
|
Protein Properties |
Number of Residues
| Not Available |
Molecular Weight
| 251458.205 |
Theoretical pI
| 7.099 |
Pfam Domain Function
|
|
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>gi|76880486|ref|NP_006819.2| activating signal cointegrator 1 complex subunit 3 isoform a [Homo sapiens]
MALPRLTGALRSFSNVTKQDNYNEEVADLKIKRSKLHEQVLDLGLTWKKIIKFLNEKLEK
SKMQSINEDL
|
External Links |
GenBank ID Protein
| Not Available |
UniProtKB/Swiss-Prot ID
| Q8N3C0 |
UniProtKB/Swiss-Prot Entry Name
| Not Available |
PDB IDs
|
Not Available |
GenBank Gene ID
| Not Available |
GeneCard ID
| Not Available |
GenAtlas ID
| Not Available |
HGNC ID
| HGNC:18697 |
References |
General References
| Not Available |