Identification |
HMDB Protein ID
| CDBP05157 |
Secondary Accession Numbers
| Not Available |
Name
| Activation-induced cytidine deaminase |
Description
| Not Available |
Synonyms
|
- Cytidine aminohydrolase
|
Gene Name
| AICDA |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Not Available |
Specific Function
| Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation, gene conversion, and class-switch recombination in B-lymphocytes. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation.
|
GO Classification
|
Biological Process |
B cell differentiation |
cellular response to lipopolysaccharide |
isotype switching |
mRNA processing |
negative regulation of methylation-dependent chromatin silencing |
somatic diversification of immunoglobulins |
DNA demethylation |
Cellular Component |
cytoplasm |
nucleus |
Molecular Function |
metal ion binding |
cytidine deaminase activity |
zinc ion binding |
|
Cellular Location
|
Not Available
|
Pathways
|
Name | SMPDB/Pathwhiz | KEGG | Intestinal immune network for IgA production | Not Available | | Primary immunodeficiency | Not Available | |
|
Gene Properties |
Chromosome Location
| 12 |
Locus
| 12p13 |
SNPs
| Not Available |
Gene Sequence
|
Not Available
|
Protein Properties |
Number of Residues
| Not Available |
Molecular Weight
| 23953.265 |
Theoretical pI
| 9.394 |
Pfam Domain Function
|
Not Available |
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>gi|10190700|ref|NP_065712.1| activation-induced cytidine deaminase [Homo sapiens]
MDSLLMNRRKFLYQFKNVRWAKGRRETYLCYVVKRRDSATSFSLDFGYLRNKNGCHVELL
FLRYISDWDL
|
External Links |
GenBank ID Protein
| Not Available |
UniProtKB/Swiss-Prot ID
| Q9GZX7 |
UniProtKB/Swiss-Prot Entry Name
| Not Available |
PDB IDs
|
Not Available |
GenBank Gene ID
| Not Available |
GeneCard ID
| Not Available |
GenAtlas ID
| Not Available |
HGNC ID
| HGNC:13203 |
References |
General References
| Not Available |