| Identification |
|---|
| HMDB Protein ID
| CDBP05140 |
| Secondary Accession Numbers
| Not Available |
| Name
| S-acyl fatty acid synthase thioesterase, medium chain |
| Description
| Not Available |
| Synonyms
|
- Oleoyl-ACP hydrolase
- Thioesterase II
- Thioesterase domain-containing protein 1
- Augmented in rheumatoid arthritis 1
- AURA1
|
| Gene Name
| OLAH |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in biosynthetic process |
| Specific Function
| In fatty acid biosynthesis chain termination and release of the free fatty acid product is achieved by hydrolysis of the thio ester by a thioesterase I, a component of the fatty acid synthetase complex. The chain length of the released fatty acid is usually C16. However, in the mammary glands of non-ruminant mammals, and in the uropygial gland of certain waterfowl there exists a second thioesterase which releases medium-chain length fatty acids (C8 to C2) (By similarity).
|
| GO Classification
|
| Biological Process |
| fatty acid biosynthetic process |
| Function |
| hydrolase activity, acting on ester bonds |
| catalytic activity |
| hydrolase activity |
| Molecular Function |
| myristoyl-[acyl-carrier-protein] hydrolase activity |
| oleoyl-[acyl-carrier-protein] hydrolase activity |
| palmitoyl-[acyl-carrier-protein] hydrolase activity |
| Process |
| biosynthetic process |
| metabolic process |
|
| Cellular Location
|
- Cytoplasmic
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 10 |
| Locus
| 10p13 |
| SNPs
| OLAH |
| Gene Sequence
|
>798 bp
ATGGAGAGAGGAGACCAACCTAAGAGAACCAGGAATGAAAACATTTTCAACTGCTTATAC
AAAAACCCTGAGGCAACTTTTAAGCTGATTTGCTTTCCCTGGATGGGAGGTGGCTCCACT
CATTTTGCCAAATGGGGCCAAGATACTCATGATTTGCTGGAAGTGCACTCCTTAAGGCTT
CCTGGAAGAGAAAGCAGAGTTGAAGAACCTCTTGAAAATGACATCTCCCAGTTAGTTGAT
GAAGTTGTTTGTGCTCTGCAGCCAGTCATCCAGGATAAACCATTTGCATTTTTTGGCCAC
AGTATGGGATCCTACATTGCTTTTAGGACTGCACTAGGTCTAAAAGAAAACAATCAACCA
GAACCATTGCATTTATTTTTGTCAAGTGCAACTCCTGTACATTCAAAGGCCTGGCATCGC
ATTCCCAAAGATGATGAATTGTCAGAAGAACAAATAAGTCATTACCTTATGGAATTTGGA
GGCACCCCCAAGCATTTTGCTGAAGCCAAGGAATTTGTGAAACAATGTAGTCCCATCATA
AGGGCAGATCTGAACATTGTTAGAAGTTGCACCTCTAACGTACCATCTAAGGCTGTTCTT
TCCTGTGACTTGACATGTTTTGTTGGATCTGAAGACATAGCAAAGGACATGGAAGCCTGG
AAAGATGTAACCAGTGGAAATGCTAAAATTTACCAGCTTCCAGGGGGTCACTTTTATCTT
CTGGATCCTGCGAACGAGAAATTAATCAAGAACTACATAATCAAGTGTCTAGAAGTATCA
TCGATATCCAATTTTTAG
|
| Protein Properties |
|---|
| Number of Residues
| 265 |
| Molecular Weight
| 29930.82 |
| Theoretical pI
| 6.223 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>S-acyl fatty acid synthase thioesterase, medium chain
MERGDQPKRTRNENIFNCLYKNPEATFKLICFPWMGGGSTHFAKWGQDTHDLLEVHSLRL
PGRESRVEEPLENDISQLVDEVVCALQPVIQDKPFAFFGHSMGSYIAFRTALGLKENNQP
EPLHLFLSSATPVHSKAWHRIPKDDELSEEQISHYLMEFGGTPKHFAEAKEFVKQCSPII
RADLNIVRSCTSNVPSKAVLSCDLTCFVGSEDIAKDMEAWKDVTSGNAKIYQLPGGHFYL
LDPANEKLIKNYIIKCLEVSSISNF
|
| External Links |
|---|
| GenBank ID Protein
| 7023364 |
| UniProtKB/Swiss-Prot ID
| Q9NV23 |
| UniProtKB/Swiss-Prot Entry Name
| SAST_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AK001844 |
| GeneCard ID
| OLAH |
| GenAtlas ID
| OLAH |
| HGNC ID
| HGNC:25625 |
| References |
|---|
| General References
| Not Available |