Identification
HMDB Protein ID CDBP05130
Secondary Accession Numbers Not Available
Name Ubiquitin carboxyl-terminal hydrolase 2
Description Not Available
Synonyms
  1. 41 kDa ubiquitin-specific protease
  2. Deubiquitinating enzyme 2
  3. Ubiquitin thiolesterase 2
  4. Ubiquitin-specific-processing protease 2
Gene Name USP2
Protein Type Enzyme
Biological Properties
General Function Involved in ubiquitin thiolesterase activity
Specific Function Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1. Isoform 1 and isoform 4 possess both ubiquitin-specific peptidase and isopeptidase activities. Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity. Has no deubiquitinase activity against p53/TP53. Prevents MDM2-mediated degradation of MDM4. Plays a role in the G1/S cell-cycle progression in normal and cancer cells. Plays a role in the regulation of myogenic differentiation of embryonic muscle cells
GO Classification
Function
hydrolase activity, acting on ester bonds
catalytic activity
hydrolase activity
ubiquitin thiolesterase activity
thiolester hydrolase activity
Process
ubiquitin-dependent protein catabolic process
metabolic process
catabolic process
macromolecule catabolic process
cellular macromolecule catabolic process
modification-dependent macromolecule catabolic process
modification-dependent protein catabolic process
Cellular Location
  1. Isoform 4:Nucleus
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 11q23.3
SNPs USP2
Gene Sequence
>1818 bp
ATGTCCCAGCTCTCCTCCACCCTGAAGCGCTACACAGAATCGGCCCGCTACACAGATGCC
CACTATGCCAAGTCGGGCTATGGTGCCTACACCCCGTCCTCCTATGGGGCCAATCTGGCT
GCCTCCTTACTGGAGAAGGAGAAACTTGGTTTCAAGCCGGTCCCCACCAGCAGCTTCCTC
ACCCGTCCCCGTACCTATGGCCCCTCCTCCCTCCTGGACTATGACCGGGGCCGCCCCCTG
CTGAGACCCGACATCACTGGGGGTGGTAAGCGGGCAGAGAGCCAGACCCGGGGTACTGAG
CGGCCTTTAGGCAGTGGCCTCAGCGGGGGCAGCGGATTCCCTTATGGAGTGACCAACAAC
TGCCTCAGCTACCTGCCCATCAATGCCTATGACCAGGGGGTGACCCTAACCCAGAAGCTG
GACAGCCAATCAGACCTGGCCCGGGATTTCTCCAGCCTCCGGACCTCAGATAGCTACCGG
ATAGACCCCAGGAACCTGGGCCGCAGCCCCATGCTGGCCCGGACGCGCAAGGAGCTCTGC
ACCCTGCAGGGGCTCTACCAGACAGCCAGCTGCCCTGAATACCTGGTCGACTACCTGGAG
AACTATGGTCGCAAGGGCAGTGCATCTCAGGTGCCCTCCCAGGCCCCTCCCTCACGAGTC
CCTGAAATCATCAGCCCAACCTACCGACCCATTGGCCGCTACACGCTGTGGGAGACGGGA
AAGGGTCAGGCCCCTGGGCCCAGCCGCTCCAGCTCCCCGGGAAGAGACGGCATGAATTCT
AAGAGTGCCCAGGGTCTGGCTGGTCTTCGAAACCTTGGGAACACGTGCTTCATGAACTCA
ATTCTGCAGTGCCTGAGCAACACTCGGGAGTTGAGAGATTACTGCCTCCAGAGGCTCTAC
ATGCGGGACCTGCACCACGGCAGCAATGCACACACAGCCCTCGTGGAAGAGTTTGCAAAA
CTAATTCAGACCATATGGACTTCATCCCCCAATGATGTGGTGAGCCCATCTGAGTTCAAG
ACCCAGATCCAGAGATACGCACCGCGCTTTGTTGGCTATAATCAGCAGGATGCTCAGGAG
TTCCTTCGCTTTCTTCTGGATGGGCTCCATAACGAGGTGAACCGAGTGACACTGAGACCT
AAGTCCAACCCTGAGAACCTCGATCATCTTCCTGATGACGAGAAAGGCCGACAGATGTGG
AGAAAATATCTAGAACGGGAAGACAGTAGGATCGGGGATCTCTTTGTTGGGCAGCTAAAG
AGCTCGCTGACGTGTACAGATTGTGGTTACTGTTCTACGGTCTTCGACCCCTTCTGGGAC
CTCTCACTGCCCATTGCTAAGCGAGGTTATCCTGAGGTGACATTAATGGACTGCATGAGG
CTCTTCACCAAAGAGGATGTGCTTGATGGAGATGAAAAGCCAACATGCTGTCGCTGCCGA
GGCAGAAAACGGTGTATAAAGAAGTTCTCCATCCAGAGGTTCCCAAAGATCTTGGTGCTC
CATCTGAAGCGGTTCTCAGAATCCAGGATCCGAACCAGCAAGCTCACAACATTTGTGAAC
TTCCCCCTAAGAGACCTGGACTTAAGAGAATTTGCCTCAGAAAACACCAACCATGCTGTT
TACAACCTGTACGCTGTGTCCAATCACTCCGGAACCACCATGGGTGGCCACTATACAGCC
TACTGTCGCAGTCCAGGGACAGGAGAATGGCACACTTTCAACGACTCCAGCGTCACTCCC
ATGTCCTCCAGCCAAGTGCGCACCAGCGACGCCTACCTGCTCTTCTACGAACTGGCCAGC
CCGCCCTCCCGAATGTAG
Protein Properties
Number of Residues 605
Molecular Weight 68071.0
Theoretical pI 9.17
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["None"]
Protein Sequence
>Ubiquitin carboxyl-terminal hydrolase 2
MSQLSSTLKRYTESARYTDAHYAKSGYGAYTPSSYGANLAASLLEKEKLGFKPVPTSSFL
TRPRTYGPSSLLDYDRGRPLLRPDITGGGKRAESQTRGTERPLGSGLSGGSGFPYGVTNN
CLSYLPINAYDQGVTLTQKLDSQSDLARDFSSLRTSDSYRIDPRNLGRSPMLARTRKELC
TLQGLYQTASCPEYLVDYLENYGRKGSASQVPSQAPPSRVPEIISPTYRPIGRYTLWETG
KGQAPGPSRSSSPGRDGMNSKSAQGLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQRLY
MRDLHHGSNAHTALVEEFAKLIQTIWTSSPNDVVSPSEFKTQIQRYAPRFVGYNQQDAQE
FLRFLLDGLHNEVNRVTLRPKSNPENLDHLPDDEKGRQMWRKYLEREDSRIGDLFVGQLK
SSLTCTDCGYCSTVFDPFWDLSLPIAKRGYPEVTLMDCMRLFTKEDVLDGDEKPTCCRCR
GRKRCIKKFSIQRFPKILVLHLKRFSESRIRTSKLTTFVNFPLRDLDLREFASENTNHAV
YNLYAVSNHSGTTMGGHYTAYCRSPGTGEWHTFNDSSVTPMSSSQVRTSDAYLLFYELAS
PPSRM
GenBank ID Protein 188528692
UniProtKB/Swiss-Prot ID O75604
UniProtKB/Swiss-Prot Entry Name UBP2_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_004205.4
GeneCard ID USP2
GenAtlas ID USP2
HGNC ID HGNC:12618
References
General References Not Available