| Identification |
|---|
| HMDB Protein ID
| CDBP05127 |
| Secondary Accession Numbers
| Not Available |
| Name
| Tyrosine-protein phosphatase non-receptor type 23 |
| Description
| Not Available |
| Synonyms
|
- HD-PTP
- His domain-containing protein tyrosine phosphatase
- PTP-TD14
- Protein tyrosine phosphatase TD14
|
| Gene Name
| PTPN23 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in phosphatase activity |
| Specific Function
| May act as a negative regulator of Ras-mediated mitogenic activity. Plays a role in ciliogenesis.
|
| GO Classification
|
| Biological Process |
| cilium morphogenesis |
| peptidyl-tyrosine dephosphorylation |
| Cellular Component |
| cilium |
| nucleus |
| microtubule basal body |
| cytoplasmic membrane-bounded vesicle |
| endosome |
| Function |
| hydrolase activity |
| phosphoric ester hydrolase activity |
| phosphatase activity |
| phosphoprotein phosphatase activity |
| protein tyrosine phosphatase activity |
| hydrolase activity, acting on ester bonds |
| catalytic activity |
| Molecular Function |
| protein tyrosine phosphatase activity |
| Process |
| phosphorus metabolic process |
| phosphate metabolic process |
| dephosphorylation |
| protein amino acid dephosphorylation |
| metabolic process |
| cellular metabolic process |
|
| Cellular Location
|
- Cytoplasmic vesicle
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 3 |
| Locus
| 3p21.3 |
| SNPs
| PTPN23 |
| Gene Sequence
|
>4911 bp
ATGGAGGCCGTGCCCCGCATGCCCATGATCTGGCTGGACCTGAAGGAGGCCGGTGACTTT
CACTTCCAGCCAGCTGTGAAGAAGTTCGTCCTGAAGAATTATGGAGAGAACCCAGAAGCC
TACAATGAAGAACTGAAGAAGCTGGAGTTGCTCAGACAGAATGCTGTCCGTGTCCCACGA
GACTTTGAGGGCTGTAGTGTCCTCCGCAAGTACCTCGGCCAGCTTCATTACCTGCAGAGT
CGGGTCCCCATGGGCTCGGGCCAGGAGGCCGCTGTCCCTGTCACCTGGACAGAGATCTTC
TCAGGCAAGTCTGTGGCCCATGAGGACATCAAGTACGAGCAGGCCTGTATTCTCTACAAC
CTTGGAGCGCTGCACTCCATGCTGGGGGCCATGGACAAGCGGGTGTCTGAGGAGGGCATG
AAGGTCTCCTGTACCCATTTCCAGTGCGCAGCCGGCGCCTTCGCCTACCTACGGGAGCAC
TTCCCTCAAGCCTACAGCGTCGACATGAGCCGCCAGATCCTTACGCTCAACGTCAACCTC
ATGCTGGGCCAGGCTCAGGAGTGCCTCCTGGAGAAGTCGATGTTGGACAACAGGAAGAGC
TTTCTGGTGGCCCGCATCAGTGCACAGGTGGTAGATTACTACAAGGAGGCATGCCGGGCC
TTGGAGAACCCCGACACTGCCTCACTGCTGGGCCGGATCCAGAAGGACTGGAAGAAACTT
GTGCAGATGAAGATCTACTACTTCGCAGCCGTGGCTCATCTGCACATGGGAAAGCAGGCC
GAGGAGCAGCAGAAGTTCGGGGAGCGGGTTGCATACTTCCAGAGCGCCCTGGACAAGCTC
AATGAAGCCATCAAGTTGGCCAAGGGCCAGCCTGACACTGTGCAAGACGCGCTTCGCTTC
ACTATGGATGTCATTGGGGGAAAGTACAATTCTGCCAAGAAGGACAACGACTTCATTTAC
CATGAGGCTGTCCCAGCATTGGACACCCTTCAGCCTGTAAAAGGAGCCCCCTTGGTGAAG
CCCTTGCCAGTGAACCCCACAGACCCAGCTGTTACAGGCCCTGACATCTTTGCCAAACTG
GTACCCATGGCTGCCCACGAGGCCTCGTCACTGTACAGTGAGGAGAAGGCCAAGCTGCTC
CGGGAGATGATGGCCAAGATTGAGGACAAGAATGAGGTCCTGGACCAGTTCATGGATTCA
ATGCAGTTGGATCCCGAGACGGTGGACAACCTTGATGCCTACAGCCACATCCCACCCCAG
CTCATGGAGAAGTGCGCGGCTCTCAGCGTCCGGCCCGACACTGTCAGGAACCTTGTACAG
TCCATGCAAGTGCTGTCAGGTGTGTTCACGGATGTGGAGGCTTCCCTGAAGGACATCAGA
GATCTGTTGGAGGAGGATGAGCTGCTAGAGCAGAAGTTTCAGGAGGCGGTGGGCCAGGCA
GGGGCCATCTCCATCACCTCCAAGGCTGAGCTGGCAGAGGTGAGGCGAGAATGGGCCAAG
TACATGGAAGTCCATGAGAAGGCCTCCTTCACCAACAGTGAGCTGCACCGTGCCATGAAC
CTGCACGTCGGCAACCTGCGCCTGCTCAGCGGGCCGCTTGACCAGGTCCGGGCTGCCCTG
CCCACACCGGCCCTCTCCCCAGAGGACAAGGCCGTGCTGCAAAACCTAAAGCGCATCCTG
GCTAAGGTGCAGGAGATGCGGGACCAGCGCGTGTCCCTGGAGCAGCAGCTGCGTGAGCTT
ATCCAGAAAGATGACATCACTGCCTCGCTGGTCACCACAGACCACTCAGAGATGAAGAAG
TTGTTCGAGGAGCAGCTGAAAAAGTATGACCAGCTGAAGGTGTACCTGGAGCAGAACCTG
GCCGCCCAGGACCGTGTCCTCTGTGCACTGACAGAGGCCAACGTGCAGTACGCAGCCGTG
CGGCGGGTACTCAGCGACTTGGACCAAAAGTGGAACTCCACGCTGCAGACCCTGGTGGCC
TCGTATGAAGCCTATGAGGACCTGATGAAGAAGTCGCAGGAGGGCAGGGACTTCTACGCA
GATCTGGAGAGCAAGGTGGCTGCTCTGCTGGAGCGCACGCAGTCCACCTGCCAGGCCCGC
GAGGCTGCCCGCCAGCAGCTCCTGGACAGGGAGCTGAAGAAGAAGCCGCCGCCACGGCCC
ACAGCCCCAAAGCCGCTGCTGCCCCGCAGGGAGGAGAGTGAGGCAGTGGAAGCAGGAGAC
CCCCCTGAGGAGCTGCGCAGCCTCCCCCCTGACATGGTGGCTGGCCCACGACTGCCTGAC
ACCTTCCTGGGAAGTGCCACCCCGCTCCACTTTCCTCCCAGCCCCTTCCCCAGCTCCACA
GGCCCAGGACCCCACTATCTCTCAGGCCCCTTGCCCCCTGGTACCTACTCGGGCCCCACC
CAGCTGATACAGCCCAGGGCCCCAGGGCCCCATGCAATGCCCGTAGCACCTGGGCCTGCC
CTCTACCCAGCCCCTGCATACACACCGGAGCTGGGCCTTGTGCCCCGATCCTCCCCACAG
CATGGCGTGGTGAGCAGTCCCTATGTGGGGGTAGGGCCGGCCCCACCAGTTGCAGGTCTC
CCCTCGGCCCCACCTCCTCAATTCTCAGGCCCCGAGTTGGCCATGGCGGTTCGGCCAGCC
ACCACCACAGTAGATAGCATCCAGGCGCCCATCCCCAGCCACACAGCCCCACGGCCAAAC
CCCACCCCTGCTCCTCCCCCGCCCTGCTTCCCTGTGCCCCCACCGCAGCCACTGCCCACG
CCTTACACCTACCCTGCAGGGGCTAAGCAACCCATCCCAGCACAGCACCACTTCTCTTCT
GGGATCCCCGCAGGTTTTCCAGCCCCAAGGATTGGGCCCCAGCCCCAGCCCCATCCTCAG
CCCCATCCTTCACAAGCGTTTGGGCCTCAGCCCCCACAGCAGCCCCTTCCACTCCAGCAT
CCACATCTCTTCCCACCCCAGGCCCCAGGACTCCTACCCCCACAATCCCCCTACCCCTAT
GCCCCTCAGCCTGGGGTCCTGGGGCAGCCGCCACCCCCCCTACACACCCAGCTCTACCCA
GGTCCCGCTCAAGACCCTCTGCCAGCCCACTCAGGGGCTCTGCCTTTCCCCAGCCCTGGG
CCCCCTCAGCCTCCCCATCCCCCACTGGCATATGGTCCTGCCCCTTCTACCAGACCCATG
GGCCCCCAGGCAGCCCCTCTTACCATTCGAGGGCCCTCGTCTGCTGGCCAGTCCACCCCT
AGTCCCCACCTGGTGCCTTCACCTGCCCCATCTCCAGGGCCTGGTCCGGTACCCCCTCGC
CCCCCAGCAGCAGAACCACCCCCTTGCCTGCGCCGAGGCGCCGCAGCTGCAGACCTGCTC
TCCTCCAGCCCGGAGAGCCAGCATGGCGGCACTCAGTCTCCTGGGGGTGGGCAGCCCCTG
CTGCAGCCCACCAAGGTGGATGCAGCTGAGGGTCGTCGGCCGCAGGCCCTGCGGCTGATT
GAGCGGGACCCCTATGAGCATCCTGAGAGGCTGCGGCAGTTGCAGCAGGAGCTGGAGGCC
TTTCGGGGTCAGCTGGGGGATGTGGGAGCTCTGGACACTGTCTGGCGAGAGCTGCAAGAT
GCGCAGGAACATGATGCCCGAGGCCGTTCCATCGCCATTGCCCGCTGCTACTCACTGAAG
AACCGGCACCAGGATGTCATGCCCTATGACAGTAACCGTGTGGTGCTGCGCTCAGGCAAG
GATGACTACATCAATGCCAGCTGCGTGGAGGGGCTCTCCCCATACTGCCCCCCGCTAGTG
GCAACCCAGGCCCCACTGCCTGGCACAGCTGCTGACTTCTGGCTCATGGTCCATGAGCAG
AAAGTGTCAGTCATTGTCATGCTGGTTTCTGAGGCTGAGATGGAGAAGCAAAAAGTGGCA
CGCTACTTCCCCACCGAGAGGGGCCAGCCCATGGTGCACGGTGCCCTGAGCCTGGCATTG
AGCAGCGTCCGCAGCACCGAAACCCATGTGGAGCGCGTGCTGAGCCTGCAGTTCCGAGAC
CAGAGCCTCAAGCGCTCTCTTGTGCACCTGCACTTCCCCACTTGGCCTGAGTTAGGCCTG
CCCGACAGCCCCAGCAACTTGCTGCGCTTCATCCAGGAGGTGCACGCACATTACCTGCAT
CAGCGGCCGCTGCACACGCCCATCATTGTGCACTGCAGCTCTGGTGTGGGCCGCACGGGA
GCCTTTGCACTGCTCTATGCAGCTGTGCAGGAGGTGGAGGCTGGGAACGGAATCCCTGAG
CTGCCTCAGCTGGTGCGGCGCATGCGGCAGCAGAGAAAGCACATGCTGCAGGAGAAGCTG
CACCTCAGGTTCTGCTATGAGGCAGTGGTGAGACACGTGGAGCAGGTCCTGCAGCGCCAT
GGTGTGCCTCCTCCATGCAAACCCTTGGCCAGTGCAAGCATCAGCCAGAAGAACCACCTT
CCTCAGGACTCCCAGGACCTGGTCCTCGGTGGGGATGTGCCCATCAGCTCCATCCAGGCC
ACCATTGCCAAGCTCAGCATTCGGCCTCCTGGGGGGTTGGAGTCCCCGGTTGCCAGCTTG
CCAGGCCCTGCAGAGCCCCCAGGCCTCCCGCCAGCCAGCCTCCCAGAGTCTACCCCAATC
CCATCTTCCTCCCCACCCCCCCTTTCCTCCCCACTACCTGAGGCTCCCCAGCCTAAGGAG
GAGCCGCCAGTGCCTGAAGCCCCCAGCTCGGGGCCCCCCTCCTCCTCCCTGGAATTGCTG
GCCTCCTTGACCCCAGAGGCCTTCTCCCTGGACAGCTCCCTGCGGGGCAAACAGCGGATG
AGCAAGCATAACTTTCTGCAGGCCCATAACGGGCAAGGGCTGCGGGCCACCCGGCCCTCT
GACGACCCCCTCAGCCTTCTGGATCCACTCTGGACACTCAACAAGACCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 1636 |
| Molecular Weight
| 178971.945 |
| Theoretical pI
| 6.918 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Tyrosine-protein phosphatase non-receptor type 23
MEAVPRMPMIWLDLKEAGDFHFQPAVKKFVLKNYGENPEAYNEELKKLELLRQNAVRVPR
DFEGCSVLRKYLGQLHYLQSRVPMGSGQEAAVPVTWTEIFSGKSVAHEDIKYEQACILYN
LGALHSMLGAMDKRVSEEGMKVSCTHFQCAAGAFAYLREHFPQAYSVDMSRQILTLNVNL
MLGQAQECLLEKSMLDNRKSFLVARISAQVVDYYKEACRALENPDTASLLGRIQKDWKKL
VQMKIYYFAAVAHLHMGKQAEEQQKFGERVAYFQSALDKLNEAIKLAKGQPDTVQDALRF
TMDVIGGKYNSAKKDNDFIYHEAVPALDTLQPVKGAPLVKPLPVNPTDPAVTGPDIFAKL
VPMAAHEASSLYSEEKAKLLREMMAKIEDKNEVLDQFMDSMQLDPETVDNLDAYSHIPPQ
LMEKCAALSVRPDTVRNLVQSMQVLSGVFTDVEASLKDIRDLLEEDELLEQKFQEAVGQA
GAISITSKAELAEVRREWAKYMEVHEKASFTNSELHRAMNLHVGNLRLLSGPLDQVRAAL
PTPALSPEDKAVLQNLKRILAKVQEMRDQRVSLEQQLRELIQKDDITASLVTTDHSEMKK
LFEEQLKKYDQLKVYLEQNLAAQDRVLCALTEANVQYAAVRRVLSDLDQKWNSTLQTLVA
SYEAYEDLMKKSQEGRDFYADLESKVAALLERTQSTCQAREAARQQLLDRELKKKPPPRP
TAPKPLLPRREESEAVEAGDPPEELRSLPPDMVAGPRLPDTFLGSATPLHFPPSPFPSST
GPGPHYLSGPLPPGTYSGPTQLIQPRAPGPHAMPVAPGPALYPAPAYTPELGLVPRSSPQ
HGVVSSPYVGVGPAPPVAGLPSAPPPQFSGPELAMAVRPATTTVDSIQAPIPSHTAPRPN
PTPAPPPPCFPVPPPQPLPTPYTYPAGAKQPIPAQHHFSSGIPAGFPAPRIGPQPQPHPQ
PHPSQAFGPQPPQQPLPLQHPHLFPPQAPGLLPPQSPYPYAPQPGVLGQPPPPLHTQLYP
GPAQDPLPAHSGALPFPSPGPPQPPHPPLAYGPAPSTRPMGPQAAPLTIRGPSSAGQSTP
SPHLVPSPAPSPGPGPVPPRPPAAEPPPCLRRGAAAADLLSSSPESQHGGTQSPGGGQPL
LQPTKVDAAEGRRPQALRLIERDPYEHPERLRQLQQELEAFRGQLGDVGALDTVWRELQD
AQEHDARGRSIAIARCYSLKNRHQDVMPYDSNRVVLRSGKDDYINASCVEGLSPYCPPLV
ATQAPLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPTERGQPMVHGALSLAL
SSVRSTETHVERVLSLQFRDQSLKRSLVHLHFPTWPELGLPDSPSNLLRFIQEVHAHYLH
QRPLHTPIIVHCSSGVGRTGAFALLYAAVQEVEAGNGIPELPQLVRRMRQQRKHMLQEKL
HLRFCYEAVVRHVEQVLQRHGVPPPCKPLASASISQKNHLPQDSQDLVLGGDVPISSIQA
TIAKLSIRPPGGLESPVASLPGPAEPPGLPPASLPESTPIPSSSPPPLSSPLPEAPQPKE
EPPVPEAPSSGPPSSSLELLASLTPEAFSLDSSLRGKQRMSKHNFLQAHNGQGLRATRPS
DDPLSLLDPLWTLNKT
|
| External Links |
|---|
| GenBank ID Protein
| 11862816 |
| UniProtKB/Swiss-Prot ID
| Q9H3S7 |
| UniProtKB/Swiss-Prot Entry Name
| PTN23_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AB025194 |
| GeneCard ID
| PTPN23 |
| GenAtlas ID
| PTPN23 |
| HGNC ID
| HGNC:14406 |
| References |
|---|
| General References
| Not Available |