| Identification |
|---|
| HMDB Protein ID
| CDBP05124 |
| Secondary Accession Numbers
| Not Available |
| Name
| Ubiquitin carboxyl-terminal hydrolase 37 |
| Description
| Not Available |
| Synonyms
|
- Deubiquitinating enzyme 37
- Ubiquitin thiolesterase 37
- Ubiquitin-specific-processing protease 37
|
| Gene Name
| USP37 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in ubiquitin thiolesterase activity |
| Specific Function
| Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C- terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal) |
| GO Classification
|
| Function |
| hydrolase activity, acting on ester bonds |
| catalytic activity |
| hydrolase activity |
| ubiquitin thiolesterase activity |
| thiolester hydrolase activity |
| Process |
| modification-dependent protein catabolic process |
| ubiquitin-dependent protein catabolic process |
| metabolic process |
| catabolic process |
| macromolecule catabolic process |
| cellular macromolecule catabolic process |
| modification-dependent macromolecule catabolic process |
|
| Cellular Location
|
- Cytoplasmic
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:2 |
| Locus
| 2q35 |
| SNPs
| USP37 |
| Gene Sequence
|
>2940 bp
ATGTCTCCTCTGAAGATACATGGTCCTATCAGAATTCGAAGTATGCAGACTGGGATTACA
AAGTGGAAAGAAGGATCCTTTGAAATTGTAGAAAAAGAGAATAAAGTCAGCCTAGTAGTT
CACTACAATACTGGAGGAATTCCAAGGATATTTCAGCTAAGTCATAACATTAAAAATGTG
GTGCTTCGACCCAGTGGAGCGAAACAAAGCCGCCTAATGTTAACTCTGCAAGATAACAGC
TTCTTGTCTATTGACAAAGTACCAAGTAAGGATGCAGAGGAAATGAGGTTGTTTCTAGAT
GCAGTCCATCAAAACAGACTTCCTGCAGCCATGAAACCGTCTCAGGGGTCTGGTAGTTTT
GGAGCCATTCTGGGCAGCAGGACCTCACAGAAGGAAACCAGCAGGCAGCTTTCTTACTCA
GACAATCAGGCTTCTGCAAAAAGAGGAAGTTTGGAAACTAAAGATGATATTCCATTTCGA
AAAGTTCTTGGTAATCCGGGTAGAGGATCGATTAAGACTGTAGCAGGAAGTGGAATAGCT
CGGACGATTCCTTCTTTGACATCTACTTCAACACCTCTTAGATCAGGGTTGCTAGAAAAT
CGTACTGAAAAGAGGAAAAGAATGATATCAACTGGCTCAGAATTGAATGAAGATTACCCT
AAGGAAAATGATTCATCATCGAACAACAAGGCCATGACAGATCCCTCCAGAAAGTATTTA
ACCAGCAGTAGAGAAAAGCAGCTGAGTTTGAAACAGTCAGAAGAGAATAGGACATCAGGG
CTTTTACCTTTACAGTCATCATCCTTTTATGGTAGCAGAGCTGGATCCAAGGAACACTCT
TCTGGTGGCACTAACTTAGACAGGACTAATGTTTCAAGCCAGACTCCCTCTGCCAAAAGA
AGTTTGGGATTTCTTCCTCAGCCAGTTCCTCTTTCTGTTAAAAAACTGAGGTGTAACCAG
GATTACACTGGCTGGAATAAACCAAGAGTGCCCCTTTCCTCTCACCAACAGCAGCAACTG
CAGGGCTTCTCCAATTTGGGAAATACCTGCTATATGAATGCTATTCTACAATCTCTATTT
TCACTCCAGTCATTTGCAAATGACTTGCTTAAACAAGGTATCCCATGGAAGAAAATTCCA
CTCAATGCACTTATCAGACGCTTTGCACACTTGCTTGTTAAAAAAGATATCTGTAATTCA
GAGACCAAAAAGGATTTACTCAAGAAGGTTAAAAATGCCATTTCAGCTACAGCAGAGAGA
TTCTCTGGTTATATGCAGAATGATGCTCATGAATTTTTAAGTCAGTGTTTGGACCAGCTG
AAAGAAGATATGGAAAAATTAAATAAAACTTGGAAGACTGAACCTGTTTCTGGAGAAGAA
AATTCACCAGATATTTCAGCTACCAGAGCATACACTTGCCCTGTTATTACTAATTTGGAG
TTTGAGGTTCAGCACTCCATCATTTGTAAAGCATGTGGAGAGATTATCCCCAAAAGAGAA
CAGTTTAATGACCTCTCTATTGACCTTCCTCGTAGGAAAAAACCACTCCCTCCTCGTTCA
ATTCAAGATTCTCTTGATCTTTTCTTTAGGGCCGAAGAACTGGAGTATTCTTGTGAGAAG
TGTGGTGGGAAGTGTGCTCTTGTCAGGCACAAATTTAACAGGCTTCCTAGGGTCCTCATT
CTCCATTTGAAACGATATAGCTTCAATGTGGCTCTCTCGCTTAACAATAAGATTGGGCAG
CAAGTCATCATTCCAAGATACCTGACCCTGTCATCTCATTGCACTGAAAATACAAAACCA
CCTTTTACCCTTGGTTGGAGTGCACATATGGCAATTTCTAGACCATTGAAAGCCTCTCAA
ATGGTGAATTCCTGCATCACCAGCCCTTCTACACCTTCAAAGAAATTCACCTTCAAATCC
AAGAGCTCCTTGGCTTTATGCCTTGATTCAGACAGTGAGGATGAGCTAAAACGTTCTGTG
GCCCTCAGCCAGAGACTTTGTGAAATGTTAGGCAACGAACAGCAGCAGGAAGACCTGGAA
AAAGATTCAAAATTATGCCCAATAGAGCCTGACAAGTCTGAATTGGAAAACTCAGGATTT
GACAGAATGAGCGAAGAAGAGCTTCTAGCAGCTGTCTTGGAGATAAGTAAGAGAGATGCT
TCACCATCTCTGAGTCATGAAGATGATGATAAGCCAACTAGCAGCCCAGATACCGGATTT
GCAGAAGATGATATTCAAGAAATGCCAGAAAATCCAGACACTATGGAAACTGAGAAGCCC
AAAACAATCACAGAGCTGGATCCTGCCAGTTTTACTGAGATAACTAAAGACTGTGATGAG
AATAAAGAAAACAAAACTCCAGAAGGATCTCAGGGAGAAGTTGATTGGCTCCAGCAGTAT
GATATGGAGCGTGAAAGGGAAGAGCAAGAGCTTCAGCAGGCACTGGCTCAGAGCCTTCAA
GAGCAAGAGGCTTGGGAACAGAAAGAAGATGATGACCTCAAAAGAGCTACCGAGTTAAGT
CTTCAAGAGTTTAACAACTCCTTTGTGGATGCATTGGGTTCTGATGAGGACTCTGGAAAT
GAGGATGTTTTTGATATGGAGTACACAGAAGCTGAAGCTGAGGAACTGAAAAGAAATGCT
GAGACAGGAAATCTGCCTCATTCGTACCGGCTCATCAGTGTTGTCAGTCACATTGGTAGC
ACTTCTTCTTCAGGTCATTACATTAGTGATGTATATGACATTAAGAAGCAAGCGTGGTTT
ACTTACAATGACCTGGAGGTATCAAAAATCCAAGAGGCTGCCGTGCAGAGTGATCGAGAT
CGGAGTGGCTACATCTTCTTTTATATGCACAAGGAGATCTTTGATGAGCTGCTGGAAACA
GAAAAGAACTCTCAGTCACTTAGCACGGAAGTGGGGAAGACTACCCGTCAGGCCTCGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 979 |
| Molecular Weight
| 110168.6 |
| Theoretical pI
| 6.1 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Ubiquitin carboxyl-terminal hydrolase 37
MSPLKIHGPIRIRSMQTGITKWKEGSFEIVEKENKVSLVVHYNTGGIPRIFQLSHNIKNV
VLRPSGAKQSRLMLTLQDNSFLSIDKVPSKDAEEMRLFLDAVHQNRLPAAMKPSQGSGSF
GAILGSRTSQKETSRQLSYSDNQASAKRGSLETKDDIPFRKVLGNPGRGSIKTVAGSGIA
RTIPSLTSTSTPLRSGLLENRTEKRKRMISTGSELNEDYPKENDSSSNNKAMTDPSRKYL
TSSREKQLSLKQSEENRTSGLLPLQSSSFYGSRAGSKEHSSGGTNLDRTNVSSQTPSAKR
SLGFLPQPVPLSVKKLRCNQDYTGWNKPRVPLSSHQQQQLQGFSNLGNTCYMNAILQSLF
SLQSFANDLLKQGIPWKKIPLNALIRRFAHLLVKKDICNSETKKDLLKKVKNAISATAER
FSGYMQNDAHEFLSQCLDQLKEDMEKLNKTWKTEPVSGEENSPDISATRAYTCPVITNLE
FEVQHSIICKACGEIIPKREQFNDLSIDLPRRKKPLPPRSIQDSLDLFFRAEELEYSCEK
CGGKCALVRHKFNRLPRVLILHLKRYSFNVALSLNNKIGQQVIIPRYLTLSSHCTENTKP
PFTLGWSAHMAISRPLKASQMVNSCITSPSTPSKKFTFKSKSSLALCLDSDSEDELKRSV
ALSQRLCEMLGNEQQQEDLEKDSKLCPIEPDKSELENSGFDRMSEEELLAAVLEISKRDA
SPSLSHEDDDKPTSSPDTGFAEDDIQEMPENPDTMETEKPKTITELDPASFTEITKDCDE
NKENKTPEGSQGEVDWLQQYDMEREREEQELQQALAQSLQEQEAWEQKEDDDLKRATELS
LQEFNNSFVDALGSDEDSGNEDVFDMEYTEAEAEELKRNAETGNLPHSYRLISVVSHIGS
TSSSGHYISDVYDIKKQAWFTYNDLEVSKIQEAAVQSDRDRSGYIFFYMHKEIFDELLET
EKNSQSLSTEVGKTTRQAL
|
| External Links |
|---|
| GenBank ID Protein
| 188497648 |
| UniProtKB/Swiss-Prot ID
| Q86T82 |
| UniProtKB/Swiss-Prot Entry Name
| UBP37_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_020935.2 |
| GeneCard ID
| USP37 |
| GenAtlas ID
| USP37 |
| HGNC ID
| HGNC:20063 |
| References |
|---|
| General References
| Not Available |