Identification |
HMDB Protein ID
| CDBP05114 |
Secondary Accession Numbers
| Not Available |
Name
| Ubiquitin carboxyl-terminal hydrolase 38 |
Description
| Not Available |
Synonyms
|
- Deubiquitinating enzyme 38
- HP43.8KD
- Ubiquitin thiolesterase 38
- Ubiquitin-specific-processing protease 38
|
Gene Name
| USP38 |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in ubiquitin thiolesterase activity |
Specific Function
| Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C- terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal) |
GO Classification
|
Function |
hydrolase activity, acting on ester bonds |
catalytic activity |
hydrolase activity |
ubiquitin thiolesterase activity |
thiolester hydrolase activity |
Process |
metabolic process |
catabolic process |
macromolecule catabolic process |
cellular macromolecule catabolic process |
modification-dependent macromolecule catabolic process |
modification-dependent protein catabolic process |
ubiquitin-dependent protein catabolic process |
|
Cellular Location
|
- Cytoplasmic
|
Pathways
|
Not Available
|
Gene Properties |
Chromosome Location
| Not Available |
Locus
| Not Available |
SNPs
| USP38 |
Gene Sequence
|
>3129 bp
ATGGACAAGATCCTGGAGGGCCTTGTGAGTTCCTCGCATCCCCTGCCCCTCAAGCGGGTG
ATTGTGCGGAAGGTGGTGGAATCGGCGGAGCACTGGCTAGACGAGGCGCAGTGCGAGGCC
ATGTTTGACCTGACGACCCGGCTCATCCTGGAGGGCCAGGACCCTTTCCAGCGGCAGGTG
GGGCACCAGGTGCTGGAGGCCTACGCACGATACCACCGGCCAGAGTTCGAGTCCTTCTTC
AACAAGACCTTCGTGTTGGGCCTCCTTCATCAGGGCTACCACTCTCTGGACAGGAAGGAT
GTAGCCATCCTGGACTACATTCACAACGGCCTGAAGCTGATTATGAGCTGTCCGTCGGTG
CTGGATCTCTTTAGCCTCCTGCAGGTAGAGGTGTTACGGATGGTGTGTGAGAGGCCGGAG
CCGCAGCTCTGTGCCCGACTGAGCGACCTTCTGACCGACTTTGTGCAATGCATCCCCAAG
GGGAAATTGTCCATCACGTTCTGTCAACAGCTGGTTCGAACGATAGGCCATTTCCAGTGC
GTGTCCACCCAGGAAAGAGAGCTGCGGGAATATGTCTCCCAGGTGACAAAAGTGAGTAAC
TTGCTGCAGAACATCTGGAAGGCCGAGCCTGCCACACTACTGCCTTCCCTGCAAGAAGTT
TTTGCAAGCATCTCTTCCACAGATGCATCATTTGAACCTTCTGTAGCATTGGCAAGCCTT
GTGCAGCATATTCCTCTTCAGATGATTACAGTTCTCATCAGGAGCCTTACTACGGATCCA
AATGTAAAAGATGCAAGTATGACCCAAGCCCTTTGCAGAATGATTGACTGGCTATCCTGG
CCATTGGCTCAGCATGTGGATACATGGGTAATTGCACTCCTGAAAGGACTGGCAGCTGTC
CAGAAGTTTACTATTTTGATAGATGTTACTTTGCTGAAAATAGAACTGGTTTTTAATCGA
CTTTGGTTTCCTCTTGTGAGACCTGGTGCTCTTGCAGTTCTTTCTCACATGCTGCTTAGC
TTTCAGCATTCTCCAGAGGCGTTCCATTTGATTGTTCCTCATGTGGTTAATTTGGTTCAT
TCTTTCAAAAATGATGGTCTGCCTTCAAGTACAGCCTTCTTAGTACAATTAACAGAATTG
ATACACTGTATGATGTATCATTATTCTGGATTTCCAGATCTCTATGAACCTATTCTGGAG
GCAATAAAGGATTTTCCTAAGCCCAGTGAAGAGAAGATTAAGTTAATTCTCAATCAAAGT
GCCTGGACTTCTCAATCCAATTCTTTGGCGTCTTGCTTGTCTAGACTTTCTGGAAAATCT
GAAACTGGGAAAACTGGTCTTATTAACCTAGGAAATACATGTTATATGAACAGTGTTATA
CAAGCCTTGTTTATGGCCACAGATTTCAGGAGACAAGTATTATCTTTAAATCTAAATGGG
TGCAATTCATTAATGAAAAAATTACAGCATCTTTTTGCCTTTCTGGCCCATACACAGAGG
GAAGCATACGCACCTCGGATATTCTTTGAGGCTTCCAGACCTCCATGGTTTACTCCCAGA
TCACAGCAAGACTGTTCTGAATACCTCAGATTTCTCCTTGACAGGCTCCATGAAGAAGAA
AAGATCTTGAAAGTTCAGGCCTCACACAAGCCTTCTGAAATTCTGGAATGCAGTGAAACT
TCTTTACAGGAAGTAGCTAGTAAAGCAGCAGTACTAACAGAGACCCCTCGTACAAGTGAC
GGTGAGAAGACTTTAATAGAAAAAATGTTTGGAGGAAAACTACGAACTCACATACGTTGT
TTGAACTGCAGGAGTACCTCACAAAAAGTGGAAGCCTTTACAGATCTTTCGCTTGCCTTT
TGTCCTTCCTCTTCTTTGGAAAACATGTCTGTCCAAGATCCAGCATCATCACCCAGTATA
CAAGATGGTGGTCTAATGCAAGCCTCTGTACCCGGTCCTTCAGAAGAACCAGTAGTTTAT
AATCCAACAACAGCTGCCTTCATCTGTGACTCACTTGTGAATGAAAAAACCATAGGCAGT
CCTCCTAATGAGTTTTACTGTTCTGAAAACACTTCTGTCCCTAACGAATCTAACAAGATT
CTTGTTAATAAAGATGTACCTCAGAAACCAGGAGGTGAAACCACACCTTCAGTAACTGAC
TTACTAAATTATTTTTTGGCTCCAGAGATTCTTACTGGTGATAACCAATATTATTGTGAA
AACTGTGCCTCTCTGCAAAATGCTGAGAAAACTATGCAAATCACGGAGGAACCTGAATAC
CTTATTCTTACTCTCCTGAGATTTTCATATGATCAGAAGTATCATGTGAGAAGGAAAATT
TTAGACAATGTATCACTGCCACTGGTTTTGGAGTTGCCAGTTAAAAGAATTACTTCTTTC
TCTTCATTGTCAGAAAGTTGGTCTGTAGATGTTGACTTCACTGATCTTAGTGAGAACCTT
GCTAAAAAATTAAAGCCTTCAGGGACTGATGAAGCTTCCTGCACAAAATTGGTGCCCTAT
CTATTAAGTTCCGTTGTGGTTCACTCTGGTATATCCTCTGAAAGTGGGCATTACTATTCT
TATGCCAGGAATATCACAAGTACAGACTCTTCATATCAGATGTACCACCAGTCTGAGGCT
CTGGCATTAGCATCCTCCCAGAGTCATTTACTAGGGAGAGATAGTCCCAGTGCAGTTTTT
GAACAGGATTTGGAAAATAAGGAAATGTCAAAAGAATGGTTTTTATTTAATGACAGTAGA
GTGACATTTACTTCATTTCAGTCAGTCCAGAAAATTACGAGCAGGTTTCCAAAGGACACA
GCTTATGTGCTTTTGTATAAAAAACAGCATAGTACTAATGGTTTAAGTGGTAATAACCCA
ACCAGTGGACTCTGGATAAATGGAGACCCACCTCTACAGAAAGAACTTATGGATGCTATA
ACAAAAGACAATAAACTATATTTACAGGAACAAGAGTTGAATGCTCGAGCCCGGGCCCTC
CAAGCTGCATCTGCTTCATGTTCATTTCGGCCCAATGGATTTGATGACAACGACCCACCA
GGAAGCTGTGGACCAACTGGTGGAGGGGGTGGAGGAGGATTTAATACAGTTGGCAGACTC
GTATTTTGA
|
Protein Properties |
Number of Residues
| 1042 |
Molecular Weight
| 116545.0 |
Theoretical pI
| 6.16 |
Pfam Domain Function
|
|
Signals
|
|
Transmembrane Regions
|
|
Protein Sequence
|
>Ubiquitin carboxyl-terminal hydrolase 38
MDKILEGLVSSSHPLPLKRVIVRKVVESAEHWLDEAQCEAMFDLTTRLILEGQDPFQRQV
GHQVLEAYARYHRPEFESFFNKTFVLGLLHQGYHSLDRKDVAILDYIHNGLKLIMSCPSV
LDLFSLLQVEVLRMVCERPEPQLCARLSDLLTDFVQCIPKGKLSITFCQQLVRTIGHFQC
VSTQERELREYVSQVTKVSNLLQNIWKAEPATLLPSLQEVFASISSTDASFEPSVALASL
VQHIPLQMITVLIRSLTTDPNVKDASMTQALCRMIDWLSWPLAQHVDTWVIALLKGLAAV
QKFTILIDVTLLKIELVFNRLWFPLVRPGALAVLSHMLLSFQHSPEAFHLIVPHVVNLVH
SFKNDGLPSSTAFLVQLTELIHCMMYHYSGFPDLYEPILEAIKDFPKPSEEKIKLILNQS
AWTSQSNSLASCLSRLSGKSETGKTGLINLGNTCYMNSVIQALFMATDFRRQVLSLNLNG
CNSLMKKLQHLFAFLAHTQREAYAPRIFFEASRPPWFTPRSQQDCSEYLRFLLDRLHEEE
KILKVQASHKPSEILECSETSLQEVASKAAVLTETPRTSDGEKTLIEKMFGGKLRTHIRC
LNCRSTSQKVEAFTDLSLAFCPSSSLENMSVQDPASSPSIQDGGLMQASVPGPSEEPVVY
NPTTAAFICDSLVNEKTIGSPPNEFYCSENTSVPNESNKILVNKDVPQKPGGETTPSVTD
LLNYFLAPEILTGDNQYYCENCASLQNAEKTMQITEEPEYLILTLLRFSYDQKYHVRRKI
LDNVSLPLVLELPVKRITSFSSLSESWSVDVDFTDLSENLAKKLKPSGTDEASCTKLVPY
LLSSVVVHSGISSESGHYYSYARNITSTDSSYQMYHQSEALALASSQSHLLGRDSPSAVF
EQDLENKEMSKEWFLFNDSRVTFTSFQSVQKITSRFPKDTAYVLLYKKQHSTNGLSGNNP
TSGLWINGDPPLQKELMDAITKDNKLYLQEQELNARARALQAASASCSFRPNGFDDNDPP
GSCGPTGGGGGGGFNTVGRLVF
|
External Links |
GenBank ID Protein
| 27545313 |
UniProtKB/Swiss-Prot ID
| Q8NB14 |
UniProtKB/Swiss-Prot Entry Name
| UBP38_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| NM_032557.5 |
GeneCard ID
| USP38 |
GenAtlas ID
| USP38 |
HGNC ID
| HGNC:20067 |
References |
General References
| Not Available |