Showing Protein Hyaluronan-binding protein 2 (CDBP05111)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 0 compounds
Identification
HMDB Protein ID CDBP05111
Secondary Accession Numbers Not Available
Name Hyaluronan-binding protein 2
Description Not Available
Synonyms
  1. FSAP
  2. Factor VII-activating protease
  3. Factor seven-activating protease
  4. Hepatocyte growth factor activator-like protein
  5. Hyaluronan-binding protein 2 27 kDa light chain
  6. Hyaluronan-binding protein 2 27 kDa light chain alternate form
  7. Hyaluronan-binding protein 2 50 kDa heavy chain
  8. Hyaluronan-binding protein 2 50 kDa heavy chain alternate form
  9. Plasma hyaluronan-binding protein
Gene Name HABP2
Protein Type Enzyme
Biological Properties
General Function Involved in serine-type endopeptidase activity
Specific Function Cleaves the alpha-chain at multiple sites and the beta- chain between 'Lys-53' and 'Lys-54' but not the gamma-chain of fibrinogen and therefore does not initiate the formation of the fibrin clot and does not cause the fibrinolysis directly. It does not cleave (activate) prothrombin and plasminogen but converts the inactive single chain urinary plasminogen activator (pro- urokinase) to the active two chain form. Activates coagulation factor VII
GO Classification
Function
endopeptidase activity
serine-type endopeptidase activity
catalytic activity
hydrolase activity
peptidase activity
peptidase activity, acting on l-amino acid peptides
Process
proteolysis
metabolic process
macromolecule metabolic process
protein metabolic process
Cellular Location
  1. Secreted
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 10q25.3
SNPs HABP2
Gene Sequence 
>1683 bp
ATGTTTGCCAGGATGTCTGATCTCCATGTTCTGCTGTTAATGGCTCTGGTGGGAAAGACA
GCCTGTGGGTTCTCCCTGATGTCTTTATTGGAAAGCCTGGACCCAGACTGGACCCCTGAC
CAGTATGATTACAGCTACGAGGATTATAATCAGGAAGAGAACACCAGTAGCACACTTACC
CATGCTGAGAATCCTGACTGGTACTACACTGAGGACCAAGCTGATCCATGCCAGCCCAAC
CCCTGTGAACACGGTGGGGACTGCCTCGTCCATGGGAGCACCTTCACATGCAGCTGCCTG
GCTCCTTTCTCTGGGAATAAGTGTCAGAAAGTGCAAAATACGTGCAAGGACAACCCATGT
GGCCGGGGCCAATGTCTCATTACCCAGAGTCCTCCCTACTACCGCTGTGTCTGTAAACAC
CCTTACACAGGTCCCAGCTGCTCCCAAGTGGTTCCTGTATGCAGGCCAAACCCCTGCCAG
AATGGGGCTACCTGCTCCCGGCATAAGCGGAGATCCAAGTTCACCTGTGCCTGTCCCGAC
CAGTTCAAGGGGAAATTCTGTGAAATAGGTTCTGATGACTGCTATGTTGGCGATGGCTAC
TCTTACCGAGGGAAAATGAATAGGACAGTCAACCAGCATGCGTGCCTTTACTGGAACTCC
CACCTCCTCTTGCAGGAGAATTACAACATGTTTATGGAGGATGCTGAAACCCATGGGATT
GGGGAACACAATTTCTGCAGAAACCCAGATGCGGACGAAAAGCCCTGGTGCTTTATTAAA
GTTACCAATGACAAGGTGAAATGGGAATACTGTGATGTCTCAGCCTGCTCAGCCCAGGAC
GTTGCCTACCCAGAGGAAAGCCCCACTGAGCCATCAACCAAGCTTCCGGGGTTTGACTCC
TGTGGAAAGACTGAGATAGCAGAGAGGAAGATCAAGAGAATCTATGGAGGCTTTAAGAGC
ACGGCGGGCAAGCACCCATGGCAGGCGTCCCTCCAGTCCTCGCTGCCTCTGACCATCTCC
ATGCCCCAGGGCCACTTCTGTGGTGGGGCGCTGATCCACCCCTGCTGGGTGCTCACTGCT
GCCCACTGCACCGACATAAAAACCAGACATCTAAAGGTGGTGCTAGGGGACCAGGACCTG
AAGAAAGAAGAATTTCATGAGCAGAGCTTTAGGGTGGAGAAGATATTCAAGTACAGCCAC
TACAATGAAAGAGATGAGATTCCCCACAATGATATTGCATTGCTCAAGTTAAAGCCAGTG
GATGGTCACTGTGCTCTAGAATCCAAATACGTGAAGACTGTGTGCTTGCCTGATGGGTCC
TTTCCCTCTGGGAGTGAGTGCCACATCTCTGGCTGGGGTGTTACAGAAACAGGAAAAGGG
TCCCGCCAGCTCCTGGATGCCAAAGTCAAGCTGATTGCCAACACTTTGTGCAACTCCCGC
CAACTCTATGACCACATGATTGATGACAGTATGATCTGTGCAGGAAATCTTCAGAAACCT
GGGCAAGACACCTGCCAGGGTGACTCTGGAGGCCCCCTGACCTGTGAGAAGGACGGCACC
TACTACGTCTATGGGATAGTGAGCTGGGGCCTGGAGTGTGGGAAGAGGCCAGGGGTCTAC
ACCCAAGTTACCAAATTCCTGAATTGGATCAAAGCCACCATCAAAAGTGAAAGTGGCTTC
TAA
Protein Properties
Number of Residues 560
Molecular Weight 62671.3
Theoretical pI 6.52
Pfam Domain Function
Signals
  • ["1-23"]
Transmembrane Regions
  • ["None"]
Protein Sequence 
>Hyaluronan-binding protein 2
MFARMSDLHVLLLMALVGKTACGFSLMSLLESLDPDWTPDQYDYSYEDYNQEENTSSTLT
HAENPDWYYTEDQADPCQPNPCEHGGDCLVHGSTFTCSCLAPFSGNKCQKVQNTCKDNPC
GRGQCLITQSPPYYRCVCKHPYTGPSCSQVVPVCRPNPCQNGATCSRHKRRSKFTCACPD
QFKGKFCEIGSDDCYVGDGYSYRGKMNRTVNQHACLYWNSHLLLQENYNMFMEDAETHGI
GEHNFCRNPDADEKPWCFIKVTNDKVKWEYCDVSACSAQDVAYPEESPTEPSTKLPGFDS
CGKTEIAERKIKRIYGGFKSTAGKHPWQASLQSSLPLTISMPQGHFCGGALIHPCWVLTA
AHCTDIKTRHLKVVLGDQDLKKEEFHEQSFRVEKIFKYSHYNERDEIPHNDIALLKLKPV
DGHCALESKYVKTVCLPDGSFPSGSECHISGWGVTETGKGSRQLLDAKVKLIANTLCNSR
QLYDHMIDDSMICAGNLQKPGQDTCQGDSGGPLTCEKDGTYYVYGIVSWGLECGKRPGVY
TQVTKFLNWIKATIKSESGF
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q14520
UniProtKB/Swiss-Prot Entry Name HABP2_HUMAN
PDB IDs Not Available
GenBank Gene ID S83182
GeneCard ID HABP2
GenAtlas ID HABP2
HGNC ID HGNC:4798
References
General References Not Available